EA202090699A2 - Композиции, содержащие буфер, вакцины, которые содержат композиции, содержащие буфер, и пути их применения - Google Patents

Композиции, содержащие буфер, вакцины, которые содержат композиции, содержащие буфер, и пути их применения

Info

Publication number
EA202090699A2
EA202090699A2 EA202090699A EA202090699A EA202090699A2 EA 202090699 A2 EA202090699 A2 EA 202090699A2 EA 202090699 A EA202090699 A EA 202090699A EA 202090699 A EA202090699 A EA 202090699A EA 202090699 A2 EA202090699 A2 EA 202090699A2
Authority
EA
Eurasian Patent Office
Prior art keywords
compositions containing
buffer
vaccines
application
contain
Prior art date
Application number
EA202090699A
Other languages
English (en)
Other versions
EA202090699A3 (ru
Inventor
Чарльз Ричардсон
Роберт Ф. Баргаце
Пол М. Мендельман
Original Assignee
Такеда Вэксинс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47506489&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA202090699(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Такеда Вэксинс, Инк. filed Critical Такеда Вэксинс, Инк.
Publication of EA202090699A2 publication Critical patent/EA202090699A2/ru
Publication of EA202090699A3 publication Critical patent/EA202090699A3/ru

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/125Picornaviridae, e.g. calicivirus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5258Virus-like particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505Inorganic adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55572Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/70Multivalent vaccine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/16011Caliciviridae
    • C12N2770/16034Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

Настоящее изобретение относится к парентеральным композициям вакцины однократной дозы, содержащим смеси моновалентных вирусоподобных частиц норовируса. Также раскрыты способы обеспечения защитного иммунитета к норовирусным инфекциям у субъектов, являющихся людьми, посредством введения таких композиций.
EA202090699A 2011-07-11 2012-07-11 Композиции, содержащие буфер, вакцины, которые содержат композиции, содержащие буфер, и пути их применения EA202090699A3 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161506447P 2011-07-11 2011-07-11

Publications (2)

Publication Number Publication Date
EA202090699A2 true EA202090699A2 (ru) 2020-07-31
EA202090699A3 EA202090699A3 (ru) 2020-11-30

Family

ID=47506489

Family Applications (3)

Application Number Title Priority Date Filing Date
EA201490258A EA029470B1 (ru) 2011-07-11 2012-07-11 Способ стимулирования формирования защитного иммунитета против норовируса
EA202090699A EA202090699A3 (ru) 2011-07-11 2012-07-11 Композиции, содержащие буфер, вакцины, которые содержат композиции, содержащие буфер, и пути их применения
EA201792407A EA035442B1 (ru) 2011-07-11 2012-07-11 Композиции, содержащие буфер, вакцины, которые содержат композиции, содержащие буфер, и пути их применения

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA201490258A EA029470B1 (ru) 2011-07-11 2012-07-11 Способ стимулирования формирования защитного иммунитета против норовируса

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA201792407A EA035442B1 (ru) 2011-07-11 2012-07-11 Композиции, содержащие буфер, вакцины, которые содержат композиции, содержащие буфер, и пути их применения

Country Status (29)

Country Link
US (5) US9801934B2 (ru)
EP (3) EP2731621B1 (ru)
JP (2) JP6208659B2 (ru)
KR (1) KR102096937B1 (ru)
CN (3) CN108567975A (ru)
AU (2) AU2012282658B2 (ru)
BR (1) BR112014000656A2 (ru)
CA (1) CA2841356C (ru)
CL (1) CL2014000082A1 (ru)
CR (2) CR20190540A (ru)
DK (1) DK3299030T3 (ru)
DO (2) DOP2014000004A (ru)
EA (3) EA029470B1 (ru)
EC (1) ECSP14013201A (ru)
ES (2) ES2926487T3 (ru)
GE (1) GEP201706668B (ru)
HK (3) HK1198136A1 (ru)
IL (1) IL230356B (ru)
MA (1) MA35414B1 (ru)
MX (1) MX356586B (ru)
MY (1) MY170746A (ru)
PE (1) PE20140845A1 (ru)
PH (1) PH12018501515A1 (ru)
PL (2) PL2731621T3 (ru)
SG (1) SG10201605644WA (ru)
TN (1) TN2014000008A1 (ru)
UA (1) UA117732C2 (ru)
WO (1) WO2013009849A1 (ru)
ZA (2) ZA201401012B (ru)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201502490YA (en) 2006-09-29 2015-05-28 Ligocyte Pharmaceuticals Inc Norovirus vaccine formulations
US10130696B2 (en) 2007-09-18 2018-11-20 Takeda Vaccines, Inc. Method of conferring a protective immune response to norovirus
US20100266636A1 (en) 2007-09-18 2010-10-21 Ligocyte Pharmaceuticals, Inc. Method of conferring a protective immune response to norovirus
EA029470B1 (ru) 2011-07-11 2018-03-30 Такеда Вэксинс, Инк. Способ стимулирования формирования защитного иммунитета против норовируса
JP2016533172A (ja) 2013-10-03 2016-10-27 タケダ ワクチン,インコーポレイテッド 細胞株からラブドウイルスを検出および除去する方法
US20160310412A1 (en) 2013-12-16 2016-10-27 Takeda Pharmaceutical Company Limited Microneedle
CN107184970A (zh) * 2017-02-16 2017-09-22 北京生物制品研究所有限责任公司 口服诺如病毒亚单位疫苗及lt作为该疫苗佐剂的用途
GB201703644D0 (en) 2017-03-07 2017-04-19 Elopak As Improvements in or relating to toller mounting arrangements
AU2018269319A1 (en) * 2017-05-15 2019-11-07 Janssen Vaccines & Prevention B.V. Stable virus-containing composition
WO2019158653A1 (en) * 2018-02-15 2019-08-22 Icon Genetics Gmbh Immunogenic composition and vaccine for generating an immune response to norovirus
WO2019231712A1 (en) * 2018-05-29 2019-12-05 Stc.Unm Virus-like particle compositions and methods of using same
CN109265542B (zh) * 2018-09-27 2021-06-15 国药中生生物技术研究院有限公司 特异性结合诺如病毒gii.4基因型vp1蛋白或vlp的抗体及其制备方法和应用
AR117462A1 (es) * 2018-12-20 2021-08-04 Takeda Vaccines Inc Vacuna contra norovirus, formulaciones y métodos
WO2021140524A1 (en) 2020-01-08 2021-07-15 Bharat Biotech International Limited Viral vaccine compositions and methods of preparations thereof
KR20230140464A (ko) 2021-03-29 2023-10-06 덴카 주식회사 노로바이러스 유래의 펩티드, 폴리뉴클레오티드, 항체, 조성물, 노로바이러스의 중화 에피토프를 동정하는 방법
EP4340874A1 (en) 2021-05-21 2024-03-27 Takeda Vaccines, Inc. Solid composition, freeze-drying method and glass vial

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6572862B1 (en) 1989-11-08 2003-06-03 Baylor College Of Medicine Methods and reagents to detect and characterize Norwalk and related viruses
AU1893592A (en) 1991-03-25 1992-10-21 Board Of Trustees Of The Leland Stanford Junior University Norwalk virus human gastroenteritis agent and molecular cloning of corresponding cdnas
CA2133339A1 (en) 1992-04-08 1993-10-09 Jennifer S. Rota Wild-type measles virus glycoproteins: vaccine and detection method therefor
JPH08500250A (ja) 1992-09-07 1996-01-16 ベイラー・カレッジ・オブ・メディシン ノーウォークおよび関連ウイルスを検出し、かつ特徴付けるための方法並びに試薬
ATE157882T1 (de) 1993-03-23 1997-09-15 Smithkline Beecham Biolog 3-0-deazylierte monophosphoryl lipid a enthaltende impfstoff-zusammensetzungen
US5788970A (en) 1994-03-29 1998-08-04 The University Of Maryland College Park Chimeric infectious bursal disease virus CDNA clones, expression products and vaccines based thereon
SK147696A3 (en) 1994-05-16 1997-08-06 Merck & Co Inc Isolated and purified protein of papillomavirus, a capside, a viral particle, pharmaceutical composition comprising its, a method of making them and their use
US5645051A (en) 1995-04-21 1997-07-08 Dura Pharmaceuticals, Inc. Unit dose dry powder inhaler
US5861241A (en) 1995-08-16 1999-01-19 University Of Massachusetts Monoclonal antibodies for detecting Norwalk virus
GB9525083D0 (en) 1995-12-07 1996-02-07 Danbiosyst Uk Vaccine compositions
US5834015A (en) * 1996-09-11 1998-11-10 Albany Medical College Protein-lipid vesicles and autogenous vaccine comprising the same
US5953727A (en) 1996-10-10 1999-09-14 Incyte Pharmaceuticals, Inc. Project-based full-length biomolecular sequence database
US6491919B2 (en) 1997-04-01 2002-12-10 Corixa Corporation Aqueous immunologic adjuvant compostions of monophosphoryl lipid A
AU739829B2 (en) 1997-04-08 2001-10-18 Merck Sharp & Dohme Corp. Stabilized human papillomavirus formulations
JP2002508748A (ja) 1997-05-01 2002-03-19 カイロン コーポレイション アジュバントとしてのウイルス様粒子の使用
US20040265377A1 (en) 1997-10-27 2004-12-30 Harry Seager Solid dispersing vaccine composition for oral delivery
ES2262333T3 (es) 1998-08-14 2006-11-16 MERCK & CO., INC. Procedimiento para purificar particulas similares a virus de papilomavirus humano.
WO2000035479A1 (en) 1998-12-17 2000-06-22 Merck & Co., Inc. Synthetic virus-like particles with heterologous epitopes
JP4841726B2 (ja) * 1999-02-05 2011-12-21 メルク・シャープ・エンド・ドーム・コーポレイション ヒトパピローマウイルスワクチン製剤
KR100762092B1 (ko) 1999-06-22 2007-10-04 국립감염증연구소장이 대표하는 일본국 Srsv 검출 킷트
JP2002020399A (ja) 2000-07-10 2002-01-23 Osaka Prefecture ノルウォークウイルス(nv)を認識するモノクローナル抗体
GB0118249D0 (en) 2001-07-26 2001-09-19 Chiron Spa Histidine vaccines
AU2003219760A1 (en) 2002-02-14 2003-09-04 Novavax, Inc. Optimization of gene sequences of virus-like particles for expression in insect cells
GB0206359D0 (en) 2002-03-18 2002-05-01 Glaxosmithkline Biolog Sa Viral antigens
GB0206360D0 (en) 2002-03-18 2002-05-01 Glaxosmithkline Biolog Sa Viral antigens
US7135180B2 (en) 2002-04-11 2006-11-14 Medimmune Vaccines, Inc. Preservation of bioactive materials by freeze dried foam
GB0302218D0 (en) 2003-01-30 2003-03-05 Chiron Sri Vaccine formulation & Mucosal delivery
CA2486118A1 (en) 2002-06-07 2003-12-18 Large Scale Biology Corporation Flexible vaccine assembly and vaccine delivery platform
JP4598519B2 (ja) 2002-06-20 2010-12-15 サイトス バイオテクノロジー アーゲー アジュバントとして使用するためのパッケージ化されたウィルス様粒子:調製法及び使用法
US20050106178A1 (en) 2003-01-30 2005-05-19 Chiron Corporation Adjuvanted influenza vaccine
WO2004073652A2 (en) 2003-02-20 2004-09-02 Becton Dickinson And Company Powder formulations of recombinant staphylococcal enterotoxin b (rseb) made by atmospheric spray-freeze drying for improved vaccination
US8592197B2 (en) 2003-07-11 2013-11-26 Novavax, Inc. Functional influenza virus-like particles (VLPs)
US7879338B2 (en) 2003-07-21 2011-02-01 Boyce Thompson Institute For Plant Research Vectors and methods for immunization against norovirus using transgenic plants
WO2005030806A2 (en) 2003-09-24 2005-04-07 Montana State University Norovirus monoclonal antibodies and peptides
US7795242B2 (en) 2003-10-15 2010-09-14 The Brigham And Women's Hospital, Inc. Methods and compositions for immunomodulation
US20050215501A1 (en) 2003-10-24 2005-09-29 Coley Pharmaceutical Group, Inc. Methods and products for enhancing epitope spreading
FR2863890B1 (fr) 2003-12-19 2006-03-24 Aventis Pasteur Composition immunostimulante
US7481997B1 (en) 2004-02-12 2009-01-27 Montana State University Snow mountain virus genome sequence, virus-like particles and methods of use
US20050260225A1 (en) 2004-05-18 2005-11-24 Goldberg Joanna B Intranasal recombinant Salmonella vaccine encoding heterologous polysaccharide antigens
CU23496A1 (es) 2004-09-03 2010-02-23 Ct Ingenieria Genetica Biotech Composición vacunal contra el virus de la hepatitis c
CA2584228C (en) 2004-10-20 2015-05-05 Acambis Inc. Vaccines against japanese encephalitis virus and west nile virus
GB0428394D0 (en) 2004-12-24 2005-02-02 Chiron Srl Saccharide conjugate vaccines
US20060177468A1 (en) 2005-01-05 2006-08-10 Philadelphia Health and Education Corporation (d/b/a Drexel University College of Medicine Delivery vehicles, bioactive substances and viral vaccines
EP1846439A2 (en) 2005-01-31 2007-10-24 The Johns Hopkins University Use of consensus sequence as vaccine antigen to enhance recognition of virulent viral variants
MX291624B (es) 2005-02-18 2011-11-04 Novartis Vaccines & Diagnostic Inmunogenos de escherichia coli uropatogenica.
AU2006224529B2 (en) 2005-03-18 2012-05-24 Cytos Biotechnology Ag Cat allergen fusion proteins and uses thereof
BRPI0611336A2 (pt) 2005-06-01 2010-08-31 Dow Global Technologies Inc método para produzir uma partìcula multivalente semelhante a vìrus, partìcula multivalente semelhante a vìrus, método de aumentar a solubilidade de uma partìcula multivalente semelhante a vìrus e vacina
EP1736538A1 (en) 2005-06-21 2006-12-27 Cytos Biotechnology AG Process for the preparative purification of virus-like-particles (VLPs)
CA2630220C (en) 2005-11-22 2020-10-13 Doris Coit Norovirus and sapovirus antigens
JP2007145775A (ja) 2005-11-29 2007-06-14 Falco Life Science:Kk ノロウイルスgiの高感度検出方法
US20080029915A1 (en) * 2006-08-02 2008-02-07 Courtoy Nv Rotary tablet press
SG10201502490YA (en) 2006-09-29 2015-05-28 Ligocyte Pharmaceuticals Inc Norovirus vaccine formulations
WO2008068631A2 (en) 2006-12-06 2008-06-12 Novartis Ag Vaccines including antigen from four strains of influenza virus
ES2559421T3 (es) * 2007-03-14 2016-02-12 Takeda Vaccines, Inc. Purificación de partículas similares a virus
AU2008299589B2 (en) 2007-09-12 2014-06-26 Australian Centre For Plant Functional Genomics Pty Ltd Plant seed active transcriptional control sequences
US20100266636A1 (en) 2007-09-18 2010-10-21 Ligocyte Pharmaceuticals, Inc. Method of conferring a protective immune response to norovirus
US10130696B2 (en) * 2007-09-18 2018-11-20 Takeda Vaccines, Inc. Method of conferring a protective immune response to norovirus
WO2010017542A1 (en) 2008-08-08 2010-02-11 Ligocyte Pharmaceuticals, Inc. Virus-like particles comprising composite capsid amino acid sequences for enhanced cross reactivity
EP2381959A1 (en) * 2009-01-22 2011-11-02 Pharmathene Inc. Stable vaccine compositions and methods of use
CA2752039A1 (en) * 2009-02-10 2010-08-19 Novartis Ag Influenza vaccine regimens for pandemic-associated strains
US20110070260A1 (en) 2009-09-09 2011-03-24 Baric Ralph S Multivalent Immunogenic Compositions Against Noroviruses and Methods of Use
KR20120125627A (ko) * 2010-01-21 2012-11-16 리고사이트 파머슈티컬즈 인코퍼레이티드 칼리시바이러스 바이러스 유사 입자들 상에 표적화된 이종 항원 제공
ES2661978T3 (es) * 2010-05-26 2018-04-04 Selecta Biosciences, Inc. Vacunas multivalentes de nanovehículos sintéticos
EA029470B1 (ru) 2011-07-11 2018-03-30 Такеда Вэксинс, Инк. Способ стимулирования формирования защитного иммунитета против норовируса
JOP20130186B1 (ar) 2012-06-22 2021-08-17 Takeda Vaccines Montana Inc تنقية الجزيئات الشبيهة بالفيروسات
ES2952064T3 (es) 2015-12-16 2023-10-26 Walter & Eliza Hall Inst Medical Res Inhibición de la proteína SH2 inducida por citocinas en células NK
EP3529359B1 (en) 2016-10-18 2023-12-13 Regents of the University of Minnesota Tumor infiltrating lymphocytes for use in therapy
MX2020011697A (es) 2018-05-03 2020-12-10 Univ Texas Células exterminadoras naturales diseñadas para expresar receptores de antígeno quimérico con bloqueo de punto de control inmunitario.
EP3840778A1 (en) 2018-08-20 2021-06-30 Takeda Vaccines, Inc. Vlp formulations
AR117462A1 (es) 2018-12-20 2021-08-04 Takeda Vaccines Inc Vacuna contra norovirus, formulaciones y métodos
EP3924467A1 (en) 2019-02-15 2021-12-22 Editas Medicine, Inc. Modified natural killer (nk) cells for immunotherapy

Also Published As

Publication number Publication date
PE20140845A1 (es) 2014-08-03
US10675341B2 (en) 2020-06-09
CL2014000082A1 (es) 2014-07-04
CN108567975A (zh) 2018-09-25
NZ620865A (en) 2015-08-28
AU2015200836B2 (en) 2016-08-25
ES2656527T3 (es) 2018-02-27
SG10201605644WA (en) 2016-09-29
ZA201401012B (en) 2015-05-27
DOP2014000004A (es) 2014-10-31
PL3299030T3 (pl) 2022-12-05
NZ710919A (en) 2017-12-22
EA035442B1 (ru) 2020-06-17
CA2841356C (en) 2022-03-01
PH12018501515B1 (en) 2019-02-04
HK1199202A1 (en) 2015-06-26
UA117732C2 (uk) 2018-09-25
AU2012282658B2 (en) 2014-11-27
JP2017214357A (ja) 2017-12-07
KR20140066160A (ko) 2014-05-30
ECSP14013201A (es) 2014-05-31
EA201792407A3 (ru) 2018-07-31
US20130273102A1 (en) 2013-10-17
US9801934B2 (en) 2017-10-31
PL2731621T3 (pl) 2018-10-31
WO2013009849A1 (en) 2013-01-17
HK1215154A1 (zh) 2016-08-19
CN105031637A (zh) 2015-11-11
TN2014000008A1 (en) 2015-07-01
PH12018501515A1 (en) 2019-02-04
CR20190540A (es) 2022-04-04
JP2014520852A (ja) 2014-08-25
US20180185468A1 (en) 2018-07-05
KR102096937B1 (ko) 2020-04-03
CR20140069A (es) 2014-06-27
IL230356B (en) 2019-05-30
EP3299030B1 (en) 2022-06-08
EP4112074A1 (en) 2023-01-04
CA2841356A1 (en) 2013-01-17
DK3299030T3 (da) 2022-09-05
MY170746A (en) 2019-08-27
DOP2022000030A (es) 2022-06-30
EP2731621B1 (en) 2017-11-01
ZA201500915B (en) 2016-06-29
BR112014000656A2 (pt) 2017-02-14
CN103874507A (zh) 2014-06-18
EA201490258A1 (ru) 2014-05-30
EP2731621A1 (en) 2014-05-21
EP2731621A4 (en) 2015-03-25
EA202090699A3 (ru) 2020-11-30
AU2012282658A1 (en) 2013-03-14
US20230338503A1 (en) 2023-10-26
GEP201706668B (en) 2017-05-25
EA201792407A2 (ru) 2018-03-30
MA35414B1 (fr) 2014-09-01
AU2015200836A1 (en) 2015-03-12
US9867876B2 (en) 2018-01-16
JP6208659B2 (ja) 2017-10-04
JP6613259B2 (ja) 2019-11-27
HK1198136A1 (en) 2015-03-13
MX2014000411A (es) 2014-08-26
EA029470B1 (ru) 2018-03-30
MX356586B (es) 2018-06-05
EP3299030A1 (en) 2018-03-28
ES2926487T3 (es) 2022-10-26
US20210085778A1 (en) 2021-03-25
US20160000899A1 (en) 2016-01-07
US11701420B2 (en) 2023-07-18

Similar Documents

Publication Publication Date Title
EA202090699A2 (ru) Композиции, содержащие буфер, вакцины, которые содержат композиции, содержащие буфер, и пути их применения
MX2018007627A (es) Vacuna contra el virus del zika.
CY1122483T1 (el) Λυοφιλοποιημενες παρασκευες μελφαλανης φλουφεναμιδης
EA201992133A1 (ru) Производные пиперидино-пиримидина для лечения вирусных инфекций
MX2016003419A (es) Metodos y composiciones para sindrome respiratorio coronavirus de oriente medio (mers-cov) inmunogenico.
EA201391515A1 (ru) Инактивированная вакцина вируса денге
MY168959A (en) Vaccine compositions for the prevention of dengue virus infection
EA202090547A3 (ru) Макроциклические деаза-оксипурины для лечения вирусных инфекций
PH12014502875A1 (en) Vaccine compositions for prevention against dengue virus infection
EA201590491A1 (ru) Иммуногенная композиция
EA201500383A1 (ru) Производные 1,2,4-триазина для лечения вирусных инфекций
EA201590667A1 (ru) Ациламинопиримидиновые производные для лечения вирусных инфекций и других заболеваний
MX2013013801A (es) Oligodesoxinucleotidos inmunoestimuladores.
EA201490610A1 (ru) Соединения и способы усиления врожденных иммунных ответов
MX346596B (es) Oligodesoxinucleotidos inmunoestimuladores.
PH12015501716A1 (en) Anti-mycoplasma spp. subunit vaccine
NZ630831A (en) Compositions and methods for administration of vaccines against dengue virus
UA114298C2 (uk) Пептид торк та вакцина, що його містить
PH12015502844B1 (en) Mammalian milk osteopontin for enhancing immune responsiveness
IN2014DN09445A (ru)
EA201690378A1 (ru) Вакцинные композиции против наркотической зависимости
UA106111C2 (ru) Способ получения человеческого интерферона с использованием наночастиц оксида церия