EA201691478A1 - Новый полисахарид и его применения - Google Patents

Новый полисахарид и его применения

Info

Publication number
EA201691478A1
EA201691478A1 EA201691478A EA201691478A EA201691478A1 EA 201691478 A1 EA201691478 A1 EA 201691478A1 EA 201691478 A EA201691478 A EA 201691478A EA 201691478 A EA201691478 A EA 201691478A EA 201691478 A1 EA201691478 A1 EA 201691478A1
Authority
EA
Eurasian Patent Office
Prior art keywords
bioconjugates
compositions
coli
host cells
document
Prior art date
Application number
EA201691478A
Other languages
English (en)
Other versions
EA035991B9 (ru
EA035991B1 (ru
Inventor
Михель Т. Коварик
Михель Л. Веттер
Стэфан Дж. Кеммлер
Миха А. Хойптле
Вероника Гамбиллара
Мануэла Малли
Original Assignee
Гликоваксин Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Гликоваксин Аг filed Critical Гликоваксин Аг
Publication of EA201691478A1 publication Critical patent/EA201691478A1/ru
Publication of EA035991B1 publication Critical patent/EA035991B1/ru
Publication of EA035991B9 publication Critical patent/EA035991B9/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0258—Escherichia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0066—Isolation or extraction of proteoglycans from organs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55583—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6087—Polysaccharides; Lipopolysaccharides [LPS]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

В данном документе предложен новый О-полисахарид Е. coli. - O25В. В данном документе также предложены прокариотические клетки-хозяева, содержащие ферменты (например гликозилтрансферазы), используемые в получении O25В. Клетки-хозяева, предложенные здесь, продуцируют биоконъюгаты O25В, которые содержат O25В, связанный с белком-носителем. Кроме того, здесь предложены композиции, например фармацевтические композиции, содержащие O25В, и/или биоконъюгаты, содержащие O25В. Такие композиции могут быть использованы в качестве вакцин против инфекции ЕхРЕС (внекишечные патогенные Е. coli) и могут дополнительно содержать один или более дополнительных биоконъюгатов.
EA201691478A 2014-02-24 2015-02-23 Новый полисахарид и его применения EA035991B9 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461943710P 2014-02-24 2014-02-24
PCT/EP2015/053739 WO2015124769A1 (en) 2014-02-24 2015-02-23 Novel polysaccharide and uses thereof

Publications (3)

Publication Number Publication Date
EA201691478A1 true EA201691478A1 (ru) 2017-02-28
EA035991B1 EA035991B1 (ru) 2020-09-10
EA035991B9 EA035991B9 (ru) 2020-10-21

Family

ID=52589386

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201691478A EA035991B9 (ru) 2014-02-24 2015-02-23 Новый полисахарид и его применения

Country Status (21)

Country Link
US (5) US9700612B2 (ru)
EP (1) EP3110441B1 (ru)
JP (2) JP6276427B2 (ru)
KR (1) KR101855142B1 (ru)
CN (1) CN106535927B (ru)
AR (1) AR100859A1 (ru)
AU (1) AU2015220723C1 (ru)
CA (1) CA2940547C (ru)
CL (1) CL2016002123A1 (ru)
DK (1) DK3110441T3 (ru)
EA (1) EA035991B9 (ru)
FI (1) FI3110441T3 (ru)
IL (1) IL247344B (ru)
LT (1) LT3110441T (ru)
MX (1) MX2016011055A (ru)
NZ (1) NZ723328A (ru)
PH (1) PH12016501671A1 (ru)
PT (1) PT3110441T (ru)
SG (1) SG11201606889PA (ru)
TW (1) TWI639439B (ru)
WO (1) WO2015124769A1 (ru)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014111516A1 (en) 2013-01-17 2014-07-24 Arsanis Biosciences Gmbh Mdr e. coli specific antibody
FI3110441T3 (fi) 2014-02-24 2024-05-06 Glaxosmithkline Biologicals Sa Uusi polysakkaridi ja sen käyttöjä
US10722580B2 (en) * 2015-05-13 2020-07-28 University Of Washington Compositions and methods for treatment and prevention of uropathogenic E. coli infection
TWI715617B (zh) 2015-08-24 2021-01-11 比利時商葛蘭素史密斯克藍生物品公司 對抗腸道外病原性大腸桿菌之免疫保護之方法及組合物
AR109621A1 (es) 2016-10-24 2018-12-26 Janssen Pharmaceuticals Inc Formulaciones de vacunas contra glucoconjugados de expec
GB201711637D0 (en) * 2017-07-19 2017-08-30 Glaxosmithkline Biologicals Sa Immunogenic composition
WO2019175147A1 (en) 2018-03-12 2019-09-19 Janssen Vaccines & Prevention B.V. Vaccines against intra-abdominal infections
CN108531439B (zh) * 2018-04-16 2020-04-07 南京工业大学 一种大肠杆菌基因工程菌及其构建方法与应用
US11260119B2 (en) 2018-08-24 2022-03-01 Pfizer Inc. Escherichia coli compositions and methods thereof
JP2022525773A (ja) 2019-03-18 2022-05-19 ヤンセン ファーマシューティカルズ，インコーポレーテッド 大腸菌ｏ抗原多糖のバイオコンジュゲートを製造する方法、その組成物およびその使用方法
MX2021011445A (es) 2019-03-18 2021-10-13 Janssen Pharmaceuticals Inc Bioconjugados de polisacaridos de antigenos o de e. coli, metodos de produccion y metodos de uso de los mismos.
CN110018253A (zh) * 2019-04-15 2019-07-16 艾美卫信生物药业（浙江）有限公司 一种生物制品中游离蛋白含量的高效液相测定方法
CN111855826B (zh) * 2019-04-24 2022-09-16 岛津企业管理（中国）有限公司 破伤风类毒素或白喉类毒素的监测方法
GB201908528D0 (en) * 2019-06-13 2019-07-31 Univ Dundee Rhamnose-polysaccharides
CA3168108A1 (en) 2020-01-16 2021-07-22 Janssen Pharmaceuticals, Inc. Fimh mutant, compositions therewith and use thereof
WO2021255684A1 (en) 2020-06-18 2021-12-23 Glaxosmithkline Biologicals Sa Shigella-tetravalent (shigella4v) bioconjugate
CA3185642A1 (en) 2020-06-25 2021-12-30 Glaxosmithkline Biologicals Sa Modified exotoxin a proteins
CN115803087A (zh) 2020-09-17 2023-03-14 杨森制药公司 多价疫苗组合物及其用途
IL301880A (en) 2020-11-30 2023-06-01 Janssen Pharmaceuticals Inc Analytical method for glycoconjugation using a capillary-based immunoassay system
MX2023008251A (es) 2021-01-12 2023-07-26 Janssen Pharmaceuticals Inc Mutantes de fimh, composiciones con estos y uso de estos.
US20240131135A1 (en) 2021-02-16 2024-04-25 Duke University Vaccine compositions and methods for the treatment and prevention of urinary tract infections
MX2023011697A (es) 2021-04-01 2023-10-19 Janssen Pharmaceuticals Inc Produccion de bioconjugados o18 de e. coli.
CN117098550A (zh) 2021-04-08 2023-11-21 杨森制药公司 生物缀合物生产方法
WO2023118033A1 (en) 2021-12-22 2023-06-29 Glaxosmithkline Biologicals Sa Vaccine
US12014256B2 (en) * 2022-01-12 2024-06-18 Dell Products L.P Polysaccharide archival storage
CN114150005B (zh) * 2022-02-09 2022-04-22 广州恩宝生物医药科技有限公司 用于预防SARS-CoV-2奥密克戎株的腺病毒载体疫苗

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3700612A (en) 1971-06-23 1972-10-24 Tenneco Chem Aqueous surface-coating compositions containing hydroxyalkyl ethers of galactomannan gums as thickeners
US5057540A (en) 1987-05-29 1991-10-15 Cambridge Biotech Corporation Saponin adjuvant
US4912094B1 (en) 1988-06-29 1994-02-15 Ribi Immunochem Research Inc. Modified lipopolysaccharides and process of preparation
US5370872A (en) 1991-08-12 1994-12-06 Swiss Serum And Vaccine Institute Berne Escherichia coliO-polysaccharide-protein conjugate vaccine
EP1481057B1 (en) 2002-03-07 2006-02-15 Eidgenössische Technische Hochschule Zürich System and method for the production of recombinant glycosylated proteins in a prokaryotic host
EP1888761B1 (en) 2005-05-11 2010-09-29 ETH Zurich Recombinant n-glycosylated proteins from procaryotic cells
WO2007109813A1 (en) 2006-03-23 2007-09-27 Novartis Ag Imidazoquinoxaline compounds as immunomodulators
CA2646891A1 (en) 2006-03-23 2007-09-27 Novartis Ag Immunopotentiating compounds
US20100286067A1 (en) 2008-01-08 2010-11-11 Biogenerix Ag Glycoconjugation of polypeptides using oligosaccharyltransferases
EP3427749A1 (en) 2008-02-20 2019-01-16 GlaxoSmithKline Biologicals SA Bioconjugates made from recombinant n-glycosylated proteins from procaryotic cells
TR201803015T4 (tr) 2009-11-19 2018-03-21 Glaxosmithkline Biologicals Sa Prokaryotik hücrelerde immünojenik polisakaridler üreten biyosentetik sistem.
RU2013131795A (ru) 2010-12-10 2015-01-20 Мерк Шарп Энд Домэ Корп. Новые композиции, которые уменьшают вызываемую встряхиванием агрегацию иммуногенных композиций
JP2014526449A (ja) * 2011-09-06 2014-10-06 グリコヴァキシン アーゲー 原核細胞において製造されるバイオコンジュゲートワクチン
US9932598B2 (en) 2012-08-02 2018-04-03 The Regents Of The University Of California Metabolic engineering of microbial organisms
US20150238596A1 (en) 2012-09-10 2015-08-27 Glycovaxyn Ag Bioconjugates comprising modified antigens and uses thereof
TR201904022T4 (tr) 2012-10-12 2019-04-22 Glaxosmithkline Biologicals Sa Konakçı hücre modifikasyon yöntemleri.
JP2016501550A (ja) 2012-12-27 2016-01-21 グリコヴァキシン アーゲー Ｃｒｍ１９７に関する方法及び組成物
WO2014111516A1 (en) * 2013-01-17 2014-07-24 Arsanis Biosciences Gmbh Mdr e. coli specific antibody
SG11201602546RA (en) 2013-10-11 2016-04-28 Glycovaxyn Ag Methods of host cell modification
JP6590413B2 (ja) 2014-02-06 2019-10-16 エックスフォー・ファーマシューティカルズ（オーストリア）ゲーエムべーハー 大腸菌特異的抗体配列
FI3110441T3 (fi) 2014-02-24 2024-05-06 Glaxosmithkline Biologicals Sa Uusi polysakkaridi ja sen käyttöjä
PT3240895T (pt) 2014-12-30 2022-03-02 Glaxosmithkline Biologicals Sa Composições e métodos para glicosilação de proteínas
TWI715617B (zh) 2015-08-24 2021-01-11 比利時商葛蘭素史密斯克藍生物品公司 對抗腸道外病原性大腸桿菌之免疫保護之方法及組合物
AR109621A1 (es) 2016-10-24 2018-12-26 Janssen Pharmaceuticals Inc Formulaciones de vacunas contra glucoconjugados de expec
GB201711635D0 (en) 2017-07-19 2017-08-30 Glaxosmithkline Biologicals Sa Immunogenic composition
JP2022525773A (ja) 2019-03-18 2022-05-19 ヤンセン ファーマシューティカルズ，インコーポレーテッド 大腸菌ｏ抗原多糖のバイオコンジュゲートを製造する方法、その組成物およびその使用方法
MX2021011445A (es) 2019-03-18 2021-10-13 Janssen Pharmaceuticals Inc Bioconjugados de polisacaridos de antigenos o de e. coli, metodos de produccion y metodos de uso de los mismos.

Also Published As

Publication number Publication date
WO2015124769A1 (en) 2015-08-27
JP2017507178A (ja) 2017-03-16
FI3110441T3 (fi) 2024-05-06
US9700612B2 (en) 2017-07-11
PH12016501671B1 (en) 2016-10-03
MX2016011055A (es) 2017-10-24
BR112016019341A2 (pt) 2018-01-16
NZ723328A (en) 2018-01-26
KR20160125494A (ko) 2016-10-31
US11738076B2 (en) 2023-08-29
CN106535927B (zh) 2019-09-20
PH12016501671A1 (en) 2016-10-03
AU2015220723A1 (en) 2016-09-22
CA2940547A1 (en) 2015-08-27
US20200129605A1 (en) 2020-04-30
AR100859A1 (es) 2016-11-09
TWI639439B (zh) 2018-11-01
EP3110441B1 (en) 2024-04-03
US20210154286A1 (en) 2021-05-27
SG11201606889PA (en) 2016-09-29
LT3110441T (lt) 2024-04-25
EA035991B9 (ru) 2020-10-21
US10441647B2 (en) 2019-10-15
IL247344A0 (en) 2016-11-30
EA035991B1 (ru) 2020-09-10
KR101855142B1 (ko) 2018-05-08
JP2018087197A (ja) 2018-06-07
AU2015220723C1 (en) 2018-04-05
JP6771499B2 (ja) 2020-10-21
CA2940547C (en) 2021-01-05
US10940192B2 (en) 2021-03-09
CL2016002123A1 (es) 2018-02-16
CN106535927A (zh) 2017-03-22
US20230364214A1 (en) 2023-11-16
IL247344B (en) 2020-06-30
JP6276427B2 (ja) 2018-02-07
PT3110441T (pt) 2024-05-03
US20150238588A1 (en) 2015-08-27
AU2015220723B2 (en) 2017-12-14
EP3110441A1 (en) 2017-01-04
DK3110441T3 (da) 2024-05-06
TW201615211A (zh) 2016-05-01
US20170340718A1 (en) 2017-11-30

Similar Documents

Publication Publication Date Title
EA201691478A1 (ru) Новый полисахарид и его применения
BR112018070187A2 (pt) receptores quiméricos para flt3 e seus métodos de uso
MX2017004838A (es) Composiciones de interleucina-15 y usos de estas.
AU2015296298A8 (en) Flagellin-based agents and uses including effective vaccination
MX2016014807A (es) Singenes de alfa(1,2)fucosiltransferasa para su utilizacion en la produccion de oligosacaridos fucosilados.
AR105464A1 (es) Composiciones probióticas secas estables para usos dietarios especiales
BR112019007803A2 (pt) formulações de vacina de glicoconjugado contra expec
CY1123403T1 (el) Τροποποιημενα κυτταρα ξενιστες και χρησεις αυτων
EA201690859A1 (ru) Предотвращение инфекций, вызываемых staphylococcus aureus, гликопротеиновыми вакцинами, синтезированными в escherichia coli
TN2015000411A1 (en) Ceftolozane antibiotic compositions
EA201790787A1 (ru) Снижение вязкости фармацевтических составов
BR112015025748A2 (pt) construção de dna para imunomodulação, composição farmacêutica, vacina, e uso de uma construção de dna
CA3010667A1 (en) Use of 4-bora-3a,4a-diaza-s-indacenes for security purposes
BR112015011697A2 (pt) antibióticos macrocíclicos de amplo espectro
EA201891577A1 (ru) Системы и способы для приготовления тромбоцитов
BR112017000246A2 (pt) composto, sal farmaceuticamente aceitável de um composto, composição farmacêutica, e, uso de um composto ou de um sal
PH12017500450A1 (en) Flavivirus virus like particle
EP4241851A3 (en) Immunogenic compositions
PH12018502120A1 (en) Live attenuated alphavirus constructs and methods and uses thereof
MX2023011670A (es) Formulacion estable de anticuerpo contra el receptor de oncostatina m (osmr).
EP4226936A3 (en) Non-neuroinvasive viruses and uses thereof
EA201991319A1 (ru) Вакцины аттенуированного свиного гриппа и способы их изготовления и применения
PL404229A1 (pl) Wyizolowany immunogenny antygen bakteryjny i jego zastosowanie w profilaktyce i leczeniu zakażeń wywołanych przez Gram-ujemne bakterie
EA202091403A1 (ru) Производные 2-оксо-1-пирролидинилимидазотиадиазола
AR106716A1 (es) Anticuerpos anti-factor d y conjugados

Legal Events

Date Code Title Description
TH4A Publication of the corrected specification to eurasian patent