EA201890072A1 - Новые соединения в качестве модуляторов ror-гамма - Google Patents

Новые соединения в качестве модуляторов ror-гамма

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Publication number
EA201890072A1
EA201890072A1 EA201890072A EA201890072A EA201890072A1 EA 201890072 A1 EA201890072 A1 EA 201890072A1 EA 201890072 A EA201890072 A EA 201890072A EA 201890072 A EA201890072 A EA 201890072A EA 201890072 A1 EA201890072 A1 EA 201890072A1
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Eurasian Patent Office
Prior art keywords
rorγt
ror
new connections
inhibit
ring
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EA201890072A
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English (en)
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EA034201B1 (ru
Inventor
Санджиб Дас
Лаксмикант Атмарам Гарат
Раджендра Лаксман Харде
Сандип Ядунат Шелке
Шайлеш Рамеш Пардеши
Абрахам Томас
Неелима Каираткар-Джоши
Дайси Маниш Шах
Малини Бажпай
Original Assignee
Гленмарк Фармасьютикалс С.А.
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Application filed by Гленмарк Фармасьютикалс С.А. filed Critical Гленмарк Фармасьютикалс С.А.
Publication of EA201890072A1 publication Critical patent/EA201890072A1/ru
Publication of EA034201B1 publication Critical patent/EA034201B1/ru

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
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  • Life Sciences & Earth Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
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  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Изобретение относится к соединениям формулы (I) и их фармацевтически приемлемым солям, где кольцо A, кольцо B, L, R, R, R, R, R, R, R, n, m, p и q являются такиими, как определено в настоящем описании, которые обладают активностью модуляторов ретиноид-родственного орфанного рецептора гамма t (RORγt). Указанные соединения предотвращают, ингибируют или подавляют действие RORγt и, таким образом, подходят для лечения заболеваний, нарушений, синдромов или состояний, опосредованных RORγt, таких как, например, боль, воспаление, ХОБЛ, астма, ревматоидный артрит, колит, рассеянный склероз, псориаз, нейродегенеративные заболевания и рак.
EA201890072A 2015-08-03 2016-08-02 Соединения в качестве модуляторов ror-гамма EA034201B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2930MU2015 2015-08-03
PCT/IB2016/054639 WO2017021879A1 (en) 2015-08-03 2016-08-02 Novel compounds as ror gamma modulators

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EA201890072A1 true EA201890072A1 (ru) 2018-07-31
EA034201B1 EA034201B1 (ru) 2020-01-16

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AU (1) AU2016303540B2 (ru)
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CN112292183A (zh) * 2018-06-18 2021-01-29 詹森药业有限公司 作为RORγt的调节剂的6-氨基吡啶-3-基吡唑
JP2021528405A (ja) * 2018-06-18 2021-10-21 ヤンセン ファーマシューティカ エヌ．ベー． ＲＯＲγｔのモジュレータとしてのアミド置換チアゾール
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