EP1370206A1 - Dispositif d'administration locale et systemique de substances actives, et ses procedes de fabrication - Google Patents

Dispositif d'administration locale et systemique de substances actives, et ses procedes de fabrication

Info

Publication number
EP1370206A1
EP1370206A1 EP02704082A EP02704082A EP1370206A1 EP 1370206 A1 EP1370206 A1 EP 1370206A1 EP 02704082 A EP02704082 A EP 02704082A EP 02704082 A EP02704082 A EP 02704082A EP 1370206 A1 EP1370206 A1 EP 1370206A1
Authority
EP
European Patent Office
Prior art keywords
delivery disc
uniform mixture
delivery
agents
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02704082A
Other languages
German (de)
English (en)
Other versions
EP1370206A4 (fr
Inventor
Spiros Lavipharm Laboratories Inc. FOTINOS
David Lavipharm Laboratories Inc. O'HALLORAN
Yelena Lavipharm Laboratories Inc. ZOLOTARSKY
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lavipharm Laboratories Inc
Original Assignee
Lavipharm Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lavipharm Laboratories Inc filed Critical Lavipharm Laboratories Inc
Publication of EP1370206A1 publication Critical patent/EP1370206A1/fr
Publication of EP1370206A4 publication Critical patent/EP1370206A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/042—Gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0208—Tissues; Wipes; Patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/06—Preparations for care of the skin for countering cellulitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations

Definitions

  • the present invention relates to solid gel film compositions for local and systemic delivery of active substances through the skin or mucosal epithelial layer of a subject. More particularly, the present invention relates to delivery discs containing a uniform mixture, wherein the uniform mixture contains a filmogenic polymer and a therapeutically effective dose of an active substance for pharmaceutical or cosmetic application, wherein the delivery disc might contain water-soluble dyes, wherein the delivery disc is a single uniform layer device which is non-tacky and which dissolves onto a skin tissue with few drops of water or lotion or mucosal epithelial tissue of a subject when applied thereto.
  • the present invention also relates to a method of administering an active substance to a subject using a delivery disc of the present invention.
  • the present invention further relates to a method or producing the delivery discs of the present invention.
  • a delivery disc containing a uniform mixture wherein the uniform mixture contains a filmogenic polymer and an effective dose of an active substance, wherein the delivery disc is a single uniform layer device which is non-tacky.
  • the delivery disc dissolves onto a skin tissue with few drops of water or lotion or mucosal epithelial tissue of a subject when applied thereto.
  • the uniform mixture further contains at least one additive selected from the group of a stabilizer, a solubilizer, a permeation enhancer, a surfactant and a plasticizer.
  • the uniform mixture preferably contains 0.1 to 15wt% active substance.
  • the active substance is selected from the group of cosmetic agents and therapeutic agents.
  • the cosmetic agents are selected from the group of anti-hyperpigmentation agents, anti-acne agents, keratolytic agents, anti-blotching agents, anti-aging agents, eye contour agents, slimming agents, anti-cellulite agents, soothing/sunburn anti-irritating agents, skin firming and lifting agents, anti-elastase and anti-collagenase substances, free radical scavengers, seboregulators, hydratives and alpha- hydroxy acids.
  • the therapeutic agents are selected from the group of cardiovascular agents, hormones, neurotransmitters, antibiotics, antimicrobials, catecholamines and sympathomimetic drugs, adrenergic receptor agonists and antagonists, anesthetics, benzodiazepines, analgesics, antidepressants, hypnotics, sedatives, antipsychotic agents, muscle relaxants and anti-cancer agents.
  • the uniform mixture preferably contains 0.01 to 15wt% permeation enhancer.
  • the permeation enhancer is selected from the group of a glycolipid, a non-esterified fatty acid, an aliphatic alcohol, a fatty acid ester of an aliphatic alcohol, a cyclohexanol, a fatty acid ester of glycerol, a glycol, an aliphatic alcohol ether of a clycol and mixtures thereof.
  • the uniform mixture preferably contains 5 to 100wt% filmogenic polymer. In one preferred embodiment of the present invention, the uniform mixture preferably contains 5 to 50wt% filmogenic polymer. In another preferred embodiment, the uniform mixture preferably contains at least 75wt% filmogenic polymer, in which embodiment the site of application of the delivery disc is preferably prewetted before application of the delivery disc. In another preferred embodiment, the uniform mixture preferably contains 90 to 95wt% filmogenic polymer.
  • the filmogenic polymer is selected from the group of poly vinyl pyrrolidone, chitin, chitosan, xanthan gum, karaya gum, zein, hordein, gliadin and mixtures thereof, most preferably polyvinyl pyrrolidone.
  • the uniform mixture preferably contains 0 to 60wt% plasticizer. In one preferred embodiment of the present invention, the uniform mixture contains 30 to 60wt% plasticizer. In another preferred embodiment, the uniform mixture contains less than 30wt% plasticizer.
  • the plasticizer is polyethylene glycol, most preferably polyethylene glycol 400 and polyethylene glycol 4000.
  • the uniform mixture preferably contains 1 to 20wt% surfactant/emulsifier.
  • the surfactant is selected from the group of ethoxylated alcohols, sodium lauryl sulfate and betaine.
  • a method for transdermally administering an active substance to a subject includes: (a) wetting a skin tissue of the subject at a site of application; and, (b) applying to the site of application a delivery disc of the present invention containing a uniform mixture, wherein the uniform mixture preferably contains a filmogenic polymer and an effective dose of an active substance, wherein the delivery disc is preferably a single uniform layer device which preferably is non-tacky and which preferably dissolves onto the wetted skin tissue or mucosal epithealial tissue of a subject when administered thereto.
  • the delivery discs are preferably administered to a skin tissue with few drops of water or lotion with gentle rubbing or mucosal epithealial tissue.
  • a method for transmucosally administering an active substance to a subject includes: (a) applying a delivery disc of the present invention to a mucosal epithelial layer of the subject; wherein the delivery disc contains a uniform mixture, wherein the uniform mixture contains a filmogenic polymer and an effective dose of an active substance, wherein the delivery disc is preferably a single uniform layer device which preferably is non-tacky and which preferably dissolves onto the wetted skin tissue or mucosal epithelial tissue of the suject when administered thereto.
  • the delivery discs are preferably administered to a skin tissue with few drops of water or lotion with gentle rubbing or mucosal epithealial tissue.
  • a method for cleansing a skin tissue of a subject includes: (a) wetting the skin tissue of the subject to be cleansed; and (b) applying a delivery disc to the wetted skin tissue; or vice versa (first applying the disc, and then wetting it) wherein the delivery disc comprises a uniform mixture, wherein the uniform mixture comprises a filmogenic polymer and a surfactant.
  • the delivery disc used in this method of the present invention preferably is non-tacky and preferably dissolves and foams on the wetted skin tissue of the subject when administered thereto.
  • the delivery discs are preferably administered to a skin tissue with water and worked into a lather (foam) with gentle rubbing and then rinsed from the skin.
  • transdermal as used herein and in the appended claims means a route of delivery for an active substance across the epithelial layer of a patient, including across the stratum corneum comprising dead differentiated epithelial cells that have produced a dry keratinized layer.
  • transmucosal as used herein and in the appended claims means a route of delivery for an active substance across a mucosal epithelial layer, for example, in an oral cavity and a vaginal cavity of a subject.
  • the present invention provides delivery discs for administering an active substance to a subject and/or for cleansing a skin tissue of a subject.
  • the delivery discs of the present invention contain a uniform mixture containing a filmogenic polymer and an effective dose of an active substance and/or a surfactant.
  • the delivery discs of the present invention dissolves onto a skin tissue with few drops of water or lotion or a mucosal epithelial tissue of a subject when administered thereto.
  • the delivery discs of the present invention preferably contain a filmogenic polymer and an effective dose of an active substance.
  • the delivery discs of the present invention are preferably a single uniform layer device which is preferably non-tacky and which preferably dissolves onto a skin tissue with few drops of water or lotion or mucosal epithelial tissue of a subject when applied thereto.
  • the delivery discs of the present invention may preferably be biodegradable.
  • the delivery discs of the present invention may be rigid or flexible. Rigid delivery discs of the present invention do not require additional support structures such as backing layers and or release layers.
  • the uniform mixture used in the delivery discs of the present invention may preferably contain at least one optional additive selected from the group of stabilizers, solubilizers, permeation enhancers, surfactants, plasticizers and water soluble dies.
  • Active substances suitable for use with the present invention preferably include cosmetic agents and therapeutic agents.
  • the delivery discs of the present invention may contain 0.1 to 15wt% active substances.
  • the active substances may be incorporated into a carrier system.
  • Carrier systems suitable for use with the present invention include, but are by no means limited to, liposomes and cyclodextrin complexes.
  • Cosmetic agents suitable for use with the present invention include, but are by no means limited to, anti-hyperpigmentation agents, anti-acne, keratolytic, anti-blotching agents, anti-aging agents, eye contour agents, slimming agents, anti-cellulite agents, soothing/sunburn anti-irritating agents, skin firming and lifting agents, anti-elastase and anti-collagenase substances, free radical scavengers, seboregulators, hydratives and alpha-hydroxy acids.
  • Therapeutic agents suitable for use with the present invention include, but are by no means limited to, cardiovascular agents, hormones, neurotransmitters, antibiotics, antimicrobials, catecholamines and sympathomimetic drugs, adrenergic receptor agaonists and antagonists, anesthetics, benzodiasepines, analgesics, antidepressants, hypnotics, sedatives, antipsychotic agents, muscle relaxants and anti-cancer agents.
  • Filmogenic polymers suitable for use with the present invention include, but are by no means limited to, any synthetic polymers with filmogenic properties, any natural polymers with filmogenic properties and mixtures thereof.
  • the filmogenic polymer may be selected from the group of poly vinyl pyrrolidone, chitin, chitosan, xanthan gum, kara a gum, zein, hordein, gliadin and mixtures thereof; preferably polyvinyl pyrrolidone.
  • the delivery discs of the present invention may preferably contain 5 to 100wt% filmogenic polymer, preferably 5 to 50wt% filmogenic polymer, alternatively preferably at least 75wt% filmogenic polymer.
  • Plasticizers suitable for use with the present invention include, but are by no means limited to, any plasticizers conventionally used in transdermal and transmucosal delivery devices.
  • Preferred plasticizers may include polyethylene glycol, more preferably polyethylene glycol - 4000.
  • the delivery discs of the present invention may contain 0 to 60wt% plasticizer. In one preferred embodiment of the present invention, the uniform mixture may contain 30 to 60wt% plasticizer. In another preferred embodiment, the delivery discs of the present invention may contain less than 30wt% plasticizer.
  • Delivery discs using a uniform mixture containing less than 50wt% filmogenic polymer preferably contain 30 to 60wt% plasticizer.
  • Delivery discs using a uniform mixture containing at least 75wt% filmogenic polymer preferably contain less than 30wt% plasticizer.
  • Prewetting of a skin tissue at a non-mucosal epithelial tissue site of administration of a delivery discs of the present invention may not be necessary when the uniform mixture contains 30 to 60wt% plasticizer. Prewetting is generally required, however, when the uniform mixture contains less than 30wt% plasticizer.
  • Permeation enhancers suitable for use with the present invention include, but are by no means limited to, glycolipids, non-esterified fatty acids, aliphatic alcohols, fatty acid esters of aliphatic alcohols, cyclohexanol, fatty acid esters of glycerols, glycols, aliphatic alcohol ethers of a glycol and mixtures thereof.
  • the delivery discs of the present invention may contain 0.01 to 15 wt% permeation enhancers.
  • Surfactants suitable for use with the present invention include, but are y no means limited to, any anionic, cationic or nonionic surfactants or emulsifiers conventionally used in cosmetics.
  • Preferred surfactants may include ethoxylated alcohols, sodium lauryl sulfate and betaine.
  • the delivery discs of the present invention may contain 1 to 20wt% surfactants.
  • Water soluble dies suitable for use with the present invention include, but are by no means limited to, any water soluble dies conventionally used in cosmetics.
  • Preferred water soluble dies may include FD&C and D&C Dyes.
  • the delivery discs of the present invention may contain 0.001 to 2.00 wt% water soluble dies.
  • the use of water soluble dies in the delivery discs of the present invention provide the opportunity to add fun to the application of the given discs. That is, the delivery discs may be colored using these water soluble dies such that the color dissappears as the delivery disc dissolves into the skin. This aspect of the invention provides vast opportunity to advance marketing concepts in a fun way.
  • the present invention further provides a method for transdermally administering an active substance to a subject, which method includes: (a) wetting a skin tissue of the subject at a site of application; and, (b) applying to the site of application a delivery disc of the present invention containing a uniform mixture, wherein the uniform mixture preferably contains a filmogenic polymer and an effective dose of an active substance, wherein the delivery disc is preferably a single uniform layer device which preferably is non-tacky and which preferably dissolves onto a skin tissue with few drops of water or mucosal epithealial tissue of a subject when administered thereto.
  • the delivery discs are preferably administered to a skin tissue with few drops of water / lotion with gentle rubbing or mucosal epithealial tissue.
  • the present invention further provides a method for transmucosally administering an active substance to a subject, which method includes: (a) applying a delivery disc of the present invention to a mucosal epithelial layer of the subject; wherein the delivery disc contains a uniform mixture, wherein the uniform mixture contains a filmogenic polymer and an effective dose of an active substance, wherein the delivery disc is preferably a single uniform layer device which preferably is non-tacky and which preferably dissolves onto skin tissue with few drops of watei or mucosal epithelial tissue of the subject when administered thereto.
  • the delivery discs are preferably administered to a skin tissue with few drops of water or lotion with gentle rubbing or mucosal epithealial tissue.
  • the present invention further provides a method for cleansing a skin tissue of a subject, which method includes: (a) wetting the skin tissue of the subject to be cleansed; and (b) applying a delivery disc to the wetted skin tissue or vice versa (first applying the disc, and then wetting it); wherein the delivery disc comprises a uniform mixture, wherein the uniform mixture comprises a filmogenic polymer and a surfactant.
  • the delivery disc used in this method of the present invention preferably is non-tacky and preferably dissolves and foams on wetted skin tissue of the subject when administered thereto.
  • the delivery discs are preferably administered to a skin tissue with water and then worked into a lather (foam) and then rinsed from the skin.
  • Example 1 The uniform mixture formulation identified in Table 1 as Example 1 was prepared as follows:
  • Example 2 The uniform mixture formulation identified in Table 1 as Example 2 was prepared as follows:
  • Example 3 The uniform mixture formulation identified in Table 1 as Example 3 was prepared as follows: (a) adding the polyvinyl pyrrolidone to a volume of alcohol; (b) adding the polyethylene glycol to the product of (a); (c) blending the salicylic acid, the butylene glycol and a volume of water and adding the blend to the product of (b);
  • Example 4 [0036] The uniform mixture formulation identified in Table 1 as Example 4 was prepared as follows: (a) adding polyvinyl pyrrolidone to a volume of alcohol; (b) adding the polyethylene glycol to the product of (a); (c) dissolving ascorbic acid into a volume of water; (d) adding butylene glycol to the product of (c); (e) mixing the products of (b) and (d); (f) removing air from the product of (e); (g) adding silica to the product of (f); (h) casting the product of (g) onto a release liner at 15-mil thickness; and,
  • Example 5 The uniform mixture formulation identified in Table 1 as Example 5 was prepared as follows:
  • Example 6 [0039] The uniform mixture formulation identified in Table 2 as Example 6 was prepared as follows: (a) adding the polyvinyl pyrrolidone to ethyl alcohol blending well; (b) adding the polyethylene glycol to the product of (a); (c) adding the lactic acid and the butylene glycol to the product of (b); (d) adding the alkyl glucoside and sodium lauryl sulfate to the product of (c); (e) removing air from the product of (d); (i) adding silica to the product of (e); (g) casting the product of (f) onto a release liner at 15-mil thickness; and, (h) drying the product of (g) in an oven to produce a uniform non-tacky film.
  • Example 7 The uniform mixture formulation identified in Table 2 as Example 7 was prepared as follows: (a) adding the polyvinyl pyrrolidone to ethyl alcohol, then adding to this mixture the
  • Laponite XL (which is dispersed into a volume of water under vigorous agitation); (b) adding the magnesium laureth sulfate to the product of (a); (c) adding the polyethylene glycol to the product of (b); (d) blending avalure and glycerin until uniform; (e) mixing the products of (c) and (d); (f) adding betaine to the product of (e); (g) removing air from the product of (f); (h) adding nylon 66 to the product of (g); 0) casting the product of (h) onto a release liner at 15-mil thickness; and,
  • Example 7 The uniform mixture formulation identified in Table 2 as Example 7 was prepared as follows: (a) mixing the polyvinyl pyrrolidone into ethanol;
  • Linoleic acid is a fatty acid commercially available from Croda Chemicals Ltd. 2 Lipocol-12 is 12 mole polyethylene glycol ether of lauryl alcohol commercially available from LIPO Chemicals Inc. J Eutanol G 16S is hexyldecyl stearate commercially available from Henkel KgaA. L-Menthol is commercially available from Sigma Chemical Co.
  • Montane 80 VGA is polysorbate monooleate commercially available from Seppic.
  • Polyvinyl pyrrolidone is commercially available from BASF Aktiengesellschaft under the trademark "Kollidon 90 F”.
  • Polyethylene glycol 400 is commercially available from ICI Surfactants.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention porte sur des compositions de films de gel solide servant à l'administration systémique de substances actives à travers la couche épithéliale de la peau ou des muqueuses, et plus particulièrement sur des disques d'administration contenant un mélange uniforme d'un polymère filmogène et une dose à effet thérapeutique d'une substance active. Le disque d'administration est un dispositif fait d'une couche uniforme non collante qui se dissout dans quelques gouttes d'eau ou de lotion lorsqu'appliquée sur les tissus cutanés ou lorsqu'appliquée sur des tissus muqueux épithéliaux. L'invention porte également sur des procédés d'administration d'une substance active à l'aide du susdit disque, et sur un procédé de préparation du susdit disque.
EP02704082A 2001-01-09 2002-01-07 Dispositif d'administration locale et systemique de substances actives, et ses procedes de fabrication Withdrawn EP1370206A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26058701P 2001-01-09 2001-01-09
US260587P 2001-01-09
PCT/US2002/000481 WO2002054997A1 (fr) 2001-01-09 2002-01-07 Dispositif d'administration locale et systemique de substances actives, et ses procedes de fabrication

Publications (2)

Publication Number Publication Date
EP1370206A1 true EP1370206A1 (fr) 2003-12-17
EP1370206A4 EP1370206A4 (fr) 2006-04-05

Family

ID=22989770

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02704082A Withdrawn EP1370206A4 (fr) 2001-01-09 2002-01-07 Dispositif d'administration locale et systemique de substances actives, et ses procedes de fabrication

Country Status (3)

Country Link
EP (1) EP1370206A4 (fr)
JP (1) JP2004532814A (fr)
WO (1) WO2002054997A1 (fr)

Families Citing this family (7)

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Publication number Priority date Publication date Assignee Title
US6800295B2 (en) * 2002-10-09 2004-10-05 The Dial Corporation Water soluble sheet composition
FR2878745B1 (fr) 2004-12-07 2007-03-09 Oreal Dispositif transungeal
FR2881348B1 (fr) * 2005-01-31 2008-12-26 Oreal Composition cosmetique nettoyante sous forme solide
FR2909552B1 (fr) 2006-12-12 2009-11-20 Oreal Utilisation cosmetique de l'acide anisique pour favoriser la desquamation
US11622929B2 (en) 2016-03-08 2023-04-11 Living Proof, Inc. Long lasting cosmetic compositions
WO2019055445A2 (fr) 2017-09-13 2019-03-21 Living Proof, Inc. Compositions de protection de couleur
CN111133023B (zh) 2017-09-13 2022-10-18 生活实验公司 持久化妆品组合物

Citations (7)

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