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The compounds and the method for their preparation are applicable in the pharmaceutical industry for preparation of antibacterial agents. The cephem derivatives of 5-carboxy-2-benzoxazolon have the following general formula:<IMAGE>where R represents hydrogen, acetoxy group, 1-methyl-1H-tetrazol-5-ylthio group; R1 is methyl or ethyl group; R2 is -NH-CH/Ph/-CO group or has no substitute. Following the method, 7-aminodesacetoxycephalosporanic acid, 7-aminocephalosporanic acid, 7-amino-3-/1-methyl-1H-tetrazol-5-ylthiomethyl/-3- cephem-4-carboxylic acid and cephalexin is acylated with N-alkyl-5-carboxy-2-benzoxazolon in organic solvent medium at a low temperature of -5 to -10 degrees C.
BG9481291A1991-07-161991-07-16Cephem derivatives of 5-carboxy-2-benzoxazolon and a method for their production
BG51517A1
(en)
Method for the synthesis of semi-synthetic antibiotics in thermodynamically controlled water-cosolvent organic miscible apolar systems by using penicillin g acylase.