EP1143948A3 - Leberspezischer glukokorticoid-antagonist zur behandlung von diabetes - Google Patents

Leberspezischer glukokorticoid-antagonist zur behandlung von diabetes

Info

Publication number
EP1143948A3
EP1143948A3 EP99925232A EP99925232A EP1143948A3 EP 1143948 A3 EP1143948 A3 EP 1143948A3 EP 99925232 A EP99925232 A EP 99925232A EP 99925232 A EP99925232 A EP 99925232A EP 1143948 A3 EP1143948 A3 EP 1143948A3
Authority
EP
European Patent Office
Prior art keywords
liver
treating diabetes
selective glucocorticoid
glucocorticoid antagonist
antagonist
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99925232A
Other languages
English (en)
French (fr)
Other versions
EP1143948A2 (de
Inventor
Theresa Apelqvist
Suad Efendic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Karo Pharma AB
Original Assignee
Karo Bio AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9812314.4A external-priority patent/GB9812314D0/en
Priority claimed from GBGB9815149.1A external-priority patent/GB9815149D0/en
Application filed by Karo Bio AB filed Critical Karo Bio AB
Publication of EP1143948A2 publication Critical patent/EP1143948A2/de
Publication of EP1143948A3 publication Critical patent/EP1143948A3/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP99925232A 1998-06-08 1999-06-07 Leberspezischer glukokorticoid-antagonist zur behandlung von diabetes Withdrawn EP1143948A3 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9812314 1998-06-08
GBGB9812314.4A GB9812314D0 (en) 1998-06-08 1998-06-08 Treatment of diabetes
GB9815149 1998-07-13
GBGB9815149.1A GB9815149D0 (en) 1998-07-13 1998-07-13 Treatment of diabetes
PCT/IB1999/001175 WO1999063976A2 (en) 1998-06-08 1999-06-07 Liver-selective glucocorticoid antagonist for treating diabetes

Publications (2)

Publication Number Publication Date
EP1143948A2 EP1143948A2 (de) 2001-10-17
EP1143948A3 true EP1143948A3 (de) 2002-09-11

Family

ID=26313822

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99925232A Withdrawn EP1143948A3 (de) 1998-06-08 1999-06-07 Leberspezischer glukokorticoid-antagonist zur behandlung von diabetes

Country Status (7)

Country Link
EP (1) EP1143948A3 (de)
JP (1) JP2002527355A (de)
KR (1) KR20010052431A (de)
AU (1) AU751569B2 (de)
CA (1) CA2334116A1 (de)
IL (1) IL139865A0 (de)
WO (1) WO1999063976A2 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9816935D0 (en) * 1998-08-05 1998-09-30 Karobio Ab Novel glucocortoid and thyroid receptor ligands for the treatment of metabolic disorders
GB9907048D0 (en) 1999-03-27 1999-05-19 Karobio Ab Novel glucocorticoid receptor ligands for the treatment of meta bolic disorders
GB9928805D0 (en) * 1999-12-07 2000-02-02 Karobio Ab Compounds active at the Glucocorticoid and Thyroid Hormone Receptors
DE60113032T2 (de) 2000-10-30 2006-07-06 Pfizer Products Inc., Groton Glukokortikoidrezeptor-Modulatoren
GB0029100D0 (en) * 2000-11-29 2001-01-10 Karobio Ab Compounds active at the glucocorticoid receptor
GB0029102D0 (en) 2000-11-29 2001-01-10 Karobio Ab Compounds active at the glucocorticoid receptor
CA2430595A1 (en) * 2000-12-20 2002-06-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Dissociated glucocorticoid receptor antagonists for the treatment of glucocorticoid associated side-effect
US6583180B2 (en) 2001-02-14 2003-06-24 Abbott Laboratories Glucocorticoid receptor modulators
EP1363876B1 (de) * 2001-02-14 2009-07-29 Karo Bio Ab Glucocorticoid-rezeptoren-modulatoren
EP1285927A3 (de) 2001-08-16 2005-06-29 Schering Aktiengesellschaft Verwendung von Glucocorticoid-Rezeptorantagonisten zur Vorbeugung und Behandlung von Erkrankungen des männlichen Reproduktionssystems
EP1572126A4 (de) * 2001-12-21 2006-07-05 Smithkline Beecham Corp Zusammensetzungen und verfahren zur veränderung der glukoseproduktion
EP1490062B1 (de) 2002-03-26 2007-12-19 Boehringer Ingelheim Pharmaceuticals Inc. Glucocorticoid-mimetika, deren herstellung, pharmazeutische zusammensetzungen und verwendung
US7186864B2 (en) 2002-05-29 2007-03-06 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
US7074806B2 (en) 2002-06-06 2006-07-11 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
US8097606B2 (en) 2003-07-23 2012-01-17 Corcept Therapeutics, Inc. Antiglucocorticoids for the treatment of catatonia
KR101055706B1 (ko) 2003-07-31 2011-08-11 소켄 케미칼 앤드 엔지니어링 캄파니, 리미티드 유동성 콜로이드 결정체 및 이를 이용하여 삼차원 정합체를제조하는 방법
UY28526A1 (es) 2003-09-24 2005-04-29 Boehringer Ingelheim Pharma Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos
US7795272B2 (en) 2004-03-13 2010-09-14 Boehringer Ingelheim Pharmaceutical, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
US7635711B2 (en) 2004-12-27 2009-12-22 Boehringer-Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
KR20090097908A (ko) 2006-12-06 2009-09-16 베링거 인겔하임 인터내셔날 게엠베하 글루코코르티코이드 모사물, 이의 제조 방법, 이의 약제학적 조성물 및 용도
EP2300472B1 (de) 2008-06-06 2012-01-18 Boehringer Ingelheim International GmbH Glucocorticoidmimetika, verfahren zu deren herstellung, pharmazeutische zusammensetzungen und anwendungen davon
US8138189B2 (en) * 2009-03-26 2012-03-20 Hoffman-La Roche Inc. Substituted benzene compounds as modulators of the glucocorticoid receptor
WO2011016050A2 (en) 2009-07-31 2011-02-10 Cadila Healthcare Limited Novel compounds as modulators of glucocorticoid receptors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4374148A (en) * 1980-10-21 1983-02-15 Pfizer Inc. Carboxylic acid therapeutic agents
AU5729098A (en) * 1996-12-24 1998-07-17 Zymogenetics Inc. Treatment agents and methods for treating type ii diabetes and symptoms of type ii diabetes

Also Published As

Publication number Publication date
WO1999063976A3 (en) 2001-12-20
WO1999063976A2 (en) 1999-12-16
CA2334116A1 (en) 1999-12-16
AU4160699A (en) 1999-12-30
IL139865A0 (en) 2002-02-10
EP1143948A2 (de) 2001-10-17
JP2002527355A (ja) 2002-08-27
AU751569B2 (en) 2002-08-22
KR20010052431A (ko) 2001-06-25

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