MX360141B - Anticuerpos contra integrina alfavhbeta6 y uso de los mismos para tratar cancer. - Google Patents
Anticuerpos contra integrina alfavhbeta6 y uso de los mismos para tratar cancer.Info
- Publication number
- MX360141B MX360141B MX2014009751A MX2014009751A MX360141B MX 360141 B MX360141 B MX 360141B MX 2014009751 A MX2014009751 A MX 2014009751A MX 2014009751 A MX2014009751 A MX 2014009751A MX 360141 B MX360141 B MX 360141B
- Authority
- MX
- Mexico
- Prior art keywords
- antibodies
- same
- treat cancer
- avb6
- integrin avb6
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 102000006495 integrins Human genes 0.000 title abstract 2
- 108010044426 integrins Proteins 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
Abstract
La presente invención se refiere a anticuerpos que se unen específicamente a integrina avß6. Los anticuerpos son útiles para el tratamiento y el diagnóstico de diversos tipos de cáncer, así como la detección de avß6.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261600499P | 2012-02-17 | 2012-02-17 | |
US201261602511P | 2012-02-23 | 2012-02-23 | |
PCT/US2013/026087 WO2013123152A2 (en) | 2012-02-17 | 2013-02-14 | ANTIBODIES TO INTEGRIN αVβ6 AND USE OF SAME TO TREAT CANCER |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014009751A MX2014009751A (es) | 2015-02-24 |
MX360141B true MX360141B (es) | 2018-10-24 |
Family
ID=48984888
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014009751A MX360141B (es) | 2012-02-17 | 2013-02-14 | Anticuerpos contra integrina alfavhbeta6 y uso de los mismos para tratar cancer. |
Country Status (14)
Country | Link |
---|---|
US (5) | US9493566B2 (es) |
EP (1) | EP2814509B1 (es) |
JP (1) | JP6273214B2 (es) |
KR (1) | KR102084806B1 (es) |
CN (2) | CN104220094A (es) |
AU (1) | AU2013221585B2 (es) |
BR (1) | BR112014019861A2 (es) |
CA (1) | CA2862319C (es) |
EA (1) | EA031069B1 (es) |
HK (1) | HK1211035A1 (es) |
IL (1) | IL233742B (es) |
MX (1) | MX360141B (es) |
SG (1) | SG11201404354UA (es) |
WO (1) | WO2013123152A2 (es) |
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WO2009143411A2 (en) | 2008-05-23 | 2009-11-26 | Siwa Corporation | Methods, compositions and apparatus for facilitating regeneration |
JP6527508B2 (ja) * | 2013-10-01 | 2019-06-05 | メディミューン リミテッド | αVβ6を過剰発現する癌を治療及び診断する方法 |
KR102645430B1 (ko) | 2013-10-15 | 2024-03-11 | 씨젠 인크. | 개선된 리간드-약물 컨쥬게이트 약물동력학을 위한 peg화된 약물-링커 |
JP6716461B2 (ja) | 2014-02-17 | 2020-07-01 | シアトル ジェネティックス, インコーポレイテッド | 親水性抗体−薬物コンジュゲート |
US20170233452A1 (en) * | 2014-04-23 | 2017-08-17 | Immusoft Corporation | Chimeric antigen receptors specific to avb6 integrin and methods of use thereof to treat cancer |
US9993535B2 (en) | 2014-12-18 | 2018-06-12 | Siwa Corporation | Method and composition for treating sarcopenia |
US10358502B2 (en) | 2014-12-18 | 2019-07-23 | Siwa Corporation | Product and method for treating sarcopenia |
CA3006000A1 (en) | 2015-12-04 | 2017-06-08 | Seattle Genetics, Inc. | Conjugates of quaternized tubulysin compounds |
US11793880B2 (en) | 2015-12-04 | 2023-10-24 | Seagen Inc. | Conjugates of quaternized tubulysin compounds |
CN109071675A (zh) | 2016-02-19 | 2018-12-21 | Siwa有限公司 | 使用高级糖化终产物(age)的抗体治疗癌症、杀死转移性癌细胞和预防癌症转移的方法和组合物 |
KR102626498B1 (ko) | 2016-03-25 | 2024-01-19 | 씨젠 인크. | 페길화된 약물-링커 및 그의 중간체의 제조를 위한 공정 |
KR20180133452A (ko) | 2016-04-15 | 2018-12-14 | 시와 코퍼레이션 | 신경퇴행성 질환을 치료하기 위한 항-노화 항체 |
CA3032147A1 (en) | 2016-08-09 | 2018-02-15 | Seattle Genetics, Inc. | Drug conjugates with self-stabilizing linkers having improved physiochemical properties |
EA201990890A1 (ru) | 2016-10-18 | 2019-10-31 | Целевая доставка ингибиторов реутилизационного пути никотинамидадениндинуклеотида | |
CA3039618A1 (en) | 2016-11-01 | 2018-05-11 | Arrowhead Pharmaceuticals, Inc. | Alpha-v beta-6 integrin ligands and uses thereof |
WO2018107116A1 (en) * | 2016-12-09 | 2018-06-14 | Abbvie Stemcentrx Llc | Methods of reducing toxicity of antibody drug conjugates, and compositions produced thereby |
JP7244987B2 (ja) | 2016-12-14 | 2023-03-23 | シージェン インコーポレイテッド | 多剤抗体薬物コンジュゲート |
JP2020512312A (ja) | 2017-03-24 | 2020-04-23 | シアトル ジェネティックス, インコーポレイテッド | グルクロニド薬物−リンカーの調製のためのプロセスおよびその中間体 |
JP2020516648A (ja) * | 2017-04-13 | 2020-06-11 | シワ コーポレーション | ヒト化モノクローナル終末糖化産物抗体 |
JP7425606B2 (ja) | 2017-04-27 | 2024-01-31 | シージェン インコーポレイテッド | 四級化ニコチンアミドアデニンジヌクレオチドサルベージ経路阻害剤コンジュゲート |
JP7445594B2 (ja) * | 2017-11-01 | 2024-03-07 | アローヘッド ファーマシューティカルズ インコーポレイテッド | インテグリンリガンドおよびその使用 |
US11518801B1 (en) | 2017-12-22 | 2022-12-06 | Siwa Corporation | Methods and compositions for treating diabetes and diabetic complications |
KR20200122351A (ko) | 2018-02-20 | 2020-10-27 | 시애틀 지네틱스, 인크. | 소수성 아우리스타틴 f 화합물 및 그의 접합체 |
US11827709B2 (en) * | 2019-12-05 | 2023-11-28 | Seagen Inc. | Anti-AVB6 antibodies and antibody-drug conjugates |
EP4087657A1 (en) | 2020-01-08 | 2022-11-16 | Synthis Therapeutics, Inc. | Alk5 inhibitor conjugates and uses thereof |
EP4132588A1 (en) | 2020-04-10 | 2023-02-15 | Seagen Inc. | Charge variant linkers |
EP4326333A1 (en) | 2021-04-20 | 2024-02-28 | Seagen Inc. | Modulation of antibody-dependent cellular cytotoxicity |
AU2022283467A1 (en) | 2021-05-28 | 2023-12-07 | Seagen Inc. | Anthracycline antibody conjugates |
US20230381321A1 (en) | 2022-03-17 | 2023-11-30 | Seagan Inc., | Camptothecin conjugates |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5962643A (en) | 1991-07-11 | 1999-10-05 | The Regents Of The University Of California | Integrin β subunit and uses thereof |
DE69828614T2 (de) | 1997-08-08 | 2006-02-09 | The Regents Of The University Of California, Oakland | Behandlung von Nierenfibrose durch Antikörper gegen integrin alpha-v-beta 6 |
ES2437875T3 (es) * | 2001-04-30 | 2014-01-14 | Eli Lilly And Company | Anticuerpos humanizados que reconocen el péptido beta-amiloide |
WO2003100033A2 (en) * | 2002-03-13 | 2003-12-04 | Biogen Idec Ma Inc. | ANTI-αvβ6 ANTIBODIES |
UA90242C2 (ru) * | 2002-03-13 | 2010-04-26 | Байоджен Айдек Ма Инк. | МОНОКЛОНАЛЬНОЕ АНТИТЕЛО, КОТОРОЕ СПЕЦИФИЧЕСКИ СВЯЗЫВАЕТСЯ С αVβ6 |
WO2003087340A2 (en) | 2002-04-12 | 2003-10-23 | Raven Biotechnologies, Inc. | Antibodies that bind to integrin alpha-v-beta-6 and methods of use thereof |
US7241598B2 (en) * | 2004-06-29 | 2007-07-10 | The Chinese University Of Hong Kong | Frame-shifting PCR for germline immunoglobulin genes retrieval and antibody engineering |
EP1828251B1 (en) * | 2004-10-05 | 2012-09-26 | Janssen Alzheimer Immunotherapy | Methods and compositions for improving recombinant protein production |
US8603483B2 (en) * | 2004-12-09 | 2013-12-10 | Janssen Biotech, Inc. | Anti-integrin immunoconjugates, methods and uses |
ES2429340T3 (es) | 2005-03-10 | 2013-11-14 | Morphotek, Inc. | Anticuerpos anti-mesotelina |
CN102875681A (zh) * | 2005-07-08 | 2013-01-16 | 拜奥根Idec马萨诸塞公司 | 抗-αvβ6抗体及其用途 |
WO2007026000A2 (en) | 2005-08-31 | 2007-03-08 | Novo Nordisk Health Care Ag | Human fvii monoclonal antibodies binding the gla domain and use thereof |
CL2007002225A1 (es) | 2006-08-03 | 2008-04-18 | Astrazeneca Ab | Agente de union especifico para un receptor del factor de crecimiento derivado de plaquetas (pdgfr-alfa); molecula de acido nucleico que lo codifica; vector y celula huesped que la comprenden; conjugado que comprende al agente; y uso del agente de un |
ES2746925T3 (es) | 2006-08-03 | 2020-03-09 | Medimmune Ltd | Anticuerpos dirigidos hacia alfaVbeta6 y uso de los mismos |
JP2010506944A (ja) | 2006-10-19 | 2010-03-04 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | インテグリンαVβ6のアンタゴニストを用いる慢性喘息の処置および予防 |
US9274119B2 (en) * | 2008-01-11 | 2016-03-01 | The University Of Tokyo | Anti-CLDN6 antibody |
BRPI0906498A2 (pt) * | 2008-01-22 | 2015-07-14 | Biogen Idec Inc | Anticorpo ron e seus usos |
CN101959929B (zh) | 2008-03-27 | 2013-05-01 | 泰尔茂株式会社 | 生物体吸收性材料及使用其的生物体内留置物 |
EP2279209A2 (en) | 2008-05-09 | 2011-02-02 | Ablynx NV | Amino acid sequences directed against integrins and uses thereof |
JP2010210772A (ja) | 2009-03-13 | 2010-09-24 | Dainippon Screen Mfg Co Ltd | 液晶表示装置の製造方法 |
WO2011046309A2 (en) * | 2009-10-12 | 2011-04-21 | Korea Research Institute Of Bioscience And Biotechnology | A diagnostic marker for hepatocellular carcinoma comprising anti-fasn autoantibodies and a diagnostic composition for hepatocellular carcinoma comprising antigens thereof |
KR101138460B1 (ko) | 2009-10-12 | 2012-04-26 | 한국생명공학연구원 | 항-fasn 자가면역 항체를 포함하는 간암 진단 마커 및 이의 항원을 포함하는 간암 진단용 조성물 |
WO2012068540A2 (en) | 2010-11-19 | 2012-05-24 | Toshio Imai | Neutralizing anti-ccl20 antibodies |
WO2013148316A1 (en) | 2012-03-29 | 2013-10-03 | Biogen Idec Ma Inc. | Biomarkers for use in integrin therapy applications |
-
2013
- 2013-02-14 AU AU2013221585A patent/AU2013221585B2/en active Active
- 2013-02-14 MX MX2014009751A patent/MX360141B/es active IP Right Grant
- 2013-02-14 WO PCT/US2013/026087 patent/WO2013123152A2/en active Application Filing
- 2013-02-14 EP EP13749647.7A patent/EP2814509B1/en active Active
- 2013-02-14 US US14/378,746 patent/US9493566B2/en active Active
- 2013-02-14 BR BR112014019861A patent/BR112014019861A2/pt not_active IP Right Cessation
- 2013-02-14 JP JP2014557760A patent/JP6273214B2/ja active Active
- 2013-02-14 KR KR1020147025536A patent/KR102084806B1/ko active IP Right Grant
- 2013-02-14 CA CA2862319A patent/CA2862319C/en active Active
- 2013-02-14 CN CN201380009160.6A patent/CN104220094A/zh active Pending
- 2013-02-14 CN CN201510418545.9A patent/CN105017420B/zh active Active
- 2013-02-14 EA EA201491541A patent/EA031069B1/ru unknown
- 2013-02-14 SG SG11201404354UA patent/SG11201404354UA/en unknown
-
2014
- 2014-07-22 IL IL233742A patent/IL233742B/en active IP Right Grant
-
2015
- 2015-11-25 HK HK15111593.1A patent/HK1211035A1/xx unknown
-
2016
- 2016-09-07 US US15/258,699 patent/US20160376368A1/en not_active Abandoned
-
2019
- 2019-09-30 US US16/588,331 patent/US20200031938A1/en not_active Abandoned
-
2021
- 2021-01-08 US US17/144,869 patent/US20210340260A1/en not_active Abandoned
-
2023
- 2023-02-17 US US18/170,742 patent/US20230242648A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CN105017420A (zh) | 2015-11-04 |
SG11201404354UA (en) | 2014-10-30 |
JP2015509938A (ja) | 2015-04-02 |
CA2862319C (en) | 2021-11-30 |
US20160376368A1 (en) | 2016-12-29 |
EA201491541A1 (ru) | 2016-05-31 |
IL233742A0 (en) | 2014-09-30 |
CN105017420B (zh) | 2019-05-28 |
IL233742B (en) | 2019-08-29 |
EP2814509A2 (en) | 2014-12-24 |
CA2862319A1 (en) | 2013-08-22 |
WO2013123152A2 (en) | 2013-08-22 |
KR20140127875A (ko) | 2014-11-04 |
MX2014009751A (es) | 2015-02-24 |
US20210340260A1 (en) | 2021-11-04 |
US20160009806A1 (en) | 2016-01-14 |
EP2814509B1 (en) | 2018-05-16 |
AU2013221585B2 (en) | 2017-03-30 |
AU2013221585A1 (en) | 2014-08-14 |
WO2013123152A3 (en) | 2014-11-13 |
CN104220094A (zh) | 2014-12-17 |
HK1211035A1 (en) | 2016-05-13 |
US9493566B2 (en) | 2016-11-15 |
BR112014019861A2 (pt) | 2017-07-04 |
KR102084806B1 (ko) | 2020-03-04 |
EA031069B1 (ru) | 2018-11-30 |
US20230242648A1 (en) | 2023-08-03 |
US20200031938A1 (en) | 2020-01-30 |
JP6273214B2 (ja) | 2018-01-31 |
EP2814509A4 (en) | 2015-12-09 |
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