EE200400022A - Pürrolidiinoksadiasooli ja -tiadiasooli derivaadid, nende valmistamise meetod ja neid sisaldavad ravimkoostised - Google Patents

Pürrolidiinoksadiasooli ja -tiadiasooli derivaadid, nende valmistamise meetod ja neid sisaldavad ravimkoostised

Info

Publication number
EE200400022A
EE200400022A EEP200400022A EEP200400022A EE200400022A EE 200400022 A EE200400022 A EE 200400022A EE P200400022 A EEP200400022 A EE P200400022A EE P200400022 A EEP200400022 A EE P200400022A EE 200400022 A EE200400022 A EE 200400022A
Authority
EE
Estonia
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
thiadiazole derivatives
pyrrolidine oxadiazole
Prior art date
Application number
EEP200400022A
Other languages
English (en)
Inventor
Schwarz Matthias
Quattropani Anna
Page Patrick
J. Russell Thomas
Pomel Vincent
Original Assignee
Applied Research Systems Ars Holding N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems Ars Holding N.V. filed Critical Applied Research Systems Ars Holding N.V.
Publication of EE200400022A publication Critical patent/EE200400022A/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
EEP200400022A 2001-06-18 2002-06-14 Pürrolidiinoksadiasooli ja -tiadiasooli derivaadid, nende valmistamise meetod ja neid sisaldavad ravimkoostised EE200400022A (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01113632 2001-06-18
PCT/EP2002/006629 WO2002102799A2 (en) 2001-06-18 2002-06-14 Pyrrolidine oxadiazole- and thiadiazole oxime derivatives being oxytocin receptor antagonists

Publications (1)

Publication Number Publication Date
EE200400022A true EE200400022A (et) 2004-04-15

Family

ID=8177641

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200400022A EE200400022A (et) 2001-06-18 2002-06-14 Pürrolidiinoksadiasooli ja -tiadiasooli derivaadid, nende valmistamise meetod ja neid sisaldavad ravimkoostised

Country Status (27)

Country Link
US (2) US7115639B2 (et)
EP (1) EP1444225B1 (et)
JP (1) JP4426284B2 (et)
KR (1) KR20040030678A (et)
CN (1) CN100564378C (et)
AR (1) AR036108A1 (et)
AU (1) AU2002319237B2 (et)
BG (1) BG108424A (et)
BR (1) BR0211030A (et)
CA (1) CA2449578C (et)
CZ (1) CZ20033475A3 (et)
EA (1) EA006212B1 (et)
EE (1) EE200400022A (et)
ES (1) ES2397305T3 (et)
HK (1) HK1074204A1 (et)
HR (1) HRP20031017A2 (et)
HU (1) HUP0400238A2 (et)
IL (1) IL159219A0 (et)
MX (1) MXPA03011441A (et)
MY (1) MY128890A (et)
NO (1) NO20035399L (et)
PL (1) PL367275A1 (et)
RS (1) RS99503A (et)
SK (1) SK15552003A3 (et)
UA (1) UA75145C2 (et)
WO (1) WO2002102799A2 (et)
ZA (1) ZA200309402B (et)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20040030678A (ko) 2001-06-18 2004-04-09 어플라이드 리서치 시스템스 에이알에스 홀딩 엔.브이. 피롤리딘 옥사디아졸 및 티아디아졸 유도체
US7557136B2 (en) * 2003-02-27 2009-07-07 Laboratoires Serono Sa Pyrrolidine derivatives as oxytocin antagonists
EP1725526B1 (en) * 2004-02-26 2007-12-12 Laboratoires Serono SA Method for preparing pyrrolidine oximes
KR101562549B1 (ko) 2005-05-10 2015-10-23 인사이트 홀딩스 코포레이션 인돌아민 2,3-디옥시게나제의 조절제 및 이의 사용방법
TWI382974B (zh) 2005-12-20 2013-01-21 Incyte Corp 作為吲哚胺２，３-二氧化酶調節劑之ｎ-羥基甲脒基雜環化物
US20080125470A1 (en) 2006-09-19 2008-05-29 Incyte Corporation N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
CL2007002650A1 (es) 2006-09-19 2008-02-08 Incyte Corp Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras.
PE20110308A1 (es) 2008-07-08 2011-06-10 Incyte Corp 1,2,5-oxadiazoles como inhibidores de indolamina 2,3-dioxigenasa
EP2845850A1 (en) 2013-09-10 2015-03-11 ObsEva S.A. Pyrrolidine derivatives as oxytocin/vasopressin V1a receptors antagonists
EP3066085B1 (en) 2013-11-08 2020-05-13 Incyte Holdings Corporation Process for the synthesis of an indoleamine 2,3-dioxygenase inhibitor
EP2886107A1 (en) 2013-12-17 2015-06-24 ObsEva S.A. Oral formulations of pyrrolydine derivatives
CN114105850A (zh) 2014-07-02 2022-03-01 奥布赛瓦股份公司 治疗ot-r活性相关的病症的方法中可用的晶体

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2722190B1 (fr) 1994-07-05 1996-10-04 Sanofi Sa Derives de 1-benzyl-1,3-dihydro-2h-benzimidazol-2-one, leur preparation, les compositions pharmaceutique en contenant
AU4763896A (en) 1995-01-24 1996-08-14 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists
US5756497A (en) 1996-03-01 1998-05-26 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists
FR2757157B1 (fr) 1996-12-13 1999-12-31 Sanofi Sa Derives d'indolin-2-one, procede pour leur preparation et compositions pharmaceutiques les contenant
JP2002543129A (ja) 1999-05-05 2002-12-17 メルク エンド カムパニー インコーポレーテッド 抗微生物剤としての新規なプロリン類
WO2001074769A1 (en) * 2000-03-27 2001-10-11 Applied Research Systems Ars Holding N.V. Pharmaceutically active pyrrolidine derivatives as bax inhibitors
AU2001256209B2 (en) * 2000-03-27 2006-02-16 Merck Serono Sa Pharmaceutically active pyrrolidine derivatives
AU1401902A (en) * 2000-10-17 2002-04-29 Applied Research Systems Pharmaceutically active sulfanilide derivatives
ATE394371T1 (de) * 2001-03-20 2008-05-15 Serono Lab Pyrrolidinesterderivate mit oxytocinmodulierender wirkung
KR20040030678A (ko) 2001-06-18 2004-04-09 어플라이드 리서치 시스템스 에이알에스 홀딩 엔.브이. 피롤리딘 옥사디아졸 및 티아디아졸 유도체
WO2003053437A1 (en) * 2001-12-20 2003-07-03 Applied Research Systems Ars Holding N.V. Triazoles as oxytocin antagonists
UA78058C2 (en) * 2002-07-05 2007-02-15 Applied Research Systems Pyrrolidine derivative as oxitocin antagonists

Also Published As

Publication number Publication date
EP1444225B1 (en) 2012-10-10
EA200400049A1 (ru) 2004-08-26
JP4426284B2 (ja) 2010-03-03
NO20035399D0 (no) 2003-12-04
HUP0400238A2 (hu) 2004-07-28
MY128890A (en) 2007-02-28
JP2004534804A (ja) 2004-11-18
KR20040030678A (ko) 2004-04-09
CA2449578A1 (en) 2002-12-27
US7115639B2 (en) 2006-10-03
ZA200309402B (en) 2004-12-03
CA2449578C (en) 2011-12-13
US20060229343A1 (en) 2006-10-12
AR036108A1 (es) 2004-08-11
SK15552003A3 (sk) 2004-05-04
BG108424A (en) 2005-03-31
WO2002102799A2 (en) 2002-12-27
BR0211030A (pt) 2004-06-22
CZ20033475A3 (en) 2004-05-12
WO2002102799A3 (en) 2003-04-03
UA75145C2 (en) 2006-03-15
MXPA03011441A (es) 2004-07-01
NO20035399L (no) 2004-02-17
HRP20031017A2 (en) 2004-04-30
ES2397305T3 (es) 2013-03-06
EP1444225A2 (en) 2004-08-11
AU2002319237B2 (en) 2008-01-03
RS99503A (en) 2006-12-15
PL367275A1 (en) 2005-02-21
CN1639155A (zh) 2005-07-13
HK1074204A1 (en) 2005-11-04
IL159219A0 (en) 2004-06-01
CN100564378C (zh) 2009-12-02
US20040220238A1 (en) 2004-11-04
EA006212B1 (ru) 2005-10-27

Similar Documents

Publication Publication Date Title
EE200000707A (et) Oksasolidinooni derivaadid, nende valmistamismeetod ja neid sisaldavad farmatseutilised kompositsioonid
EE04779B1 (et) 1,3-dihüdro-2H-indool-2-ooni derivaadid, nende valmistamismeetod ja neid sisaldavad farmatseutilised kompositsioonid
NO20024175L (no) Azetidinderivater, deres fremstilling og farmasöytiske preparater inneholdende forbindelsene
EE200300054A (et) Kinaasi inhibiitoritena toimivad bitsüklopürasoolid, nende valmistamismeetod, kasutamine ja neid sisaldavad farmatseutilised kompositsioonid
EE200200486A (et) Farmatseutilised kompositsioonid, mis sisaldavad 3-aminoasetidiini derivaate, uued derivaadid ja nende valmistamismeetodid
EE200100484A (et) Bitsüklilised heterotsüklilised ühendid, neid ühendeid sisaldavad farmatseutilised kompositsioonid,ja nende valmistamise meetodid
IL164798A0 (en) Benzothiadiazepine derivatives, processes for their preparation and pharmaceutical compositions containing them
NO20016038D0 (no) Benzenderivater, fremgangsmåte for deres fremstilling og farmasöytiske preparater inneholdende de samme
EE200300254A (et) Heterotsüklilised ühendid, millel on antibakteriaalne toime, nende valmistamismeetod ja neid sisaldavad farmatseutilised kompositsioonid
HUP0401747A3 (en) Piridazine derivatives of hydrazono-malonitriles, their use, process for preparation of the compounds and pharmaceutical compositions containing the compounds
EE200400022A (et) Pürrolidiinoksadiasooli ja -tiadiasooli derivaadid, nende valmistamise meetod ja neid sisaldavad ravimkoostised
HUP0400156A3 (en) Pyrrolidine derivatives as factor xa inhibitors, their preparation and pharmaceutical compositions containing them
PL356911A1 (en) Novel heterocyclic derivatives, preparation method and pharmaceutical compositions containing same
EE05004B1 (et) Aminotiasooli derivaadid, nende valmistamine ja neid sisaldavad farmatseutilised kompositsioonid
SI1118610T1 (en) Benzenesulfonamide derivatives, process for their preparation and pharmaceutical compositions containing them
HUP0204001A3 (en) Substituted aminomethyl-phenyl-cyclohexane derivatives, process for their preparation and pharmaceutical compositions containing them
HUP0303361A3 (en) Substituted 1-aminobutan-3-ol derivatives, process for their preparation and pharmaceutical compositions containing them
HUP0303105A3 (en) Novel aminocyclohexane derivatives, process for their preparation, pharmaceutical compositions containing them and their use
EE200300553A (et) Piperidiinkarboksamiidi derivaadid, nende valmistamise meetod ja neid sisaldavad farmatseutilised kompositsioonid
EE04778B1 (et) Hargnenud ahelaga asendatud 3-amino-1-fenüül-1H-[1,2,4]triasooli aminoderivaadid, nende valmistamismeetod ja neid sisaldavad farmatseutilised kompositsioonid
EE200100499A (et) Uued morfoliini derivaadid, nende valmistamismeetod ja neid sisaldavad farmatseutilised kompositsioonid
AU2002306687A1 (en) Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them
EE04437B1 (et) (1-fenatsüül-3-fenüül-3-piperidinüületüül)piperidiini derivaadid, nende valmistamismeetod ja neid sisaldavad farmatseutilised kompositsioonid
SI1245565T1 (en) Indenoindolone derivatives, process for their preparation and pharmaceutical compositions containing them
EE200300548A (et) Uudsed 5-tio-ß-D-ksülopüranosiidi derivaadid, nende valmistamise meetod, neid sisaldavad farmatseutilised kompositsioonid ja nende terapeutiline kasutamine