EA202190686A1 - 5-7-членные гетероциклические амиды в качестве ингибиторов jak - Google Patents

5-7-членные гетероциклические амиды в качестве ингибиторов jak

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Publication number
EA202190686A1
EA202190686A1 EA202190686A EA202190686A EA202190686A1 EA 202190686 A1 EA202190686 A1 EA 202190686A1 EA 202190686 A EA202190686 A EA 202190686A EA 202190686 A EA202190686 A EA 202190686A EA 202190686 A1 EA202190686 A1 EA 202190686A1
Authority
EA
Eurasian Patent Office
Prior art keywords
member heterocyclic
jak inhibitors
heterocyclic amides
compounds
amides
Prior art date
Application number
EA202190686A
Other languages
English (en)
Inventor
Дэниэл Д. Лонг
Камерон Смит
Корбин Томпсон
Original Assignee
ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи filed Critical ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи
Publication of EA202190686A1 publication Critical patent/EA202190686A1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

Изобретение предоставляет соединения формулы (I)где переменные определены в описании, или их фармацевтически приемлемую соль, которые пригодны в качестве ингибиторов киназы JAK. Изобретение также предоставляет фармацевтические композиции, содержащие такие соединения, и способы применения таких соединений для лечения респираторных заболеваний.
EA202190686A 2018-09-04 2019-09-03 5-7-членные гетероциклические амиды в качестве ингибиторов jak EA202190686A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862726583P 2018-09-04 2018-09-04
PCT/US2019/049342 WO2020051139A1 (en) 2018-09-04 2019-09-03 5 to 7 membered heterocyclic amides as jak inhibitors

Publications (1)

Publication Number Publication Date
EA202190686A1 true EA202190686A1 (ru) 2021-07-23

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA202190686A EA202190686A1 (ru) 2018-09-04 2019-09-03 5-7-членные гетероциклические амиды в качестве ингибиторов jak

Country Status (19)

Country Link
US (2) US10836763B2 (ru)
EP (1) EP3837010B1 (ru)
JP (1) JP7383696B2 (ru)
KR (1) KR20210056380A (ru)
CN (1) CN112703037B (ru)
AR (1) AR116114A1 (ru)
AU (1) AU2019335200A1 (ru)
BR (1) BR112021004063A2 (ru)
CL (1) CL2021000515A1 (ru)
CO (1) CO2021002976A2 (ru)
EA (1) EA202190686A1 (ru)
ES (1) ES2955717T3 (ru)
IL (1) IL281150B2 (ru)
MX (1) MX2021002484A (ru)
PH (1) PH12021550324A1 (ru)
SG (1) SG11202101751XA (ru)
TW (1) TWI793365B (ru)
UA (1) UA127328C2 (ru)
WO (1) WO2020051139A1 (ru)

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AR111242A1 (es) 2017-03-09 2019-06-19 Theravance Biopharma R&D Ip Llc Compuestos de imidazo-piperidina fusionada que contienen una amida heterocíclica de 4 miembros como inhibidores de jak
US10844057B2 (en) 2018-09-04 2020-11-24 Theravance Biopharma R&D Ip, Llc Process for preparing JAK inhibitors and intermediates thereof
AU2019336167A1 (en) 2018-09-04 2021-03-11 Theravance Biopharma R&D Ip, Llc Dimethyl amino azetidine amides as JAK inhibitors
CN112703037B (zh) * 2018-09-04 2023-10-20 施万生物制药研发Ip有限责任公司 作为jak抑制剂的5至7元杂环酰胺
TW202144343A (zh) 2020-03-02 2021-12-01 美商施萬生物製藥研發 Ip有限責任公司 Jak抑制劑化合物之結晶水合物
WO2022081872A1 (en) * 2020-10-16 2022-04-21 Gb008, Inc. Janus kinase inhibitors

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Publication number Publication date
WO2020051139A1 (en) 2020-03-12
US20210024517A1 (en) 2021-01-28
IL281150B1 (en) 2023-11-01
JP2021535174A (ja) 2021-12-16
BR112021004063A2 (pt) 2021-05-25
AU2019335200A1 (en) 2021-03-11
AR116114A1 (es) 2021-03-31
SG11202101751XA (en) 2021-03-30
EP3837010C0 (en) 2023-07-05
ES2955717T3 (es) 2023-12-05
EP3837010B1 (en) 2023-07-05
CL2021000515A1 (es) 2021-07-23
MX2021002484A (es) 2021-05-12
PH12021550324A1 (en) 2021-10-04
KR20210056380A (ko) 2021-05-18
UA127328C2 (uk) 2023-07-19
TW202024075A (zh) 2020-07-01
US20200071325A1 (en) 2020-03-05
CO2021002976A2 (es) 2021-05-31
IL281150B2 (en) 2024-03-01
CN112703037B (zh) 2023-10-20
US10836763B2 (en) 2020-11-17
CN112703037A (zh) 2021-04-23
TWI793365B (zh) 2023-02-21
IL281150A (en) 2021-04-29
EP3837010A1 (en) 2021-06-23
US11713315B2 (en) 2023-08-01
JP7383696B2 (ja) 2023-11-20

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