EE200200441A - 2-arüülpropioonhappe amiidide R-enantiomeerid, nende valmistamismeetod, farmatseutiline kompositsioon ja 2-arüülpropioonhapete R-enantiomeerid - Google Patents

2-arüülpropioonhappe amiidide R-enantiomeerid, nende valmistamismeetod, farmatseutiline kompositsioon ja 2-arüülpropioonhapete R-enantiomeerid

Info

Publication number
EE200200441A
EE200200441A EEP200200441A EEP200200441A EE200200441A EE 200200441 A EE200200441 A EE 200200441A EE P200200441 A EEP200200441 A EE P200200441A EE P200200441 A EEP200200441 A EE P200200441A EE 200200441 A EE200200441 A EE 200200441A
Authority
EE
Estonia
Prior art keywords
enantiomers
arylpropionic
preparation
amides
pharmaceutical composition
Prior art date
Application number
EEP200200441A
Other languages
English (en)
Inventor
Allegretti Marcello
Bertini Riccardo
Bizzarri Cinzia
Sabbatini Vilma
Caselli Gianfranco
Candida Cesta Maria
Gandolfi Carmelo
Colotta Francesco
Original Assignee
Domp S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Domp S.P.A. filed Critical Domp S.P.A.
Publication of EE200200441A publication Critical patent/EE200200441A/et
Publication of EE05284B1 publication Critical patent/EE05284B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/22—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/51—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/52—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C07C235/76—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C235/78—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/62—Compounds containing any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylcarbamates
    • C07C271/64—Y being a hydrogen or a carbon atom, e.g. benzoylcarbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Neurology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Indole Compounds (AREA)
EEP200200441A 2000-02-11 2001-02-06 2-arlpropioonhappe amiidide R-enantiomeerid, nende valmistamismeetod, farmatseutiline kompositsioon ja 2-arlpropioonhapete R-enantiomeerid EE05284B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2000MI000227A IT1317826B1 (it) 2000-02-11 2000-02-11 Ammidi, utili nell'inibizione della chemiotassi dei neutrofiliindotta da il-8.
PCT/EP2001/001285 WO2001058852A2 (en) 2000-02-11 2001-02-06 (r)-2-aryl-propionamides, useful in the inhibition of il-8-induced chemiotaxis of neutrophils

Publications (2)

Publication Number Publication Date
EE200200441A true EE200200441A (et) 2003-12-15
EE05284B1 EE05284B1 (et) 2010-04-15

Family

ID=11443980

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200200441A EE05284B1 (et) 2000-02-11 2001-02-06 2-arlpropioonhappe amiidide R-enantiomeerid, nende valmistamismeetod, farmatseutiline kompositsioon ja 2-arlpropioonhapete R-enantiomeerid

Country Status (28)

Country Link
US (1) US7705050B2 (et)
EP (1) EP1255726B1 (et)
JP (1) JP4937479B2 (et)
KR (1) KR100884417B1 (et)
CN (1) CN100513386C (et)
AT (1) ATE448195T1 (et)
AU (2) AU4412501A (et)
BR (2) BR0108152A (et)
CA (1) CA2396937C (et)
CY (1) CY1109780T1 (et)
CZ (1) CZ302945B6 (et)
DE (1) DE60140429D1 (et)
DK (1) DK1255726T3 (et)
EE (1) EE05284B1 (et)
ES (1) ES2336301T3 (et)
HK (1) HK1062675A1 (et)
HU (1) HU229447B1 (et)
IL (1) IL150523A0 (et)
IT (1) IT1317826B1 (et)
MX (1) MXPA02007714A (et)
NO (1) NO331460B1 (et)
NZ (1) NZ519925A (et)
PL (1) PL207126B1 (et)
PT (1) PT1255726E (et)
RU (1) RU2273630C2 (et)
SI (1) SI1255726T1 (et)
SK (1) SK287224B6 (et)
WO (1) WO2001058852A2 (et)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1318466B1 (it) * 2000-04-14 2003-08-25 Dompe Spa Ammidi di acidi r-2-(amminoaril)-propionici, utili nella prevenzionedell'attivazione leucocitaria.
TWI243164B (en) 2001-02-13 2005-11-11 Aventis Pharma Gmbh Acylated indanyl amines and their use as pharmaceuticals
ITMI20010395A1 (it) 2001-02-27 2002-08-27 Dompe Spa Omega-amminoalchilammidi di acidi r-2-aril-propionici come inibitori della chemiotassi di cellule polimorfonucleate e mononucleate
ITMI20012025A1 (it) 2001-09-28 2003-03-28 Dompe Spa Sali di ammonio quaternari di omega-amminoalchilammidi di acidi r 2-aril-propionici e composizioni farmaceutiche che li contengono
ITMI20012434A1 (it) 2001-11-20 2003-05-20 Dompe Spa Acidi 2-aril-propionici e composizioni farmaceutiche che li contengono
PT1581474E (pt) 2002-12-10 2008-12-09 Dompe Spa Arilcetonas quirais no tratamento de doenças inflamatórias dependentes de neutrófilos
HUE026285T2 (en) 2003-02-06 2016-05-30 Dompe Farm Spa 2-arylacetic acid compounds and their derivatives and pharmaceutical compositions containing them
EP1457485A1 (en) * 2003-03-14 2004-09-15 Dompé S.P.A. Sulfonic acids, their derivatives and pharmaceutical compositions containing them
CA2539842C (en) * 2003-09-25 2013-02-12 Dompe S.P.A. Amidines and derivatives thereof and pharmaceutical compositions containing them
CN1934077B (zh) * 2004-03-23 2010-09-29 冬姆佩制药股份公司 2-苯基丙酸衍生物及含有它们的药物组合物
ATE423760T1 (de) * 2004-12-15 2009-03-15 Dompe Pha R Ma Spa Res & Mfg 2-arylpropionsäurederivate und pharmazeutische zusammensetzungen, die diese enthalten
EP1676834A1 (en) 2004-12-30 2006-07-05 Sanofi-Aventis Deutschland GmbH Fused bicyclic carboxamide derivates for use as CXCR2 inhibitors in the treatment of inflammation
AU2006208729A1 (en) * 2005-01-25 2006-08-03 Dompe' Pha.R.Ma S.P.A Metabolites of 2-arylpropionic acid derivatives and pharmaceutical compositions containing them
AU2007253424B2 (en) * 2006-05-18 2013-03-07 Dompe' Farmaceutici S.P.A. (2R)-2-[(4-sulfonyl)aminophenyl]propanamides and pharmaceutical compositions containing them
JP5232144B2 (ja) 2006-06-28 2013-07-10 サノフイ Ｃｘｃｒ２阻害剤
EP2041072B1 (en) 2006-06-28 2013-09-11 Sanofi Cxcr2 antagonists
KR20090023645A (ko) 2006-06-28 2009-03-05 사노피-아벤티스 신규한 ｃｘｃｒ2 억제제
JP5352455B2 (ja) * 2006-06-30 2013-11-27 サノフイ Ｃｘｃｒ２阻害剤
US20090238763A1 (en) 2006-07-09 2009-09-24 Chongxi Yu High penetration compositions and uses thereof
US20090221703A1 (en) 2006-07-09 2009-09-03 Chongxi Yu High penetration composition and uses thereof
CN103772258B (zh) * 2006-08-08 2016-09-28 于崇曦 具有快速皮肤穿透速度的带正电荷的芳基和杂芳基乙酸类前药
PT2049482E (pt) * 2006-08-08 2016-02-24 Techfields Biochem Co Ltd Profármacos solúveis em água carregados positivamente de ácidos aril- e heteroarilacéticos com velocidade de penetração na pele muito rápida
CN103772259B (zh) * 2006-08-08 2016-08-31 于崇曦 具有快速皮肤穿透速度的带正电荷的芳基和杂芳基乙酸类前药
JP5424880B2 (ja) * 2006-08-15 2014-02-26 テックフィールズ バイオケム カンパニー リミテッド 非常に速い皮膚透過率を有するアリール−及びヘテロアリールプロピオン酸の正荷電水溶性プロドラッグ
CN105820107B (zh) 2007-06-04 2022-09-09 泰飞尔公司 具有快速皮肤和生物膜穿透速度的非甾体抗炎药的前药及其新的医药用途
CN101820879B (zh) * 2007-10-08 2013-01-02 疟疾药物投资公司 具有柔性侧链的抗疟用化合物
RU2527177C2 (ru) 2007-12-20 2014-08-27 Энвиво Фармасьютикалз, Инк. Четырехзамещенные бензолы
EP2166006A1 (en) 2008-09-18 2010-03-24 Dompe' S.P.A. 2-aryl-propionic acids and derivatives and pharmaceutical compositions containing them
KR20200022525A (ko) 2008-12-04 2020-03-03 충시 위 고투과력을 가진 조성물 및 이의 적용
EP2635278B1 (en) * 2010-11-03 2019-12-11 Dow AgroSciences LLC Pesticidal compositions and processes related thereto
CN103159674A (zh) * 2013-04-03 2013-06-19 苏州安诺生物医药技术有限公司 2-苯烷酰胺类化合物及其制备方法、药物组合物和用途
US11850220B2 (en) * 2020-05-19 2023-12-26 Augusta University Research Institute, Inc. Synthesis of ibuprofen hybrid conjugates as anti-inflammatory and analgesic agents
KR20230093944A (ko) 2021-12-20 2023-06-27 주식회사 우아한형제들 자율이동장치의 최적 주행 경로를 결정하기 위한 방법 및 이를 수행하는 컴퓨팅 시스템

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54141754A (en) * 1978-04-26 1979-11-05 Takayuki Shioiri Manufacture of 22*33benzoylphenyl*propionic acid
IT1193955B (it) * 1980-07-22 1988-08-31 Real Di Alberto Reiner S A S Derivati ammidici dell'acido p-isobutilfenilpropionico, procedimento per la loro preparazione e relative composizioni farmaceutici
IT1203605B (it) * 1985-04-18 1989-02-15 Alfa Chem Ital Processo per la risoluzione ottica di miscigli racemi di acidi e naftilpropionici
GB8719886D0 (en) 1987-08-22 1987-09-30 British Petroleum Co Plc Carboxylic acid esters/acids
JPH0791216B2 (ja) * 1988-10-10 1995-10-04 日本石油化学株式会社 α−（３−（１−フエニルエチル）フェニル）プロピオン酸
WO1994003209A1 (en) * 1992-07-29 1994-02-17 Merck & Co., Inc. Dexibuprofen/antacid/simethicone combinations
EP0618223A3 (en) * 1993-03-08 1996-06-12 Sandoz Ltd Peptides, the release of Interleukin 1-Bêta, useful as anti-inflammatory agents.
JPH07149646A (ja) * 1993-11-29 1995-06-13 Asahi Chem Ind Co Ltd ケミカルメディエーター遊離抑制剤
US6040321A (en) * 1997-11-12 2000-03-21 Bristol-Myers Squibb Company Aminothiazole inhibitors of cyclin dependent kinases
MY153569A (en) * 1998-01-20 2015-02-27 Mitsubishi Tanabe Pharma Corp Inhibitors of ?4 mediated cell adhesion
WO2000002903A1 (en) * 1998-07-10 2000-01-20 Cytel Corporation Cs-1 peptidomimetics, compositions and methods of using the same
GB9823871D0 (en) 1998-10-30 1998-12-23 Pharmacia & Upjohn Spa 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents

Also Published As

Publication number Publication date
WO2001058852A3 (en) 2002-03-14
SI1255726T1 (sl) 2010-03-31
NO20023817D0 (no) 2002-08-12
DE60140429D1 (de) 2009-12-24
HK1062675A1 (en) 2004-11-19
ES2336301T3 (es) 2010-04-12
PL207126B1 (pl) 2010-11-30
IT1317826B1 (it) 2003-07-15
CN1479715A (zh) 2004-03-03
CZ302945B6 (cs) 2012-01-25
PT1255726E (pt) 2010-02-11
BRPI0108152B1 (pt) 2017-09-26
HUP0301576A2 (hu) 2003-11-28
CZ20022728A3 (cs) 2003-01-15
CA2396937C (en) 2011-09-13
US20040181073A1 (en) 2004-09-16
CA2396937A1 (en) 2001-08-16
MXPA02007714A (es) 2002-10-23
RU2273630C2 (ru) 2006-04-10
EP1255726B1 (en) 2009-11-11
JP2003522750A (ja) 2003-07-29
DK1255726T3 (da) 2010-03-22
BR0108152A (pt) 2003-03-25
AU4412501A (en) 2001-08-20
IL150523A0 (en) 2003-02-12
SK11412002A3 (sk) 2003-01-09
RU2002124136A (ru) 2004-01-10
ATE448195T1 (de) 2009-11-15
EP1255726A2 (en) 2002-11-13
PL362506A1 (en) 2004-11-02
NO20023817L (no) 2002-08-12
HUP0301576A3 (en) 2004-10-28
AU2001244125B2 (en) 2006-11-09
KR20020073194A (ko) 2002-09-19
HU229447B1 (en) 2013-12-30
ITMI20000227A1 (it) 2001-08-11
CY1109780T1 (el) 2014-09-10
ITMI20000227A0 (it) 2000-02-11
KR100884417B1 (ko) 2009-02-19
NZ519925A (en) 2004-12-24
WO2001058852A2 (en) 2001-08-16
SK287224B6 (sk) 2010-03-08
JP4937479B2 (ja) 2012-05-23
US7705050B2 (en) 2010-04-27
CN100513386C (zh) 2009-07-15
EE05284B1 (et) 2010-04-15
NO331460B1 (no) 2012-01-09

Similar Documents

Publication Publication Date Title
EE05284B1 (et) 2-arlpropioonhappe amiidide R-enantiomeerid, nende valmistamismeetod, farmatseutiline kompositsioon ja 2-arlpropioonhapete R-enantiomeerid
MXPA03006786A (es) Omega-aminoalquilamidas de los acidos r-2-aril-propionicos como inhibidores de la quimiotaxis de las celulas mononucleadas y polimorfonucleadas.
CA2458035A1 (en) Quaternary ammonium salts of omega-aminoalkylamides of r-2-aryl-propionic acids and pharmaceutical compositions containing them
ATE326453T1 (de) Antithrombotische amide
HRP20050663A2 (en) Malonamide derivatives as gamma-secretase inhibitors
ATE374765T1 (de) Substituierte heterocyclische amide
DK0661269T3 (da) Substituerede heterocykliske carboxylsyreamider, deres fremstilling og anvendelse som lægemidler.
DE69919212D1 (de) Aromatische amiden
BR0008015A (pt) Uso de um composto, composto, composições farmacêuticas, e, processo para preparar um composto
BRPI9914741B8 (pt) n-(2-aril-proprionil)-sulfonamidas, usos e composições farmacêuticas contendo as mesmas.
HK1094650A1 (en) The use of fumaric acid derivatives in the manufacture of a medicament for treating asthma and chronic obstructive pulmonary diseases
EA200401108A1 (ru) Соли толтеродина
CY1107078T1 (el) Αμιδια του r-2-(αμινοαρυλ)-προπιονικου οξεος για χρηση στην προληψη της ενεργοποιησης των λευκοκυτταρων
BR0313727A (pt) Derivados de isoquinolina como inibidores de metaloproteinase da matriz
ATE268337T1 (de) C11-carbamate von antibakteriellen makroliden
HUP0402515A2 (hu) Szubsztituált új N-[4-(1H-imidazol-1-il)-2-fluor-fenil]-3-(trifluor-metil)-1H-pirazol-5-karboxamidok Xa faktor inhibitorok, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények
ATE521589T1 (de) Amidine und derivate davon und pharmazeutische zusammensetzungen, die diese enthalten
CY1110814T1 (el) Νεα υποκατεστημενα αρυλοεξαδιενικα οξεα και εστερες αυτων τα οποια μπορουν να χρησιμοποιηθουν για την αγωγη και προληψη του διαβητη, δυσλιπιδαιμιας και αθηροσκληρωσης, φαρμακευτικες συνθεσεις που τα περιλαμβανουν και διεργασιες για την παρασκευη αυτων
ATE222583T1 (de) Derivate substituierter amidinonaphthylester

Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20101231

GB1A Change in the ownership or in the address of the owner
MM4A Lapsed by not paying the annual fees

Effective date: 20190206