EA201592255A1 - Производные пиразолопирролидин-4-она в качестве ингибиторов вет и их применение при лечении заболевания - Google Patents

Производные пиразолопирролидин-4-она в качестве ингибиторов вет и их применение при лечении заболевания

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Publication number
EA201592255A1
EA201592255A1 EA201592255A EA201592255A EA201592255A1 EA 201592255 A1 EA201592255 A1 EA 201592255A1 EA 201592255 A EA201592255 A EA 201592255A EA 201592255 A EA201592255 A EA 201592255A EA 201592255 A1 EA201592255 A1 EA 201592255A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyrazolopirrolidin
disease
derivatives
treatment
application
Prior art date
Application number
EA201592255A
Other languages
English (en)
Other versions
EA028175B1 (ru
Inventor
Ютта Бланк
Гвидо Больд
Симона Котеста
Вито Гуаньяно
Хайнрих Рюэгер
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA201592255A1 publication Critical patent/EA201592255A1/ru
Publication of EA028175B1 publication Critical patent/EA028175B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

Настоящее изобретение относится к соединению формулы (I) или его фармацевтически приемлемой соли; к способу получения соединений согласно данному изобретению и их терапевтическим применениям. Настоящее изобретение, далее, относится к комбинации фармакологически активных агентов и фармацевтической композиции.
EA201592255A 2013-05-28 2014-05-27 Производные пиразолопирролидин-4-она в качестве ингибиторов вет и их применение при лечении заболевания EA028175B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13169441 2013-05-28
PCT/IB2014/061736 WO2014191906A1 (en) 2013-05-28 2014-05-27 Pyrazolo-pyrrolidin-4-one derivatives as bet inhibitors and their use in the treatment of disease

Publications (2)

Publication Number Publication Date
EA201592255A1 true EA201592255A1 (ru) 2016-04-29
EA028175B1 EA028175B1 (ru) 2017-10-31

Family

ID=48470849

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201592255A EA028175B1 (ru) 2013-05-28 2014-05-27 Производные пиразолопирролидин-4-она в качестве ингибиторов вет и их применение при лечении заболевания

Country Status (14)

Country Link
US (1) US9624247B2 (ru)
EP (1) EP3004108B1 (ru)
JP (1) JP2016520118A (ru)
KR (1) KR20160012195A (ru)
CN (1) CN105263934B (ru)
AU (1) AU2014272695B2 (ru)
BR (1) BR112015029401A8 (ru)
CA (1) CA2912986A1 (ru)
EA (1) EA028175B1 (ru)
ES (1) ES2656471T3 (ru)
MX (1) MX2015016421A (ru)
PL (1) PL3004108T3 (ru)
PT (1) PT3004108T (ru)
WO (1) WO2014191906A1 (ru)

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US9315501B2 (en) 2013-11-26 2016-04-19 Incyte Corporation Bicyclic heterocycles as BET protein inhibitors
WO2015081203A1 (en) 2013-11-26 2015-06-04 Incyte Corporation Bicyclic heterocycles as bet protein inhibitors
US9309246B2 (en) 2013-12-19 2016-04-12 Incyte Corporation Tricyclic heterocycles as BET protein inhibitors
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CN114466849A (zh) * 2019-07-12 2022-05-10 欣尼克免疫有限公司 作为isoqc和/或qc酶的抑制剂的n-取代的-3,4-(稠合5-环)-5-苯基-吡咯烷-2-酮化合物
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Also Published As

Publication number Publication date
US20160102107A1 (en) 2016-04-14
CA2912986A1 (en) 2014-12-04
AU2014272695B2 (en) 2016-10-20
BR112015029401A8 (pt) 2020-03-17
PT3004108T (pt) 2018-01-24
EP3004108B1 (en) 2017-10-18
EA028175B1 (ru) 2017-10-31
MX2015016421A (es) 2016-03-03
AU2014272695A1 (en) 2015-11-26
BR112015029401A2 (pt) 2017-07-25
CN105263934A (zh) 2016-01-20
EP3004108A1 (en) 2016-04-13
US9624247B2 (en) 2017-04-18
JP2016520118A (ja) 2016-07-11
CN105263934B (zh) 2017-09-08
KR20160012195A (ko) 2016-02-02
ES2656471T3 (es) 2018-02-27
PL3004108T3 (pl) 2018-03-30
WO2014191906A1 (en) 2014-12-04

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