EA202090746A1 - Двойные ингибиторы путей tim-3 и pd-1 - Google Patents

Двойные ингибиторы путей tim-3 и pd-1

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Publication number
EA202090746A1
EA202090746A1 EA202090746A EA202090746A EA202090746A1 EA 202090746 A1 EA202090746 A1 EA 202090746A1 EA 202090746 A EA202090746 A EA 202090746A EA 202090746 A EA202090746 A EA 202090746A EA 202090746 A1 EA202090746 A1 EA 202090746A1
Authority
EA
Eurasian Patent Office
Prior art keywords
tim
inhibitors
double
relates
path
Prior art date
Application number
EA202090746A
Other languages
English (en)
Inventor
Поттайил Говиндан Наир Сасикумар
Муралидхара Рамачандра
Ситхарамайя Сетти Сударсхан Наремаддепалли
Нагарадж Говда
Original Assignee
Ориджен Дискавери Текнолоджис Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ориджен Дискавери Текнолоджис Лимитед filed Critical Ориджен Дискавери Текнолоджис Лимитед
Publication of EA202090746A1 publication Critical patent/EA202090746A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Настоящее изобретение относится к 3-замещенным 1,2,4-оксадиазольным соединениям и их производным, которые можно применять в качестве ингибиторов белка 3, содержащего Т-клеточный иммуноглобулин и домен муцина (TIM-3) или двойных ингибиторов TIM-3 и сигнального пути белка запрограммированной гибели клеток 1 (PD-1). Изобретение также относится к лечению нарушения путем ингибирования иммуносупрессивного сигнала, индуцируемого TIM-3, PD-1, PD-L1 и/или PD-L2.
EA202090746A 2017-11-03 2018-10-31 Двойные ингибиторы путей tim-3 и pd-1 EA202090746A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201741039298 2017-11-03
PCT/IB2018/058526 WO2019087087A1 (en) 2017-11-03 2018-10-31 Dual inhibitors of tim-3 and pd-1 pathways

Publications (1)

Publication Number Publication Date
EA202090746A1 true EA202090746A1 (ru) 2020-08-17

Family

ID=65033624

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202090746A EA202090746A1 (ru) 2017-11-03 2018-10-31 Двойные ингибиторы путей tim-3 и pd-1

Country Status (14)

Country Link
US (3) US11497734B2 (ru)
EP (1) EP3703683A1 (ru)
JP (2) JP7378394B2 (ru)
KR (1) KR20200083503A (ru)
CN (1) CN111372584A (ru)
AU (1) AU2018360386B2 (ru)
BR (1) BR112020008537A2 (ru)
CA (1) CA3080098A1 (ru)
EA (1) EA202090746A1 (ru)
IL (2) IL274380A (ru)
MX (1) MX2020004531A (ru)
PH (1) PH12020550511A1 (ru)
SG (1) SG11202003625VA (ru)
WO (1) WO2019087087A1 (ru)

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Also Published As

Publication number Publication date
CA3080098A1 (en) 2019-05-09
JP7378394B2 (ja) 2023-11-13
MX2020004531A (es) 2020-08-03
CN111372584A (zh) 2020-07-03
PH12020550511A1 (en) 2021-05-10
SG11202003625VA (en) 2020-05-28
BR112020008537A2 (pt) 2020-10-06
US20200368210A1 (en) 2020-11-26
JP2021502965A (ja) 2021-02-04
US20240100024A1 (en) 2024-03-28
IL287959A (en) 2022-01-01
EP3703683A1 (en) 2020-09-09
IL274380A (en) 2020-06-30
AU2018360386B2 (en) 2023-11-09
WO2019087087A1 (en) 2019-05-09
US11497734B2 (en) 2022-11-15
AU2018360386A1 (en) 2020-05-07
KR20200083503A (ko) 2020-07-08
US20230062570A1 (en) 2023-03-02
JP2023182598A (ja) 2023-12-26

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