EA201790540A1 - НОВЫЙ СПОСОБ ХИРАЛЬНОГО СИНТЕЗА N-АЦИЛ-(3-ЗАМЕЩЕННЫХ)-(8-ЗАМЕЩЕННЫХ)-5,6-ДИГИДРО[1,2,4]ТРИАЗОЛО[4,3-a]ПИРАЗИНОВ - Google Patents

НОВЫЙ СПОСОБ ХИРАЛЬНОГО СИНТЕЗА N-АЦИЛ-(3-ЗАМЕЩЕННЫХ)-(8-ЗАМЕЩЕННЫХ)-5,6-ДИГИДРО[1,2,4]ТРИАЗОЛО[4,3-a]ПИРАЗИНОВ

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Publication number
EA201790540A1
EA201790540A1 EA201790540A EA201790540A EA201790540A1 EA 201790540 A1 EA201790540 A1 EA 201790540A1 EA 201790540 A EA201790540 A EA 201790540A EA 201790540 A EA201790540 A EA 201790540A EA 201790540 A1 EA201790540 A1 EA 201790540A1
Authority
EA
Eurasian Patent Office
Prior art keywords
substituted
pyrazines
triazolo
dihydro
acyl
Prior art date
Application number
EA201790540A
Other languages
English (en)
Other versions
EA032052B1 (ru
Inventor
Хамид Ховейда
Гийом Дутой
Original Assignee
Огеда Са
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Огеда Са filed Critical Огеда Са
Publication of EA201790540A1 publication Critical patent/EA201790540A1/ru
Publication of EA032052B1 publication Critical patent/EA032052B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

Данное изобретение относится к новому способу хирального синтеза N-ацил-(3-замещенных)-(8-замещенных)-5,6-дигидро[1,2,4]триазоло[4,3-а]пиразинов формулы I, без использования стадий установки и удаления защитных групп.
EA201790540A 2014-09-25 2015-09-25 СПОСОБ ХИРАЛЬНОГО СИНТЕЗА N-АЦИЛ-(3-ЗАМЕЩЕННЫХ)-(8-ЗАМЕЩЕННЫХ)-5,6-ДИГИДРО-[1,2,4]ТРИАЗОЛО[4,3-a]ПИРАЗИНОВ EA032052B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14186447 2014-09-25
PCT/EP2015/072167 WO2016046398A1 (en) 2014-09-25 2015-09-25 Novel chiral synthesis of n-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines

Publications (2)

Publication Number Publication Date
EA201790540A1 true EA201790540A1 (ru) 2017-07-31
EA032052B1 EA032052B1 (ru) 2019-03-29

Family

ID=51730305

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201790540A EA032052B1 (ru) 2014-09-25 2015-09-25 СПОСОБ ХИРАЛЬНОГО СИНТЕЗА N-АЦИЛ-(3-ЗАМЕЩЕННЫХ)-(8-ЗАМЕЩЕННЫХ)-5,6-ДИГИДРО-[1,2,4]ТРИАЗОЛО[4,3-a]ПИРАЗИНОВ

Country Status (18)

Country Link
US (2) US20170298070A1 (ru)
EP (1) EP3197876B1 (ru)
JP (1) JP6469214B2 (ru)
KR (1) KR102558711B1 (ru)
CN (1) CN107001289B (ru)
AU (1) AU2015323702B2 (ru)
CA (1) CA2961984C (ru)
EA (1) EA032052B1 (ru)
ES (1) ES2711095T3 (ru)
IL (1) IL251304B (ru)
MX (1) MX367633B (ru)
NZ (1) NZ730295A (ru)
PL (1) PL3197876T3 (ru)
PT (1) PT3197876T (ru)
SG (2) SG11201702368PA (ru)
TR (1) TR201902080T4 (ru)
WO (1) WO2016046398A1 (ru)
ZA (1) ZA201701949B (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS54833B1 (sr) 2011-10-03 2016-10-31 Euroscreen Sa Novi hiralni n-acil-5,6,7, (8-supstituisan)-tetrahidro-[1,2,4]triazolo [4,3-a]pirazini kao selektivni antagonisti nk-3 receptora, farmaceutsko jedinjenje, i postupci za upotrebu u nk-3 receptorom posredovanim poremećajima
US10183948B2 (en) 2013-03-29 2019-01-22 Ogeda Sa N-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists
JP6316932B2 (ja) 2013-03-29 2018-04-25 オゲダ エス．エー． 選択的ＮＫ−３受容体拮抗薬としての新規なＮ−アシル−（３位置換）−（８位置換）−５，６−ジヒドロ−［１，２，４］トリアゾロ［４，３−ａ］ピラジン、医薬組成物、ＮＫ−３受容体媒介性障害における使用方法
SG11201707521QA (en) 2015-03-16 2017-10-30 Ogeda Sa Nk-3 receptor antagonists for therapeutic or cosmetic treatment of excess body fat
JP2021014404A (ja) * 2017-10-13 2021-02-12 アステラス製薬株式会社 トリアゾロピラジン誘導体の塩及び結晶
WO2022031773A1 (en) 2020-08-04 2022-02-10 Teva Pharmaceuticals International Gmbh Solid state forms of fezolinetant and salts thereof

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3252483B2 (ja) 1992-10-20 2002-02-04 東レ株式会社 ３環性トリアゾロ誘導体の製造方法
SK13532001A3 (sk) 1999-04-01 2003-02-04 Pfizer Products Inc. Aminopiridíny ako inhibítory sorbitoldehydrogenázy
DE60316416T2 (de) 2002-03-25 2008-06-26 Merck & Co., Inc. Heterocyclische beta-aminoverbindungen als inhibitoren der dipeptidylpeptidase zur behandlung bzw. prävention von diabetes
ATE335744T1 (de) 2002-08-07 2006-09-15 Novartis Pharma Gmbh Organische verbindungen als mittel zur behandlung von aldosteronbedingten zuständen
MY139563A (en) 2002-09-04 2009-10-30 Bristol Myers Squibb Co Heterocyclic aromatic compounds useful as growth hormone secretagogues
AR043443A1 (es) 2003-03-07 2005-07-27 Merck & Co Inc Procedimiento de preparacion de tetrahidrotriazolopirazinas y productos intermedios
DE602005008558D1 (de) 2004-02-18 2008-09-11 Astrazeneca Ab Kondensierte heterocyclische verbindungen und deren verwendung als antagonisten des metabotropen reznkungen
TWI378091B (en) 2006-03-09 2012-12-01 Eisai R&D Man Co Ltd Multi-cyclic cinnamide derivatives
JP5635910B2 (ja) 2008-01-09 2014-12-03 アレイ バイオファーマ、インコーポレイテッド ＡＫＴタンパク質キナーゼ阻害剤としての５Ｈ−シクロペンタ［ｄ］ピリミジン
WO2009090055A1 (en) 2008-01-17 2009-07-23 Grünenthal GmbH Substituted sulfonamide derivatives
JP5654001B2 (ja) * 2009-04-29 2015-01-14 グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ Ｐ２Ｘ７調節因子としての５，６，７，８−テトラヒドロ［１，２，４］トリアゾロ［４，３−ａ］ピラジン誘導体
WO2011007756A1 (ja) 2009-07-13 2011-01-20 武田薬品工業株式会社 複素環化合物及びその用途
BR112012025101B1 (pt) 2010-04-02 2021-08-31 Ogeda S.A. Compostos antagonistas seletivos de receptor nk-3, composição farmacêutica e medicamento compreendendo os mesmos
US10065960B2 (en) 2010-04-02 2018-09-04 Ogeda Sa NK-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in NK-3 receptors mediated disorders
RS54833B1 (sr) 2011-10-03 2016-10-31 Euroscreen Sa Novi hiralni n-acil-5,6,7, (8-supstituisan)-tetrahidro-[1,2,4]triazolo [4,3-a]pirazini kao selektivni antagonisti nk-3 receptora, farmaceutsko jedinjenje, i postupci za upotrebu u nk-3 receptorom posredovanim poremećajima
CA2907813C (en) 2013-03-29 2021-09-07 Euroscreen Sa Novel n-acyl-(3-substituted)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective nk-3 receptor antagonists, pharmaceutical composition, methods for use in nk-3 receptor-mediated disorders
JP6316932B2 (ja) 2013-03-29 2018-04-25 オゲダ エス．エー． 選択的ＮＫ−３受容体拮抗薬としての新規なＮ−アシル−（３位置換）−（８位置換）−５，６−ジヒドロ−［１，２，４］トリアゾロ［４，３−ａ］ピラジン、医薬組成物、ＮＫ−３受容体媒介性障害における使用方法
EP2989103B1 (en) 2013-03-29 2019-02-20 Ogeda Sa N-acyl-(3-substituted)-(8-methyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective nk-3 receptor antagonists, pharmaceutical composition, methods for use in nk-3 receptor-mediated disorders

Also Published As

Publication number Publication date
US10787458B2 (en) 2020-09-29
PT3197876T (pt) 2019-02-21
MX2017003980A (es) 2017-05-08
US20190218225A1 (en) 2019-07-18
SG11201702368PA (en) 2017-04-27
CA2961984A1 (en) 2016-03-31
ES2711095T3 (es) 2019-04-30
BR112017005880A2 (pt) 2018-02-06
ZA201701949B (en) 2021-06-30
TR201902080T4 (tr) 2019-03-21
US20170298070A1 (en) 2017-10-19
CA2961984C (en) 2023-01-24
CN107001289A (zh) 2017-08-01
MX367633B (es) 2019-08-29
WO2016046398A1 (en) 2016-03-31
SG10201800162RA (en) 2018-02-27
EA032052B1 (ru) 2019-03-29
JP6469214B2 (ja) 2019-02-13
AU2015323702B2 (en) 2020-03-12
AU2015323702A1 (en) 2017-04-13
JP2017529370A (ja) 2017-10-05
EP3197876B1 (en) 2018-11-28
IL251304A0 (en) 2017-05-29
EP3197876A1 (en) 2017-08-02
IL251304B (en) 2019-07-31
NZ730295A (en) 2023-05-26
PL3197876T3 (pl) 2019-05-31
CN107001289B (zh) 2019-12-31
KR102558711B1 (ko) 2023-07-21
KR20170072898A (ko) 2017-06-27

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