EE04679B1 - Tuumorivastase toimega kamptotetsiini derivaadid,meetod nende valmistamiseks ja neid hendeid sisaldavad farmatseutilised kompositsioonid - Google Patents

Tuumorivastase toimega kamptotetsiini derivaadid,meetod nende valmistamiseks ja neid hendeid sisaldavad farmatseutilised kompositsioonid

Info

Publication number
EE04679B1
EE04679B1 EEP200100466A EEP200100466A EE04679B1 EE 04679 B1 EE04679 B1 EE 04679B1 EE P200100466 A EEP200100466 A EE P200100466A EE P200100466 A EEP200100466 A EE P200100466A EE 04679 B1 EE04679 B1 EE 04679B1
Authority
EE
Estonia
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
antitumor activity
camptothecin derivatives
Prior art date
Application number
EEP200100466A
Other languages
English (en)
Estonian (et)
Inventor
Penco Sergio
Merlini Lucio
Zunino Franco
Carminati Paolo
Original Assignee
Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.
Istituto Nazionale Per Lo Studio E La Cura Dei Tumori
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma-Tau Industrie Farmaceutiche Riunite S.P.A., Istituto Nazionale Per Lo Studio E La Cura Dei Tumori filed Critical Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.
Publication of EE200100466A publication Critical patent/EE200100466A/xx
Publication of EE04679B1 publication Critical patent/EE04679B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EEP200100466A 1999-03-09 2000-03-08 Tuumorivastase toimega kamptotetsiini derivaadid,meetod nende valmistamiseks ja neid hendeid sisaldavad farmatseutilised kompositsioonid EE04679B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99830124A EP1044977B1 (en) 1999-03-09 1999-03-09 Camptothecin derivatives having antitumor activity
PCT/EP2000/001570 WO2000053607A1 (en) 1999-03-09 2000-03-08 Camptothecin derivatives having antitumor activity

Publications (2)

Publication Number Publication Date
EE200100466A EE200100466A (et) 2002-12-16
EE04679B1 true EE04679B1 (et) 2006-08-15

Family

ID=8243303

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200100466A EE04679B1 (et) 1999-03-09 2000-03-08 Tuumorivastase toimega kamptotetsiini derivaadid,meetod nende valmistamiseks ja neid hendeid sisaldavad farmatseutilised kompositsioonid

Country Status (39)

Country Link
US (2) US6242457B1 (zh)
EP (1) EP1044977B1 (zh)
JP (1) JP4610743B2 (zh)
KR (1) KR100702085B1 (zh)
CN (1) CN1139592C (zh)
AR (1) AR022860A1 (zh)
AT (1) ATE216998T1 (zh)
AU (1) AU774174B2 (zh)
BG (1) BG65032B1 (zh)
BR (1) BR0008840B1 (zh)
CA (1) CA2362760C (zh)
CO (1) CO5180590A1 (zh)
CZ (1) CZ304465B6 (zh)
DE (1) DE69901379T2 (zh)
DK (1) DK1044977T3 (zh)
EA (1) EA003605B1 (zh)
EE (1) EE04679B1 (zh)
EG (1) EG23999A (zh)
ES (1) ES2175919T3 (zh)
HK (1) HK1031222A1 (zh)
HR (1) HRP20010667B1 (zh)
HU (1) HU229506B1 (zh)
IL (2) IL144958A0 (zh)
IS (1) IS2003B (zh)
ME (2) ME00017B (zh)
MX (1) MXPA01009081A (zh)
NO (1) NO328363B1 (zh)
NZ (1) NZ513393A (zh)
PE (1) PE20001485A1 (zh)
PL (1) PL222208B1 (zh)
PT (1) PT1044977E (zh)
RS (1) RS50405B (zh)
SI (1) SI1044977T1 (zh)
SK (1) SK287561B6 (zh)
TN (1) TNSN00045A1 (zh)
TR (1) TR200102603T2 (zh)
TW (1) TWI272272B (zh)
WO (1) WO2000053607A1 (zh)
ZA (1) ZA200107408B (zh)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE376824T1 (de) 1999-01-13 2007-11-15 Alchemia Oncology Pty Ltd Verwendung von hyaluronan zur herstellung eines medikaments zur erhöhung der wirksamkeit von zytotoxischen arzneimitteln
US7105492B2 (en) * 1999-03-09 2006-09-12 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Camptothecin derivatives having antitumor activity
FR2794123B1 (fr) * 1999-05-28 2001-07-27 Aventis Pharma Sa Preparation de derives de la camptothecine et de la nothapodytine
US6352996B1 (en) * 1999-08-03 2002-03-05 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US9066919B2 (en) * 2000-07-14 2015-06-30 Alchemia Oncology Pty Limited Hyaluronan as a chemo-sensitizer in the treatment of cancer
AUPQ879500A0 (en) * 2000-07-14 2000-08-10 Meditech Research Limited Hyaluronan as cytotoxic agent, drug presensitizer and chemo-sensitizer in the treatment of disease
US20040029906A1 (en) * 2001-07-31 2004-02-12 Michael Christman Inhibitors of dna polymerase sigma
WO2003018062A1 (en) * 2001-08-27 2003-03-06 Meditech Research Limited Improved therapeutic protocols
WO2003033525A1 (en) * 2001-10-12 2003-04-24 Debio Recherche Pharmacuetique S.A. Amino-substituted camptothecin polymer derivatives and use of the same for the manufacture of a medicament
ITRM20020305A1 (it) 2002-05-31 2003-12-01 Sigma Tau Ind Farmaceuti Camptotecine con anello lattonico modificato.
ITRM20020306A1 (it) * 2002-05-31 2003-12-01 Sigma Tau Ind Farmaceuti Esteri in posizione 20 di camptotecine.
FR2852606A1 (fr) * 2003-03-18 2004-09-24 Inst Nat Sante Rech Med Moyens pour inhiber simultanement l'expression de plusieurs genes impliques dans une pathologie
US20040204435A1 (en) * 2003-04-09 2004-10-14 Joachim Liehr Alternating treatment with topoisomerase I and topoisomerase II inhibitors
ITRM20030344A1 (it) 2003-07-14 2005-01-15 Ist Naz Stud Cura Dei Tumori 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi.
CA2559532A1 (en) * 2004-03-26 2005-10-06 Novartis Ag Use of camptothecin derivates for the treatment of proliferative diseases in a fixed dosing regimen
WO2005113018A2 (en) 2004-04-27 2005-12-01 Wellstat Biologics Corporation Cancer treatment using viruses and camptothecins
ITRM20040242A1 (it) * 2004-05-13 2004-08-13 Ist Naz Stud Cura Dei Tumori "7-t-butossiimminometilcamptotecina coniugata in posizione 20 con antagonisti delle integrine.
ITRM20040241A1 (it) * 2004-05-13 2004-08-13 Ist Naz Stud Cura Dei Tumori Camptotecine coniugate in posizione 20 con antagonisti delle integrine.
ITRM20040240A1 (it) * 2004-05-13 2004-08-13 Ist Naz Stud Cura Dei Tumori Camptotecine coniugate in posizione 7 con antagonisti delle integrine.
ITRM20040288A1 (it) * 2004-06-11 2004-09-11 Sigma Tau Ind Farmaceuti Uso della 7-t-butossiimminometilcamptotecina per la preparazione di un medicamento per il trattamento delle neoplasie dell'utero.
CN100334089C (zh) * 2004-07-21 2007-08-29 王洋 一种9－硝基喜树碱的生产方法
GT200500310A (es) * 2004-11-19 2006-06-19 Compuestos organicos
CA2589521C (en) * 2004-12-15 2014-04-01 Novartis Ag Combinations of 7-t-butoxyiminomethylcamptothecin with one or more chemotherapeutic agents for treating cancers
EP1828196B1 (en) 2004-12-21 2012-10-17 SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. Stereoselective process and crystalline forms of a camptothecin
SA06270147B1 (ar) 2005-06-09 2009-12-22 نوفارتيس ايه جي عملية لتخليق 5-(مثيل–1h–إيميدازول–1-يل )–3-(ثلاثي فلـورو مثيل)–بنزامـين
WO2007011601A2 (en) 2005-07-14 2007-01-25 Wellstat Biologics Corporation Cancer treatment using viruses, fluoropyrimidines and camptothecins
CN103784960A (zh) * 2005-07-27 2014-05-14 阿尔卡米亚肿瘤学股份有限公司 使用乙酰透明质酸的治疗方案
ITRM20050418A1 (it) * 2005-08-04 2007-02-05 Sigma Tau Ind Farmaceuti Sistemi terapeutici a rilascio immediato per il migliorato assorbimento orale di 7-[(e)-t-butilossimminometil] camptotecina.
BRPI0614267A2 (pt) * 2005-08-10 2012-01-24 Novartis Ag composição de nanopartìculas de 7-t-butóxiiminometilcamptotecina, seu método de produção e uso das referidas nanopartìculas
CN101287475B (zh) * 2005-09-07 2012-11-14 阿尔卡米亚肿瘤学股份有限公司 包含透明质酸和治疗抗体的治疗组合物以及制药用途
DK1962850T3 (da) 2005-12-21 2012-06-18 Sigma Tau Ind Farmaceuti Behandling af lægemiddelresistente tumorer
WO2007098091A2 (en) * 2006-02-17 2007-08-30 Novacea, Inc. Treatment of hyperproliferative diseases with vinca alkaloid n-oxide and analogs
AU2007232206B2 (en) 2006-03-30 2013-04-04 Drais Pharmaceuticals, Inc. Camptothecin-cell penetrating peptide conjugates and pharmaceutical compositions containing the same
JP2010518012A (ja) * 2007-02-01 2010-05-27 シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ カンプトテシン誘導体を含む医薬組成物
US8853233B2 (en) * 2007-02-13 2014-10-07 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Broad-spectrum anti-cancer treatment based on iminocamptothecin derivatives
EA015933B1 (ru) * 2007-08-01 2011-12-30 Сигма-Тау Индустрие Фармасьютике Риуните С.П.А. Лечение детских опухолей
EP2096113A1 (en) * 2008-02-05 2009-09-02 SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. 9-substituted camptothecin derivatives as antitumor compounds
TWI482621B (zh) 2009-12-23 2015-05-01 Sigma Tau Ind Farmaceuti 青蒿素基藥物與其他化學治療劑的抗癌組合物
CN108135917B (zh) 2015-09-25 2021-07-09 Zy医疗 基于包含多糖-维生素缀合物的颗粒的药物制剂

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399276A (en) * 1981-01-09 1983-08-16 Kabushiki Kaisha Yakult Honsha 7-Substituted camptothecin derivatives
EP0612248B1 (en) * 1991-11-15 2003-08-20 Smithkline Beecham Corporation Composition containing cisplatin and topotecan as antitumor agent.
US5614529A (en) * 1994-09-22 1997-03-25 Research Triangle Institute Inhibition of plasmodia parasites by camptothecin compounds
US5972955A (en) * 1995-06-06 1999-10-26 Dr. Reddy's Research Foundation Water soluble C-ring analogues of 20(S)-camptothecin
GB9512670D0 (en) * 1995-06-21 1995-08-23 Sod Conseils Rech Applic Camptothecin analogues
IT1282673B1 (it) * 1996-02-23 1998-03-31 Ist Naz Stud Cura Dei Tumori Derivati della camptotecina e loro uso come agenti antitumorali
CA2262745C (en) * 1996-08-19 2006-04-04 Bionumerik Pharmaceuticals, Inc. Highly lipophilic camptothecin derivatives

Also Published As

Publication number Publication date
CZ304465B6 (cs) 2014-05-21
HRP20010667B1 (en) 2003-06-30
KR20010102519A (ko) 2001-11-15
AU774174B2 (en) 2004-06-17
ME00017B (me) 2010-06-10
MEP4008A (xx) 2010-02-10
TNSN00045A1 (fr) 2005-11-10
EE200100466A (et) 2002-12-16
US6242457B1 (en) 2001-06-05
SK11642001A3 (sk) 2002-01-07
SI1044977T1 (en) 2002-08-31
PE20001485A1 (es) 2000-12-07
EA200100954A1 (ru) 2002-04-25
EP1044977B1 (en) 2002-05-02
ZA200107408B (en) 2002-05-29
TR200102603T2 (tr) 2002-01-21
DE69901379D1 (de) 2002-06-06
CA2362760C (en) 2009-08-18
US20010008939A1 (en) 2001-07-19
PL355094A1 (en) 2004-03-22
AR022860A1 (es) 2002-09-04
TWI272272B (en) 2007-02-01
HUP0200210A2 (hu) 2002-05-29
EA003605B1 (ru) 2003-06-26
NO20014128D0 (no) 2001-08-24
BR0008840A (pt) 2002-01-08
HU229506B1 (en) 2014-01-28
ATE216998T1 (de) 2002-05-15
YU64301A (sh) 2005-07-19
DK1044977T3 (da) 2002-07-08
HUP0200210A3 (en) 2004-03-29
DE69901379T2 (de) 2002-11-07
IL144958A (en) 2009-08-03
EP1044977A1 (en) 2000-10-18
HK1031222A1 (en) 2001-06-08
IS2003B (is) 2005-04-15
AU3160400A (en) 2000-09-28
CA2362760A1 (en) 2000-09-14
MXPA01009081A (es) 2002-08-30
CN1343209A (zh) 2002-04-03
EG23999A (en) 2008-03-19
NZ513393A (en) 2003-04-29
KR100702085B1 (ko) 2007-04-02
SK287561B6 (sk) 2011-02-04
PL222208B1 (pl) 2016-07-29
CO5180590A1 (es) 2002-07-30
CZ20013077A3 (cs) 2002-01-16
JP4610743B2 (ja) 2011-01-12
RS50405B (sr) 2009-12-31
JP2002539128A (ja) 2002-11-19
IS6031A (is) 2001-07-31
HRP20010667A2 (en) 2002-08-31
US6589939B2 (en) 2003-07-08
NO20014128L (no) 2001-08-24
BG105810A (en) 2002-06-28
CN1139592C (zh) 2004-02-25
IL144958A0 (en) 2002-06-30
ES2175919T3 (es) 2002-11-16
BG65032B1 (bg) 2006-12-29
NO328363B1 (no) 2010-02-01
PT1044977E (pt) 2002-09-30
BR0008840B1 (pt) 2011-12-27
WO2000053607A1 (en) 2000-09-14

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Legal Events

Date Code Title Description
HK1A Erratum in gazette
KB4A Valid patent at the end of a year

Effective date: 20061231

KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

KB4A Valid patent at the end of a year

Effective date: 20101231

MM4A Lapsed by not paying the annual fees

Effective date: 20170308