ES2009747T3 - Procedimiento de preparacion de compuestos heterociclicos policiclicos y composicion cosmetica que los contiene. - Google Patents

Procedimiento de preparacion de compuestos heterociclicos policiclicos y composicion cosmetica que los contiene.

Info

Publication number
ES2009747T3
ES2009747T3 ES198888401062T ES88401062T ES2009747T3 ES 2009747 T3 ES2009747 T3 ES 2009747T3 ES 198888401062 T ES198888401062 T ES 198888401062T ES 88401062 T ES88401062 T ES 88401062T ES 2009747 T3 ES2009747 T3 ES 2009747T3
Authority
ES
Spain
Prior art keywords
image
hydrogen
procedure
preparation
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198888401062T
Other languages
English (en)
Other versions
ES2009747A4 (es
Inventor
Braham Villa 35 Shroot
Jacques Eustache
Jean-Michel Bernardon
Philippe Nedoncelle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Galderma Research and Development SNC
Original Assignee
Centre International de Recherches Dermatologiques Galderma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre International de Recherches Dermatologiques Galderma filed Critical Centre International de Recherches Dermatologiques Galderma
Publication of ES2009747A4 publication Critical patent/ES2009747A4/es
Application granted granted Critical
Publication of ES2009747T3 publication Critical patent/ES2009747T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4986—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with sulfur as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/008—Preparations for oily hair
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/06—Compounds containing nitro groups bound to a carbon skeleton having nitro groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
    • C07C205/20—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings
    • C07C205/25—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings having nitro groups bound to carbon atoms of six-membered aromatic rings being part of a condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/60—Naphthoxazoles; Hydrogenated naphthoxazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92—Naphthofurans; Hydrogenated naphthofurans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/74—Naphthothiophenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/008—Preparations for oily skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth

Abstract

COMPUESTOS HETEROCICLICOS POLICICLICOS. ESTOS COMPUESTOS RESPONDEN A LA FORMULA SIGUIENTE (I), EN LA CUAL: N ES 1 O 2; R1 REPRESENTA : (I) UN RADICAL ALQUILO INFERIOR, (II) - CH2OH, O (III) - C - R2; R2 REPRESENTA: (A) UN ATOMO DE HIDROGENO, (B) EL RACICAL O (C) EL RADICAL -O>R3; R3 REPRESENTA UN ATOMO DE HIDROGENO, UN RADICAL ALQUILO C1 - C20, UN RADICAL MONO O POLIHIDROXIALQUILO, UN RADICAL ARILO O ARALQUILO EVENTUALMENTE SUBSTITUIDO (1) O UN RESTO DE UN AZUCAR O AUN ASI REPRESENTA EL RADICAL: SIENDO P= 1, 2 O 3; R'' Y R'''' REPRESENTANDO UN ATOMO DE HIDROGENO, UN RADICAL ALQUILO INFERIOR, UN RADICAL MONOHIDROXIALQUILO O POLIHIDROXIALQUILO, UN RADICAL ARILO EVENTUALMENTE SUBSTITUIDO, UN RESTO DE AMINOACIDO O DE AZUCAR AMINADA O TODAVIA UNA TOMA CONJUNTO FORMANDO UN HETEROCICLO. X REPRESENTA UN ATOMO DE OXIGENO, UN ATOMO DE AZUFRE, SO, SO2 O EL RADICAL - NR4. Y REPRESENTA CR4 O UN ATOMO DE NITROGENO. R4 REPRESENTA UN ATOMO DE HIDROGENO O UN RADICAL ALQUILO INFERIOR. ESTOS DERIVADOS ENCUENTRAN APLICACION EN MEDICINA HUMANA Y VETERINARIZ ESPECIALMENTE EN EL TRATAMIENTO TOPICO Y SISTEMICO DE AFECCIONES DERMATOLOGICAS.
ES198888401062T 1987-04-30 1988-04-29 Procedimiento de preparacion de compuestos heterociclicos policiclicos y composicion cosmetica que los contiene. Expired - Lifetime ES2009747T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8706152A FR2614618B1 (fr) 1987-04-30 1987-04-30 Derives heterocycliques polycycliques, leur procede de preparation et leur utilisation en medecine humaine et veterinaire

Publications (2)

Publication Number Publication Date
ES2009747A4 ES2009747A4 (es) 1989-10-16
ES2009747T3 true ES2009747T3 (es) 1993-05-16

Family

ID=9350670

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198888401062T Expired - Lifetime ES2009747T3 (es) 1987-04-30 1988-04-29 Procedimiento de preparacion de compuestos heterociclicos policiclicos y composicion cosmetica que los contiene.

Country Status (17)

Country Link
US (2) US4874747A (es)
EP (1) EP0292348B1 (es)
JP (1) JP2579339B2 (es)
AT (1) ATE56714T1 (es)
AU (1) AU613618B2 (es)
CA (1) CA1313372C (es)
DE (2) DE3860640D1 (es)
DK (1) DK175098B1 (es)
ES (1) ES2009747T3 (es)
FI (1) FI92930C (es)
FR (1) FR2614618B1 (es)
GR (2) GR890300124T1 (es)
IE (1) IE61903B1 (es)
NO (1) NO171159C (es)
NZ (1) NZ224428A (es)
PT (1) PT87358B (es)
ZA (1) ZA883079B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5166170A (en) * 1989-07-03 1992-11-24 Hoechst-Roussel Pharmaceuticals Incorporated 2-(aminoaryl) indoles and indolines as topical antiinflammatory agents for the treatment of skin disorders
WO1994014777A1 (en) * 1992-12-28 1994-07-07 Eisai Co., Ltd. Heterocyclic carbonic acid derivatives which bind to retinoid receptors (rar)
US5770383A (en) * 1994-12-30 1998-06-23 Ligand Pharmaceuticals, Inc. Tricyclic retinoids, methods for their production and use
US5770378A (en) * 1994-12-30 1998-06-23 Ligand Pharmaceuticals, Inc. Tricyclic retinoids, methods for their production and use
US5770382A (en) * 1994-12-30 1998-06-23 Ligand Pharmaceuticals, Inc. Tricyclic retinoids, methods for their production and use
KR100625255B1 (ko) 1995-10-06 2008-01-30 리간드 파마슈티칼스 인코포레이티드 다이머-선택적rxr변조물질및그의사용방법
FR2750426B1 (fr) * 1996-06-28 1998-08-07 Cird Galderma Nouveaux composes biaryles heterocycliques et leur utilisation en medecine humaine ou veterinaire ainsi qu'en cosmetique
EP1093362A1 (en) * 1998-06-12 2001-04-25 Ligand Pharmaceuticals Incorporated Treatment of anti-estrogen resistant breast cancer using rxr modulators
JP2003508397A (ja) 1999-08-27 2003-03-04 リガンド・ファーマシューティカルズ・インコーポレイテッド アンドロゲンレセプターモジュレーターとしての８−置換−６−トリフルオロメチル−９−ピリド［３，２−ｇ］キノリン化合物
US6566372B1 (en) 1999-08-27 2003-05-20 Ligand Pharmaceuticals Incorporated Bicyclic androgen and progesterone receptor modulator compounds and methods
CZ2002711A3 (cs) 1999-08-27 2003-11-12 Ligand Pharmaceuticals Incorporated Modulátory androgenních receptorů, způsoby jejich výroby a způsoby jejich použití
EP1216221A2 (en) 1999-09-14 2002-06-26 Ligand Pharmaceuticals Incorporated Rxr modulators with improved pharmacologic profile
FR2804323B1 (fr) * 2000-01-31 2006-07-07 Galderma Res & Dev Utilisation de composes de type retinoides en tant qu'agents anti-bacteriens
US9050310B2 (en) * 2004-06-25 2015-06-09 Minas Theodore Coroneo Treatment of ocular lesions
US20060204474A1 (en) * 2005-02-25 2006-09-14 Coroneo Minas T Treatment of epithelial layer lesions
FR2910321B1 (fr) 2006-12-21 2009-07-10 Galderma Res & Dev S N C Snc Gel creme comprenant au moins un retinoide et du peroxyde de benzole
FR2910320B1 (fr) 2006-12-21 2009-02-13 Galderma Res & Dev S N C Snc Emulsion comprenant au moins un retinoide et du peroxyde de benzole
FR2931661B1 (fr) 2008-05-30 2010-07-30 Galderma Res & Dev Nouvelles compositions depigmentantes sous forme d'une composition anhydre sans vaseline et sans elastomere comprenant un derive phenolique solubilise et un retinoide.
US11045441B2 (en) 2015-10-13 2021-06-29 Wisconsin Alumni Research Foundation Use of retinoic acid and analogs thereof to treat central neural apneas

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1519474A1 (de) * 1965-12-27 1970-02-19 Hoechst Ag Optische Aufhellungsmittel
CH644116A5 (de) * 1980-08-21 1984-07-13 Hoffmann La Roche Imidazolderivate.
DE3047043A1 (de) * 1980-12-13 1982-07-22 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von 2-amino-benzimidazolen
US4368201A (en) * 1981-07-20 1983-01-11 Usv Pharmaceutical Corporation Tetrahydronaphthoxazoles
LU85544A1 (fr) * 1984-09-19 1986-04-03 Cird Derives heterocycliques aromatiques,leur procede de preparation et leur application dans les domaines therapeutique et cosmetique
US4659360A (en) * 1984-11-30 1987-04-21 Fmc Corporation Plant growth and development modification using benzoxazole derivatives
LU87040A1 (fr) * 1987-11-04 1989-06-14 Oreal Esters aromatiques polycycliques d'antibiotiques macrolidiques et lincosamidiques,leur procede de preparation et compositions pharmaceutiques et cosmetiques les contenant

Also Published As

Publication number Publication date
DK232688D0 (da) 1988-04-28
EP0292348B1 (fr) 1990-09-19
NO881896L (no) 1988-10-31
ES2009747A4 (es) 1989-10-16
NO171159B (no) 1992-10-26
JP2579339B2 (ja) 1997-02-05
IE881279L (en) 1988-10-30
DE3860640D1 (de) 1990-10-25
JPS63295556A (ja) 1988-12-01
ATE56714T1 (de) 1990-10-15
GR3001088T3 (en) 1992-04-17
NO171159C (no) 1993-02-03
FI882030A (fi) 1988-10-31
PT87358B (pt) 1992-08-31
NZ224428A (en) 1990-05-28
FI92930B (fi) 1994-10-14
PT87358A (pt) 1988-05-01
DE292348T1 (de) 1990-02-08
NO881896D0 (no) 1988-04-29
DK175098B1 (da) 2004-06-01
US4874747A (en) 1989-10-17
FR2614618B1 (fr) 1989-07-07
CA1313372C (fr) 1993-02-02
AU1535088A (en) 1988-11-03
FR2614618A1 (fr) 1988-11-04
DK232688A (da) 1988-10-31
GR890300124T1 (en) 1990-01-31
FI92930C (fi) 1995-01-25
FI882030A0 (fi) 1988-04-29
AU613618B2 (en) 1991-08-08
EP0292348A1 (fr) 1988-11-23
IE61903B1 (en) 1994-11-30
ZA883079B (en) 1989-01-25
USRE33533E (en) 1991-02-05

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