BR112015029401A2 - derivados pirazolo-pirrolidin-4-ona e seu uso no tratamento de doenças - Google Patents

derivados pirazolo-pirrolidin-4-ona e seu uso no tratamento de doenças

Info

Publication number
BR112015029401A2
BR112015029401A2 BR112015029401A BR112015029401A BR112015029401A2 BR 112015029401 A2 BR112015029401 A2 BR 112015029401A2 BR 112015029401 A BR112015029401 A BR 112015029401A BR 112015029401 A BR112015029401 A BR 112015029401A BR 112015029401 A2 BR112015029401 A2 BR 112015029401A2
Authority
BR
Brazil
Prior art keywords
pyrazolo
pyrrolidin
diseases
derivatives
treatment
Prior art date
Application number
BR112015029401A
Other languages
English (en)
Other versions
BR112015029401A8 (pt
Inventor
Bold Guido
Rueeger Heinrich
Blank Jutta
Cotesta Simona
Guagnano Vito
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BR112015029401A2 publication Critical patent/BR112015029401A2/pt
Publication of BR112015029401A8 publication Critical patent/BR112015029401A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

resumo patente de invenção: "derivados pirazolo-pirrolidin-4-ona e seu uso no tratamento de doenças". a presente invenção fornece um composto de fórmula (i) ou um sal farmaceuticamente aceitável do mesmo: (i) um método para fabricação dos compostos da invenção e seus usos terapêuticos. a presente invenção fornece ainda uma combinação de agentes farmacologicamente ativos e uma composição farmacêutica.
BR112015029401A 2013-05-28 2014-05-27 derivados de pirazolo-pirrolidin-4-ona, seus usos, e composição e combinação farmacêuticas BR112015029401A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13169441 2013-05-28
PCT/IB2014/061736 WO2014191906A1 (en) 2013-05-28 2014-05-27 Pyrazolo-pyrrolidin-4-one derivatives as bet inhibitors and their use in the treatment of disease

Publications (2)

Publication Number Publication Date
BR112015029401A2 true BR112015029401A2 (pt) 2017-07-25
BR112015029401A8 BR112015029401A8 (pt) 2020-03-17

Family

ID=48470849

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015029401A BR112015029401A8 (pt) 2013-05-28 2014-05-27 derivados de pirazolo-pirrolidin-4-ona, seus usos, e composição e combinação farmacêuticas

Country Status (14)

Country Link
US (1) US9624247B2 (pt)
EP (1) EP3004108B1 (pt)
JP (1) JP2016520118A (pt)
KR (1) KR20160012195A (pt)
CN (1) CN105263934B (pt)
AU (1) AU2014272695B2 (pt)
BR (1) BR112015029401A8 (pt)
CA (1) CA2912986A1 (pt)
EA (1) EA028175B1 (pt)
ES (1) ES2656471T3 (pt)
MX (1) MX2015016421A (pt)
PL (1) PL3004108T3 (pt)
PT (1) PT3004108T (pt)
WO (1) WO2014191906A1 (pt)

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US9290514B2 (en) 2013-07-08 2016-03-22 Incyte Holdings Corporation Tricyclic heterocycles as BET protein inhibitors
US9315501B2 (en) 2013-11-26 2016-04-19 Incyte Corporation Bicyclic heterocycles as BET protein inhibitors
WO2015081203A1 (en) 2013-11-26 2015-06-04 Incyte Corporation Bicyclic heterocycles as bet protein inhibitors
US9309246B2 (en) 2013-12-19 2016-04-12 Incyte Corporation Tricyclic heterocycles as BET protein inhibitors
CR20160542A (es) 2014-04-23 2017-04-25 Incyte Corp 1 H-PIRROLO[2,3-c]PIRIDIN-7(6H)-ONAS YPIRAZOLO[3,4-c]PlRIDIN-7(6H)-ONAS COMO INHIBIDORES DE PROTEINAS BET
JP6599979B2 (ja) 2014-09-15 2019-10-30 インサイト・コーポレイション Ｂｅｔタンパク質阻害剤として用いるための三環式複素環化合物
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Also Published As

Publication number Publication date
ES2656471T3 (es) 2018-02-27
MX2015016421A (es) 2016-03-03
AU2014272695B2 (en) 2016-10-20
US20160102107A1 (en) 2016-04-14
CN105263934A (zh) 2016-01-20
PL3004108T3 (pl) 2018-03-30
EP3004108A1 (en) 2016-04-13
AU2014272695A1 (en) 2015-11-26
EA201592255A1 (ru) 2016-04-29
PT3004108T (pt) 2018-01-24
KR20160012195A (ko) 2016-02-02
CA2912986A1 (en) 2014-12-04
EA028175B1 (ru) 2017-10-31
US9624247B2 (en) 2017-04-18
BR112015029401A8 (pt) 2020-03-17
CN105263934B (zh) 2017-09-08
WO2014191906A1 (en) 2014-12-04
EP3004108B1 (en) 2017-10-18
JP2016520118A (ja) 2016-07-11

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements
B350 Update of information on the portal [chapter 15.35 patent gazette]