EP1351584A2 - Ernährungszusammensetzung für beschaffenheit von knochen - Google Patents

Ernährungszusammensetzung für beschaffenheit von knochen

Info

Publication number: EP1351584A2
Authority: EP; European Patent Office
Prior art keywords: composition according; vitamin; composition; inulin; fos
Prior art date: 2001-01-08
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP02702265A

Other languages

English (en)

French (fr)

Inventor

Denis Barclay

Ferdinand Haschke

Véronique Jaussan

Evelyn Spivey-Krobath

Claude Cavadini

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Societe des Produits Nestle SA

Nestle SA

Original Assignee

Societe des Produits Nestle SA

Nestle SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-01-08

Filing date

2002-01-08

Publication date

2003-10-15

2002-01-08 Application filed by Societe des Produits Nestle SA, Nestle SA filed Critical Societe des Produits Nestle SA

2003-10-15 Publication of EP1351584A2 publication Critical patent/EP1351584A2/de

Status Withdrawn legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title claims abstract description 81
235000016709 nutrition Nutrition 0.000 title claims abstract description 26
210000000988 bone and bone Anatomy 0.000 title claims abstract description 22
239000011575 calcium Substances 0.000 claims abstract description 16
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235000001465 calcium Nutrition 0.000 claims abstract description 16
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 15
230000002265 prevention Effects 0.000 claims abstract description 13
229920001202 Inulin Polymers 0.000 claims abstract description 12
JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims abstract description 12
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Classifications

- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

the present invention relates to a nutritional composition for prevention or treatment of a bone condition, a method of production of the composition, use of the composition in the manufacture of a medicament for the prevention or treatment of a bone condition, and a method of treatment of a bone condition which comprises administering an effective amount of the composition.
bone condition is taken to mean a condition in which the health of osseous tissue including bone or teeth is affected. It includes an ailment selected from the group which comprises osteoporosis; osteoporotic fractures and bone fractures, typically hip and forearm fractures; as well as conditions in which deficient calcium absorption, retention, resorption or calcification is implicated.
composition is required to address the problems of preventing bone loss and recovery from bone trauma in the elderly as well as in clinical and performance settings.
composition has now been found that can be used to provide nutrition to an elderly patient as well as performance nutrition or clinical nutrition eg. to a hospital patient.
the invention provides a composition for prevention or treatment of a bone condition which comprises a source of protein, a source of carbohydrate, a source of fat, calcium, magnesium, zinc, vitamin D and vitamin K.
the invention provides a method of producing a composition according to a first aspect of the invention which comprises a step of blending the required nutrients, minerals or vitamins together in the required amounts.
the invention provides use of a composition according to a first aspect of the invention in the prevention or treatment of a bone condition.
the invention provides use of a composition according to a first aspect of the invention in the manufacture of a functional food or medicament for the prevention or treatment of a bone condition.
the invention provides a method of prevention or treatment of a bone condition which comprises administering an effective amount of an embodiment of a composition according to a first aspect of the invention.
a composition according to an embodiment of the invention comprises calcium derived from milk calcium. This is a complex form of calcium which is present in milk.
an embodiment of a composition according to the invention comprises one or more nutrients, minerals or vitamins selected from the group which consists of copper, vitamin E, vitamin C.
the embodiment comprises at least one nutrient, mineral or vitamin selected from the group that consists of soy isoflavones, inulin, fructo-oligosaccharides, caseino- glycomacropeptide (CGMP), casein phosphopeptide or a mixture thereof. Even more preferably the embodiment comprises two or more of these nutrients. Most preferably it comprises all of these nutrients.
inulin and fructo-oligosaccharides are provided in the form of a blend.
the blend has a ratio of inulin:FOS of about 20 to about 45 : about 80 to about 55 by weight. More preferably the ratio of inulin:FOS is about 30:about 70 by weight.
an embodiment comprises 10-110% of the recommended dietary intake for the elderly of the above nutrients, minerals or vitamins. More preferably it comprises the following amounts of nutrients, minerals or vitamins (if present) per 300 g of the composition. Preferably this is the amount of composition administered per day.
Calcium preferably about 120 mg to about 1200 mg, more preferably about 800 mg
Magnesium preferably about 42 mg to about 420 mg, more preferably about 210 mg
Zinc preferably about 1.5 mg to about 15 mg , more preferably about 15 mg
Vitamin D preferably about 1.5 ug to about 15 ug, more preferably about 10 ug
Vitamin K preferably about 0.8 ug to about 80 ug, more preferably about 60 ug
Copper preferably about 0.3 mg to about 3 mg, more preferably about 1.5 mg Vitamin E.
Soy isoflavones preferably about 10 mg to about 200 mg, more preferably about 90 mg
Inulin/Fructo-oligosaccharide (FOS) blend preferably about 4 g to about 50 g, more preferably about 6 g
Caseinglycomacropeptide (CGMP) preferably about 1 g to about 100 g, more preferably about 5 g
Casein phosphopeptide preferably about 0.1 g to about 10 g, more preferably about 0.5 g.
an embodiment of a method according to the invention comprises the steps of blending the nutrients, minerals or vitamins in the required amounts and/or extruding the blended mixture. More preferably it includes spray drying the mixture.
An advantage of the present invention is that it provides a nutritional composition that can be disolved instantaneously in water to provide a beverage or soup. It does not require cooking.
Another advantage of the present invention is that it provides a single composition that can be adapted and administered simply in a food for the prevention or treatment of a bone condition.
the compostion can be provided in clinical or performance nutrition settings and is particularly suitable for an elderly patient.
Yet another advantage of the present invention is that it provides a composition beneficial for diabetics. This is due to the specific composition of macronutrients, protein, carbohydrate and fat which provides a low glycemic index.
a nutritional composition comprises a source of protein.
the protein source preferably provides about 5% to about 55% of the energy of the nutritional formula; for example about 20% to about 50%, preferably 26%, of the energy.
Dietary protein is preferred as a source of protein.
the dietary protein may be any suitable dietary protein; for example animal protein (such as milk protein, meat protein or egg protein); vegetable protein (such as soy protein, wheat protein, rice protein, and pea protein); a mixture of free amino acids; or a combination thereof. Milk proteins such as casein, whey proteins and soy proteins are particularly preferred.
the composition also comprises a source of carbohydrates and a source of fat.
a fat source preferably provides about 5% to about 55% of the energy of the nutritional formula; for example about 20% to about 50%, preferably 23%, of the energy.
Lipid making up the fat source may be any suitable fat or fat mixture.
Vegetable fat is particularly suitable; for example soy oil, palm oil, coconut oil, safflower oil, sunflower oil, com oil, canola oil, lecithins, and the like. Most preferably it is a mixture of canola and soy oils.
Animal fat such as milk fat may also be added if desired.
the composition comprises saturated fat which preferably comprises about 1% to about 5%, more preferably 2.5% of the total energy of the product.
it comprises monounsaturated fat which preferably comprises about 5 % to about 15%, more preferably 9.9% of the total energy of the product.
the composition comprises polyunsaturated fat which preferably comprises about 5% to about 15%, more preferably 10.1% ofthe total energy of the product.
the composition comprises linoleic acid which preferably comprises about 5% to about 15%, more preferably 8.5%> of the total energy of the product.
the composition comprises linolenic acid which preferably comprises about 0.5% to about 5%, more preferably 1.6% ofthe total energy ofthe product.
the ratio of linoleic acid to linolenic acid is about 3 to about 8, more preferably about 5.3.
a source of carbohydrate preferably provides about 40% to about 80%, more preferably about 51% of the energy of the nutritional composition.
Any suitable carbohydrate may be used, for example sucrose, lactose, glucose, fructose, corn syrup solids, maltodextrin, or a mixture thereof.
This embodiment of the composition additionally comprises about 800mg milk calcium, about 210mg magnesium, about 15mg zinc, about lOmg of vitamin D and about 60mg of vitamin K per 300g ofthe composition.
Dietary fibre may also be added. It preferably comprises up to about 5% ofthe energy of the nutritional composition.
the dietary fibre may be from any suitable origin, preferably fructooligosaccharide, acacia gum, or a mixture thereof.
Isoflavone may be included. This provides the advantage of increasing bone mineral density and/or bone mineral content.
Calcium may be included. Preferably this calcium is derived from milk or milk protein fractions.
Additional suitable vitamins and minerals are included in the composition as described above.
Monosodium glutamate may be added as a flavour enhancer.
the nutritional composition is preferably used orally and could alternatively be enterally administrable; for example in the form of a powder, a liquid concentrate, or a ready-to-drink beverage. If it is desired to produce a powdered nutritional formula, the homogenized mixture is transferred to a suitable drying apparatus such as a spray drier or freeze drier and converted to powder.
a usual food product may be enriched with an embodiment of composition.
the amount of the composition added is preferably at least about 0.01% by weight.
compositions Two nutritional compositions were made by blending the required constituents. Their compositions are indicated below in Table 1. The compositions are intended to be consumed in the form of two oral supplements per day based on an enriched beverage and/or milk product desert. The total daily dose ofthe composition is intended to be approximately 300g or 300ml ofthe composition. Table 1

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Physical Education & Sports Medicine (AREA)
Polymers & Plastics (AREA)
Food Science & Technology (AREA)
Nutrition Science (AREA)
Mycology (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Pharmacology & Pharmacy (AREA)
Pediatric Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Inorganic Chemistry (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

EP02702265A 2001-01-08 2002-01-08 Ernährungszusammensetzung für beschaffenheit von knochen Withdrawn EP1351584A2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB0100273.2A GB0100273D0 (en)	2001-01-08	2001-01-08	Nutritional composition for a bone condition
GB0100273		2001-01-08
PCT/EP2002/000296 WO2002052954A2 (en)	2001-01-08	2002-01-08	Nutritional composition for a bone condition

Publications (1)

Publication Number	Publication Date
EP1351584A2 true EP1351584A2 (de)	2003-10-15

Family

ID=9906309

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP02702265A Withdrawn EP1351584A2 (de)	2001-01-08	2002-01-08	Ernährungszusammensetzung für beschaffenheit von knochen

Country Status (4)

Country	Link
EP (1)	EP1351584A2 (de)
AU (1)	AU2002235836A1 (de)
GB (1)	GB0100273D0 (de)
WO (1)	WO2002052954A2 (de)

Cited By (1)

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CN107853702A (zh) *	2017-11-03	2018-03-30	广州彤博士健康科技有限公司	复合微晶粉配方及其制备方法

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GB0027761D0 (en) *	2000-11-14	2000-12-27	Nestle Sa	Nutritional composition for an immune condition
FR2858181B1 (fr) *	2003-07-30	2008-02-29	Christian Fenioux	Preparation alimentaire hyperproteinee comportant au moins un polyphenol
US8663679B2 (en)	2004-04-29	2014-03-04	Abbott Laboratories	Compositions for improving breast health in women
US7601370B2 (en)	2004-07-28	2009-10-13	Abbott Laboratories	Method for controlling body weight in estrogen-insufficient women
US7435431B2 (en)	2004-07-28	2008-10-14	Abbott Laboratories	Method for controlling body weight in estrogen-insufficient women
ES2314692T3 (es) *	2004-07-28	2009-03-16	Abbott Laboratories	Composiciones nutricionales y metodos para tratar o prevenir la osteoporosis.
DE102005033630A1 (de) *	2005-07-19	2007-01-25	Humana Gmbh	Calcium-Peptid-Komponente
DE102006052915A1 (de) *	2006-07-28	2008-01-31	Humana Gmbh	Polyphenol-Peptid-Zusammensetzung
DE102006052560B4 (de) *	2006-11-06	2010-01-21	Humana Milchunion Eg	Anti-diabetogene Calcium-Peptid-Zusammensetzung
US20080118603A1 (en) *	2006-11-21	2008-05-22	Lada Mark W	Nutritional beverage for optimal bone health
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2001
- 2001-01-08 GB GBGB0100273.2A patent/GB0100273D0/en not_active Ceased
2002
- 2002-01-08 AU AU2002235836A patent/AU2002235836A1/en not_active Abandoned
- 2002-01-08 EP EP02702265A patent/EP1351584A2/de not_active Withdrawn
- 2002-01-08 WO PCT/EP2002/000296 patent/WO2002052954A2/en not_active Application Discontinuation

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Also Published As

Publication number	Publication date
GB0100273D0 (en)	2001-02-14
WO2002052954A2 (en)	2002-07-11
WO2002052954A3 (en)	2002-10-31
AU2002235836A1 (en)	2002-07-16

Legal Events

Date	Code	Title	Description
2003-08-29	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2003-10-15	AK	Designated contracting states	Kind code of ref document: A2 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
2003-10-15	AX	Request for extension of the european patent	Extension state: AL LT LV MK RO SI
2003-10-29	17P	Request for examination filed	Effective date: 20030726
2003-11-19	D17P	Request for examination filed (deleted)
2003-12-05	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2004-01-21	18D	Application deemed to be withdrawn	Effective date: 20030809

Publication	Publication Date	Title
US6929793B2 (en)	2005-08-16	Nutritional composition for treating an immune condition
WO2002052954A2 (en)	2002-07-11	Nutritional composition for a bone condition
AU2002221860A1 (en)	2002-08-01	Nutritional composition for an immune condition
CN102687750B (zh)	2013-05-15	一种减肥代餐蛋白型固体饮料
CN103054046B (zh)	2015-04-22	高能量液体肠营养组合物
RU2385647C2 (ru)	2010-04-10	Питание для пациентов, страдающих ожирением
CN106473153A (zh)	2017-03-08	全营养配方食品及其制备方法
EP1401293A1 (de)	2004-03-31	Kalorisch dichtes flüssiges orales nahrungsergänzungsmittel
NO333819B1 (no)	2013-09-23	Spedbarn- eller barne-ernæringssammensetning omfattende sialsyre og fremgangsmåte for fremstilling
WO2009072869A1 (en)	2009-06-11	High energy liquid enteral nutritional composition
FI107014B (fi)	2001-05-31	Terveysravintovalmiste
KR20100016068A (ko)	2010-02-12	고농도의 나트륨을 함유한 액상 영양 조성물 및 그의 제조 방법
US20030091613A1 (en)	2003-05-15	Gelled nutritional composition and process
KR20060024766A (ko)	2006-03-17	혈중 저분자량질소함유화합물의 농도를 저감시키는질병개선용식품
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WO2014157717A1 (ja)	2014-10-02	半固形状高栄養食品
WO2019223819A1 (en)	2019-11-28	Nutritional composition
AU2002312973A1 (en)	2002-12-16	Calorically dense liquid oral supplement
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EP1351584A2 - Ernährungszusammensetzung für beschaffenheit von knochen - Google Patents

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Publications (1)

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ID=9906309

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Cited By (1)

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