EP0888191A1 - Testbesteck und seine verwendung - Google Patents
Testbesteck und seine verwendungInfo
- Publication number
- EP0888191A1 EP0888191A1 EP97906969A EP97906969A EP0888191A1 EP 0888191 A1 EP0888191 A1 EP 0888191A1 EP 97906969 A EP97906969 A EP 97906969A EP 97906969 A EP97906969 A EP 97906969A EP 0888191 A1 EP0888191 A1 EP 0888191A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- blister
- test
- siphon
- test kit
- blisters
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/505—Containers for the purpose of retaining a material to be analysed, e.g. test tubes flexible containers not provided for above
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L1/00—Enclosures; Chambers
- B01L1/52—Transportable laboratories; Field kits
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0663—Whole sensors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
Definitions
- the present invention relates to test kits with test vessels which are formed by appropriate shaping of a plastic film and the welding of this shaped film to a base, and the use thereof for carrying out analytical tests, in particular immunological tests.
- blisters Vessels which are formed as described above by deforming a plastic film and welding this film to a base are referred to in the art as "blisters".
- the blister technique is used primarily for the assembly of tablets or pills of all kinds. But it is also used for packaging biological and technical products; e.g. Flower bulbs or screws blistered.
- elongated bags are formed from two plastic films welded together; the bags are tapered to a point at the bottom and left open at the top. After entering If a serum sample is filled, for example, the opening is welded closed. To take the sample, the tip is cut through or slit open on the side. The bags are to be used for storing, centrifuging or sending samples.
- U.S. Patent No. 3,660,033 (L.L. Schwartz) describes a flexible polyethylene bag for analysis e.g. a urine sample.
- the bag successively comprises a sample inlet opening, a reservoir chamber which can be closed with respect to the former, and a reaction chamber which contains a reagent for the sample and is connected to the reservoir chamber by a narrow, closable channel. Part of the sample is led from the reservoir into the reaction chamber, the rest can be stored or used for further tests; for this purpose the connection openings are closed and the reservoir chamber is cut off along the cutting lines.
- Patent application WO 91/16086 (Target Research Inc.) describes a transparent plastic bag for the analysis of physiological liquids. On the top half of the bag, the edge for loading samples is open; the lower half is formed into several compartments, which are open towards the upper half, but closable, tapered at the lower end to a tip that can be cut through, and separated individually along the welding lines. Individual samples are taken up in the compartments, which are arranged on at least one of the bag halves, and brought into contact with chemical reagents. For many analytical tests, a test strip is used which contains the agents necessary for the test on porous material (eg cellulose, nitrocellulose). In the course of some test procedures, the test strip has to be washed once or several times with a washing solution.
- porous material eg cellulose, nitrocellulose
- test kit In EP 0 139 373 (The Regents of the University of California) a test kit is used, among other things. for an ELISA test (Enzyme-Lmked Lmmuno Sorbent Assay). However, blister technology does not use this test kit. It consists of a test strip in the form of a column made up of several layers e.g. made of filter paper or plastic, which sits in a glass tube open at both ends. One or more layers of the column carry a reagent bound to it, in particular a known antigen or the corresponding antibody; they are kept apart by inert separating layers. The solution to be tested, as well as any washing solutions, are sucked into the tube by applying a vacuum to the upper end of the tube. The solutions are removed from the tube by applying excess pressure.
- ELISA test Enzyme-Lmked Lmmuno Sorbent Assay
- Patent application WO 93/07474 (Hawaii Chemtect International) describes an analysis kit for testing food, in particular for detecting fish toxins. It comprises a rigid, but flexible, non-porous, preferably waterproof base on which a transparent plastic film deformed into blisters is attached.
- the blisters contain liquid reagents.
- Halfway up, the film and the backing have a crease line that also runs through the upper part of the blister. If the cutlery is bent back along this line, it takes the form of a gable roof and can therefore stand upright be used; at the same time, the blisters are thereby exposed at their upper ends and the reagents contained are accessible for the intended reaction. Blisters are provided away from the fold line, which contain the test strips required for the detection.
- a blister known as a "washing compartment" is disclosed, which is constructed in the same way as the reaction blister.
- the washing process described in EP 0 139 373 allows the washing solution to flow up and down several times on the test strip by means of a pulsating vacuum, but is technically complex.
- the washing compartment from WO 93/07474 only permits washing of the test strip by static incubation in washing solution, the entire analysis set, including the reaction blister with reaction solutions, having to be emptied to change the washing solution.
- test set consisting of a water-impermeable base and glued or welded thereon to a transparent plastic film which is deformed to form one or more blisters arranged parallel to one another, this test set being characterized in that a blister is shaped in such a way that it can act as a siphon.
- polystyrene polyvinyl chloride, polyvinyl carbonate or polyethylene.
- the material of the film advantageously consists of hydrophobic or hydrophobic plastic in order to facilitate the filling of the solutions.
- the blister can act as a container of an unused test strip before the reaction or after the reaction to store the used test strip as evidence, so to speak for archiving the test strip; in this case they preferably have an elongated shape.
- the blister contains a reaction component in solid form, e.g. contain a sodium bicarbonate pill as a buffer substance, they can have, at least for the part intended as a container, a round shape or an elongated shape other than the one already mentioned.
- the material from which the underlay is made is impermeable to water.
- the impermeability to water results from the fact that in most cases the solutions contained in the blisters are aqueous solutions or the reactions that take place take place in water or in an aqueous medium.
- Examples of the material of the underlay are aluminum foil, plastics such as PVC, and plasticized paper or cardboard. These materials are opaque, which is probably the more common case; however, the opacity to the light is not an imperative feature of the base.
- the base can in particular have a square shape.
- the base and the film can optionally consist of the same material, in any case, their materials should be selected in such a way that they can be welded and / or glued to one another and form a tight connection when welding or gluing.
- test kit according to the invention is produced (shaping the film and connecting it to the base) by known methods; see e.g. the textbook “Packaging with plastics” by Günther Kühne, published by Carl Hanser, Kunststoff 1974.
- the test kit according to the invention is particularly suitable for carrying out analytical tests with test strips in, for example, chemistry, clinical chemistry, enzymology, molecular biology, cell biology and in particular immunology.
- the blister with a siphon function is referred to below as a siphon blister; the blisters intended for reactions are referred to below as reaction blisters.
- FIG. 1 shows a test kit according to the invention with just one siphon blister 1 open at both ends.
- FIG 3 shows a test set according to the invention, in which the siphon blister 1 is closed before the test and is used for the previous storage of one or more test strips 2.
- FIG. 4 shows a test set according to the invention with a siphon blister 1 and three reaction blisters 3, 4 and 5, the siphon blister being open and the reaction blister closed.
- FIG. 5a and 5b show test kits according to the invention in which test strips 2 are stored in one of the reaction blisters and the siphon blister is already open (FIG. 5a), or one or more test strips 2 are stored in the still closed siphon blister 1 (FIG 5b).
- the cutlery comprises just one, on both ends the open siphon blister 1. Its branch pointing upwards consists of a container part 11 and, subsequently, a removal part 12 (the cross section of which can be enlarged compared to that of the container part in order to facilitate the handling of test strips).
- the elongated, flat container part 11 of the siphon blister 1 is elongated and bent at the end facing away from the removal part 12 by a rinsing part 13, so that the container part 11 and rinsing part 13 together form a siphon.
- the siphon blister is shown in an open form at the removal part 12 and at the end of the rinsing part 13, since here it mostly serves only to carry out the washing step and therefore no sterility of the siphon blister is necessary.
- the test strip 2 is introduced into the container part 11 and, with the container part 11 oriented at least approximately vertically, washing solution is supplied, which can then flow off again via the rinsing part 13.
- the test strip 2 is washed either with a flowing or standing washing solution, in the latter case initially only enough washing solution is poured into the container part 11 that no solution escapes via the rinsing part 13 (FIG. 2a).
- the siphon is then emptied by adding even more washing solution (FIG. 2b) due to the siphon effect (FIG. 2c).
- This washing procedure is applicable to all embodiments of the invention it ⁇ according to the test kit.
- the siphon blister can also be used for the time being to carry out a reaction by filling in a reagent solution and dipping a test strip into it.
- test kit In a second embodiment of the test kit according to the invention (FIG. 3), there is also just one phonblister 1 provided. However, it now serves to store one or more test strips 2 before the test and is initially closed. In the production of this test kit, analogously to the blistering of other goods, the test strip or strips are placed in the preformed film and only then are these connected to the base.
- the test strip 2 consists, for example, of a plastic strip 21 which is long enough to extend beyond the end of the container part 11 into the removal part 12, and on one side of which at least partially an absorbent material 22, e.g. Celluloe, nitrocellulose or very fine glass wool, is applied.
- an absorbent material 22 e.g. Celluloe, nitrocellulose or very fine glass wool.
- the antibodies, antigens or other reaction partners required for the respective test are arranged thereon, and one or more test areas can be formed.
- both ends of the siphon blister are cut through.
- the test kit can be pre-perforated along lines 3, 3 ', which lie at the upper or lower end of the test kit.
- closed reaction blisters 4, 5, 6 are arranged next to the container part 11 of the siphon blister 1. They each consist of a flat reaction part 41, 51, 61 and a filler part 42, 52, 62 with a larger cross section than the reaction part 41, 51, 61.
- the filling part 42, 52, 62 enables the test strip 2 to be inserted into the reaction part 41, 51, 61 by hand introduce and remove it again.
- it is funnel-shaped to facilitate the filling of reagents.
- the filling parts 42, 52, 62 of the reaction blister and the filling part 12 of the siphon blister preferably lie next to one another and can be cut along a single straight line.
- the straight line can be marked on the test kit by a pre-perforated line 3.
- the reaction blisters 4, 5, 6 can be provided with printed numbers in the area of the filling parts 42, 52, 62 and volumetric measuring scales with which numbers can be printed next to them or in the area of the reaction parts 41, 51, 61 the filling level of the reaction blister 4, 5, 6 can be determined.
- the reaction blister can be used to store solid or liquid test reagents before the test. Any test strips required can either be stored in one of the reaction blisters 4, 5, 6 (FIG. 5a), or they may be stored in the siphon blister, which is then preferably sealed first (FIG. 5b). An embodiment in which at least one of the blisters contains a test strip is preferred.
- the siphon blister 1 is initially the storage container for one or more test strips and is closed.
- the film deformed into blisters consists of polyvinyl chloride and the base of an aluminum film.
- the film and the backing are glued with an adhesive commonly used in blister technology.
- Solid or liquid reagents can be stored in the reaction blisters 4, 5, 6.
- the reaction parts 41, 51, 61 are calibrated volumetrically with measuring scales (for example in microliter units) and have labels that identify any reagents stored therein. or assign the reaction blister to a specific reaction step in the test.
- the filler parts 42, 52, 62 are funnel-shaped.
- the test kit has a labeling field on which the type of sample and, for example, the date of the test can be noted.
- test set is cut or broken open along a pre-perforated line 3.
- the siphon blister since it is only open at the top, can now serve as a reaction blister.
- the test set is also cut 3 'along a pre-perforated line.
- the test strip can be stored, for example, in the siphon blister completely emptied by the siphon effect.
- the invention also relates to the use of the test kit for an analytical test from immunology, specifically for an ELISA test.
- the immunological tests are based on the basic reaction of an antigen with its antibody.
- ELISA Enzyme Linked I_mmuno Sorbent Assay
- one of these reaction partners is bound to a test strip.
- the analyte present in the sample is then bound by an immunological reaction with this test strip-adsorbed reaction partner.
- the unbound material is removed in a washing step.
- test strip is inserted into the blister siphon of the test kit according to the invention and washed with the washing medium in the flow or incubated in the standing washing solution.
- an embodiment is advantageously chosen which also has reaction blisters.
- Another immunological reagent which reacts with the analyte is added simultaneously with the first immune reaction or after the washing step.
- This immunological reagent is provided with an easy-to-measure label. Radioactive substances, chromophores, fluorochromes and luminescence-producing substances are used as labels.
- the use of the indicator enzyme peroxidase from horseradish is particularly suitable as a marker.
- an aqueous solution of 4-chloro-1-naphthol, hydrogen peroxide and buffer substance if a test kit with reaction blisters is used, this can be done beforehand in one of the reaction blisters 4, 5, 6 be stored) insoluble 1,4-naphthoquinone formed and fixed in the test strip.
- the proportion of the label immunologically bound to the solid phase is measured.
- test strips can be mono-indicators or multi-indicators.
- the test ⁇ surfaces are so sensi- stabilizes, that only a single analyte is nach ⁇ expelled from the sample or quantified with the immunological reactant.
- Such test strips are particularly suitable for detecting and quantifying the total IgE in serum or plasma samples.
- test kit is labeled with the name "blister card” used by laboratory personnel.
- the test strip for total IgE contains the negative control at position 1, the fields for the patient sample at positions 2 and 3, at positions 4 to 7 the IgE standards 400 kU / 1, 100 kU / 1, 20 kU / 1 and 5 kU / 1.
- 300 ⁇ l of patient serum are filled into the first blister 4 of the blister card with a pipette and 300 ⁇ l of anti-human IgE-peroxidase test solution [(monoclonal mouse), anti-human IgE antibody-peroxidase conjugate (company SBAI , Prod. N ° 9160-05) in TRIS / HC1 buffer of pH 7, 6 with the additions of 500 ml / 1 fourth (56 ° C./30 min.) fetal calf serum, 1 g / 1 phenol and 0.16 ml / 1 Kathon 886 WT, 14%)] were added to the serum presented.
- the test strip for total IgE the two solutions are mixed well by moving the blister up and down; the test strip is then incubated in this solution for one hour at RT.
- test strip 2 is then transferred to the siphon blister 1 and washed with distilled water. First of all, it is rinsed with distilled water, then the test strip is incubated in the distilled water for 10 minutes at RT, so that the excess (monoclonal mouse) anti-human IgE antibody-peroxidase conjugate can diffuse out of the pores of the nitrocellulose, then is rinsed again in the siphon blister with distilled water.
- the chromogen and the substrate buffer solution are mixed well in the third blister 6 by up and down movements; the test strip is then incubated in this solution for 15 minutes at room temperature.
- the test strip 2 is incubated in the siphon blister 1 filled with fresh distilled water for 5 minutes at 22 ° C. in order to remove the excess chromogen-hydrogen peroxide solution.
- test strip is removed from the siphon blister and dabbed lightly with a soft paper towel to remove the remaining liquid.
- the dried test strip (after 30 minutes) is placed in the densitometer in accordance with the device instructions and the color intensity of the individual color spots (dots) is measured.
- the measured color intensity of the two dots with the analysis sample (positions 2 and 3) is automatically averaged by the densitometer and the IgE concentration present in the sample is calculated on the basis of the color intensity of the IgE standard values carried.
- the N.N. contains 20 kU / 1 IgE.
- the reagents of the IgE inhalation allergen test set are brought to room temperature (22 ° C./30 min.), A blister card according to FIG. 5b is removed, according to lines 3 and 3 'cut open and the blister card and an associated patient card labeled with the name of the patient.
- the test strip 2 is incubated in this patient serum for four hours at RT.
- test strip 2 is then washed in the siphon blister 1 with distilled water.
- test strip is rinsed with distilled water, then the test strip is incubated in distilled water for 10 minutes at RT so that the unbound material of the patient serum can diffuse out of the pores of the nitrocellulose.
- siphon blister is rinsed through again with distilled water.
- the anti-human IgE peroxidase test solution [(monoclonal mouse) anti-human IgE-antibody-peroxidase conjugate (SBAI, Prod. N ° 9160-05) in TRIS-HCl buffer is added with the dropper bottle from pH 7.6 with the additions of 500 ml / 1 heat-inactivated (56 ° C./30 min.) fetal calf serum, 1 g / 1 phenol and 0.16 ml / 1 catalyst 886 wt, 14%)] to the upper Mark added.
- the washed test strip is incubated in blister 5 for one hour at 22 ° C.
- test strip 2 is then washed in the siphon blister 1 with distilled water. First, it is rinsed with distilled water, then the test strip is incubated in distilled water for 10 minutes at RT, so that the unbound material of the patient serum can diffuse out of the pores of the nitrocellulose. Then the distilled water is rinsed through again in the siphon blister.
- chromogen solution [3 g / l 4-chloro-1-naphthol (Fluka, order no. 25328) in methanol p.a. (Jannsen)] to the lower mark and then to the second mark "substrate buffer" (11 ⁇ vmol / 1 hydrogen peroxide in 10 mmol / 1 TRIS / HCl, pH 7.6 with 150 ⁇ t ⁇ Mol / 1 NaCI and 0.2 g / 1 Kathon 886) added.
- the test strip is removed from the siphon blister and dabbed lightly with a soft paper towel to remove the remaining wash water. With the test strip, the chromogen and substrate buffer solution are mixed well in the third blister 6 by up and down movements; the test strip is then incubated in this solution for 15 minutes at RT.
- test strip is incubated in the siphon blister with distilled water for 5 minutes at RT in order to remove the excess chromogen.
- the test strip is removed from the siphon blister and dabbed lightly with a soft paper towel to remove the remaining liquid.
- the N.N. patient serum contains:
- Lead foot RAST class 0
- Birch RAST class 0
- Dermatophagoides pteronyssinus RAST class 0
- the reagents of the IgE food allergen test set are brought to room temperature (RT / 30 mm), a blister card according to 5b is removed, cut open according to lines 3 and 3 'and the blister card and an associated patient card are labeled with the name of the patient.
- test strip 2 800 ⁇ l of the patient serum to be examined are filled into the first blister 4 of the blister card with a pipette; test strip 2 is then incubated in this patient serum for four hours at RT.
- test strip 2 is then washed in the siphon blister 1 with distilled water. First, it is rinsed with distilled water, then the test strip is incubated in distilled water for 10 minutes at RT, so that the unbound material of the
- the siphon blister is rinsed again with distilled water.
- the anti-human IgE peroxidase test solution [(monoclonal mouse, anti-human IgE antibody-peroxidase conjugate (company SBAI, Prod. No. 9160-05) in TRIS / HCl buffer from pH 7.6 with the additions of 500 ml / 1 heat-inactivated (56 ° C./30 min.) fetal calf serum, 1 g / 1 phenol and 0.16 ml / 1 catalyst 886 WT, 14%)] up to the upper marking admitted.
- the washed test strip is removed from the siphon blister and incubated in blister 5 for one hour at RT.
- test strip is then reinserted into the test strip
- the third blister 6 of the blister card is filled with chromogen solution [3 g / 1 4-chloro-1-naphthol (Fluka, order no. 25328) in methanol pa (Jannsen)] up to the lower mark and then up to second marker substrate buffer (11 mmol / 1 hydrogen peroxide in 10 mmol / 1 TRIS / HCl, pH 7.6 with 150 mmol NaCl and 0.2 g / 1 Kathon 886) was added.
- the test strip is removed from the siphon blister 1 and lightly blotted with a soft paper towel in order to remove the remaining wash water.
- the chromogen and the substrate buffer solution are mixed well in the blister 6 by up and down movements; the test strip is then incubated in this solution for 15 minutes at RT.
- the test strip is incubated in the siphon blister filled with fresh distilled water for 5 minutes at 22 ° C. to remove the excess chromogen.
- test strip is removed from the siphon blister and dabbed lightly with a soft paper towel to remove the remaining liquid.
- the test strip is dried (RT / 30 min) and - according to the device instructions - inserted into the densitometer and the color intensity of the individual dots is measured. Based on the color intensity of the positive control, the measured color intensities on the different allergen spots can be calculated in RAST classes 0 - 4. Result: The N.N. contains:
- Cod RAST class 0
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Gloves (AREA)
- Table Equipment (AREA)
- Knives (AREA)
Description
Claims
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH757/96 | 1996-03-22 | ||
CH00757/96A CH690628A5 (de) | 1996-03-22 | 1996-03-22 | Testbesteck, bestehend aus einem Blister, und seine Verwendung. |
CH75796 | 1996-03-22 | ||
PCT/CH1997/000121 WO1997035663A1 (de) | 1996-03-22 | 1997-03-21 | Testbesteck und seine verwendung |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0888191A1 true EP0888191A1 (de) | 1999-01-07 |
EP0888191B1 EP0888191B1 (de) | 2001-12-12 |
Family
ID=4194477
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP97906969A Expired - Lifetime EP0888191B1 (de) | 1996-03-22 | 1997-03-21 | Testbesteck und seine verwendung |
Country Status (8)
Country | Link |
---|---|
US (1) | US6090347A (de) |
EP (1) | EP0888191B1 (de) |
JP (1) | JP3628709B2 (de) |
AT (1) | ATE210505T1 (de) |
AU (1) | AU1920097A (de) |
CH (1) | CH690628A5 (de) |
DE (1) | DE59705773D1 (de) |
WO (1) | WO1997035663A1 (de) |
Cited By (1)
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US11560449B2 (en) | 2005-04-22 | 2023-01-24 | Mitsubishi Chemical Corporation | Biomass-resource-derived polyester and production process thereof |
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US6884877B2 (en) * | 2001-10-03 | 2005-04-26 | Florida State University Research Foundation, Inc. | Purified linear epitopes from cashew nuts, nucleic acids encoding therefor, and associated methods |
JP2004251638A (ja) * | 2003-02-18 | 2004-09-09 | Arkray Inc | 自動測定用の容器 |
US7767152B2 (en) * | 2003-08-11 | 2010-08-03 | Sakura Finetek U.S.A., Inc. | Reagent container and slide reaction retaining tray, and method of operation |
ES2214162B1 (es) * | 2004-05-06 | 2005-11-01 | Certest Biotec, S.L. | Emblistado de pruebas de diagnostico inmunocromatograficas y otros test rapidos de diagnostico. |
US8691161B2 (en) | 2004-12-13 | 2014-04-08 | Bayer Healthcare Llc | Self-contained test sensor |
JP4536536B2 (ja) * | 2005-01-27 | 2010-09-01 | 株式会社エンプラス | 流体取扱装置 |
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USD806891S1 (en) * | 2016-01-11 | 2018-01-02 | Mi & Mi Technologies, Llc | Diagnostic card |
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US5770441A (en) * | 1996-09-30 | 1998-06-23 | Lipton; Stewart | Methods, apparatuses and kits for the growth and/or identification of microorganisms |
US5811296A (en) * | 1996-12-20 | 1998-09-22 | Johnson & Johnson Clinical Diagnostics, Inc. | Blocked compartments in a PCR reaction vessel |
-
1996
- 1996-03-22 CH CH00757/96A patent/CH690628A5/de not_active IP Right Cessation
-
1997
- 1997-03-21 WO PCT/CH1997/000121 patent/WO1997035663A1/de active IP Right Grant
- 1997-03-21 JP JP53390197A patent/JP3628709B2/ja not_active Expired - Fee Related
- 1997-03-21 US US09/142,381 patent/US6090347A/en not_active Expired - Fee Related
- 1997-03-21 DE DE59705773T patent/DE59705773D1/de not_active Expired - Fee Related
- 1997-03-21 AT AT97906969T patent/ATE210505T1/de not_active IP Right Cessation
- 1997-03-21 EP EP97906969A patent/EP0888191B1/de not_active Expired - Lifetime
- 1997-03-21 AU AU19200/97A patent/AU1920097A/en not_active Abandoned
Non-Patent Citations (1)
Title |
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See references of WO9735663A1 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11560449B2 (en) | 2005-04-22 | 2023-01-24 | Mitsubishi Chemical Corporation | Biomass-resource-derived polyester and production process thereof |
Also Published As
Publication number | Publication date |
---|---|
EP0888191B1 (de) | 2001-12-12 |
AU1920097A (en) | 1997-10-17 |
CH690628A5 (de) | 2000-11-15 |
WO1997035663A1 (de) | 1997-10-02 |
ATE210505T1 (de) | 2001-12-15 |
JP3628709B2 (ja) | 2005-03-16 |
DE59705773D1 (de) | 2002-01-24 |
JP2000510579A (ja) | 2000-08-15 |
US6090347A (en) | 2000-07-18 |
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