EA201491107A1 - Антитела к рецептору эпидермального фактора роста 3 (her3), направленные на домен ii her3 - Google Patents

Антитела к рецептору эпидермального фактора роста 3 (her3), направленные на домен ii her3

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Publication number
EA201491107A1
EA201491107A1 EA201491107A EA201491107A EA201491107A1 EA 201491107 A1 EA201491107 A1 EA 201491107A1 EA 201491107 A EA201491107 A EA 201491107A EA 201491107 A EA201491107 A EA 201491107A EA 201491107 A1 EA201491107 A1 EA 201491107A1
Authority
EA
Eurasian Patent Office
Prior art keywords
her3
antibodies
domain
directed
growth factor
Prior art date
Application number
EA201491107A
Other languages
English (en)
Inventor
Винфрид Элис
Сет Эттенберг
Эндрю Пол Гарнер
Кристиан Карстен Сильвестер Кунц
Тобиас Зайтц
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA201491107A1 publication Critical patent/EA201491107A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

Настоящее изобретение относится к антителам или их фрагментам, которые нацелены на эпитоп рецептора HER3, располагающийся в домене 2 рецептора HER3, для блокирования как лиганд-зависимой, так и лиганд-независимой передачи сигнала и роста опухоли; и к композициям и способам их применения.
EA201491107A 2011-12-05 2012-12-04 Антитела к рецептору эпидермального фактора роста 3 (her3), направленные на домен ii her3 EA201491107A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161566905P 2011-12-05 2011-12-05
PCT/IB2012/056950 WO2013084148A2 (en) 2011-12-05 2012-12-04 Antibodies for epidermal growth factor receptor 3 (her3) directed to domain ii of her3

Publications (1)

Publication Number Publication Date
EA201491107A1 true EA201491107A1 (ru) 2014-11-28

Family

ID=47681974

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201491107A EA201491107A1 (ru) 2011-12-05 2012-12-04 Антитела к рецептору эпидермального фактора роста 3 (her3), направленные на домен ii her3

Country Status (17)

Country Link
US (1) US20130273029A1 (ru)
EP (1) EP2788382A2 (ru)
JP (1) JP2015500829A (ru)
KR (1) KR20140103135A (ru)
CN (1) CN104105709A (ru)
AR (1) AR089084A1 (ru)
AU (1) AU2012349736A1 (ru)
BR (1) BR112014013568A8 (ru)
CA (1) CA2857601A1 (ru)
EA (1) EA201491107A1 (ru)
IL (1) IL232951A0 (ru)
IN (1) IN2014CN04373A (ru)
MX (1) MX2014006733A (ru)
SG (1) SG11201402739YA (ru)
TW (1) TW201328707A (ru)
UY (1) UY34486A (ru)
WO (1) WO2013084148A2 (ru)

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BR112013004012B1 (pt) 2010-08-20 2021-03-23 Novartis Ag Anticorpo monoclonal isolado ou fragmento de ligação ao antígeno do mesmo ao receptor her3, seu uso e composição farmacêutica
SG11201402783YA (en) * 2011-12-05 2014-06-27 Novartis Ag Antibodies for epidermal growth factor receptor 3 (her3)
PE20150956A1 (es) 2012-11-08 2015-06-20 Hoffmann La Roche Proteinas ligantes de antigeno her3 de union a la horquilla beta de her3
MX2015005756A (es) 2012-11-08 2015-09-16 Hoffmann La Roche Proteinas de unión a antígeno anti-her3/her4 de unión a la horquilla beta de her3 y a la horquilla beta de her4.
BR112016024457A2 (pt) * 2014-05-14 2018-01-23 Hoffmann La Roche anticorpo isolado, imunoconjugado, uso do anticorpo, formulação farmacêutica, ácido nucleico isolado, célula hospedeira e método de produção de um anticorpo
WO2015173248A1 (en) * 2014-05-14 2015-11-19 F. Hoffmann-La Roche Ag Her3/her2 bispecific antibodies binding to the beta-hairpin of her3 and domain ii of her2
EP3169708B1 (en) 2014-07-16 2019-03-20 Dana-Farber Cancer Institute Inc. et Al. Her3 inhibition in low-grade serous ovarian cancers
ES2855075T3 (es) 2014-10-17 2021-09-23 Novartis Ag Combinación de ceritinib con un inhibidor de EGFR
WO2019185164A1 (en) 2018-03-29 2019-10-03 Hummingbird Bioscience Holdings Pte. Ltd. Her3 antigen-binding molecules
USD912097S1 (en) 2019-06-03 2021-03-02 Yeti Coolers, Llc Ice pack
CN110760003A (zh) * 2019-09-10 2020-02-07 广东药科大学 一种抗her3单链抗体的制备方法
WO2023021319A1 (en) * 2021-08-19 2023-02-23 Oncoquest Pharmaceuticals Inc. Monoclonal antibodies against her2/neu and uses thereof

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AU2012349736A1 (en) 2014-06-26
IL232951A0 (en) 2014-07-31
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AR089084A1 (es) 2014-07-30
TW201328707A (zh) 2013-07-16
JP2015500829A (ja) 2015-01-08
WO2013084148A3 (en) 2013-08-15
UY34486A (es) 2013-07-31
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US20130273029A1 (en) 2013-10-17

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