EA201491268A1 - Соединения и композиции для ингибирования взаимодействия bcl2 с партнерами по связыванию - Google Patents

Соединения и композиции для ингибирования взаимодействия bcl2 с партнерами по связыванию

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Publication number
EA201491268A1
EA201491268A1 EA201491268A EA201491268A EA201491268A1 EA 201491268 A1 EA201491268 A1 EA 201491268A1 EA 201491268 A EA201491268 A EA 201491268A EA 201491268 A EA201491268 A EA 201491268A EA 201491268 A1 EA201491268 A1 EA 201491268A1
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EA
Eurasian Patent Office
Prior art keywords
compounds
interaction
bcl2
partners
linkage
Prior art date
Application number
EA201491268A
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English (en)
Inventor
Майкл Скотт Виссер
Наим Юсуфф
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA201491268A1 publication Critical patent/EA201491268A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Изобретение относится к соединениям формулы (I), в которой R, R, Rи Rопределены в описании изобретения. Соединения формулы (I) способны нарушать BCL-2 взаимодействия с белками, содержащими ВН3 домен. Нарушение данного взаимодействия может восстанавливать антиапоптозную функцию BCL-2 в раковых клетках и опухолевой ткани, экспрессирующих BCL-2. Кроме того, изобретение относится к способу получения соединений, фармацевтических препаратов, содержащих данные соединения, и способам применения данных соединений в лечении раковых заболеваний.
EA201491268A 2011-12-23 2012-12-12 Соединения и композиции для ингибирования взаимодействия bcl2 с партнерами по связыванию EA201491268A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161579731P 2011-12-23 2011-12-23
PCT/US2012/069181 WO2013096049A1 (en) 2011-12-23 2012-12-12 Compounds for inhibiting the interaction of bcl2 with binding partners

Publications (1)

Publication Number Publication Date
EA201491268A1 true EA201491268A1 (ru) 2014-11-28

Family

ID=47429049

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201491268A EA201491268A1 (ru) 2011-12-23 2012-12-12 Соединения и композиции для ингибирования взаимодействия bcl2 с партнерами по связыванию

Country Status (11)

Country Link
US (1) US9126980B2 (ru)
EP (1) EP2794588A1 (ru)
JP (1) JP2015503515A (ru)
KR (1) KR20140107573A (ru)
CN (1) CN104125955A (ru)
AU (1) AU2012355613A1 (ru)
BR (1) BR112014015274A2 (ru)
CA (1) CA2859862A1 (ru)
EA (1) EA201491268A1 (ru)
MX (1) MX2014007729A (ru)
WO (1) WO2013096049A1 (ru)

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FR3008978A1 (fr) * 2013-07-23 2015-01-30 Servier Lab "nouveaux derives d'indole et de pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent"
US10195213B2 (en) 2015-03-13 2019-02-05 Unity Biotechnology, Inc. Chemical entities that kill senescent cells for use in treating age-related disease
CA3073656C (en) 2017-09-22 2024-03-05 Jubilant Epipad LLC Heterocyclic compounds as pad inhibitors
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SG11202004143XA (en) 2017-11-06 2020-06-29 Jubilant Prodel LLC Pyrimidine derivatives as inhibitors of pd1/pd-l1 activation
CN111542523B (zh) 2017-11-24 2024-03-29 朱比连特埃皮斯科瑞有限责任公司 作为prmt5抑制剂的杂环化合物
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Also Published As

Publication number Publication date
MX2014007729A (es) 2015-01-12
JP2015503515A (ja) 2015-02-02
CN104125955A (zh) 2014-10-29
BR112014015274A8 (pt) 2017-06-13
KR20140107573A (ko) 2014-09-04
CA2859862A1 (en) 2013-06-27
EP2794588A1 (en) 2014-10-29
WO2013096049A1 (en) 2013-06-27
BR112014015274A2 (pt) 2017-06-13
US20150080428A1 (en) 2015-03-19
AU2012355613A1 (en) 2014-07-17
US9126980B2 (en) 2015-09-08

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