EP1157275A4 - Neue transduktionsmoleküle und verfahren zum benutzen derselben - Google Patents

Neue transduktionsmoleküle und verfahren zum benutzen derselben

Info

Publication number
EP1157275A4
EP1157275A4 EP00962058A EP00962058A EP1157275A4 EP 1157275 A4 EP1157275 A4 EP 1157275A4 EP 00962058 A EP00962058 A EP 00962058A EP 00962058 A EP00962058 A EP 00962058A EP 1157275 A4 EP1157275 A4 EP 1157275A4
Authority
EP
European Patent Office
Prior art keywords
methods
same
transduction molecules
novel transduction
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00962058A
Other languages
English (en)
French (fr)
Other versions
EP1157275A1 (de
Inventor
Steven F Dowdy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
Washington University in St Louis WUSTL
Original Assignee
University of Washington
Washington University in St Louis WUSTL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Washington, Washington University in St Louis WUSTL filed Critical University of Washington
Publication of EP1157275A1 publication Critical patent/EP1157275A1/de
Publication of EP1157275A4 publication Critical patent/EP1157275A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
    • C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
EP00962058A 1999-02-28 2000-02-28 Neue transduktionsmoleküle und verfahren zum benutzen derselben Withdrawn EP1157275A4 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12275799P 1999-02-28 1999-02-28
US122757P 1999-02-28
US15129199P 1999-08-29 1999-08-29
PCT/US2000/005097 WO2000062067A1 (en) 1999-02-28 2000-02-28 Novel transduction molecules and methods for using same
US151291P 2009-02-10

Publications (2)

Publication Number Publication Date
EP1157275A1 EP1157275A1 (de) 2001-11-28
EP1157275A4 true EP1157275A4 (de) 2003-01-15

Family

ID=26820859

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00962058A Withdrawn EP1157275A4 (de) 1999-02-28 2000-02-28 Neue transduktionsmoleküle und verfahren zum benutzen derselben

Country Status (5)

Country Link
EP (1) EP1157275A4 (de)
JP (1) JP2003514765A (de)
AU (1) AU7497000A (de)
CA (1) CA2364690A1 (de)
WO (1) WO2000062067A1 (de)

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CA2746824A1 (en) 1999-08-16 2001-01-22 Revaax Pharmaceuticals, Llc Neurotherapeutic composition and method
US6881825B1 (en) 1999-09-01 2005-04-19 University Of Pittsburgh Of The Commonwealth System Of Higher Education Identication of peptides that facilitate uptake and cytoplasmic and/or nuclear transport of proteins, DNA and virues
FR2816845B1 (fr) * 2000-11-20 2006-10-20 Centre Nat Rech Scient Vecteurs de transport a travers un epithelium a jonctions serrees
US20020073441A1 (en) 2000-12-13 2002-06-13 Ross Brian D. Compositions and methods for detecting proteolytic activity
FR2818982B1 (fr) * 2000-12-29 2003-10-31 Univ Rennes Inhibiteur specifique du systeme ubiquitine-proteasome et applications therapeutiques correspondantes
WO2003006619A2 (en) * 2001-07-13 2003-01-23 Clf Medical Technology Acceleration Program, Inc Calcineurin modulators
FR2829940A1 (fr) * 2001-09-27 2003-03-28 Synt Em Compositions pour la vectorisation d'anticorps a travers la barriere hematoencephalique et leur utilisation pour le diagnostic ou le traitement des maladies du systeme nerveux central
WO2004108069A2 (en) 2002-05-04 2004-12-16 Acorda Therapeutics, Inc. Compositions and methods for promoting neuronal outgrowth
AU2003238872A1 (en) * 2002-06-04 2003-12-19 Avicena Group, Inc. Methods of treating cognitive dysfunction by modulating brain energy metabolism
EP1947116B1 (de) * 2003-02-10 2017-06-21 2-BBB Medicines B.V. Differenziell exprimierte Nukleinsäuren der Blut-Hirnschranke bei einer Entzündung
US7166692B2 (en) 2003-03-04 2007-01-23 Canbrex Bio Science Walkersville, Inc. Intracellular delivery of small molecules, proteins, and nucleic acids
EP2460881B1 (de) 2003-05-16 2017-05-03 Acorda Therapeutics, Inc. Proteoglycan-abbauende Mutanten zur Behandlung des ZNS
US7959914B2 (en) 2003-05-16 2011-06-14 Acorda Therapeutics, Inc. Methods of reducing extravasation of inflammatory cells
MXPA05012306A (es) * 2003-05-16 2006-04-18 Acorda Therapeutics Inc Proteinas de fusion para el tratamiento del snc.
CA2530613A1 (en) * 2003-06-30 2005-01-06 Universite De Lausanne Rasgap derived peptide for selectively killing cancer cells
CN1648135A (zh) * 2004-01-20 2005-08-03 中国人民解放军军事医学科学院毒物药物研究所 转导肽－人源胆碱乙酰基转移酶融合蛋白及其应用
WO2005112986A2 (en) 2004-05-18 2005-12-01 Acorda Therapeutics, Inc. Purifying chondroitinase and stable formulations thereof
DK1988167T3 (da) * 2005-02-17 2020-07-13 Univ Sorbonne Intracellulære inhiberende peptider
AU2006340711C1 (en) 2005-04-05 2013-02-07 Allergan, Inc. Clostridial toxin activity assays
JP5189985B2 (ja) 2005-09-26 2013-04-24 アコーダ セラピューティクス、インク． コンドロイチナーゼａｂｃｉ変異体を用いた組成物およびその使用方法
JP4677319B2 (ja) 2005-10-05 2011-04-27 東亞合成株式会社 神経分化抑制ペプチド及びその利用
CA3065947C (en) 2005-10-18 2023-03-07 National Jewish Health Conditionally immortalized long-term stem cells and methods of making and using such cells
DK2010563T3 (da) * 2006-04-07 2011-05-23 Univ Goettingen Georg August Syntetisk MeCP2 sekvens til proteinsubstitutionsterapi
ES2473610T3 (es) 2006-10-10 2014-07-07 Acorda Therapeutics, Inc. Composiciones y métodos de uso de mutantes de condroitinasa ABCI
CA2680613A1 (en) 2007-03-13 2008-09-18 National Jewish Medical And Research Center Methods for generation of antibodies
US8986702B2 (en) 2008-05-16 2015-03-24 Taiga Biotechnologies, Inc. Antibodies and processes for preparing the same
EP2746387A1 (de) 2008-07-21 2014-06-25 Taiga Biotechnologies, Inc. Differenzierte anukleierte Zellen und Verfahren zu ihrer Herstellung
ES2681478T3 (es) 2008-08-28 2018-09-13 Taiga Biotechnologies, Inc. Moduladores de MYC, métodos de uso de los mismos y métodos para identificar agentes que modulan MYC
JP5626717B2 (ja) * 2009-03-26 2014-11-19 学校法人日本大学 レチノイン酸受容体αを含む融合タンパク質
JP5817038B2 (ja) * 2009-06-22 2015-11-18 洋孝 松尾 尿酸トランスポーター、並びに、尿酸輸送関連疾患素因及び炎症関連疾患素因の評価方法及び評価キット、検査体及び薬
WO2011046983A2 (en) 2009-10-12 2011-04-21 Smith Holdings, Llc Methods and compositions for modulating gene expression using oligonucleotide based drugs administered in vivo or in vitro
WO2012038950A1 (en) 2010-09-20 2012-03-29 Ramot At Tel-Aviv University Ltd. Activatable toxin complexes comprising a cleavable inhibitory peptide
US20150299696A1 (en) 2012-05-02 2015-10-22 Sirna Therapeutics, Inc. SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS
CA3133302A1 (en) 2012-07-20 2014-01-23 Taiga Biotechnologies, Inc. Enhanced reconstitution and autoreconstitution of the hematopoietic compartment comprising a myc polypeptide
US9365825B2 (en) 2013-03-11 2016-06-14 Taiga Biotechnologies, Inc. Expansion of adult stem cells in vitro
US10272115B2 (en) 2013-03-11 2019-04-30 Taiga Biotechnologies, Inc. Production and use of red blood cells
US20160102140A1 (en) * 2013-05-30 2016-04-14 Arizona Board Of Regents On Behalf Of Arizona State University Methods and compositions for treating brain diseases
EP4242298A2 (de) 2016-12-02 2023-09-13 Taiga Biotechnologies, Inc. Nanopartikelformulierungen
US10781435B2 (en) 2017-06-22 2020-09-22 Catalyst Biosciences, Inc. Modified membrane type serine protease 1 (MTSP-1) polypeptides and methods of use
US10149898B2 (en) 2017-08-03 2018-12-11 Taiga Biotechnologies, Inc. Methods and compositions for the treatment of melanoma
US11613744B2 (en) 2018-12-28 2023-03-28 Vertex Pharmaceuticals Incorporated Modified urokinase-type plasminogen activator polypeptides and methods of use
CN113661239A (zh) 2018-12-28 2021-11-16 催化剂生物科学公司 经修饰的尿激酶型纤溶酶原激活物多肽和使用方法

Citations (2)

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Publication number Priority date Publication date Assignee Title
US5652122A (en) * 1989-12-21 1997-07-29 Frankel; Alan Nucleic acids encoding and methods of making tat-derived transport polypeptides
WO1999029721A1 (en) * 1997-12-10 1999-06-17 Washington University Anti-pathogen system and methods of use thereof

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US5328984A (en) * 1991-03-04 1994-07-12 The United States As Represented By The Department Of Health & Human Services Recombinant chimeric proteins deliverable across cellular membranes into cytosol of target cells
EP1019071A4 (de) * 1997-05-15 2003-07-30 Cytogen Corp Willkürliche peptide welche transportrezeptoren des gastro-intestinalen trakts binden und verfahren damit

Patent Citations (2)

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US5652122A (en) * 1989-12-21 1997-07-29 Frankel; Alan Nucleic acids encoding and methods of making tat-derived transport polypeptides
WO1999029721A1 (en) * 1997-12-10 1999-06-17 Washington University Anti-pathogen system and methods of use thereof

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BONIFACI N ET AL: "NUCLEAR TRANSLOCATION OF AN EXOGENOUS FUSION PROTEIN CONTAINING HIV TAT REQUIRES UNFOLDING", AIDS, LONDON, GB, vol. 9, no. 9, 1995, pages 995 - 1000, XP002913782, ISSN: 0269-9370 *
CHEN L L ET AL: "INCREASED CELLULAR UPTAKE OF THE HUMAN IMMUNODEFICIENCY VIRUS-1 TATPROTEIN AFTER MODIFICATION WITH BIOTIN", ANALYTICAL BIOCHEMISTRY, ACADEMIC PRESS, SAN DIEGO, CA, US, vol. 227, 1995, pages 168 - 169,172-175, XP002917757, ISSN: 0003-2697 *
NAGAHARA H ET AL: "TRANSDUCTION OF FULL-LENGTH TAT FUSION PROTEINS INTO MAMMALIAN CELLS: TAT-P27KIP1 INDUCES CELL MIGRATION", NATURE MEDICINE, NATURE PUBLISHING, CO, US, vol. 4, no. 12, December 1998 (1998-12-01), pages 1449 - 1452, XP002927987, ISSN: 1078-8956 *
PHELAN A ET AL: "INTERCELLULAR DELIVERY OF FUNCTIONAL P53 BY THE HERPESVIRUS PROTEIN VP22", NATURE BIOTECHNOLOGY, NATURE PUB. CO, NEW YORK, NY, US, vol. 16, no. 5, May 1998 (1998-05-01), pages 440 - 443, XP000979081, ISSN: 1087-0156 *
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See also references of WO0062067A1 *

Also Published As

Publication number Publication date
EP1157275A1 (de) 2001-11-28
WO2000062067A1 (en) 2000-10-19
WO2000062067A9 (en) 2002-07-11
JP2003514765A (ja) 2003-04-22
CA2364690A1 (en) 2000-10-19
AU7497000A (en) 2000-11-14

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