EA201791117A1 - Частичные агонисты инсулинового рецептора - Google Patents

Частичные агонисты инсулинового рецептора

Info

Publication number
EA201791117A1
EA201791117A1 EA201791117A EA201791117A EA201791117A1 EA 201791117 A1 EA201791117 A1 EA 201791117A1 EA 201791117 A EA201791117 A EA 201791117A EA 201791117 A EA201791117 A EA 201791117A EA 201791117 A1 EA201791117 A1 EA 201791117A1
Authority
EA
Eurasian Patent Office
Prior art keywords
partial agonists
insulin receptor
agonists insulin
insulin
dimers
Prior art date
Application number
EA201791117A
Other languages
English (en)
Other versions
EA036714B1 (ru
Inventor
Суннянь Линь
Линь Янь
Пэй Хо
Дмитрий Писсарницки
Даньцин Фэн
Рави Наргунд
Юйпин Чжу
Ахмет Кекедж
Кристина Б. Мадсен-Дугган
Чжи-цай Ши
Чжицай У
Инцзюнь Му
Original Assignee
Мерк Шарп И Доум Корп.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Шарп И Доум Корп. filed Critical Мерк Шарп И Доум Корп.
Publication of EA201791117A1 publication Critical patent/EA201791117A1/ru
Publication of EA036714B1 publication Critical patent/EA036714B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

Раскрыты димеры инсулинов и димеры аналогов инсулина, которые действуют на инсулиновый рецептор как частичные агонисты.
EA201791117A 2014-11-21 2015-11-19 Частичные агонисты инсулинового рецептора EA036714B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462082857P 2014-11-21 2014-11-21
US201562242503P 2015-10-16 2015-10-16
PCT/US2015/061445 WO2016081670A2 (en) 2014-11-21 2015-11-19 Insulin receptor partial agonists

Publications (2)

Publication Number Publication Date
EA201791117A1 true EA201791117A1 (ru) 2017-11-30
EA036714B1 EA036714B1 (ru) 2020-12-10

Family

ID=54838417

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201791117A EA036714B1 (ru) 2014-11-21 2015-11-19 Частичные агонисты инсулинового рецептора

Country Status (27)

Country Link
US (4) US10017556B2 (ru)
EP (4) EP3221343B1 (ru)
JP (5) JP6484337B2 (ru)
KR (2) KR102101136B1 (ru)
CN (2) CN112494656B (ru)
AR (1) AR102712A1 (ru)
AU (3) AU2015349890B2 (ru)
BR (2) BR122024000898A2 (ru)
CA (2) CA2966765C (ru)
CL (3) CL2017001288A1 (ru)
CO (1) CO2017004976A2 (ru)
CR (1) CR20170208A (ru)
DO (1) DOP2017000124A (ru)
EA (1) EA036714B1 (ru)
ES (1) ES2946247T3 (ru)
GT (1) GT201700104A (ru)
IL (1) IL252257A0 (ru)
MX (3) MX2017006651A (ru)
NI (1) NI201700060A (ru)
PE (1) PE20170957A1 (ru)
PH (1) PH12017500935A1 (ru)
SG (4) SG10201809428UA (ru)
SV (1) SV2017005445A (ru)
TN (1) TN2017000178A1 (ru)
TW (1) TW201625673A (ru)
WO (1) WO2016081670A2 (ru)
ZA (1) ZA201703238B (ru)

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MX2017006651A (es) 2017-08-21
JP2020097572A (ja) 2020-06-25
US10183981B2 (en) 2019-01-22
SG10201809428UA (en) 2018-11-29
BR112017010481A8 (pt) 2023-04-11
JP2019014734A (ja) 2019-01-31
AU2015349890A1 (en) 2017-06-01
ES2946247T3 (es) 2023-07-14
US20170107268A1 (en) 2017-04-20
JP6931033B2 (ja) 2021-09-01
CN112494656A (zh) 2021-03-16
AU2018211208A1 (en) 2018-08-16
EP3666792A2 (en) 2020-06-17
PH12017500935A1 (en) 2017-11-27
US20190092833A1 (en) 2019-03-28
AU2015349890B2 (en) 2018-08-30
JP6943825B2 (ja) 2021-10-06
JP2019014735A (ja) 2019-01-31
CA2966765A1 (en) 2016-05-26
US20170355743A1 (en) 2017-12-14
EP3221343B1 (en) 2020-09-16
AU2018211208B2 (en) 2020-09-10
EP3221343A2 (en) 2017-09-27
JP6484337B2 (ja) 2019-03-13
SV2017005445A (es) 2018-04-04
PE20170957A1 (es) 2017-07-13
US20180291078A1 (en) 2018-10-11
WO2016081670A2 (en) 2016-05-26
KR102049647B1 (ko) 2019-11-29
CN108064173A (zh) 2018-05-22
EP3666792A3 (en) 2020-07-29
EP3660040A3 (en) 2020-07-29
AR102712A1 (es) 2017-03-22
CN108064173B (zh) 2021-05-18
BR122024000903A2 (pt) 2024-02-27
CL2019001144A1 (es) 2019-07-19
CA3014641C (en) 2020-08-18
BR112017010481A2 (pt) 2018-04-03
EP3660041A1 (en) 2020-06-03
CO2017004976A2 (es) 2017-10-10
WO2016081670A3 (en) 2016-08-04
CA2966765C (en) 2020-04-14
TW201625673A (zh) 2016-07-16
AU2018211207A1 (en) 2018-08-16
MX2020014121A (es) 2021-03-25
SG10201809427SA (en) 2018-11-29
EP3660041B1 (en) 2023-04-19
BR122024000898A2 (pt) 2024-02-27
AU2018211207B2 (en) 2020-04-09
KR20190069622A (ko) 2019-06-19
EP3660040A2 (en) 2020-06-03
IL252257A0 (en) 2017-07-31
CR20170208A (es) 2017-07-17
JP6703068B2 (ja) 2020-06-03
NI201700060A (es) 2017-07-18
KR20170084300A (ko) 2017-07-19
GT201700104A (es) 2018-11-27
CN112494656B (zh) 2024-01-30
MX2020014120A (es) 2021-03-25
JP2018501203A (ja) 2018-01-18
SG11201704064TA (en) 2017-06-29
ZA201703238B (en) 2018-05-30
KR102101136B1 (ko) 2020-04-14
CL2019001143A1 (es) 2019-07-19
US10017556B2 (en) 2018-07-10
SG10201809457YA (en) 2018-11-29
DOP2017000124A (es) 2017-08-15
TN2017000178A1 (en) 2018-10-19
CA3014641A1 (en) 2016-05-26
US10800827B2 (en) 2020-10-13
JP2019011357A (ja) 2019-01-24
EA036714B1 (ru) 2020-12-10
CL2017001288A1 (es) 2017-12-15

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