EA202190064A1 - Цианотриазоловые соединения и варианты их применения - Google Patents

Цианотриазоловые соединения и варианты их применения

Info

Publication number
EA202190064A1
EA202190064A1 EA202190064A EA202190064A EA202190064A1 EA 202190064 A1 EA202190064 A1 EA 202190064A1 EA 202190064 A EA202190064 A EA 202190064A EA 202190064 A EA202190064 A EA 202190064A EA 202190064 A1 EA202190064 A1 EA 202190064A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
variants
application
compositions containing
present
Prior art date
Application number
EA202190064A
Other languages
English (en)
Inventor
Ян Йирицек
Шуи Пирли Нг
Сриниваса П С Рао
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA202190064A1 publication Critical patent/EA202190064A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Abstract

В настоящем изобретении предусмотрено соединение формулы (I) или его фармацевтически приемлемая сольгде R1, R2, R3 и R4 определены в данном документе. В настоящем изобретении дополнительно предусмотрены варианты терапевтического применения таких соединений, например, для лечения африканского трипаносомоза человека; фармацевтические композиции, содержащие такие соединения, и композиции, содержащие такие соединения с совместно применяемым терапевтическим средством.
EA202190064A 2018-06-19 2019-06-18 Цианотриазоловые соединения и варианты их применения EA202190064A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862687045P 2018-06-19 2018-06-19
PCT/IB2019/055123 WO2019244049A1 (en) 2018-06-19 2019-06-18 Cyanotriazole compounds and uses thereof

Publications (1)

Publication Number Publication Date
EA202190064A1 true EA202190064A1 (ru) 2021-03-29

Family

ID=67841115

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202190064A EA202190064A1 (ru) 2018-06-19 2019-06-18 Цианотриазоловые соединения и варианты их применения

Country Status (21)

Country Link
US (1) US20220106296A1 (ru)
EP (1) EP3810598A1 (ru)
JP (1) JP2021528397A (ru)
KR (1) KR20210022646A (ru)
CN (1) CN112313217A (ru)
AU (1) AU2019291490B2 (ru)
BR (1) BR112020025538A2 (ru)
CA (1) CA3100954A1 (ru)
CL (1) CL2020003252A1 (ru)
CR (1) CR20200619A (ru)
CU (1) CU20200102A7 (ru)
EA (1) EA202190064A1 (ru)
EC (1) ECSP20080991A (ru)
IL (1) IL279483A (ru)
JO (1) JOP20200327A1 (ru)
MA (1) MA52977A (ru)
MX (1) MX2020013729A (ru)
PE (1) PE20210780A1 (ru)
PH (1) PH12020552186A1 (ru)
SG (1) SG11202012628XA (ru)
WO (1) WO2019244049A1 (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115181060B (zh) * 2022-08-19 2024-03-19 江苏禾裕泰化学有限公司 一种生产2-氨基-3-氯-5-三氟甲基吡啶的清洁生产工艺
CN116284772B (zh) * 2023-02-09 2024-02-27 四川大学 一种联吡啶***共价有机聚合物及其制备方法和应用
CN116836111A (zh) * 2023-09-01 2023-10-03 峰成医药科技(天津)有限公司 一种氟代吡啶的连续化合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007524596A (ja) 2003-02-28 2007-08-30 トランスフォーム・ファーマシューティカルズ・インコーポレイテッド 共結晶医薬組成物
US8642774B2 (en) * 2011-12-08 2014-02-04 Boehringer Ingelheim International Gmbh Compounds
DK2790705T3 (en) * 2011-12-15 2018-03-12 Novartis Ag Use of inhibitors of the activity or function of PI3K
UY36469A (es) * 2014-12-22 2016-06-30 Glaxosmithkline Ip Dev Ltd Nuevo compuesto de tiotriazol

Also Published As

Publication number Publication date
IL279483A (en) 2021-01-31
MA52977A (fr) 2021-04-28
PE20210780A1 (es) 2021-04-21
JOP20200327A1 (ar) 2020-12-15
WO2019244049A1 (en) 2019-12-26
EP3810598A1 (en) 2021-04-28
ECSP20080991A (es) 2021-02-26
AU2019291490B2 (en) 2022-02-10
JP2021528397A (ja) 2021-10-21
SG11202012628XA (en) 2021-01-28
CL2020003252A1 (es) 2021-07-09
KR20210022646A (ko) 2021-03-03
CR20200619A (es) 2021-01-21
AU2019291490A1 (en) 2021-02-04
MX2020013729A (es) 2021-05-12
CU20200102A7 (es) 2021-08-06
CN112313217A (zh) 2021-02-02
CA3100954A1 (en) 2019-12-26
BR112020025538A2 (pt) 2021-03-16
US20220106296A1 (en) 2022-04-07
PH12020552186A1 (en) 2021-06-07

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