EA201491541A1 - АНТИТЕЛА ПРОТИВ ИНТЕГРИНОВ αvβ6 И ИХ ПРИМЕНЕНИЕ ДЛЯ ЛЕЧЕНИЯ ЗЛОКАЧЕСТВЕННЫХ НОВООБРАЗОВАНИЙ - Google Patents
АНТИТЕЛА ПРОТИВ ИНТЕГРИНОВ αvβ6 И ИХ ПРИМЕНЕНИЕ ДЛЯ ЛЕЧЕНИЯ ЗЛОКАЧЕСТВЕННЫХ НОВООБРАЗОВАНИЙInfo
- Publication number
- EA201491541A1 EA201491541A1 EA201491541A EA201491541A EA201491541A1 EA 201491541 A1 EA201491541 A1 EA 201491541A1 EA 201491541 A EA201491541 A EA 201491541A EA 201491541 A EA201491541 A EA 201491541A EA 201491541 A1 EA201491541 A1 EA 201491541A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- treatment
- malignant
- noroves
- integrines
- application
- Prior art date
Links
- 230000003211 malignant effect Effects 0.000 title abstract 2
- 238000003745 diagnosis Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 102000006495 integrins Human genes 0.000 abstract 1
- 108010044426 integrins Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
Abstract
Изобретение относится к антителам, которые специфично связываются с интегрином αvβ6. Антитела могут быть полезными для лечения и диагностики различных видов злокачественных заболеваний, а также для детекции αvβ6.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261600499P | 2012-02-17 | 2012-02-17 | |
US201261602511P | 2012-02-23 | 2012-02-23 | |
PCT/US2013/026087 WO2013123152A2 (en) | 2012-02-17 | 2013-02-14 | ANTIBODIES TO INTEGRIN αVβ6 AND USE OF SAME TO TREAT CANCER |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201491541A1 true EA201491541A1 (ru) | 2016-05-31 |
EA031069B1 EA031069B1 (ru) | 2018-11-30 |
Family
ID=48984888
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201491541A EA031069B1 (ru) | 2012-02-17 | 2013-02-14 | АНТИТЕЛА ПРОТИВ ИНТЕГРИНОВ αVβ6 И ИХ ПРИМЕНЕНИЕ ДЛЯ ЛЕЧЕНИЯ ЗЛОКАЧЕСТВЕННЫХ НОВООБРАЗОВАНИЙ |
Country Status (14)
Country | Link |
---|---|
US (5) | US9493566B2 (ru) |
EP (1) | EP2814509B1 (ru) |
JP (1) | JP6273214B2 (ru) |
KR (1) | KR102084806B1 (ru) |
CN (2) | CN105017420B (ru) |
AU (1) | AU2013221585B2 (ru) |
BR (1) | BR112014019861A2 (ru) |
CA (1) | CA2862319C (ru) |
EA (1) | EA031069B1 (ru) |
HK (1) | HK1211035A1 (ru) |
IL (1) | IL233742B (ru) |
MX (1) | MX360141B (ru) |
SG (1) | SG11201404354UA (ru) |
WO (1) | WO2013123152A2 (ru) |
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HUE051389T2 (hu) | 2013-10-15 | 2021-03-01 | Seagen Inc | Pegilezett gyógyszer-linkerek ligandum-gyógyszer konjugátum javított farmakokinetikájához |
US10933112B2 (en) | 2014-02-17 | 2021-03-02 | Seagen Inc. | Hydrophilic antibody-drug conjugates |
US20170233452A1 (en) * | 2014-04-23 | 2017-08-17 | Immusoft Corporation | Chimeric antigen receptors specific to avb6 integrin and methods of use thereof to treat cancer |
US9993535B2 (en) | 2014-12-18 | 2018-06-12 | Siwa Corporation | Method and composition for treating sarcopenia |
US10358502B2 (en) | 2014-12-18 | 2019-07-23 | Siwa Corporation | Product and method for treating sarcopenia |
US11793880B2 (en) | 2015-12-04 | 2023-10-24 | Seagen Inc. | Conjugates of quaternized tubulysin compounds |
US11229708B2 (en) | 2015-12-04 | 2022-01-25 | Seagen Inc. | Conjugates of quaternized tubulysin compounds |
KR20230074837A (ko) | 2016-02-19 | 2023-05-31 | 시와 코퍼레이션 | 고급 당화 최종 산물(age)에 대한 항체를 사용하여 암을 치료하고, 전이성 암 세포를 사멸시키고, 암 전이를 예방하기 위한 방법 및 조성물 |
SG11201807827VA (en) | 2016-03-25 | 2018-10-30 | Seattle Genetics Inc | Process for the preparation of pegylated drug-linkers and intermediates thereof |
KR20180133452A (ko) | 2016-04-15 | 2018-12-14 | 시와 코퍼레이션 | 신경퇴행성 질환을 치료하기 위한 항-노화 항체 |
CN109562152B (zh) | 2016-08-09 | 2024-04-02 | 西雅图基因公司 | 含有具有改善的生理化学性质的自稳定性接头的药物缀合物 |
MA46660A (fr) | 2016-10-18 | 2019-08-28 | Seattle Genetics Inc | Administration ciblée d'inhibiteurs de la voie de récupération de nicotinamide adénine dinucléotide |
KR102634762B1 (ko) | 2016-11-01 | 2024-02-06 | 애로우헤드 파마슈티컬스 인코포레이티드 | 알파-v 베타-6 인테그린 리간드 및 그의 용도 |
WO2018107116A1 (en) * | 2016-12-09 | 2018-06-14 | Abbvie Stemcentrx Llc | Methods of reducing toxicity of antibody drug conjugates, and compositions produced thereby |
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JP2020512312A (ja) | 2017-03-24 | 2020-04-23 | シアトル ジェネティックス, インコーポレイテッド | グルクロニド薬物−リンカーの調製のためのプロセスおよびその中間体 |
JP2020516648A (ja) * | 2017-04-13 | 2020-06-11 | シワ コーポレーション | ヒト化モノクローナル終末糖化産物抗体 |
CN110799217A (zh) | 2017-04-27 | 2020-02-14 | 西雅图基因公司 | 季铵化烟酰胺腺嘌呤二核苷酸补救途径抑制剂缀合物 |
TN2020000059A1 (en) | 2017-11-01 | 2022-01-06 | Arrowhead Pharmaceuticals Inc | Integrin ligands and uses thereof |
US11518801B1 (en) | 2017-12-22 | 2022-12-06 | Siwa Corporation | Methods and compositions for treating diabetes and diabetic complications |
EP3755707A1 (en) | 2018-02-20 | 2020-12-30 | Seagen Inc. | Hydrophobic auristatin f compounds and conjugates thereof |
MX2022006132A (es) | 2019-12-05 | 2022-06-17 | Seagen Inc | Anticuerpos anti alfa-v beta-6 (avb6) y conjugados de anticuerpo-farmaco. |
US20230090552A1 (en) | 2020-01-08 | 2023-03-23 | Synthis Therapeutics, Inc. | Alk5 inhibitor conjugates and uses thereof |
CA3176248A1 (en) | 2020-04-10 | 2021-10-14 | Seagen Inc. | Charge variant linkers |
EP4326333A1 (en) | 2021-04-20 | 2024-02-28 | Seagen Inc. | Modulation of antibody-dependent cellular cytotoxicity |
CN117580593A (zh) | 2021-05-28 | 2024-02-20 | 思进公司 | 蒽环霉素抗体结合物 |
US20230381321A1 (en) | 2022-03-17 | 2023-11-30 | Seagan Inc., | Camptothecin conjugates |
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US5962643A (en) | 1991-07-11 | 1999-10-05 | The Regents Of The University Of California | Integrin β subunit and uses thereof |
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DE60230736D1 (de) * | 2001-04-30 | 2009-02-26 | Lilly Co Eli | HUMANISIERTE ANTIKÖRPER DIE DAS BETA-AMYLOID PEPTID ERKENNEN& x9; |
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WO2009135953A2 (en) | 2008-05-09 | 2009-11-12 | Ablynx Nv | Amino acid sequences directed against integrins and uses thereof |
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WO2011046309A2 (en) * | 2009-10-12 | 2011-04-21 | Korea Research Institute Of Bioscience And Biotechnology | A diagnostic marker for hepatocellular carcinoma comprising anti-fasn autoantibodies and a diagnostic composition for hepatocellular carcinoma comprising antigens thereof |
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MX361929B (es) | 2010-11-19 | 2018-12-19 | Eisai R&D Man Co Ltd Star | Anticuerpos anti-ligando de quimiocina cc 20 (ccl20) neutralizantes. |
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-
2013
- 2013-02-14 SG SG11201404354UA patent/SG11201404354UA/en unknown
- 2013-02-14 EP EP13749647.7A patent/EP2814509B1/en active Active
- 2013-02-14 EA EA201491541A patent/EA031069B1/ru unknown
- 2013-02-14 US US14/378,746 patent/US9493566B2/en active Active
- 2013-02-14 CN CN201510418545.9A patent/CN105017420B/zh active Active
- 2013-02-14 JP JP2014557760A patent/JP6273214B2/ja active Active
- 2013-02-14 CN CN201380009160.6A patent/CN104220094A/zh active Pending
- 2013-02-14 KR KR1020147025536A patent/KR102084806B1/ko active IP Right Grant
- 2013-02-14 CA CA2862319A patent/CA2862319C/en active Active
- 2013-02-14 MX MX2014009751A patent/MX360141B/es active IP Right Grant
- 2013-02-14 WO PCT/US2013/026087 patent/WO2013123152A2/en active Application Filing
- 2013-02-14 BR BR112014019861A patent/BR112014019861A2/pt not_active IP Right Cessation
- 2013-02-14 AU AU2013221585A patent/AU2013221585B2/en active Active
-
2014
- 2014-07-22 IL IL233742A patent/IL233742B/en active IP Right Grant
-
2015
- 2015-11-25 HK HK15111593.1A patent/HK1211035A1/xx unknown
-
2016
- 2016-09-07 US US15/258,699 patent/US20160376368A1/en not_active Abandoned
-
2019
- 2019-09-30 US US16/588,331 patent/US20200031938A1/en not_active Abandoned
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2021
- 2021-01-08 US US17/144,869 patent/US20210340260A1/en not_active Abandoned
-
2023
- 2023-02-17 US US18/170,742 patent/US20230242648A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
MX360141B (es) | 2018-10-24 |
BR112014019861A2 (pt) | 2017-07-04 |
KR102084806B1 (ko) | 2020-03-04 |
US20160376368A1 (en) | 2016-12-29 |
US20200031938A1 (en) | 2020-01-30 |
CN105017420B (zh) | 2019-05-28 |
US9493566B2 (en) | 2016-11-15 |
CN105017420A (zh) | 2015-11-04 |
IL233742B (en) | 2019-08-29 |
KR20140127875A (ko) | 2014-11-04 |
US20210340260A1 (en) | 2021-11-04 |
US20160009806A1 (en) | 2016-01-14 |
EP2814509A2 (en) | 2014-12-24 |
WO2013123152A3 (en) | 2014-11-13 |
AU2013221585A1 (en) | 2014-08-14 |
AU2013221585B2 (en) | 2017-03-30 |
MX2014009751A (es) | 2015-02-24 |
EP2814509A4 (en) | 2015-12-09 |
EP2814509B1 (en) | 2018-05-16 |
EA031069B1 (ru) | 2018-11-30 |
CN104220094A (zh) | 2014-12-17 |
IL233742A0 (en) | 2014-09-30 |
US20230242648A1 (en) | 2023-08-03 |
JP2015509938A (ja) | 2015-04-02 |
SG11201404354UA (en) | 2014-10-30 |
WO2013123152A2 (en) | 2013-08-22 |
CA2862319A1 (en) | 2013-08-22 |
CA2862319C (en) | 2021-11-30 |
HK1211035A1 (en) | 2016-05-13 |
JP6273214B2 (ja) | 2018-01-31 |
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