EA201592227A1 - Стабильные растворы объединенных активных фармацевтических ингредиентов для перорального применения - Google Patents

Стабильные растворы объединенных активных фармацевтических ингредиентов для перорального применения

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Publication number
EA201592227A1
EA201592227A1 EA201592227A EA201592227A EA201592227A1 EA 201592227 A1 EA201592227 A1 EA 201592227A1 EA 201592227 A EA201592227 A EA 201592227A EA 201592227 A EA201592227 A EA 201592227A EA 201592227 A1 EA201592227 A1 EA 201592227A1
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EA
Eurasian Patent Office
Prior art keywords
active pharmaceutical
pharmaceutical ingredients
oral application
stable solutions
united
Prior art date
Application number
EA201592227A
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English (en)
Other versions
EA029478B1 (ru
Inventor
Даниель Коэн
Илья Чумаков
Сергей Набирочкин
Вивьен Бертран
Original Assignee
Фарнекст
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Publication date
Application filed by Фарнекст filed Critical Фарнекст
Publication of EA201592227A1 publication Critical patent/EA201592227A1/ru
Publication of EA029478B1 publication Critical patent/EA029478B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

Данное изобретение относится к гомогенному стабильному фармацевтическому раствору, обладающему хорошими вкусовыми качествами, который содержит баклофен, сорбит и налтрексон.
EA201592227A 2013-06-05 2014-06-05 Стабильные растворы объединенных активных фармацевтических ингредиентов для перорального применения EA029478B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13170583 2013-06-05
PCT/EP2014/061664 WO2014195394A1 (en) 2013-06-05 2014-06-05 Stable oral solutions for combined api

Publications (2)

Publication Number Publication Date
EA201592227A1 true EA201592227A1 (ru) 2016-04-29
EA029478B1 EA029478B1 (ru) 2018-03-30

Family

ID=48569977

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201592227A EA029478B1 (ru) 2013-06-05 2014-06-05 Стабильные растворы объединенных активных фармацевтических ингредиентов для перорального применения

Country Status (28)

Country Link
US (2) US10300015B2 (ru)
EP (1) EP3003268B1 (ru)
JP (1) JP6300906B2 (ru)
KR (1) KR102203491B1 (ru)
CN (2) CN105473131A (ru)
AU (1) AU2014276856B2 (ru)
BR (1) BR112015030268B1 (ru)
CA (1) CA2913331C (ru)
CY (1) CY1120758T1 (ru)
DK (1) DK3003268T3 (ru)
EA (1) EA029478B1 (ru)
ES (1) ES2691309T3 (ru)
HK (1) HK1223278A1 (ru)
HR (1) HRP20181607T1 (ru)
HU (1) HUE040023T2 (ru)
IL (1) IL242735B (ru)
LT (1) LT3003268T (ru)
MX (1) MX367210B (ru)
NZ (1) NZ714684A (ru)
PL (1) PL3003268T3 (ru)
PT (1) PT3003268T (ru)
RS (1) RS57906B1 (ru)
SG (1) SG11201509824UA (ru)
SI (1) SI3003268T1 (ru)
TR (1) TR201815059T4 (ru)
UA (1) UA115811C2 (ru)
WO (1) WO2014195394A1 (ru)
ZA (1) ZA201508675B (ru)

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EP2065038A1 (en) 2007-11-30 2009-06-03 Pharnext New therapeutic approaches for treating Charcot-Marie-Tooth disease
EP2263665A1 (en) 2009-06-02 2010-12-22 Pharnext New compositions for treating CMT and related disorders
US9393241B2 (en) 2009-06-02 2016-07-19 Pharnext Compositions for treating CMT and related disorders
CN105473131A (zh) 2013-06-05 2016-04-06 法奈克斯公司 用于组合的活性药物成分的稳定口服溶液
CA2938361A1 (en) 2014-02-11 2015-08-20 Pharnext Combination of baclofen, acamprosate and medium chain triglycerides for the treatment of neurological disorders
US10383870B2 (en) 2016-06-10 2019-08-20 Pharnext Early treatment of CMT disease
EP3509592A4 (en) 2016-09-09 2020-07-22 Cutispharma, Inc. SUSPENSIONS AND DILUENTS FOR METRONIDAZOLE AND BACLOFEN
CN106389313A (zh) * 2016-10-08 2017-02-15 安徽省逸欣铭医药科技有限公司 一种巴氯芬口服液组合物
US11013702B2 (en) 2017-10-10 2021-05-25 Vertice Pharma, Llc Midodrine hydrochloride oral solution and uses thereof
US10952981B2 (en) * 2019-05-27 2021-03-23 Slayback Pharma Llc Liquid pharmaceutical compositions of baclofen for oral administration
US10792262B1 (en) * 2019-07-29 2020-10-06 Saol International Limited Stabilized formulations of 4-amino-3-substituted butanoic acid derivatives
US10610502B1 (en) 2019-08-30 2020-04-07 Metacel Pharmaceuticals, LLC Oral baclofen solutions

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EP2135607A1 (en) 2008-06-18 2009-12-23 Pharnext Combination of pilocarpin and methimazol for treating Charcot-MarieTooth disease and related disorders
EP2263665A1 (en) * 2009-06-02 2010-12-22 Pharnext New compositions for treating CMT and related disorders
US9393241B2 (en) 2009-06-02 2016-07-19 Pharnext Compositions for treating CMT and related disorders
EP2322163A1 (en) 2009-11-03 2011-05-18 Pharnext New therapeutics approaches for treating alzheimer disease
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CN105473131A (zh) 2013-06-05 2016-04-06 法奈克斯公司 用于组合的活性药物成分的稳定口服溶液
US10383870B2 (en) 2016-06-10 2019-08-20 Pharnext Early treatment of CMT disease

Also Published As

Publication number Publication date
EA029478B1 (ru) 2018-03-30
WO2014195394A1 (en) 2014-12-11
KR102203491B1 (ko) 2021-01-14
HUE040023T2 (hu) 2019-02-28
CA2913331C (en) 2021-08-24
HK1223278A1 (zh) 2017-07-28
KR20160048040A (ko) 2016-05-03
LT3003268T (lt) 2018-12-10
HRP20181607T1 (hr) 2018-12-28
BR112015030268B1 (pt) 2023-01-31
UA115811C2 (uk) 2017-12-26
US20190290578A1 (en) 2019-09-26
BR112015030268A2 (pt) 2017-07-25
EP3003268B1 (en) 2018-07-25
CA2913331A1 (en) 2014-12-11
CN105473131A (zh) 2016-04-06
SG11201509824UA (en) 2015-12-30
DK3003268T3 (en) 2018-11-05
AU2014276856B2 (en) 2018-11-15
MX2015016676A (es) 2016-06-23
MX367210B (es) 2019-08-08
NZ714684A (en) 2020-05-29
ZA201508675B (en) 2017-07-26
CY1120758T1 (el) 2019-12-11
TR201815059T4 (tr) 2018-11-21
JP2016521698A (ja) 2016-07-25
PL3003268T3 (pl) 2019-01-31
RS57906B1 (sr) 2019-01-31
EP3003268A1 (en) 2016-04-13
CN113209101A (zh) 2021-08-06
AU2014276856A1 (en) 2015-12-17
US20160113867A1 (en) 2016-04-28
US10849851B2 (en) 2020-12-01
SI3003268T1 (sl) 2019-01-31
US10300015B2 (en) 2019-05-28
ES2691309T3 (es) 2018-11-26
IL242735B (en) 2019-10-31
PT3003268T (pt) 2018-11-08
JP6300906B2 (ja) 2018-03-28

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