CY1122381T1 - Παραγωγα ιμιδαζοπυριδαζινης ως αναστολεις pi3kbhta - Google Patents
Παραγωγα ιμιδαζοπυριδαζινης ως αναστολεις pi3kbhtaInfo
- Publication number
- CY1122381T1 CY1122381T1 CY20191101031T CY191101031T CY1122381T1 CY 1122381 T1 CY1122381 T1 CY 1122381T1 CY 20191101031 T CY20191101031 T CY 20191101031T CY 191101031 T CY191101031 T CY 191101031T CY 1122381 T1 CY1122381 T1 CY 1122381T1
- Authority
- CY
- Cyprus
- Prior art keywords
- inhibitors
- pi3kbhta
- compounds
- imidazopyridazine derivatives
- present
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Abstract
Η παρούσα εφεύρεση αναφέρεται σε υποκατεστημένα παράγωγα ιμιδαζοπυριδαζίνης του Τύπου (I) όπου οι μεταβλητές έχουν την έννοια που ορίζεται στις αξιώσεις. Οι ενώσεις σύμφωνα με την παρούσα εφεύρεση είναι χρήσιμες ως αναστολείς pI3Κβ. Η εφεύρεση αναφέρεται περαιτέρω σε διεργασίες για την παρασκευή τέτοιων νέων ενώσεων, φαρμακευτικές συνθέσεις που περιλαμβάνουν τις εν λόγω ενώσεις ως δραστικό συστατικό καθώς και στη χρήση των εν λόγω ενώσεων ως φάρμακο.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14199322 | 2014-12-19 | ||
PCT/EP2015/080604 WO2016097347A1 (en) | 2014-12-19 | 2015-12-18 | IMIDAZOPYRIDAZINE DERIVATIVES AS ΡΙ3Κβ INHIBITORS |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1122381T1 true CY1122381T1 (el) | 2021-01-27 |
Family
ID=52134002
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20191101031T CY1122381T1 (el) | 2014-12-19 | 2019-10-03 | Παραγωγα ιμιδαζοπυριδαζινης ως αναστολεις pi3kbhta |
Country Status (25)
Country | Link |
---|---|
US (1) | US10087187B2 (el) |
EP (1) | EP3233862B1 (el) |
JP (1) | JP6568588B2 (el) |
KR (1) | KR20170095239A (el) |
CN (1) | CN107108634B (el) |
AU (1) | AU2015366190B2 (el) |
BR (1) | BR112017012930A2 (el) |
CA (1) | CA2967551A1 (el) |
CY (1) | CY1122381T1 (el) |
DK (1) | DK3233862T3 (el) |
EA (1) | EA029789B1 (el) |
ES (1) | ES2761051T3 (el) |
HR (1) | HRP20191550T1 (el) |
HU (1) | HUE045220T2 (el) |
IL (1) | IL252866B (el) |
LT (1) | LT3233862T (el) |
MA (1) | MA41174B1 (el) |
MD (1) | MD3233862T2 (el) |
ME (1) | ME03517B (el) |
MX (1) | MX2017008074A (el) |
PL (1) | PL3233862T3 (el) |
PT (1) | PT3233862T (el) |
RS (1) | RS59301B1 (el) |
SI (1) | SI3233862T1 (el) |
WO (1) | WO2016097347A1 (el) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA037401B1 (ru) | 2015-10-09 | 2021-03-24 | Янссен Фармацевтика Нв | Производные хиноксалина и пиридопиразина в качестве ингибиторов pi3k |
MX2018015707A (es) | 2016-06-16 | 2019-03-21 | Janssen Pharmaceutica Nv | Derivados biciclicos de piridina, pirazina y pirimidina como inhibidores de pi3k beta. |
US11130751B2 (en) | 2017-03-29 | 2021-09-28 | Janssen Pharmaceutica Nv | Quinoxaline and pyridopyrazine derivatives as PI3K-beta inhibitors |
CN110128505A (zh) * | 2019-05-21 | 2019-08-16 | 梯尔希(南京)药物研发有限公司 | 一种戈舍瑞林杂质的合成方法 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070078136A1 (en) | 2005-09-22 | 2007-04-05 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
US8217177B2 (en) | 2006-07-14 | 2012-07-10 | Amgen Inc. | Fused heterocyclic derivatives and methods of use |
PE20080403A1 (es) | 2006-07-14 | 2008-04-25 | Amgen Inc | Derivados heterociclicos fusionados y metodos de uso |
JP2009544723A (ja) | 2006-07-24 | 2009-12-17 | スミスクライン・ビーチャム・コーポレイション | Pi3キナーゼ阻害剤としてのチオゾリジンジオン誘導体 |
US20110021513A1 (en) | 2006-09-07 | 2011-01-27 | Biogen Idec Ma Inc. | Modulators of interleukin-1 receptor-associated kinase |
AU2008250328A1 (en) * | 2007-05-09 | 2008-11-20 | Novartis Ag | Substituted imidazopyridazines as PI3K lipid kinase inhibitors |
US20110046127A1 (en) | 2007-11-08 | 2011-02-24 | Paolo Pevarello | Imidazopyridazines for Use as Protein Kinase Inhibitors |
KR20100128305A (ko) * | 2008-02-28 | 2010-12-07 | 노파르티스 아게 | C-met 티로신 키나제 매개 질환의 치료를 위한 이미다조[1,2-b]피리다진 유도체 |
WO2010007099A1 (en) | 2008-07-15 | 2010-01-21 | Cellzome Limited | 2-aminoimidazo[1,2-b]pyridazine derivatives as pi3k inhibitors |
MX2012002066A (es) | 2009-08-17 | 2012-03-29 | Intellikine Inc | Compuestos heterociclicos y usos de los mismos. |
DE102009049679A1 (de) | 2009-10-19 | 2011-04-21 | Merck Patent Gmbh | Pyrazolopyrimidinderivate |
WO2011058109A1 (en) | 2009-11-12 | 2011-05-19 | Ucb Pharma S.A. | Fused bicyclic pyrrole and imidazole derivatives as kinase inhibitors |
UY33304A (es) | 2010-04-02 | 2011-10-31 | Amgen Inc | Compuestos heterocíclicos y sus usos |
EP2624696B1 (en) * | 2010-10-06 | 2016-12-21 | Glaxosmithkline LLC | Benzimidazole derivatives as pi3 kinase inhibitors |
US9127000B2 (en) | 2011-02-23 | 2015-09-08 | Intellikine, LLC. | Heterocyclic compounds and uses thereof |
WO2013028263A1 (en) | 2011-08-24 | 2013-02-28 | Glaxosmithkline Llc | Pyrazolopyrimidine derivatives as pi3 kinase inhibitors |
US8778937B2 (en) | 2011-12-20 | 2014-07-15 | Glaxosmithkline Llc | Benzimidazole boronic acid derivatives as PI3 kinase inhibitors |
US8906910B2 (en) | 2011-12-20 | 2014-12-09 | Glaxosmithkline Llc | Imidazopyridine derivatives as PI3 kinase |
TWI574962B (zh) | 2012-11-14 | 2017-03-21 | 加拓科學公司 | 作爲pi3激酶調節劑的芳雜環化合物及其使用方法和用途 |
GB201321734D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic Agents |
-
2015
- 2015-12-18 AU AU2015366190A patent/AU2015366190B2/en not_active Ceased
- 2015-12-18 ME MEP-2019-263A patent/ME03517B/me unknown
- 2015-12-18 EA EA201791396A patent/EA029789B1/ru not_active IP Right Cessation
- 2015-12-18 CA CA2967551A patent/CA2967551A1/en active Pending
- 2015-12-18 SI SI201530855T patent/SI3233862T1/sl unknown
- 2015-12-18 JP JP2017532819A patent/JP6568588B2/ja not_active Expired - Fee Related
- 2015-12-18 PL PL15810784T patent/PL3233862T3/pl unknown
- 2015-12-18 BR BR112017012930A patent/BR112017012930A2/pt active Search and Examination
- 2015-12-18 DK DK15810784.7T patent/DK3233862T3/da active
- 2015-12-18 WO PCT/EP2015/080604 patent/WO2016097347A1/en active Application Filing
- 2015-12-18 CN CN201580069133.7A patent/CN107108634B/zh not_active Expired - Fee Related
- 2015-12-18 MX MX2017008074A patent/MX2017008074A/es active IP Right Grant
- 2015-12-18 HU HUE15810784A patent/HUE045220T2/hu unknown
- 2015-12-18 KR KR1020177016722A patent/KR20170095239A/ko not_active Application Discontinuation
- 2015-12-18 RS RSP20191225 patent/RS59301B1/sr unknown
- 2015-12-18 PT PT158107847T patent/PT3233862T/pt unknown
- 2015-12-18 ES ES15810784T patent/ES2761051T3/es active Active
- 2015-12-18 US US15/537,551 patent/US10087187B2/en active Active
- 2015-12-18 MA MA41174A patent/MA41174B1/fr unknown
- 2015-12-18 LT LTEP15810784.7T patent/LT3233862T/lt unknown
- 2015-12-18 EP EP15810784.7A patent/EP3233862B1/en active Active
- 2015-12-18 MD MDE20170191 patent/MD3233862T2/ro unknown
-
2017
- 2017-06-13 IL IL252866A patent/IL252866B/en active IP Right Grant
-
2019
- 2019-08-28 HR HRP20191550 patent/HRP20191550T1/hr unknown
- 2019-10-03 CY CY20191101031T patent/CY1122381T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
WO2016097347A1 (en) | 2016-06-23 |
CN107108634B (zh) | 2020-09-15 |
JP2017538734A (ja) | 2017-12-28 |
IL252866A0 (en) | 2017-08-31 |
US10087187B2 (en) | 2018-10-02 |
JP6568588B2 (ja) | 2019-08-28 |
SI3233862T1 (sl) | 2019-09-30 |
HUE045220T2 (hu) | 2019-12-30 |
EP3233862B1 (en) | 2019-07-03 |
CA2967551A1 (en) | 2016-06-23 |
RS59301B1 (sr) | 2019-10-31 |
DK3233862T3 (da) | 2019-10-07 |
MA41174A (fr) | 2017-10-25 |
MX2017008074A (es) | 2018-01-09 |
CN107108634A (zh) | 2017-08-29 |
AU2015366190B2 (en) | 2020-01-23 |
ES2761051T3 (es) | 2020-05-18 |
IL252866B (en) | 2020-09-30 |
EA029789B1 (ru) | 2018-05-31 |
ME03517B (me) | 2020-04-20 |
LT3233862T (lt) | 2019-09-10 |
PT3233862T (pt) | 2019-10-09 |
KR20170095239A (ko) | 2017-08-22 |
PL3233862T3 (pl) | 2020-01-31 |
MD3233862T2 (ro) | 2019-11-30 |
BR112017012930A2 (pt) | 2018-01-09 |
MA41174B1 (fr) | 2019-09-30 |
US20180002336A1 (en) | 2018-01-04 |
HRP20191550T1 (hr) | 2019-11-29 |
EP3233862A1 (en) | 2017-10-25 |
EA201791396A1 (ru) | 2017-10-31 |
AU2015366190A1 (en) | 2017-05-25 |
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