EP2534163A4 - Modification génomique ciblée avec des molécules donneuses partiellement monocaténaires - Google Patents
Modification génomique ciblée avec des molécules donneuses partiellement monocaténairesInfo
- Publication number
- EP2534163A4 EP2534163A4 EP20110742576 EP11742576A EP2534163A4 EP 2534163 A4 EP2534163 A4 EP 2534163A4 EP 20110742576 EP20110742576 EP 20110742576 EP 11742576 A EP11742576 A EP 11742576A EP 2534163 A4 EP2534163 A4 EP 2534163A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- donor molecules
- targeted genomic
- partially single
- genomic modification
- stranded donor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
- C07K2319/81—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13166487.2A EP2660318A1 (fr) | 2010-02-09 | 2011-02-09 | Modification génomique ciblée de molécules partiellement donneuses à simple brin |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33775610P | 2010-02-09 | 2010-02-09 | |
US34293410P | 2010-04-21 | 2010-04-21 | |
PCT/US2011/000245 WO2011100058A1 (fr) | 2010-02-09 | 2011-02-09 | Modification génomique ciblée avec des molécules donneuses partiellement monocaténaires |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP13166487.2A Division-Into EP2660318A1 (fr) | 2010-02-09 | 2011-02-09 | Modification génomique ciblée de molécules partiellement donneuses à simple brin |
Publications (3)
Publication Number | Publication Date |
---|---|
EP2534163A1 EP2534163A1 (fr) | 2012-12-19 |
EP2534163A4 true EP2534163A4 (fr) | 2013-10-16 |
EP2534163B1 EP2534163B1 (fr) | 2015-11-04 |
Family
ID=44368049
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP13166487.2A Withdrawn EP2660318A1 (fr) | 2010-02-09 | 2011-02-09 | Modification génomique ciblée de molécules partiellement donneuses à simple brin |
EP11742576.9A Active EP2534163B1 (fr) | 2010-02-09 | 2011-02-09 | Modification génomique ciblée avec des molécules donneuses partiellement monocaténaires |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP13166487.2A Withdrawn EP2660318A1 (fr) | 2010-02-09 | 2011-02-09 | Modification génomique ciblée de molécules partiellement donneuses à simple brin |
Country Status (7)
Country | Link |
---|---|
US (3) | US9255259B2 (fr) |
EP (2) | EP2660318A1 (fr) |
JP (1) | JP2013518602A (fr) |
AU (2) | AU2011215557B2 (fr) |
CA (1) | CA2788850C (fr) |
HK (1) | HK1179628A1 (fr) |
WO (1) | WO2011100058A1 (fr) |
Families Citing this family (199)
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US20110239315A1 (en) | 2009-01-12 | 2011-09-29 | Ulla Bonas | Modular dna-binding domains and methods of use |
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AU2010327998B2 (en) | 2009-12-10 | 2015-11-12 | Iowa State University Research Foundation, Inc. | TAL effector-mediated DNA modification |
US20110197290A1 (en) * | 2010-02-11 | 2011-08-11 | Fahrenkrug Scott C | Methods and materials for producing transgenic artiodactyls |
CA2798988C (fr) | 2010-05-17 | 2020-03-10 | Sangamo Biosciences, Inc. | Polypeptides liant l'adn des tale et leurs utilisations |
EP2392208B1 (fr) * | 2010-06-07 | 2016-05-04 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Protéines de fusion comportant un domaine de liaison ADN d'une protéine TAL effectrice et domaine de clivage non spécifique d'une nucléase de restriction et leur utilisation |
US9528124B2 (en) | 2013-08-27 | 2016-12-27 | Recombinetics, Inc. | Efficient non-meiotic allele introgression |
US10920242B2 (en) | 2011-02-25 | 2021-02-16 | Recombinetics, Inc. | Non-meiotic allele introgression |
WO2013016446A2 (fr) | 2011-07-25 | 2013-01-31 | Sangamo Biosciences, Inc. | Méthodes et compositions de modification d'un gène régulateur de la conductance transmembranaire de la mucoviscidose (cftr) |
KR102061557B1 (ko) | 2011-09-21 | 2020-01-03 | 상가모 테라퓨틱스, 인코포레이티드 | 이식 유전자 발현의 조절을 위한 방법 및 조성물 |
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DK2839013T3 (da) * | 2012-04-18 | 2020-09-14 | Univ Leland Stanford Junior | Ikke-disruptiv-gen-targetering |
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- 2011-02-09 AU AU2011215557A patent/AU2011215557B2/en active Active
- 2011-02-09 CA CA2788850A patent/CA2788850C/fr active Active
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- 2011-02-09 US US12/931,760 patent/US9255259B2/en active Active
- 2011-02-09 JP JP2012552874A patent/JP2013518602A/ja active Pending
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US9005973B2 (en) | 2015-04-14 |
US20160145644A1 (en) | 2016-05-26 |
US9970028B2 (en) | 2018-05-15 |
HK1179628A1 (zh) | 2013-10-04 |
US20110207221A1 (en) | 2011-08-25 |
EP2534163B1 (fr) | 2015-11-04 |
US9255259B2 (en) | 2016-02-09 |
EP2660318A1 (fr) | 2013-11-06 |
AU2011215557B2 (en) | 2016-03-10 |
WO2011100058A1 (fr) | 2011-08-18 |
AU2011215557A1 (en) | 2012-08-23 |
AU2016200945A1 (en) | 2016-03-03 |
EP2534163A1 (fr) | 2012-12-19 |
JP2013518602A (ja) | 2013-05-23 |
CA2788850C (fr) | 2019-06-25 |
US20110287545A1 (en) | 2011-11-24 |
CA2788850A1 (fr) | 2011-08-18 |
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