EA201791530A1 - НОВЫЕ N-АЦИЛАРИЛСУЛЬФОНАМИДНЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ АМИНОАЦИЛ-тРНК СИНТЕТАЗЫ - Google Patents

НОВЫЕ N-АЦИЛАРИЛСУЛЬФОНАМИДНЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ АМИНОАЦИЛ-тРНК СИНТЕТАЗЫ

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EA201791530A1
EA201791530A1 EA201791530A EA201791530A EA201791530A1 EA 201791530 A1 EA201791530 A1 EA 201791530A1 EA 201791530 A EA201791530 A EA 201791530A EA 201791530 A EA201791530 A EA 201791530A EA 201791530 A1 EA201791530 A1 EA 201791530A1
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Prior art keywords
inhibitors
new
aminoacyl
trna
synthetasis
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EA201791530A
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English (en)
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EA036995B1 (ru
Inventor
Айгарс Йиргенсонс
Эйнарс Лоза
Майкл Чарльтон
Пол Уильям Финн
Де Поуплана Луис Рибас
Аделаида Сен-Леже
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Оксфорд Драг Дизайн Лимитед
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Priority claimed from LVP-15-14A external-priority patent/LV15146B/lv
Priority claimed from LVP-16-06A external-priority patent/LV15257A/lv
Application filed by Оксфорд Драг Дизайн Лимитед filed Critical Оксфорд Драг Дизайн Лимитед
Publication of EA201791530A1 publication Critical patent/EA201791530A1/ru
Publication of EA036995B1 publication Critical patent/EA036995B1/ru

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Abstract

Изобретение относится к новым N-ацилдиарисульфонамидам, выступающим в качестве ингибиторов бактериальной аминоацил-тРНК синтетазы. Указанные соединения можно применять в качестве лекарственных средств или в составе лекарственных средств для лечения бактериальных инфекций.
EA201791530A 2015-02-13 2016-02-11 НОВЫЕ N-АЦИЛАРИЛСУЛЬФОНАМИДНЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ АМИНОАЦИЛ-тРНК СИНТЕТАЗЫ EA036995B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
LVP-15-14A LV15146B (lv) 2015-02-13 2015-02-13 N-acil-diarilsulfonamīda atvasinājumi kā aminoacil-t-RNS sintetāžu inhibitori
LVP-16-06A LV15257A (lv) 2016-02-10 2016-02-10 Jauni N-acil-arilsulfonamīda atvasinājumi kā aminoacil-tRNS sintetāzes inhibitori
PCT/LV2016/000001 WO2016129983A1 (en) 2015-02-13 2016-02-11 Novel n-acyl-arylsulfonamide derivatives as aminoacyl-trna synthetase inhibitors

Publications (2)

Publication Number Publication Date
EA201791530A1 true EA201791530A1 (ru) 2018-01-31
EA036995B1 EA036995B1 (ru) 2021-01-25

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US (1) US11072581B2 (ru)
EP (1) EP3259250A1 (ru)
JP (1) JP6740256B2 (ru)
KR (1) KR102568859B1 (ru)
CN (1) CN107257789B (ru)
AU (1) AU2016216782C1 (ru)
CA (1) CA2975682A1 (ru)
EA (1) EA036995B1 (ru)
IL (1) IL253886B (ru)
MA (1) MA41542A (ru)
MX (1) MX2017010357A (ru)
WO (1) WO2016129983A1 (ru)
ZA (1) ZA201706108B (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6740256B2 (ja) 2015-02-13 2020-08-12 オックスフォード ドラッグ デザイン リミテッド アミノアシルｔＲＮＡシンテターゼ阻害薬としての新規なＮ−アシル−アリールスルホンアミド誘導体
GB201617064D0 (en) * 2016-10-07 2016-11-23 Inhibox Limited And Latvian Institute Of Organic Synthesis The Compounds and their therapeutic use
CN107033093B (zh) * 2017-06-07 2019-09-03 浙江工业大学 N-取代磺酰胺类化合物及其制备方法与应用
TW202120490A (zh) 2019-07-30 2021-06-01 德商拜耳動物保健有限公司 新穎異喹啉衍生物
CN112759542B (zh) * 2019-11-04 2022-04-01 上海现代制药股份有限公司 一种药物中间体及其制备和应用
CN110950863B (zh) * 2019-11-15 2021-04-02 中山大学 一种喹唑啉酮类化合物及其制备方法和应用
MX2022007500A (es) * 2019-12-19 2022-07-04 Oxford Drug Design Ltd Compuestos de 2-amino-n-(amino-oxo-aril-lambda6-sulfanilideno)acet amida y su uso terapeutico.

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05208914A (ja) 1991-09-03 1993-08-20 Fujisawa Pharmaceut Co Ltd ペプチド化合物を含有する医薬組成物
US5824657A (en) 1997-03-18 1998-10-20 Cubist Pharmaceuticals, Inc. Aminoacyl sulfamides for the treatment of hyperproliferative disorders
US20020052370A1 (en) 2000-07-06 2002-05-02 Barber Christopher Gordon Cyclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase
DE60213810T2 (de) 2001-06-06 2007-02-01 Eli Lilly And Co., Indianapolis Benzoylsulfonamide und sulfonylbenzamidine zur verwendung als antitumor-mittel
KR20060130027A (ko) * 2003-10-10 2006-12-18 버텍스 파마슈티칼스 인코포레이티드 세린 프로테아제, 특히 ｈｃｖ ｎｓ3-ｎｓ4ａ 프로테아제의억제제
CN1906208B (zh) 2003-10-10 2011-03-30 沃泰克斯药物股份有限公司 丝氨酸蛋白酶、特别是hcv ns3-ns4a蛋白酶的抑制剂
KR20060124725A (ko) * 2004-02-27 2006-12-05 쉐링 코포레이션 Ｃ형 간염 바이러스 ｎｓ3 프로테아제의 억제제
CN101203504B (zh) * 2005-05-03 2012-11-14 兰贝克赛实验室有限公司 抗微生物剂
CN102970867A (zh) 2010-03-18 2013-03-13 拜耳知识产权有限责任公司 作为活性剂对抗非生物植物应激的芳基和杂芳基磺酰胺
US20130190324A1 (en) * 2011-12-23 2013-07-25 The Regents Of The University Of Colorado, A Body Corporate Topical ocular drug delivery
AR091858A1 (es) 2012-07-25 2015-03-04 Sova Pharmaceuticals Inc INHIBIDORES DE CISTATIONIN-g-LIASA (CSE)
JP6740256B2 (ja) 2015-02-13 2020-08-12 オックスフォード ドラッグ デザイン リミテッド アミノアシルｔＲＮＡシンテターゼ阻害薬としての新規なＮ−アシル−アリールスルホンアミド誘導体
CN105198789B (zh) 2015-10-26 2018-06-05 山东大学 取代3-吲哚类Bcl-2蛋白抑制剂及制备方法和应用
GB201617064D0 (en) 2016-10-07 2016-11-23 Inhibox Limited And Latvian Institute Of Organic Synthesis The Compounds and their therapeutic use

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AU2016216782B2 (en) 2020-07-30
IL253886A0 (en) 2017-10-31
MA41542A (fr) 2021-04-14
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AU2016216782A1 (en) 2017-09-28
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CN107257789B (zh) 2021-06-29
AU2016216782C1 (en) 2021-02-18
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