EP0248758A1 - Zur Einführung in eine Körperöffnung bestimmter Applikator für den medizinischen Gebrauch - Google Patents
Zur Einführung in eine Körperöffnung bestimmter Applikator für den medizinischen Gebrauch Download PDFInfo
- Publication number
- EP0248758A1 EP0248758A1 EP87630080A EP87630080A EP0248758A1 EP 0248758 A1 EP0248758 A1 EP 0248758A1 EP 87630080 A EP87630080 A EP 87630080A EP 87630080 A EP87630080 A EP 87630080A EP 0248758 A1 EP0248758 A1 EP 0248758A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- jacket
- applicator
- balloon
- opposite side
- applicator according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/1815—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/12—Devices for heating or cooling internal body cavities
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0001—Body part
- A61F2007/0018—Trunk or parts thereof
- A61F2007/0028—Rectum
Definitions
- the present invention relates to an applicator adapted to be inserted into a body opening for various medical purposes, e.g. for medical treatment or medical diagnosis.
- the invention is particularly useful as a heating applicator for insertion through the anus into the rectum of a patient for use in hyperthermia treatments, and is therefore described below with respect to this application.
- the applicator of the present invention is particularly useful with the catheter and probe described in our Israel Application No. 78756 filed the same date as this Application.
- Hyperthermia is a recognized technique for rendering certain therapeutic treatments to a patient by the application of heat to the portion of the patient's body to be treated.
- a large number of applicators have been developed for treating cancer, or for other therapeutic purposes such as the treatment of hemorrhoids, as described for example in USA Patents 4,375,220, 4,312,364, 4,311,154, 4,227,535, 4,186,729, 4,154,246, 4,140,130, 4,016,886, 2,043,083, 2,032,859 and 1,433,286.
- An object of the present invention is to provide an applicator for insertion into a body opening for purposes of performing a medical treatment or a medical diagnosis.
- an applicator for insertion into a body opening for medical treatment or for diagnostic purposes characterized in that the applicator includes: an elongated jacket for insertion into the body opening; a disposable sleeve received on said jacket; and a balloon integrally formed on said disposable sleeve at one side of said jacket, which balloon is inflatable by a fluid to press the opposite side of the jacket and sleeve laterally against the tissue of the body opening, thereby to fix the position of the jacket within the body opening and to conform the pressed body tissue to the shape of said opposite side of the jacket.
- the applicator further includes a microwave antenna disposed within the jacket, the jacket further including cooling ducts adjacent its outer surface for circulating a cooling fluid therethrough in order to prevent undue heating of the body tissue in direct contact therewith.
- the balloon when inflated, thereby also effects efficient cooling of the body tissue in contact with the opposite side of the jacket.
- the applicator may thus be used for heating tissue directly in contact with the outer face of the applicator, in which case a cooling fluid would not be circulated through the cooling ducts; alternatively, the applicator may be used for heating more remotely-located tissue, in which case a cooling fluid would be circulated through the cooling ducts in order to prevent undue heating of the tissue in direct contact with the applicator.
- the applicator illustrated in the drawings comprises an elongated jacket, generally designated 2, for insertion into a body cavity at the location of the tissue to be heated.
- the applicator illustrated in Fig. 1 is particularly designed for insertion via the body anus into the rectum for treating this region of the body, although it will be appreciated that the invention could be applied to other body cavities and used for other therapeutic treatments or for diagnostic purposes.
- the illustrated applicator includes a heating element in the form of a microwave antenna, indicated by broken lines 4 in Fig. 1 but more particularly illustrated in Fig. 6, generating RF electromagnetic radiation for heating the body tissue.
- the applicator further includes a disposable sleeve 6, carried by the jacket 2 and integrably formed with a balloon 7 projecting laterally at the distal end of the sleeve. Balloon 7 is inflatable by air or water applied via a tubelet 8 extending through an end fitting 10 externally of the sleeve.
- the balloon 7 is of generally conical configuration when inflated, having a narrow tip 7a joined to the sleeve 6, and a wide base 7b at its opposite end engageable with the body tissue at one side of the body opening when the balloon is inflated while the applicator is within the body opening.
- Antenna 4 is more particularly illustrated in Fig. 6. It is constructed of a coaxial cable including an inner electrical conductor 12 and an outer electrical conductor braid 13 separated from the inner conductor by a dielectric layer 14.
- the dielectric layer 14 is removed from the end of the coaxial cable to bare the inner conductor 12, and the inner conductor is then covered by a dielectric layer 15, e.g. glass or ceramic having a dielectric constant of at least 2.
- the outer conductor braid at the end of the cable is folded back over itself and is separated from the underlying braid by a dielectric layer 16.
- the outer face of the antenna is then covered by a protective coating 18, as by dipping in a bath of insulating material.
- jacket 2 includes an inner, relatively thick core 20, an outer thin sleeve 22, and a solid tip 24-at the distal end of the applicator.
- Inner core 20 is formed with an axially-extending bore 26 for receiving the microwave antenna 4, and its outer face is formed with a plurality of axially-extending ribs 20a to define a plurality of recessed channels 2ó 1 as more particularly illustrated in Figs. 3 and 4.
- Channels 28 form, with the outer sleeve 22, a plurality of cooling ducts for circulating a cooling fluid, such as water.
- the cooling ducts defined by recessed channels 28 extend the complete length of the jacket in a sinuous manner from the cooling fluid inlet 30 at the proximal end of the applicator (left end in Fig. 4, but right end in Figs. 1 and 2) back and forth with respect to the opposite, distal end of the applicator, the water exiting via the water outlet 32 at the proximal end of the applicator.
- the solid tip 24 at the distal end of the applicator is formed with an annular recess 34 for receiving the distal ends of the inner core 20 and the outer sleeve 22.
- the proximal ends of these sleeves are received within a cylindrical recess 36 formed centrally of the end fitting 10.
- End fitting 10 is further formed with a central bore 40 for passing the microwave heating antenna 4 therethrough into the bore 26 of the inner core 20.
- Fitting 10 is further formed with a pair of lateral bores 42, 44 (Figs. 5, 5a) communicating with the cooling ducts 28 for circulating the cooling fluid, (e.g., water) therethrough.
- Bore 42 is the inlet for the cooling water, and bore 44 is the outlet.
- End fitting 10 is formed with a further bore 46 (Fig. 5, 5b) serving as the inlet for admitting air or water to inflate balloon 7 via tubelet 8 received within bore 46 and connected to the balloon.
- End fitting 10 includes a still further bore 48 (Figs. 5, 5c) for receiving the electrical leads of three thermocouples 50a, 50b, 50c (Fig. 1) which measure the temperature within the body opening into which the applicator has been inserted.
- the inner core 20 is formed, for approximately one-half its circumference, with the ribs 20a defining the cooling ducts 28; for the other half of its circumference, the outer face of sleeve 22 is lined with a copper reflector layer 52, as shown in Fig. 3, extending substantially along the complete length of the sleeve, this being at the side of the jacket carrying the inflatable balloon 7.
- Copper layer 52 reflects the electromagnetic radiation generated by the microwave antenna 4 in the direction away from balloon 7 so that the generated heat is concentrated in the body tissue at the side of the body opening opposite to the balloon.
- Thermocouples 50a, 50b, 50c are disposed substantially at the outer surface of jacket 2 adjacent to its distal end, and are spaced from each other a slight distance longitudinally of the jacket, as shown in Fig. 1, in order to measure the temperature at these three selected regions of the body cavity in which the applicator is inserted.
- the electrical conductors to these thermocouples pass axially along the side of the jacket occupied by reflector 52, on the outer face of the reflector as shown at 54a in Fig. 3, to the axial location of the respective thermocouple, and then pass circumferentially along the outer face of the reflector to-their respective thermocouple, as shown at 54b in Fig. 3.
- Reflector 52 thus substantially shields the electrical conductors from the electromagnetic field produced by the antenna.
- An insulating layer 56 is applied to insulate electrical conductors 54a, 54b from the reflector 52, and also to insulate the thermocouples 50a-50c from the cooling effect produced by the cooling fluid circulated through the cooling ducts 28.
- An outer thin protective layer such as a dipped coating, is applied to the outer face of jacket 2 covering the thermocouples 50a-50c and their electrical conductors 54a, 54b.
- the disposable sleeve 6, including the balloon 7 and tubelet 8, is supplied separately and may be applied to the outer face of the applicator 2 just before it is intended to be used.
- Sleeve 6 is preferably formed intergrally with balloon 7 from an elastomer, e.g., rubber latex.
- the sleeve is disposable for one-time use.
- the heating applicator illustrated in the drawings will be apparent from the above description.
- the applicator is inserted into the body opening, for example into the rectum via the anus, while balloon 7 is deflated.
- balloon 7 is inflated by pressurized air or water applied via bore 46 in end fitting 10, and tubelet 8.
- the inflation of the balloon causes it to firmly press the opposite side of the applicator against the body tissue in the opening.
- Electrical current is then applied to the microwave antenna 4 in order to generate a microwave field for heating the body tissue opposite to balloon 7, this energy being concentrated by reflector 52.
- water may be circulated via the cooling ducts 28 to cool the outer surface of the jacket, while the temperature within the body opening is measured by thermocouples 50a, 50b, 50c.
- balloon 7 at the distal end of the applicator displaces the applicator laterally within the body opening, thereby firmly pressing the side thereof through which the microwave radiation is transmitted (namely the side opposite to that occupied by balloon 7 and reflector 52) firmly against the body tissue.
- balloon 7 also enhances the cooling effect produced by the water circulated through the cooling ducts 28, thereby efficiently cooling the body tissue in direct contact with the applicator. This permits the application of relatively large amounts of heat to relatively remote tissue without undue discomfort to the subject, or heat damage to the adjacent tissue lining the body cavity receiving the applicator.
- the cooling water would not be circulated through the cooling ducts 28.
- the described applicator may therefore be used for heating relatively remote tissue, in which case cooling water would be circulated through cooling ducts, or adjacent tissue, e.g., tissue, lining the cavity receiving the applicator, in which case there would be no circulation of cooling fluid through the cooling ducts.
- thermocouples 50a-50c adjacent to the outer face of the jacket but thermally insulated from the cooling ducts 28, and the provision of the balloon pressing the thermocouples against the body tissue, produce a more precise measurement of the temperature of the body tissue being heated by the applicator.
- the electrical conductors to the thermocouples axially along the outer face of reflector 52 (conductor sections 54a, Fig. 3) and then circumferentially (conductor sections 54b, Fig. 3) to their respective thermocouples 50a-50c, the measurements produced by the thermocouples are substantially insensitive to the heat and electromagnetic field produced by the microwave antenna, thereby further increasing the precision of the temperature measurements of the body tissue.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Otolaryngology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Electromagnetism (AREA)
- Thermal Sciences (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Radiation-Therapy Devices (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
- Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT87630080T ATE66378T1 (de) | 1986-05-12 | 1987-05-07 | Zur einfuehrung in eine koerperoeffnung bestimmter applikator fuer den medizinischen gebrauch. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL78755A IL78755A0 (en) | 1986-05-12 | 1986-05-12 | Applicator for insertion into a body opening for medical purposes |
IL78755 | 1986-05-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0248758A1 true EP0248758A1 (de) | 1987-12-09 |
EP0248758B1 EP0248758B1 (de) | 1991-08-21 |
Family
ID=11056763
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP87630080A Expired - Lifetime EP0248758B1 (de) | 1986-05-12 | 1987-05-07 | Zur Einführung in eine Körperöffnung bestimmter Applikator für den medizinischen Gebrauch |
Country Status (7)
Country | Link |
---|---|
US (1) | US4823812A (de) |
EP (1) | EP0248758B1 (de) |
JP (1) | JPS6329665A (de) |
AT (1) | ATE66378T1 (de) |
DE (1) | DE3772265D1 (de) |
ES (1) | ES2025207B3 (de) |
IL (1) | IL78755A0 (de) |
Cited By (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2639238A1 (fr) * | 1988-11-21 | 1990-05-25 | Technomed Int Sa | Appareil de traitement chirurgical de tissus par hyperthermie, de preference la prostate, comprenant des moyens de protection thermique comprenant de preference des moyens formant ecran radioreflechissant |
WO1991013650A1 (en) * | 1988-11-21 | 1991-09-19 | Technomed International | Method and apparatus for the surgical treatment of tissues by thermal effect and in particular the prostate, using a urethral microwave-emitting probe means |
WO1991015708A1 (fr) * | 1990-04-06 | 1991-10-17 | Technomed International | Bras a extremite translatable et appareil de traitement therapeutique, en comportant application |
US5086786A (en) * | 1986-06-27 | 1992-02-11 | Kureha Kagaku Kogyo Kabushiki Kaisha | Electrode device for heating tumor in endotract organ |
DE4123418A1 (de) * | 1991-07-15 | 1992-04-09 | Alfred Dipl Ing Boeckmann | Hyperthermie-vorrichtung |
EP0485323A1 (de) * | 1990-11-09 | 1992-05-13 | Biodan Medical Systems Ltd | Hyperthermie Vorrichtung |
EP0521264A2 (de) * | 1991-07-03 | 1993-01-07 | W.L. Gore & Associates GmbH | Antennenanordnung mit Zuleitung |
WO1994002204A1 (en) * | 1992-07-15 | 1994-02-03 | Microwave Engineering Designs Limited | Microwave treatment apparatus |
BE1005816A3 (nl) * | 1992-05-11 | 1994-02-08 | Tecnomatix Medical Naamloze Ve | Apparaat voor het heelkundig behandelen van prostaat-weefselaandoeningen. |
FR2699069A1 (fr) * | 1992-12-15 | 1994-06-17 | Sadis Bruker Spectrospin | Applicateur, notamment pour la thermothérapie micro-onde de l'endomètre, et dispositif de traitement comportant un tel applicateur. |
US5330518A (en) * | 1992-03-06 | 1994-07-19 | Urologix, Inc. | Method for treating interstitial tissue associated with microwave thermal therapy |
US5404881A (en) * | 1990-04-06 | 1995-04-11 | Technomed International | Transrectal probe |
US5413588A (en) * | 1992-03-06 | 1995-05-09 | Urologix, Inc. | Device and method for asymmetrical thermal therapy with helical dipole microwave antenna |
US5509929A (en) * | 1988-11-21 | 1996-04-23 | Technomed Medical Systems | Urethral probe and apparatus for the therapeutic treatment of the prostate by thermotherapy |
US5792070A (en) * | 1996-08-30 | 1998-08-11 | Urologix, Inc. | Rectal thermosensing unit |
US5861021A (en) * | 1996-06-17 | 1999-01-19 | Urologix Inc | Microwave thermal therapy of cardiac tissue |
FR2768931A1 (fr) | 1997-10-01 | 1999-04-02 | Technomed Medical Systems | Sonde rectale refroidie |
US5902251A (en) * | 1996-05-06 | 1999-05-11 | Vanhooydonk; Neil C. | Transcervical intrauterine applicator for intrauterine hyperthermia |
US5938692A (en) * | 1996-03-26 | 1999-08-17 | Urologix, Inc. | Voltage controlled variable tuning antenna |
US6245062B1 (en) | 1998-10-23 | 2001-06-12 | Afx, Inc. | Directional reflector shield assembly for a microwave ablation instrument |
US6348039B1 (en) | 1999-04-09 | 2002-02-19 | Urologix, Inc. | Rectal temperature sensing probe |
US6673068B1 (en) | 2000-04-12 | 2004-01-06 | Afx, Inc. | Electrode arrangement for use in a medical instrument |
US8224455B2 (en) | 2002-02-15 | 2012-07-17 | Boston Scientific Corporation | Drug delivery |
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US5385544A (en) * | 1992-08-12 | 1995-01-31 | Vidamed, Inc. | BPH ablation method and apparatus |
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US4967759A (en) * | 1988-06-29 | 1990-11-06 | Teves Leonides Y | Cardiac monitor with endotracheal sensor |
US5080107A (en) * | 1988-06-29 | 1992-01-14 | Teves Leonides Y | Cardiac monitor with endotracheal sensor |
US5007437A (en) * | 1989-06-16 | 1991-04-16 | Mmtc, Inc. | Catheters for treating prostate disease |
US5195955A (en) * | 1989-11-14 | 1993-03-23 | Don Michael T Anthony | Device for removal of embolic debris |
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US5086786A (en) * | 1986-06-27 | 1992-02-11 | Kureha Kagaku Kogyo Kabushiki Kaisha | Electrode device for heating tumor in endotract organ |
EP0370890A1 (de) * | 1988-11-21 | 1990-05-30 | Technomed Medical Systems | Vorrichtung zur chirurgischen Behandlung von Geweben mit Hyperthermie, vorzugsweise der Prostata, versehen mit einer Hitzeabschirmung, vorzugsweise mit einer radioreflektiven Abschirmung |
JPH02180279A (ja) * | 1988-11-21 | 1990-07-13 | Technomed Internatl Sa | 尿道を介して前立腺を熱治療するための装置 |
WO1991013650A1 (en) * | 1988-11-21 | 1991-09-19 | Technomed International | Method and apparatus for the surgical treatment of tissues by thermal effect and in particular the prostate, using a urethral microwave-emitting probe means |
EP0459535A2 (de) * | 1988-11-21 | 1991-12-04 | Technomed Medical Systems | Vorrichtung zur chirurgischen Behandlung von Geweben mit Hyperthermie, vorzugsweise der Prostata versehen mit Kühlvorrichtung |
EP0459535A3 (en) * | 1988-11-21 | 1992-01-02 | Technomed International | Apparatus for the surgical treatment of tissues by hyperthermia, preferably the prostate, with cooling means |
US5509929A (en) * | 1988-11-21 | 1996-04-23 | Technomed Medical Systems | Urethral probe and apparatus for the therapeutic treatment of the prostate by thermotherapy |
FR2639238A1 (fr) * | 1988-11-21 | 1990-05-25 | Technomed Int Sa | Appareil de traitement chirurgical de tissus par hyperthermie, de preference la prostate, comprenant des moyens de protection thermique comprenant de preference des moyens formant ecran radioreflechissant |
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US5404881A (en) * | 1990-04-06 | 1995-04-11 | Technomed International | Transrectal probe |
WO1991015708A1 (fr) * | 1990-04-06 | 1991-10-17 | Technomed International | Bras a extremite translatable et appareil de traitement therapeutique, en comportant application |
EP0485323A1 (de) * | 1990-11-09 | 1992-05-13 | Biodan Medical Systems Ltd | Hyperthermie Vorrichtung |
EP0521264A2 (de) * | 1991-07-03 | 1993-01-07 | W.L. Gore & Associates GmbH | Antennenanordnung mit Zuleitung |
EP0521264A3 (en) * | 1991-07-03 | 1993-06-16 | W.L. Gore & Associates Gmbh | Antenna device with feed |
DE4123418A1 (de) * | 1991-07-15 | 1992-04-09 | Alfred Dipl Ing Boeckmann | Hyperthermie-vorrichtung |
WO1993001774A1 (de) * | 1991-07-15 | 1993-02-04 | Boeckmann Alfred | Hyperthermie-vorrichtung |
DE4123418C2 (de) * | 1991-07-15 | 1998-02-19 | Alfred Dipl Ing Boeckmann | Hyperthermie-Vorrichtung, insbesondere zur Behandlung von Prostataleiden |
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BE1005816A3 (nl) * | 1992-05-11 | 1994-02-08 | Tecnomatix Medical Naamloze Ve | Apparaat voor het heelkundig behandelen van prostaat-weefselaandoeningen. |
WO1994002204A1 (en) * | 1992-07-15 | 1994-02-03 | Microwave Engineering Designs Limited | Microwave treatment apparatus |
FR2699069A1 (fr) * | 1992-12-15 | 1994-06-17 | Sadis Bruker Spectrospin | Applicateur, notamment pour la thermothérapie micro-onde de l'endomètre, et dispositif de traitement comportant un tel applicateur. |
US6032078A (en) * | 1996-03-26 | 2000-02-29 | Urologix, Inc. | Voltage controlled variable tuning antenna |
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US5902251A (en) * | 1996-05-06 | 1999-05-11 | Vanhooydonk; Neil C. | Transcervical intrauterine applicator for intrauterine hyperthermia |
US5861021A (en) * | 1996-06-17 | 1999-01-19 | Urologix Inc | Microwave thermal therapy of cardiac tissue |
US5792070A (en) * | 1996-08-30 | 1998-08-11 | Urologix, Inc. | Rectal thermosensing unit |
FR2768931A1 (fr) | 1997-10-01 | 1999-04-02 | Technomed Medical Systems | Sonde rectale refroidie |
US6245062B1 (en) | 1998-10-23 | 2001-06-12 | Afx, Inc. | Directional reflector shield assembly for a microwave ablation instrument |
US6312427B1 (en) | 1998-10-23 | 2001-11-06 | Afx, Inc. | Directional reflector shield assembly for a microwave ablation instrument |
US6364876B1 (en) | 1998-10-23 | 2002-04-02 | Afx, Inc. | Vacuum-assisted securing apparatus for a microwave ablation instrument |
US6383182B1 (en) | 1998-10-23 | 2002-05-07 | Afx Inc. | Directional microwave ablation instrument with off-set energy delivery portion |
US6348039B1 (en) | 1999-04-09 | 2002-02-19 | Urologix, Inc. | Rectal temperature sensing probe |
US6673068B1 (en) | 2000-04-12 | 2004-01-06 | Afx, Inc. | Electrode arrangement for use in a medical instrument |
US8224455B2 (en) | 2002-02-15 | 2012-07-17 | Boston Scientific Corporation | Drug delivery |
US8374702B2 (en) | 2002-02-15 | 2013-02-12 | Medifocus, Inc. | Drug delivery |
Also Published As
Publication number | Publication date |
---|---|
IL78755A0 (en) | 1986-08-31 |
US4823812A (en) | 1989-04-25 |
EP0248758B1 (de) | 1991-08-21 |
ATE66378T1 (de) | 1991-09-15 |
JPS6329665A (ja) | 1988-02-08 |
ES2025207B3 (es) | 1992-03-16 |
DE3772265D1 (de) | 1991-09-26 |
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