ES2036149A6 - Procedimiento de sintesis de antibioticos semiestaticos en sistemas termodinamicamente controlados agua-cosolventes organicos miscibles apolares con el empleo de penicilina g acilasa. - Google Patents

Procedimiento de sintesis de antibioticos semiestaticos en sistemas termodinamicamente controlados agua-cosolventes organicos miscibles apolares con el empleo de penicilina g acilasa.

Info

Publication number
ES2036149A6
ES2036149A6 ES8904193A ES8904193A ES2036149A6 ES 2036149 A6 ES2036149 A6 ES 2036149A6 ES 8904193 A ES8904193 A ES 8904193A ES 8904193 A ES8904193 A ES 8904193A ES 2036149 A6 ES2036149 A6 ES 2036149A6
Authority
ES
Spain
Prior art keywords
acylase
penicillin
synthesis
semi
cosolvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES8904193A
Other languages
English (en)
Inventor
Jose M Guisan
Roberto Fernandez-Lafuente
Gregorio Alvaro
Rosa M Blanco
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Consejo Superior de Investigaciones Cientificas CSIC
Original Assignee
Consejo Superior de Investigaciones Cientificas CSIC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8265139&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2036149(A6) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Consejo Superior de Investigaciones Cientificas CSIC filed Critical Consejo Superior de Investigaciones Cientificas CSIC
Priority to ES8904193A priority Critical patent/ES2036149A6/es
Priority to AU69602/91A priority patent/AU6960291A/en
Priority to PCT/ES1990/000046 priority patent/WO1991009136A1/es
Priority to DE69032467T priority patent/DE69032467T2/de
Priority to EP91900808A priority patent/EP0458932B2/en
Priority to AT91900808T priority patent/ATE168134T1/de
Priority to US07/767,044 priority patent/US5268271A/en
Publication of ES2036149A6 publication Critical patent/ES2036149A6/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SINTESIS DE ANTIBIOTICOS SEMISINTETICOS MONOBACTAMICOS O BLACTAMICOS CON EL EMPLEO DE DERIVADOS ESTABILIZADOS POR DISTINTOS METODOS DE PENICILINA G ACILASA DE DISTINTAS FUENTES MICROBIANAS SEGUN UNA ESTRATEGIA TERMODINAMICAMENTE CONTROLADA EN SISTEMAS MONOFASICOS AGUA/CONSOLVENTES ORGANICOS APOLARES, DONDE LA CONCENTRACION DEL COSOLVENTE OSCILA ENTRE EL 30% Y EL 90%, LA TEMPERATURA ENTRE -10GC Y 50GC, EL PH ENTRE 4,5 Y 8,5 CON UNAS CONCENTRACIONES DE NUCLEO ANTIBIOTICO ENTRE 0,5 Y 875 MM Y DE DONADOR DE ACILO ENTRE 0,2 MM Y 1 M, CON UNA RELACION ANILLO ANTIBIOTICO/DONADOR DE ACILO LIBRE O ACTIVADO, USANDO TAMPON ENTRE 0 Y 1 M. DE APLICACION EN LA INDUSTRIA FARMACEUTICA.
ES8904193A 1989-12-12 1989-12-12 Procedimiento de sintesis de antibioticos semiestaticos en sistemas termodinamicamente controlados agua-cosolventes organicos miscibles apolares con el empleo de penicilina g acilasa. Expired - Fee Related ES2036149A6 (es)

Priority Applications (7)

Application Number Priority Date Filing Date Title
ES8904193A ES2036149A6 (es) 1989-12-12 1989-12-12 Procedimiento de sintesis de antibioticos semiestaticos en sistemas termodinamicamente controlados agua-cosolventes organicos miscibles apolares con el empleo de penicilina g acilasa.
AU69602/91A AU6960291A (en) 1989-12-12 1990-12-12 Method for the synthesis of semi-synthetic antibiotics in thermodynamically controlled water-cosolvent organic miscible apolar systems by using penicillin g acylase
PCT/ES1990/000046 WO1991009136A1 (es) 1989-12-12 1990-12-12 Procedimiento de sintesis de antibioticos semisinteticos en sistemas termodinamicamente controlados agua-cosolventes organicos miscibles apolares con el empleo de penicilina g acilasa
DE69032467T DE69032467T2 (de) 1989-12-12 1990-12-12 Verfahren zur herstellung von semisynthetischen antibiotika unter thermodynamisch kontrollierten bedingungen, in einem reaktionsmedium, das organische apolare wasserlösliche lösungsmittel enthält unter verwendung von penicillin g-acylase
EP91900808A EP0458932B2 (en) 1989-12-12 1990-12-12 Method for the synthesis of semi-synthetic antibiotics in thermodynamically controlled water-cosolvent organic miscible apolar systems by using penicillin g acylase
AT91900808T ATE168134T1 (de) 1989-12-12 1990-12-12 Verfahren zur herstellung von semisynthetischen antibiotika unter thermodynamisch kontrollierten bedingungen, in einem reaktionsmedium, das organische apolare wasserlösliche lösungsmittel enthält unter verwendung von penicillin g-acylase
US07/767,044 US5268271A (en) 1989-12-12 1991-08-02 Method for the synthesis of semi-synthetic antibiotics in thermodynamically controlled water-cosolvent organic miscible apolar systems by using penicillin G acylase

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES8904193A ES2036149A6 (es) 1989-12-12 1989-12-12 Procedimiento de sintesis de antibioticos semiestaticos en sistemas termodinamicamente controlados agua-cosolventes organicos miscibles apolares con el empleo de penicilina g acilasa.

Publications (1)

Publication Number Publication Date
ES2036149A6 true ES2036149A6 (es) 1993-05-01

Family

ID=8265139

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8904193A Expired - Fee Related ES2036149A6 (es) 1989-12-12 1989-12-12 Procedimiento de sintesis de antibioticos semiestaticos en sistemas termodinamicamente controlados agua-cosolventes organicos miscibles apolares con el empleo de penicilina g acilasa.

Country Status (7)

Country Link
US (1) US5268271A (es)
EP (1) EP0458932B2 (es)
AT (1) ATE168134T1 (es)
AU (1) AU6960291A (es)
DE (1) DE69032467T2 (es)
ES (1) ES2036149A6 (es)
WO (1) WO1991009136A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE317912T1 (de) * 1990-07-04 2006-03-15 Dsm Ip Assets Bv Verfahren zur herstellung von beta-lactamen
IT1243800B (it) * 1990-08-28 1994-06-28 Sclavo Spa Procedimento migliorato per la preparazione di cefalosporine
EP0734452A1 (en) * 1994-06-10 1996-10-02 Gist-Brocades B.V. Improved acylation method for penicillins and cephalosporins
US6048708A (en) * 1994-07-18 2000-04-11 Gist-Brocades B.V. Process for preparation of β-lactams at constantly high concentration of reactants
BE1009071A3 (nl) * 1995-02-02 1996-11-05 Dsm Nv Werkwijze voor de bereiding van een beta-lactam antibioticum.
DK0730036T3 (da) * 1995-02-28 2000-07-24 Acs Dobfar Spa Fremgangsmåde til enzymatisk syntese af Beta-lactamantibiotika i nærvær af en enzyminhibitor
EP1394262A1 (en) * 2002-08-30 2004-03-03 Bioferma Murcia, S.A. An enzymatic process for preparing beta-lactams
BRPI0205242B1 (pt) * 2002-11-29 2015-06-30 Fundação Universidade Fed De São Carlos Processo para a proteção de biocatalisadores enzimáticos insolúveis, biocatalisador obtido e biorreator com o biocatalisador imobilizado
NO329007B1 (no) * 2008-05-19 2010-07-19 Tor Mikal Ostervold Fremgangsmate og apparat til rengjoring av flater

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT233739B (de) * 1962-02-14 1964-05-25 Biochemie Gmbh Verfahren zur Heranführung von Fusarien oder Hefen für die enzymatische Spaltung von Phenoxymethylpenicillin
ES396745A1 (es) * 1970-11-07 1974-06-01 Alfa Farmaceutici Spa Procedimiento enzimatico para la preparacion de penicili- nas semisinteticas.
FR2188608A5 (en) * 1972-06-14 1974-01-18 Aries Robert Penicillins prepn by acylating 6-apa - in presence of catalytic enzymes using free acids
US3925157A (en) * 1972-07-12 1975-12-09 Pfizer Immobilized enzymes
JPS5417030B2 (es) * 1972-12-06 1979-06-27
US4167446A (en) * 1973-03-15 1979-09-11 Bayer Aktiengesellschaft Water soluble carrier-bound penicillinacylase
GB1463513A (en) * 1974-08-13 1977-02-02 Beecham Group Ltd Enzymes
GB2021119A (en) * 1978-04-19 1979-11-28 Novo Industri As Penicillin V-acylase
JPS5645196A (en) * 1979-09-19 1981-04-24 Shionogi & Co Ltd Enzymatic synthesis of beta-lactam antibacterial agent
US4693977A (en) * 1982-08-23 1987-09-15 Queen's University At Kingston Enzyme immobilization for producing cephalosporin antibiotics
JPS6066981A (ja) * 1983-09-12 1985-04-17 アメリカン・ホ−ム・プロダクツ・コ−ポレイシヨン 不溶化ペニシリンアミダ−ゼおよびその製法
DE3507403A1 (de) * 1985-03-02 1986-09-04 Hoechst Ag, 6230 Frankfurt Enzymatische semisynthese von ss-lactamantibiotika
IT1224252B (it) * 1988-04-08 1990-09-26 Sclavo Spa Metodo di protezione del gruppo carbossilico nella chimica dei composti beta lattamici
US5104800A (en) * 1989-06-27 1992-04-14 Merck & Co., Inc. One-step cephalosporin c amidase enzyme

Also Published As

Publication number Publication date
DE69032467D1 (de) 1998-08-13
WO1991009136A1 (es) 1991-06-27
ATE168134T1 (de) 1998-07-15
DE69032467T2 (de) 1999-01-14
US5268271A (en) 1993-12-07
AU6960291A (en) 1991-07-18
EP0458932B2 (en) 2003-12-17
EP0458932B1 (en) 1998-07-08
EP0458932A1 (en) 1991-12-04

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Date Code Title Description
FD1A Patent lapsed

Effective date: 20020617