EA201992340A1 - Способ очистки гиалуроновой кислоты - Google Patents

Способ очистки гиалуроновой кислоты

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Publication number
EA201992340A1
EA201992340A1 EA201992340A EA201992340A EA201992340A1 EA 201992340 A1 EA201992340 A1 EA 201992340A1 EA 201992340 A EA201992340 A EA 201992340A EA 201992340 A EA201992340 A EA 201992340A EA 201992340 A1 EA201992340 A1 EA 201992340A1
Authority
EA
Eurasian Patent Office
Prior art keywords
recirculation
hyaluronic acid
terms
steps
fermentation broth
Prior art date
Application number
EA201992340A
Other languages
English (en)
Other versions
EA039639B1 (ru
Inventor
Винченца Корса
Джанкарло Карпанэзе
Original Assignee
Фидия Фармачеутичи С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фидия Фармачеутичи С.П.А. filed Critical Фидия Фармачеутичи С.П.А.
Publication of EA201992340A1 publication Critical patent/EA201992340A1/ru
Publication of EA039639B1 publication Critical patent/EA039639B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
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    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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    • A61L27/3637—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the origin of the biological material other than human or animal, e.g. plant extracts, algae
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61Q19/08—Anti-ageing preparations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0492—Applications, solvents used
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
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    • B01D2311/25—Recirculation, recycling or bypass, e.g. recirculation of concentrate into the feed
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
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  • Genetics & Genomics (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Настоящее изобретение относится к области, касающейся способов экстракции и очистки гиалуроновой кислоты из ферментационного бульона. Оно предусматривает следующие стадии: a) разбавление отфильтрованного ферментационного бульона очищенной водой; b) принудительная рециркуляция бульона, поступающего из стадии а), образованного объединением ретентата и пермеата, внутрь кассет фильтра тангенциального потока, содержащих ультрафильтрационные мембраны, где принудительную рециркуляцию повторяют в течение времени в диапазоне от 1 до 6 ч, причем указанную рециркуляцию проводят с помощью однонаправленного потока и в замкнутой системе при постоянном объеме без введения жидкостей извне. С помощью указанных стадий способ в общем становится более удобным с точки зрения промышленного производства, наряду с общим сохранением относительно технологического времени, применением материалов и подлежащих утилизации отходов. Способ по настоящему изобретению неожиданно повышает технологический выход в целом, что обеспечивает намного большее улучшение его эффективности.
EA201992340A 2017-07-18 2018-07-17 Способ экстракции и очистки гиалуроновой кислоты EA039639B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762533798P 2017-07-18 2017-07-18
IT102017000081449A IT201700081449A1 (it) 2017-07-18 2017-07-18 Procedimento di purificazione dell'acido ialuronico
PCT/IB2018/055291 WO2019016699A1 (en) 2017-07-18 2018-07-17 PROCESS FOR THE PURIFICATION OF HYALURONIC ACID

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EA201992340A1 true EA201992340A1 (ru) 2020-03-02
EA039639B1 EA039639B1 (ru) 2022-02-21

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US (1) US11198742B2 (ru)
EP (1) EP3655138B1 (ru)
JP (1) JP7327748B2 (ru)
KR (1) KR102611970B1 (ru)
CN (1) CN110612153B (ru)
AU (1) AU2018302492B2 (ru)
CA (1) CA3062556A1 (ru)
EA (1) EA039639B1 (ru)
ES (1) ES2883110T3 (ru)
HU (1) HUE055703T2 (ru)
IT (1) IT201700081449A1 (ru)
MA (1) MA49628B1 (ru)
MD (1) MD3655138T2 (ru)
PL (1) PL3655138T3 (ru)
PT (1) PT3655138T (ru)
WO (1) WO2019016699A1 (ru)

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IT201800009444A1 (it) 2018-10-15 2020-04-15 Fidia Farm Spa Coniugati tra acido ialuronico e amminobisfosfonati e loro impiego terapeutico
EP3978103A4 (en) * 2019-05-31 2022-07-20 Asahi Kasei Kabushiki Kaisha RAW MATERIAL LIQUID CONCENTRATION SYSTEM
IT201900019762A1 (it) 2019-10-24 2021-04-24 Fidia Farm Spa Composizione farmaceutica per uso nel trattamento della cistite di varia eziologia
IT202000005692A1 (it) 2020-03-17 2021-09-17 Fidia Farm Spa Bio-inchiostro per stampa 3D, relativo coniugato e processo di preparazione di un intermedio costituito da un linker fotoreattivo
EP3895720A1 (en) * 2020-04-15 2021-10-20 Euromed, S.A. Method for obtaining a botanical extract
IT202000014017A1 (it) 2020-06-11 2021-12-11 Fidia Farm Spa Nuovi derivati ottenuti da acido ialuronico e carnosina
IT202000032243A1 (it) 2020-12-23 2022-06-23 Fidia Farm Spa Nuovi agenti antivirali
IT202100032111A1 (it) 2021-12-22 2023-06-22 Fidia Farm Spa Nuovi sostituti biocompatibili dell’umor vitreo
TR2021022266A2 (tr) * 2021-12-31 2022-01-21 Irfan Turhan Fermentasyon yoluyla üreti̇len hyaluroni̇k asi̇t?i̇n fermentasyon ortamindan çevri̇mi̇çi̇ geri̇ kazanimi i̇le üreti̇m veri̇mi̇ni̇n artirilmasi
KR20230166581A (ko) 2022-05-31 2023-12-07 엘지전자 주식회사 냉매회수기

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