BG51517A1 - Cephem derivatives of 5-carboxy-2-benzoxazolon and a method for their production - Google Patents

Cephem derivatives of 5-carboxy-2-benzoxazolon and a method for their production

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Publication number
BG51517A1
BG51517A1 BG9481291A BG9481291A BG51517A1 BG 51517 A1 BG51517 A1 BG 51517A1 BG 9481291 A BG9481291 A BG 9481291A BG 9481291 A BG9481291 A BG 9481291A BG 51517 A1 BG51517 A1 BG 51517A1
Authority
BG
Bulgaria
Prior art keywords
benzoxazolon
carboxy
methyl
group
cephem
Prior art date
Application number
BG9481291A
Inventor
Veneta B Kalcheva
Zoja P Mincheva
Veselina B Chavdarova
Evgeni V Golovinski
Svoboda V Tabakova
Original Assignee
Univ Sofijski Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Sofijski Tech filed Critical Univ Sofijski Tech
Priority to BG9481291A priority Critical patent/BG51517A1/en
Publication of BG51517A1 publication Critical patent/BG51517A1/en

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  • Cephalosporin Compounds (AREA)

Abstract

The compounds and the method for their preparation are applicable in the pharmaceutical industry for preparation of antibacterial agents. The cephem derivatives of 5-carboxy-2-benzoxazolon have the following general formula:<IMAGE>where R represents hydrogen, acetoxy group, 1-methyl-1H-tetrazol-5-ylthio group; R1 is methyl or ethyl group; R2 is -NH-CH/Ph/-CO group or has no substitute. Following the method, 7-aminodesacetoxycephalosporanic acid, 7-aminocephalosporanic acid, 7-amino-3-/1-methyl-1H-tetrazol-5-ylthiomethyl/-3- cephem-4-carboxylic acid and cephalexin is acylated with N-alkyl-5-carboxy-2-benzoxazolon in organic solvent medium at a low temperature of -5 to -10 degrees C.
BG9481291A 1991-07-16 1991-07-16 Cephem derivatives of 5-carboxy-2-benzoxazolon and a method for their production BG51517A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BG9481291A BG51517A1 (en) 1991-07-16 1991-07-16 Cephem derivatives of 5-carboxy-2-benzoxazolon and a method for their production

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BG9481291A BG51517A1 (en) 1991-07-16 1991-07-16 Cephem derivatives of 5-carboxy-2-benzoxazolon and a method for their production

Publications (1)

Publication Number Publication Date
BG51517A1 true BG51517A1 (en) 1993-06-15

Family

ID=3923887

Family Applications (1)

Application Number Title Priority Date Filing Date
BG9481291A BG51517A1 (en) 1991-07-16 1991-07-16 Cephem derivatives of 5-carboxy-2-benzoxazolon and a method for their production

Country Status (1)

Country Link
BG (1) BG51517A1 (en)

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