EA201790926A1 - Комбинированное лечение злокачественного новообразования - Google Patents

Комбинированное лечение злокачественного новообразования

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Publication number
EA201790926A1
EA201790926A1 EA201790926A EA201790926A EA201790926A1 EA 201790926 A1 EA201790926 A1 EA 201790926A1 EA 201790926 A EA201790926 A EA 201790926A EA 201790926 A EA201790926 A EA 201790926A EA 201790926 A1 EA201790926 A1 EA 201790926A1
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EA
Eurasian Patent Office
Prior art keywords
malignant
numer
formation
combined treatment
csf1r
Prior art date
Application number
EA201790926A
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English (en)
Other versions
EA036261B1 (ru
Inventor
Брайан Вонг
Джули ХАМБЛТОН
Роберт Сикорски
Эмма Мастеллер
Кевин Хестер
Дэвид Белловин
Кэтрин Э. Льюис
Original Assignee
Файв Прайм Терапьютикс, Инк.
Бристоль-Мейерз Сквибб Компани
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Application filed by Файв Прайм Терапьютикс, Инк., Бристоль-Мейерз Сквибб Компани filed Critical Файв Прайм Терапьютикс, Инк.
Publication of EA201790926A1 publication Critical patent/EA201790926A1/ru
Publication of EA036261B1 publication Critical patent/EA036261B1/ru

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
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    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069Reproductive system, e.g. ovaria, uterus, testes, prostate
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    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507Comprising a combination of two or more separate antibodies
    • AHUMAN NECESSITIES
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    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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Abstract

Настоящее изобретение относится к способам лечения злокачественного новообразования с применением антител, связывающихся с рецептором колониестимулирующего фактора 1 (CSF1R), в комбинации с ингибиторами PD-1/PD-L1.
EA201790926A 2014-10-29 2015-10-28 Комбинированное лечение злокачественного новообразования EA036261B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462072035P 2014-10-29 2014-10-29
US201562157368P 2015-05-05 2015-05-05
US201562192025P 2015-07-13 2015-07-13
PCT/US2015/057781 WO2016069727A1 (en) 2014-10-29 2015-10-28 Combination therapy for cancer

Publications (2)

Publication Number Publication Date
EA201790926A1 true EA201790926A1 (ru) 2017-09-29
EA036261B1 EA036261B1 (ru) 2020-10-20

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EA201790926A EA036261B1 (ru) 2014-10-29 2015-10-28 Комбинированное лечение злокачественного новообразования

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US (5) US9765147B2 (ru)
EP (2) EP3212670B1 (ru)
JP (3) JP6920989B2 (ru)
KR (1) KR102636539B1 (ru)
CN (1) CN107567336B (ru)
AU (1) AU2015339306B2 (ru)
BR (1) BR112017008914A2 (ru)
CA (1) CA2963147A1 (ru)
CY (1) CY1123957T1 (ru)
DK (1) DK3212670T3 (ru)
EA (1) EA036261B1 (ru)
ES (1) ES2851390T3 (ru)
HR (1) HRP20210440T1 (ru)
HU (1) HUE054012T2 (ru)
IL (1) IL251464B2 (ru)
LT (1) LT3212670T (ru)
MX (1) MX2017005553A (ru)
PL (1) PL3212670T3 (ru)
PT (1) PT3212670T (ru)
RS (1) RS61602B1 (ru)
SG (1) SG11201702723VA (ru)
SI (1) SI3212670T1 (ru)
TW (1) TWI711463B (ru)
WO (1) WO2016069727A1 (ru)
ZA (1) ZA201702382B (ru)

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