EA201790870A1 - Трициклические атропоизомерные соединения - Google Patents

Трициклические атропоизомерные соединения

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Publication number
EA201790870A1
EA201790870A1 EA201790870A EA201790870A EA201790870A1 EA 201790870 A1 EA201790870 A1 EA 201790870A1 EA 201790870 A EA201790870 A EA 201790870A EA 201790870 A EA201790870 A EA 201790870A EA 201790870 A1 EA201790870 A1 EA 201790870A1
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EA
Eurasian Patent Office
Prior art keywords
compounds
tropicometric
tricyclic
diseases
btk
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EA201790870A
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English (en)
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EA031614B1 (ru
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Скотт Хантер Ваттерсон
Эндрю Дж. Теббен
Салим Ахмад
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Бристол-Майерс Сквибб Компани
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Publication of EA201790870A1 publication Critical patent/EA201790870A1/ru
Publication of EA031614B1 publication Critical patent/EA031614B1/ru

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Abstract

Описаны соединения формулы (I)или их соль, где Q представляет собойи X, R, R, R, Rи Rопределены в описании изобретения. Также раскрыты способы применения таких соединений в качестве ингибиторов тирозинкиназы Брутона (Btk) и фармацевтических композиций, содержащих такие соединения. Эти соединения являются полезными для лечения, предупреждения или замедления прогрессирования заболеваний или расстройств в различных терапевтических областях, таких как аутоиммунные заболевания и заболевание сосудов.
EA201790870A 2014-10-24 2015-10-23 Трициклические атропоизомерные соединения EA031614B1 (ru)

Applications Claiming Priority (2)

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US201462068244P 2014-10-24 2014-10-24
PCT/US2015/057046 WO2016065222A1 (en) 2014-10-24 2015-10-23 Tricyclic atropisomer compounds

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EA201790870A1 true EA201790870A1 (ru) 2017-08-31
EA031614B1 EA031614B1 (ru) 2019-01-31

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EP (1) EP3209652B1 (ru)
JP (1) JP6592512B2 (ru)
KR (1) KR102519536B1 (ru)
CN (1) CN107108555B (ru)
AU (1) AU2015335783B2 (ru)
BR (1) BR112017007563A2 (ru)
CA (1) CA2965516A1 (ru)
EA (1) EA031614B1 (ru)
ES (1) ES2800173T3 (ru)
IL (1) IL251801A0 (ru)
MX (1) MX2017005060A (ru)
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KR20210142154A (ko) 2019-03-21 2021-11-24 옹쎄오 암 치료를 위한 키나제 억제제와 조합된 dbait 분자
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JP2023521172A (ja) * 2020-04-10 2023-05-23 ジービー００５， インコーポレイテッド キナーゼ阻害剤
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BR112017007563A2 (pt) 2017-12-19
US10023534B2 (en) 2018-07-17
CN107108555B (zh) 2020-12-01
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