EP2752495B8 - Procédé de détermination de l'activité d'une enzyme protéolytique (variantes), dispositif pour la mise en oeuvre de celui-ci et procédé de diagnostic - Google Patents
Procédé de détermination de l'activité d'une enzyme protéolytique (variantes), dispositif pour la mise en oeuvre de celui-ci et procédé de diagnostic Download PDFInfo
- Publication number
- EP2752495B8 EP2752495B8 EP12818440.5A EP12818440A EP2752495B8 EP 2752495 B8 EP2752495 B8 EP 2752495B8 EP 12818440 A EP12818440 A EP 12818440A EP 2752495 B8 EP2752495 B8 EP 2752495B8
- Authority
- EP
- European Patent Office
- Prior art keywords
- variants
- activity
- implementation
- determining
- same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 102000035195 Peptidases Human genes 0.000 title 1
- 108091005804 Peptidases Proteins 0.000 title 1
- 238000002405 diagnostic procedure Methods 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/974—Thrombin
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2011131293/10A RU2518247C2 (ru) | 2011-07-26 | 2011-07-26 | Способ определения пространственно-временного распределения активности протеолитического фермента в гетерогенной системе, устройство для реализации указанного способа и способ диагностики нарушений системы гемостаза по изменению пространственно-временного распределения активности протеолитического фермента в гетерогенной системе |
| PCT/RU2012/000570 WO2013015717A2 (fr) | 2011-07-26 | 2012-07-16 | PROCÉDÉ POUR DÉTERMINER LA RÉPARTITION SPATIALE ET TEMPORELLE DE L'ACTIVITÉ D'UN FERMENT PROTÉOLYTIQUE DANS UN SYSTÈME HÉTÉROGÈNE (ET VARIANTES), DISPOSITIF POUR METTRE EN œUVRE LEDIT PROCÉDÉ ET PROCÉDÉ DE DIAGNOSTIC DU SYSTÈME DE PERTURBATION DE L'HOMÉOSTASIE SUR LA BASE DE LA MODIFICATION DE LA RÉPARTITION SPATIALE ET TEMPORELLE DE L'ACTIVITÉ D'UN FERMENT PROTÉOLYTIQUE DANS UN SYSTÈME HÉTÉROGÈNE |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| EP2752495A2 EP2752495A2 (fr) | 2014-07-09 |
| EP2752495A4 EP2752495A4 (fr) | 2015-04-15 |
| EP2752495B1 EP2752495B1 (fr) | 2020-03-25 |
| EP2752495B8 true EP2752495B8 (fr) | 2020-04-29 |
Family
ID=47601696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP12818440.5A Active EP2752495B8 (fr) | 2011-07-26 | 2012-07-16 | Procédé de détermination de l'activité d'une enzyme protéolytique (variantes), dispositif pour la mise en oeuvre de celui-ci et procédé de diagnostic |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9938563B2 (fr) |
| EP (1) | EP2752495B8 (fr) |
| JP (1) | JP2014521952A (fr) |
| CN (1) | CN103998620A (fr) |
| CA (1) | CA2842594C (fr) |
| EA (1) | EA028341B1 (fr) |
| RU (1) | RU2518247C2 (fr) |
| WO (1) | WO2013015717A2 (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105738378A (zh) * | 2016-02-23 | 2016-07-06 | 上海航天动力科技工程有限公司 | 一种多功能自显像着色渗透剂及其应用 |
| EA037013B1 (ru) * | 2016-11-30 | 2021-01-26 | Общество с ограниченной ответственностью "ГемаКор Лабс" (ООО "ГемаКор Лабс") | Устройство мониторинга пространственно-временной динамики тромбина |
| RU2657294C1 (ru) * | 2016-12-15 | 2018-06-13 | Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" (ГБУЗ МО МОНИКИ им. М.Ф. Владимирского) | Устройство для количественной оценки флюоресценции и оптических свойств тканей in vivo |
| JP7273631B2 (ja) * | 2019-06-26 | 2023-05-15 | 株式会社日立製作所 | 検体性状識別装置、検体性状識別方法及び検体搬送システム |
| JPWO2022145475A1 (fr) * | 2020-12-28 | 2022-07-07 | ||
| CN114465969B (zh) * | 2021-12-23 | 2023-07-04 | 珠海格力电器股份有限公司 | 通讯消息组的管理方法、装置、设备和存储介质 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3516579A1 (de) * | 1984-11-19 | 1986-05-22 | Boehringer Mannheim Gmbh, 6800 Mannheim | Gerinnungstest auf teststreifen |
| ES2081618T5 (es) * | 1991-11-13 | 2005-09-01 | T.A.C. Thrombosis And Coagulation Aktiebolag | Metodo para diagnosticar anomalias de la coagulacion de la sangre. |
| US5339830A (en) * | 1992-01-21 | 1994-08-23 | Blake Joseph W Iii | Blood coagulation test system |
| EP1159448B1 (fr) * | 1999-03-04 | 2004-04-14 | Synapse B.V. | Determination des formes biologiquement actives d'enzymes proteolytiques |
| EP2405019A1 (fr) * | 2001-09-10 | 2012-01-11 | Meso Scale Technologies LLC | Procédés, réactifs, kits et appareil pour l'analyse de fonction de protéine |
| US8802386B2 (en) * | 2002-05-01 | 2014-08-12 | Synapse B.V. | Diagnostic test for determining the concentration of transient proteolytic activity in composite biological media |
| EP1717588A1 (fr) * | 2005-04-29 | 2006-11-02 | Synapse B.V. | Mesure de l'activité thrombique dans le sang total |
| EP1966389B1 (fr) * | 2005-12-27 | 2019-07-10 | McMASTER UNIVERSITY | Essai pour effectuer des mesures sur des enzymes au moyen d'un substrat modifie comprenant un substrat fixe a une macromolecule via un espaceur |
| AU2007256357A1 (en) * | 2006-06-06 | 2007-12-13 | Thrombinoscope B.V. | Method of determining enzymatic activity in biological media |
| US20100261211A1 (en) * | 2007-11-02 | 2010-10-14 | MEDPLAST S.A. c/o FIDUCIAIRE FIDAG S.A., succursale de Sion | Method and apparatus for monitoring spatial fibrin clot formation |
| EP2088435B1 (fr) * | 2008-02-07 | 2011-07-13 | Synapse B.V. | Mesure de la chronologie de l'activé enzymatique corrigée pour les impacts des perturbations liées à la réaction de l'enzyme avec un substrat |
| RU2395812C2 (ru) | 2008-11-14 | 2010-07-27 | Общество с ограниченной ответственностью "Медицинские инновации" | Устройство для исследования пространственного свертывания крови и ее компонентов |
-
2011
- 2011-07-26 RU RU2011131293/10A patent/RU2518247C2/ru active
-
2012
- 2012-07-16 EA EA201400156A patent/EA028341B1/ru not_active IP Right Cessation
- 2012-07-16 US US14/234,909 patent/US9938563B2/en active Active
- 2012-07-16 JP JP2014522787A patent/JP2014521952A/ja active Pending
- 2012-07-16 WO PCT/RU2012/000570 patent/WO2013015717A2/fr active Application Filing
- 2012-07-16 CA CA2842594A patent/CA2842594C/fr active Active
- 2012-07-16 CN CN201280045249.3A patent/CN103998620A/zh active Pending
- 2012-07-16 EP EP12818440.5A patent/EP2752495B8/fr active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EA028341B1 (ru) | 2017-11-30 |
| JP2014521952A (ja) | 2014-08-28 |
| US20140227726A1 (en) | 2014-08-14 |
| WO2013015717A8 (fr) | 2014-02-20 |
| CN103998620A (zh) | 2014-08-20 |
| RU2518247C2 (ru) | 2014-06-10 |
| US9938563B2 (en) | 2018-04-10 |
| WO2013015717A2 (fr) | 2013-01-31 |
| WO2013015717A3 (fr) | 2013-04-11 |
| EP2752495A4 (fr) | 2015-04-15 |
| EP2752495B1 (fr) | 2020-03-25 |
| CA2842594C (fr) | 2020-01-07 |
| CA2842594A1 (fr) | 2013-01-31 |
| EP2752495A2 (fr) | 2014-07-09 |
| RU2011131293A (ru) | 2013-02-10 |
| EA201400156A1 (ru) | 2014-08-29 |
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| RIC1 | Information provided on ipc code assigned before grant |
Ipc: G01N 33/48 20060101ALI20150306BHEP Ipc: C12Q 1/56 20060101AFI20150306BHEP Ipc: G01N 21/76 20060101ALI20150306BHEP Ipc: G01N 21/64 20060101ALI20150306BHEP |
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