EE05300B1 - Akrloldistamtsiini derivaati sisaldav farmatseutiline kompositsioon, derivaadi kasutamine tuumorivastase ravimi valmistamiseks ning kombineeritud ravimpreparaat - Google Patents

Akrloldistamtsiini derivaati sisaldav farmatseutiline kompositsioon, derivaadi kasutamine tuumorivastase ravimi valmistamiseks ning kombineeritud ravimpreparaat

Info

Publication number
EE05300B1
EE05300B1 EEP200200660A EEP200200660A EE05300B1 EE 05300 B1 EE05300 B1 EE 05300B1 EE P200200660 A EEP200200660 A EE P200200660A EE P200200660 A EEP200200660 A EE P200200660A EE 05300 B1 EE05300 B1 EE 05300B1
Authority
EE
Estonia
Prior art keywords
derivative
acrylamine
preparation
tumor drug
pharmaceutical composition
Prior art date
Application number
EEP200200660A
Other languages
English (en)
Inventor
Cristina Rosa Geroni Maria
Cozzi Paolo
Beria Italo
Original Assignee
Pharmacia Italia S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Italia S.P.A. filed Critical Pharmacia Italia S.P.A.
Publication of EE200200660A publication Critical patent/EE200200660A/et
Publication of EE05300B1 publication Critical patent/EE05300B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
EEP200200660A 2000-06-23 2001-06-20 Akrloldistamtsiini derivaati sisaldav farmatseutiline kompositsioon, derivaadi kasutamine tuumorivastase ravimi valmistamiseks ning kombineeritud ravimpreparaat EE05300B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0015447.6A GB0015447D0 (en) 2000-06-23 2000-06-23 Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
PCT/EP2001/007064 WO2001097790A2 (en) 2000-06-23 2001-06-20 Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and alkylating agents

Publications (2)

Publication Number Publication Date
EE200200660A EE200200660A (et) 2004-06-15
EE05300B1 true EE05300B1 (et) 2010-06-15

Family

ID=9894288

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200200660A EE05300B1 (et) 2000-06-23 2001-06-20 Akrloldistamtsiini derivaati sisaldav farmatseutiline kompositsioon, derivaadi kasutamine tuumorivastase ravimi valmistamiseks ning kombineeritud ravimpreparaat

Country Status (28)

Country Link
US (1) US8642580B2 (et)
EP (1) EP1303307B1 (et)
JP (1) JP2003535891A (et)
KR (1) KR100869037B1 (et)
CN (1) CN100479860C (et)
AT (1) ATE362365T1 (et)
AU (2) AU8186701A (et)
BR (1) BR0111740A (et)
CA (1) CA2410160C (et)
CY (1) CY1106713T1 (et)
CZ (1) CZ301053B6 (et)
DE (1) DE60128472T2 (et)
DK (1) DK1303307T3 (et)
EA (1) EA008502B1 (et)
EE (1) EE05300B1 (et)
ES (1) ES2284674T3 (et)
GB (1) GB0015447D0 (et)
HK (1) HK1054335B (et)
HU (1) HUP0301234A2 (et)
IL (2) IL152956A0 (et)
MX (1) MXPA02012209A (et)
NO (1) NO329782B1 (et)
NZ (1) NZ522999A (et)
PL (1) PL202053B1 (et)
PT (1) PT1303307E (et)
SK (1) SK18342002A3 (et)
WO (1) WO2001097790A2 (et)
ZA (1) ZA200209836B (et)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20040078118A (ko) * 2002-01-02 2004-09-08 파마시아 이탈리아 에스.피.에이. 치환된 아크릴로일 디스타마이신 유도체 및 단백질 키나제(세린/트레오닌 키나제) 저해제를 포함하는 항종양 조합요법
CA2481005C (en) * 2002-04-02 2009-06-09 Pharmacia Italia S.P.A. Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and radiotherapy
MD36Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de tratament diferenţiat al carcinomului ductal in situ neinvaziv al glandei mamare
MD24Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de tratament diferenţiat al carcinomului neinvaziv al glandei mamare
MD23Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de tratament diferenţiat al carcinomului lobular in situ neinvaziv al glandei mamare
MD35Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de apreciere a riscului dezvoltării carcinomului neinvaziv in situ al glandei mamare
DK2836494T3 (da) * 2012-04-05 2019-11-11 Nerviano Medical Sciences Srl Nye alkyleringsmidler

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56154493A (en) * 1980-04-30 1981-11-30 Shionogi & Co Ltd Novel platinum complex
CN85103908A (zh) * 1985-07-16 1986-11-05 法米塔利·卡洛·埃尔巴有限公司 制备4′-表多克索红菌素的新方法
AT387013B (de) 1985-07-16 1988-11-25 Erba Farmitalia Verfahren zur herstellung von poly-4-aminopyrrol -2-carboxamidoderivaten
GB8612218D0 (en) 1986-05-20 1986-06-25 Erba Farmitalia Site specific alkylating agents
AU605512B2 (en) 1986-10-07 1991-01-17 Boehringer Mannheim Italia S.P.A. Pharmaceutical compositions having antineoplastic activity
GB8906709D0 (en) 1989-03-23 1989-05-10 Creighton Andrew M Acryloyl substituted pyrrole derivatives
JP2919867B2 (ja) 1989-09-27 1999-07-19 千寿製薬株式会社 抗腫瘍剤
GB9000644D0 (en) * 1990-01-11 1990-03-14 Erba Carlo Spa New ureido derivatives of poly-4-amino-2-carboxy-1-methyl compounds
IT1272234B (it) 1994-05-02 1997-06-16 Consiglio Nazionale Ricerche Derivati glutationici delle antracicline e procedimento per ottenerli.
GB9416005D0 (en) 1994-08-08 1994-09-28 Erba Carlo Spa Peptidic compounds analogous to distamycin a and process for their preparation
US5880097A (en) 1996-01-04 1999-03-09 Terrapin Techologies, Inc. Tethered prodrugs
EP0880499A1 (en) 1996-02-02 1998-12-02 PHARMACIA & UPJOHN S.p.A. Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
GB9610079D0 (en) 1996-05-14 1996-07-17 Pharmacia Spa Distamycin deriratives process for preparing them and their use as antitumor and antiviral agents
GB9615692D0 (en) 1996-07-25 1996-09-04 Pharmacia Spa Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
GB9623522D0 (en) 1996-11-11 1997-01-08 Pharmacia & Upjohn Spa Benzoheterocycle distamycin derivatives process for preparing them and their use as antitumour and antiviral agents
GB9727524D0 (en) * 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Synergistic antitumor composition containing a biologically active ureido compound
GB9806689D0 (en) 1998-03-27 1998-05-27 Pharmacia & Upjohn Spa Acryloyl derivatives analogous to distamycin,process for preparing them,and their use as antitumour and antiviral agents
GB9806692D0 (en) 1998-03-27 1998-05-27 Pharmacia & Upjohn Spa Benzoheterocyclic distamycin derivatives, process for preparing them and their use as antitumour agents
GB9816653D0 (en) 1998-07-30 1998-09-30 Pharmacia & Upjohn Spa Oxidised sulfurated distamycin derivatives process for preparing them and their use as antitumor agents
GB9816652D0 (en) 1998-07-30 1998-09-30 Pharmacia & Upjohn Spa Sulfurated distamycin derivatives process for preparing them and their use as antitumor agents
GB9928703D0 (en) 1999-12-03 2000-02-02 Pharmacia & Upjohn Spa Acryloyl peptidic derivatives,process for their preparation and their use as antitumour agents
GB0011059D0 (en) 2000-05-08 2000-06-28 Pharmacia & Upjohn Spa Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione
GB0015444D0 (en) * 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors
US6576612B1 (en) * 2000-10-02 2003-06-10 Pharmacia Italia S.P.A. Antitumor therapy comprising distamycin derivatives

Also Published As

Publication number Publication date
HK1054335B (zh) 2010-06-11
CA2410160A1 (en) 2001-12-27
DE60128472T2 (de) 2008-01-24
AU8186701A (en) 2002-01-02
HUP0301234A2 (hu) 2003-08-28
EA200300061A1 (ru) 2003-04-24
NO20026077L (no) 2002-12-18
CN1437485A (zh) 2003-08-20
BR0111740A (pt) 2003-07-08
ZA200209836B (en) 2003-12-04
WO2001097790A3 (en) 2002-05-16
GB0015447D0 (en) 2000-08-16
PL202053B1 (pl) 2009-05-29
NO329782B1 (no) 2010-12-13
AU2001281867B2 (en) 2006-02-23
CZ301053B6 (cs) 2009-10-21
IL152956A (en) 2010-06-30
CZ20024106A3 (cs) 2003-05-14
CY1106713T1 (el) 2012-05-23
KR20030011105A (ko) 2003-02-06
EA008502B1 (ru) 2007-06-29
EP1303307B1 (en) 2007-05-16
US20030180383A1 (en) 2003-09-25
ES2284674T3 (es) 2007-11-16
CA2410160C (en) 2009-06-02
NO20026077D0 (no) 2002-12-18
WO2001097790A2 (en) 2001-12-27
US8642580B2 (en) 2014-02-04
MXPA02012209A (es) 2003-06-04
DK1303307T3 (da) 2007-07-16
IL152956A0 (en) 2003-06-24
JP2003535891A (ja) 2003-12-02
ATE362365T1 (de) 2007-06-15
SK18342002A3 (sk) 2003-06-03
CN100479860C (zh) 2009-04-22
EE200200660A (et) 2004-06-15
PL365158A1 (en) 2004-12-27
HK1054335A1 (en) 2003-11-28
EP1303307A2 (en) 2003-04-23
KR100869037B1 (ko) 2008-11-17
PT1303307E (pt) 2007-07-04
NZ522999A (en) 2004-10-29
DE60128472D1 (de) 2007-06-28

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Legal Events

Date Code Title Description
GB1A Change in the ownership or in the address of the owner
KB4A Valid patent at the end of a year

Effective date: 20101231

MM4A Lapsed by not paying the annual fees

Effective date: 20110620