EP0969840A4 - Inhibiteurs de thrombine - Google Patents
Inhibiteurs de thrombineInfo
- Publication number
- EP0969840A4 EP0969840A4 EP98911875A EP98911875A EP0969840A4 EP 0969840 A4 EP0969840 A4 EP 0969840A4 EP 98911875 A EP98911875 A EP 98911875A EP 98911875 A EP98911875 A EP 98911875A EP 0969840 A4 EP0969840 A4 EP 0969840A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- thrombin inhibitors
- thrombin
- inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4154397P | 1997-03-24 | 1997-03-24 | |
US41543P | 1997-03-24 | ||
US4756197P | 1997-05-22 | 1997-05-22 | |
US47561P | 1997-05-22 | ||
GBGB9716872.8A GB9716872D0 (en) | 1997-08-08 | 1997-08-08 | Thrombin Inhibitors |
GB9716872 | 1997-08-08 | ||
GBGB9800214.0A GB9800214D0 (en) | 1998-01-06 | 1998-01-06 | Throbin inibitors |
GB9800214 | 1998-01-06 | ||
PCT/US1998/005486 WO1998042342A1 (fr) | 1997-03-24 | 1998-03-20 | Inhibiteurs de thrombine |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0969840A1 EP0969840A1 (fr) | 2000-01-12 |
EP0969840A4 true EP0969840A4 (fr) | 2001-02-28 |
Family
ID=27451688
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP98911875A Withdrawn EP0969840A4 (fr) | 1997-03-24 | 1998-03-20 | Inhibiteurs de thrombine |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0969840A4 (fr) |
JP (1) | JP2001518932A (fr) |
AU (1) | AU728006B2 (fr) |
CA (1) | CA2283704A1 (fr) |
WO (1) | WO1998042342A1 (fr) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002516326A (ja) * | 1998-05-26 | 2002-06-04 | メルク エンド カムパニー インコーポレーテッド | イミダゾピリジン系トロンビン阻害薬 |
FR2786482B1 (fr) * | 1998-11-27 | 2002-08-09 | Synthelabo | Nouveaux derives de 2-pyridone, leur preparation et leur application en therapeutique |
US7015230B1 (en) | 1999-05-19 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
US6653316B1 (en) | 1999-05-19 | 2003-11-25 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
US6458952B1 (en) | 1999-05-19 | 2002-10-01 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
EP1586565A1 (fr) * | 1999-05-19 | 2005-10-19 | Pharmacia Corporation | Pyrazinones d'hétéroaryle et d'aryle polycyclique substituées utiles à l'inhibition selective de la coagulation en cascade |
US6664255B1 (en) | 1999-05-19 | 2003-12-16 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade |
NZ514876A (en) * | 1999-05-19 | 2005-03-24 | Pharmacia Corp | Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade |
WO2000069826A1 (fr) * | 1999-05-19 | 2000-11-23 | Pharmacia Corporation | Pyridones aryle et heteroaryle polycycliques substituees utilisees pour l'inhibition selective de la cascade de coagulation |
US6750342B1 (en) | 1999-05-19 | 2004-06-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
US6716838B1 (en) | 1999-05-19 | 2004-04-06 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents |
US6867217B1 (en) | 1999-05-19 | 2005-03-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade |
UA58636C2 (uk) * | 1999-06-04 | 2003-08-15 | Мерк Енд Ко., Інк. | Піразинонові інгібітори тромбіну, фармацевтична композиція, спосіб інгібування утворення тромбів у крові, спосіб лікування станів, пов'язаних із тромбоутворенням |
ES2274795T3 (es) | 1999-07-19 | 2007-06-01 | Merck Frosst Canada Ltd. | Pirazinonas, composiciones que contienen tales compuestos. |
WO2001038323A1 (fr) | 1999-11-23 | 2001-05-31 | Merck & Co., Inc. | Inhibiteurs de thrombine a base de pyrazinone |
US6852761B2 (en) | 2000-03-13 | 2005-02-08 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade |
US6693121B2 (en) | 2000-04-05 | 2004-02-17 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade |
JP2004505014A (ja) | 2000-04-05 | 2004-02-19 | ファルマシア・コーポレーション | 凝血カスケードの選択的阻害に有用な多環式アリールおよびヘテロアリール置換された4−ピロン類 |
JP2004501077A (ja) | 2000-04-17 | 2004-01-15 | ファルマシア・コーポレーション | 凝固カスケードの選択的阻害に有用な多環式アリールおよびヘテロアリール置換1,4−キノン |
US7119094B1 (en) | 2000-11-20 | 2006-10-10 | Warner-Lambert Company | Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade |
US7015223B1 (en) | 2000-11-20 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade |
CA2430037A1 (fr) | 2000-11-20 | 2002-05-30 | Michael S. South | Aryl-et-heteroaryl-pyridines polycycliques substituees utiles dans l'inhibition selective de la cascade de la coagulation |
US6969715B2 (en) | 2001-10-03 | 2005-11-29 | Pharmacia Corporation | 6-membered heterocyclic compounds useful for selective inhibition of the coagulation cascade |
MXPA04003170A (es) | 2001-10-03 | 2004-07-08 | Pharmacia Corp | Compuestos policiclicos, sustituidos, provisto de 5 miembros, utiles para la inhibicion selectiva de la cascada de coagulacion. |
SI21097A (sl) | 2001-12-04 | 2003-06-30 | Univerza V Ljubljani | Inhibitorji trombina |
GB0507577D0 (en) | 2005-04-14 | 2005-05-18 | Novartis Ag | Organic compounds |
CA2606255C (fr) | 2005-04-18 | 2013-10-08 | Sc Dicophar | Utilisation de la lecithine comme medicament dans le traitement du psoriasis |
AU2009250295B2 (en) | 2008-05-21 | 2014-05-01 | Genesis Technologies Limited | Selective caspase inhibitors and uses thereof |
WO2010133000A1 (fr) | 2009-05-21 | 2010-11-25 | New World Laboratories Inc. | Inhibiteurs sélectifs des caspases et leurs utilisations |
CA2833082C (fr) | 2011-04-15 | 2019-12-31 | New World Laboratories, Inc. | Inhibiteurs selectifs de cysteine protease et leurs utilisations |
CN103265537B (zh) * | 2013-05-14 | 2015-05-27 | 浙江医药高等专科学校 | 抗肿瘤化合物、其制备方法和用途 |
CN103396400B (zh) * | 2013-07-16 | 2014-12-17 | 浙江医药高等专科学校 | 含吡唑酰胺类化合物、其制备方法和用途 |
CN103382198B (zh) * | 2013-07-16 | 2014-11-19 | 浙江医药高等专科学校 | 吡唑酰胺类化合物、其制备方法和用途 |
CN103387568B (zh) * | 2013-07-16 | 2014-11-05 | 浙江医药高等专科学校 | 一类化合物、其制备方法和用途 |
CN103387569B (zh) * | 2013-07-16 | 2014-09-24 | 浙江医药高等专科学校 | 一类抗肿瘤化合物、其制备方法和用途 |
CN103382202B (zh) * | 2013-07-16 | 2014-11-26 | 浙江医药高等专科学校 | 含呋喃取代的化合物、其制备方法和用途 |
CN103420993B (zh) * | 2013-07-16 | 2014-12-17 | 浙江医药高等专科学校 | 含噻吩取代的化合物、其制备方法和用途 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997001338A1 (fr) * | 1995-06-27 | 1997-01-16 | Merck & Co., Inc. | Inhibiteurs de la thrombine a base de pyridinone |
WO1997040024A1 (fr) * | 1996-04-23 | 1997-10-30 | Merck & Co., Inc. | Inhibiteurs de thrombine a base de pyrazinone |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUT70045A (en) * | 1993-06-17 | 1995-09-28 | Takeda Chemical Industries Ltd | 2-piperazinone derivatives parmaceutical compositions containing them and process for producing them |
US5668289A (en) * | 1996-06-24 | 1997-09-16 | Merck & Co., Inc. | Pyridinone thrombin inhibitors |
-
1998
- 1998-03-20 CA CA002283704A patent/CA2283704A1/fr not_active Abandoned
- 1998-03-20 WO PCT/US1998/005486 patent/WO1998042342A1/fr not_active Application Discontinuation
- 1998-03-20 EP EP98911875A patent/EP0969840A4/fr not_active Withdrawn
- 1998-03-20 JP JP54582598A patent/JP2001518932A/ja active Pending
- 1998-03-20 AU AU65727/98A patent/AU728006B2/en not_active Ceased
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997001338A1 (fr) * | 1995-06-27 | 1997-01-16 | Merck & Co., Inc. | Inhibiteurs de la thrombine a base de pyridinone |
WO1997040024A1 (fr) * | 1996-04-23 | 1997-10-30 | Merck & Co., Inc. | Inhibiteurs de thrombine a base de pyrazinone |
Non-Patent Citations (1)
Title |
---|
See also references of WO9842342A1 * |
Also Published As
Publication number | Publication date |
---|---|
EP0969840A1 (fr) | 2000-01-12 |
AU6572798A (en) | 1998-10-20 |
CA2283704A1 (fr) | 1998-10-01 |
WO1998042342A1 (fr) | 1998-10-01 |
JP2001518932A (ja) | 2001-10-16 |
AU728006B2 (en) | 2001-01-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19991025 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE |
|
RIC1 | Information provided on ipc code assigned before grant |
Free format text: 7A 61K 31/495 A, 7A 61K 31/535 B, 7C 07D 401/14 B, 7C 07D 403/12 B, 7C 07D 413/06 B, 7C 07D 401/12 B, 7C 07K 5/06 B |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20001211 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20041001 |