EA201690227A1 - Азаиндольные соединения, их получение и способы их применения - Google Patents

Азаиндольные соединения, их получение и способы их применения

Info

Publication number
EA201690227A1
EA201690227A1 EA201690227A EA201690227A EA201690227A1 EA 201690227 A1 EA201690227 A1 EA 201690227A1 EA 201690227 A EA201690227 A EA 201690227A EA 201690227 A EA201690227 A EA 201690227A EA 201690227 A1 EA201690227 A1 EA 201690227A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
methods
azaindol
production
application
Prior art date
Application number
EA201690227A
Other languages
English (en)
Other versions
EA028611B1 (ru
Inventor
Правин С. Шируде
Марути Н. Наик
Викас Нараян Шинде
Шахул Хамид Пир Мохамед
Моналиса Чаттерджи
Радха К. Шандил
Original Assignee
Глоубал Элаенс Фор Тб Драг Дивелопмент
Фаундейшн Фор Ниглектид Дизиз Рисерч
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Глоубал Элаенс Фор Тб Драг Дивелопмент, Фаундейшн Фор Ниглектид Дизиз Рисерч filed Critical Глоубал Элаенс Фор Тб Драг Дивелопмент
Publication of EA201690227A1 publication Critical patent/EA201690227A1/ru
Publication of EA028611B1 publication Critical patent/EA028611B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Изобретение относится к соединениям формулы (I) и способам лечения микобактериальной инфекции или туберкулеза или ингибирования ими DprE1.
EA201690227A 2013-07-17 2014-07-10 Азаиндольные соединения, их получение и способы их применения EA028611B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN3196CH2013 2013-07-17
PCT/US2014/046100 WO2015009525A1 (en) 2013-07-17 2014-07-10 Azaindole compounds, synthesis thereof, and methods of using the same

Publications (2)

Publication Number Publication Date
EA201690227A1 true EA201690227A1 (ru) 2016-07-29
EA028611B1 EA028611B1 (ru) 2017-12-29

Family

ID=51261257

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201690227A EA028611B1 (ru) 2013-07-17 2014-07-10 Азаиндольные соединения, их получение и способы их применения

Country Status (10)

Country Link
US (1) US9163020B2 (ru)
EP (1) EP3021947B1 (ru)
JP (1) JP6366709B2 (ru)
KR (1) KR102301753B1 (ru)
CN (1) CN105636646B (ru)
AU (1) AU2014290598B2 (ru)
CA (1) CA2918487C (ru)
EA (1) EA028611B1 (ru)
ES (1) ES2644025T3 (ru)
WO (1) WO2015009525A1 (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201512197A (zh) * 2013-08-30 2015-04-01 Hoffmann La Roche 吡咯并吡啶或吡唑并吡啶衍生物
GB201317363D0 (en) * 2013-10-01 2013-11-13 Eisai Ltd Novel compounds
EP3720432A4 (en) 2017-12-06 2021-08-25 Prollergy Corporation COMPOSITION AND METHOD FOR MITIGATING AN ALLERGIC REACTION
RU2702224C2 (ru) * 2018-03-29 2019-10-07 Общество С Ограниченной Ответственностью "Мт-Медикалс" Производные фенил формамидина, обладающие антимикобактериальной активностью
KR20210021042A (ko) * 2018-06-15 2021-02-24 카딜라 핼쓰캐어 리미티드 포유동물 감염 치료를 위한 신규한 화합물
WO2020188405A1 (en) * 2019-03-20 2020-09-24 Foundation For Neglected Disease Research Benzimidazoles derivatives as anti-tuberculosis agents
CN111393435A (zh) * 2020-03-16 2020-07-10 青岛吉澳医药科技有限公司 氮杂吲哚酰胺类化合物及其制备方法和用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1532980A1 (en) * 2003-11-24 2005-05-25 Novo Nordisk A/S N-heteroaryl indole carboxamides and analogues thereof, for use as glucokinase activators in the treatment of diabetes
EA020332B1 (ru) * 2007-08-10 2014-10-30 Х. Лундбекк А/С Аналоги гетероариламидов
SG10201502109VA (en) * 2010-03-18 2015-05-28 Pasteur Institut Korea Anti-infective compounds

Also Published As

Publication number Publication date
KR102301753B1 (ko) 2021-09-15
US9163020B2 (en) 2015-10-20
KR20160058757A (ko) 2016-05-25
CA2918487C (en) 2021-08-03
CA2918487A1 (en) 2015-01-22
CN105636646B (zh) 2017-12-19
AU2014290598B2 (en) 2018-11-08
JP2016530242A (ja) 2016-09-29
WO2015009525A1 (en) 2015-01-22
JP6366709B2 (ja) 2018-08-01
ES2644025T3 (es) 2017-11-27
AU2014290598A1 (en) 2016-02-11
EP3021947B1 (en) 2017-08-23
BR112016000712A2 (pt) 2022-03-22
EA028611B1 (ru) 2017-12-29
EP3021947A1 (en) 2016-05-25
CN105636646A (zh) 2016-06-01
US20150025087A1 (en) 2015-01-22

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