AR089084A1 - Anticuerpos dirigidos al receptor del factor de crecimiento epidermico humano 3 (her3) dirigidos contra el dominio ii del her3 - Google Patents

Anticuerpos dirigidos al receptor del factor de crecimiento epidermico humano 3 (her3) dirigidos contra el dominio ii del her3

Info

Publication number
AR089084A1
AR089084A1 ARP120104558A ARP120104558A AR089084A1 AR 089084 A1 AR089084 A1 AR 089084A1 AR P120104558 A ARP120104558 A AR P120104558A AR P120104558 A ARP120104558 A AR P120104558A AR 089084 A1 AR089084 A1 AR 089084A1
Authority
AR
Argentina
Prior art keywords
her3
receiver
growth factor
directed
against domain
Prior art date
Application number
ARP120104558A
Other languages
English (en)
Inventor
Elis Winfried
Ettenberg Seth
Paul Garner Andrew
Seitz Tobias
Carsten Silvester Kunz Christian
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR089084A1 publication Critical patent/AR089084A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente se relaciona con anticuerpos o fragmentos de los mismos que actúan sobre un epítopo de un receptor HER3 que reside en el dominio 2 del receptor HER3 para bloquear la transducción de la señal tanto dependiente de ligando como independiente de ligando y el crecimiento del tumor, y composiciones y métodos de uso de los mismos.
ARP120104558A 2011-12-05 2012-12-05 Anticuerpos dirigidos al receptor del factor de crecimiento epidermico humano 3 (her3) dirigidos contra el dominio ii del her3 AR089084A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161566905P 2011-12-05 2011-12-05

Publications (1)

Publication Number Publication Date
AR089084A1 true AR089084A1 (es) 2014-07-30

Family

ID=47681974

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP120104558A AR089084A1 (es) 2011-12-05 2012-12-05 Anticuerpos dirigidos al receptor del factor de crecimiento epidermico humano 3 (her3) dirigidos contra el dominio ii del her3

Country Status (17)

Country Link
US (1) US20130273029A1 (es)
EP (1) EP2788382A2 (es)
JP (1) JP2015500829A (es)
KR (1) KR20140103135A (es)
CN (1) CN104105709A (es)
AR (1) AR089084A1 (es)
AU (1) AU2012349736A1 (es)
BR (1) BR112014013568A8 (es)
CA (1) CA2857601A1 (es)
EA (1) EA201491107A1 (es)
IL (1) IL232951A0 (es)
IN (1) IN2014CN04373A (es)
MX (1) MX2014006733A (es)
SG (1) SG11201402739YA (es)
TW (1) TW201328707A (es)
UY (1) UY34486A (es)
WO (1) WO2013084148A2 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2606070T3 (en) 2010-08-20 2017-03-27 Novartis Ag Antibodies for the epidermal growth factor receptor 3 (HER3)
ES2758433T3 (es) 2011-12-05 2020-05-05 Novartis Ag Anticuerpos contra el receptor 3 del factor de crecimiento epidérmico (HER3)
SG11201502534UA (en) * 2012-11-08 2015-05-28 Hoffmann La Roche Anti-her3/her4 antigen binding proteins binding to the beta-hairpin of her3 and the beta-hairpin of her4
SG11201502538TA (en) 2012-11-08 2015-05-28 Hoffmann La Roche Her3 antigen binding proteins binding to the beta-hairpin of her3
CA2944895A1 (en) 2014-05-14 2015-11-19 F. Hoffmann-La Roche Ag Anti-her3 antibodies binding to the beta-hairpin of her3
CN106255705B (zh) 2014-05-14 2021-01-08 豪夫迈·罗氏有限公司 结合HER3β-发夹和HER2域II的HER3/HER2双特异性抗体
JP6755235B2 (ja) 2014-07-16 2020-09-16 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド 低悪性度漿液性癌におけるｈｅｒ３阻害
ES2855075T3 (es) 2014-10-17 2021-09-23 Novartis Ag Combinación de ceritinib con un inhibidor de EGFR
WO2019185164A1 (en) * 2018-03-29 2019-10-03 Hummingbird Bioscience Holdings Pte. Ltd. Her3 antigen-binding molecules
USD912097S1 (en) 2019-06-03 2021-03-02 Yeti Coolers, Llc Ice pack
CN110760003A (zh) * 2019-09-10 2020-02-07 广东药科大学 一种抗her3单链抗体的制备方法
WO2023021319A1 (en) * 2021-08-19 2023-02-23 Oncoquest Pharmaceuticals Inc. Monoclonal antibodies against her2/neu and uses thereof

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BR112014013568A2 (pt) 2017-06-13
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WO2013084148A3 (en) 2013-08-15
KR20140103135A (ko) 2014-08-25
MX2014006733A (es) 2015-05-12
AU2012349736A1 (en) 2014-06-26
JP2015500829A (ja) 2015-01-08
BR112014013568A8 (pt) 2017-06-13
SG11201402739YA (en) 2014-06-27
EP2788382A2 (en) 2014-10-15
CA2857601A1 (en) 2013-06-13
EA201491107A1 (ru) 2014-11-28
US20130273029A1 (en) 2013-10-17
UY34486A (es) 2013-07-31
IL232951A0 (en) 2014-07-31
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