ECSP12011698A - Anticuerpos cea - Google Patents

Anticuerpos cea

Info

Publication number
ECSP12011698A
ECSP12011698A ECSP12011698A ECSP12011698A EC SP12011698 A ECSP12011698 A EC SP12011698A EC SP12011698 A ECSP12011698 A EC SP12011698A EC SP12011698 A ECSP12011698 A EC SP12011698A
Authority
EC
Ecuador
Prior art keywords
abms
relates
present
antibodies
nucleic acid
Prior art date
Application number
Other languages
English (en)
Inventor
Ekkehard Moessner
Pablo Umana
Ralf Hosse
Thomas Hofer
Original Assignee
Roche Glycart Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42985489&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP12011698(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Roche Glycart Ag filed Critical Roche Glycart Ag
Publication of ECSP12011698A publication Critical patent/ECSP12011698A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

La presente invención se refiere a moléculas de unión a antígeno (ABMs). En realizaciones particulares, la presente invención se refiere a anticuerpos monoclonales recombinantes, incluyendo anticuerpos quiméricos, primatizados o humanizados o variantes de los mismos específicos para CEA humano de superficie celular o unido a membrana. Además, la presente invención se refiere a moléculas de ácidos nucleicos codificantes de dichas ABMs, y a vectores y células huésped que comprenden dichas moléculas de ácidos nucleicos. La invención se refiere además a métodos para producir las ABMs de la invención, y a métodos de utilización de dichas ABMs en el tratamiento de enfermedades. Además, la presente invención se refiere a ABMs con glucosilación modificada que presentan propiedades terapéuticas mejoradas, incluyendo anticuerpos con unión a receptor de Fc incrementada y función efectora incrementada.
ECSP12011698 2009-08-31 2012-02-28 Anticuerpos cea ECSP12011698A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23850509P 2009-08-31 2009-08-31

Publications (1)

Publication Number Publication Date
ECSP12011698A true ECSP12011698A (es) 2012-03-30

Family

ID=42985489

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP12011698 ECSP12011698A (es) 2009-08-31 2012-02-28 Anticuerpos cea

Country Status (23)

Country Link
US (2) US9068008B2 (es)
EP (1) EP2473532B1 (es)
JP (1) JP5744872B2 (es)
KR (1) KR101528013B1 (es)
CN (1) CN102741293B (es)
AR (1) AR078111A1 (es)
AU (1) AU2010288469A1 (es)
BR (1) BR112012003983A2 (es)
CA (1) CA2770174A1 (es)
CL (1) CL2012000551A1 (es)
CO (1) CO6491105A2 (es)
CR (1) CR20120087A (es)
EC (1) ECSP12011698A (es)
HK (1) HK1176951A1 (es)
IL (1) IL218038A0 (es)
MA (1) MA33536B1 (es)
MX (1) MX339608B (es)
PE (1) PE20121552A1 (es)
RU (1) RU2570554C2 (es)
SG (1) SG178567A1 (es)
TW (1) TW201121994A (es)
WO (1) WO2011023787A1 (es)
ZA (1) ZA201200954B (es)

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CN107663240B (zh) 2016-07-29 2021-01-12 中国人民解放军第四军医大学 高度糖基化cea特异性结合的单链抗体及其在检测和治疗上的应用
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Also Published As

Publication number Publication date
CO6491105A2 (es) 2012-07-31
WO2011023787A1 (en) 2011-03-03
MX339608B (es) 2016-05-31
RU2012112340A (ru) 2013-10-10
AU2010288469A1 (en) 2012-03-01
SG178567A1 (en) 2012-04-27
JP5744872B2 (ja) 2015-07-08
BR112012003983A2 (pt) 2021-09-14
MX2012002461A (es) 2012-03-14
AR078111A1 (es) 2011-10-12
CN102741293A (zh) 2012-10-17
ZA201200954B (en) 2014-07-30
EP2473532A1 (en) 2012-07-11
KR101528013B1 (ko) 2015-06-16
IL218038A0 (en) 2012-04-30
KR20120060874A (ko) 2012-06-12
CL2012000551A1 (es) 2012-10-12
US20110104148A1 (en) 2011-05-05
TW201121994A (en) 2011-07-01
JP2013502913A (ja) 2013-01-31
RU2570554C2 (ru) 2015-12-10
US9068008B2 (en) 2015-06-30
EP2473532B1 (en) 2017-06-21
HK1176951A1 (en) 2013-08-09
MA33536B1 (fr) 2012-08-01
CR20120087A (es) 2012-03-22
PE20121552A1 (es) 2012-11-26
CA2770174A1 (en) 2011-03-03
US20160075795A1 (en) 2016-03-17
CN102741293B (zh) 2015-04-01

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