EA201391675A1 - Пептидные композиции с контролируемым высвобождением - Google Patents

Пептидные композиции с контролируемым высвобождением

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Publication number
EA201391675A1
EA201391675A1 EA201391675A EA201391675A EA201391675A1 EA 201391675 A1 EA201391675 A1 EA 201391675A1 EA 201391675 A EA201391675 A EA 201391675A EA 201391675 A EA201391675 A EA 201391675A EA 201391675 A1 EA201391675 A1 EA 201391675A1
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EA
Eurasian Patent Office
Prior art keywords
compositions
forming
peptide compositions
relates
controlled shipping
Prior art date
Application number
EA201391675A
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English (en)
Other versions
EA036213B1 (ru
Inventor
Фредрик Тиберг
Каталин Нистор
Маркус Йонссон
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Камурус Аб
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46456496&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201391675(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Камурус Аб filed Critical Камурус Аб
Publication of EA201391675A1 publication Critical patent/EA201391675A1/ru
Publication of EA036213B1 publication Critical patent/EA036213B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/31—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases, cochleates; Sponge phases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)

Abstract

Настоящее изобретение относится к композициям, образующим маловязкую смесь: (а) 20-80 мас.% по меньшей мере одного диацилглицерина и/или токоферола; (б) 20-80 мас.% по меньшей мере одного фосфатидилхолина (PC); (в) 5-20 мас.% по меньшей мере одного биосовместимого органического моноспиртового растворителя; (г) вплоть до 20 мас.% полярного растворителя; (д) по меньшей мере одного пептидного активного агента; (е) возможно, по меньшей мере одного антиоксиданта; где соотношение компонентов (а):(б) находится в диапазоне от 40:60 до 54:46; а также образующим или способным образовывать по меньшей мере одну жидкокристаллическую фазовую структуру при контакте с избытком водной жидкости. Изобретение также относится к способам лечения, включающим введение таких композиций, и к предварительно заполненным устройствам и наборам, содержащим композиции.
EA201391675A 2011-05-25 2012-05-25 Пептидные композиции с контролируемым высвобождением EA036213B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161489886P 2011-05-25 2011-05-25
PCT/EP2012/059917 WO2012160213A1 (en) 2011-05-25 2012-05-25 Controlled release peptide formulations

Publications (2)

Publication Number Publication Date
EA201391675A1 true EA201391675A1 (ru) 2014-08-29
EA036213B1 EA036213B1 (ru) 2020-10-14

Family

ID=46456496

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201391675A EA036213B1 (ru) 2011-05-25 2012-05-25 Пептидные композиции с контролируемым высвобождением

Country Status (29)

Country Link
US (2) US11433120B2 (ru)
EP (1) EP2714004B1 (ru)
JP (2) JP6265888B2 (ru)
KR (1) KR102066755B1 (ru)
CN (2) CN108283619B (ru)
AR (1) AR086577A1 (ru)
AU (2) AU2012260821B2 (ru)
BR (1) BR112013030104A8 (ru)
CA (1) CA2836847C (ru)
CL (1) CL2013003365A1 (ru)
CO (1) CO6900117A2 (ru)
CR (1) CR20130653A (ru)
CU (1) CU20130158A7 (ru)
DK (1) DK2714004T3 (ru)
DO (1) DOP2013000275A (ru)
EA (1) EA036213B1 (ru)
EC (1) ECSP13013107A (ru)
FI (1) FI2714004T3 (ru)
GT (1) GT201300292A (ru)
IL (1) IL229376B (ru)
MX (1) MX361716B (ru)
MY (1) MY177820A (ru)
NI (1) NI201300127A (ru)
PE (1) PE20141484A1 (ru)
PH (1) PH12013502550B1 (ru)
SG (1) SG194865A1 (ru)
TW (1) TWI624271B (ru)
WO (1) WO2012160213A1 (ru)
ZA (1) ZA201309653B (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5127449B2 (ja) * 2004-06-04 2013-01-23 カムルス エービー 流体デポ製剤
EP3563872A1 (en) 2012-04-05 2019-11-06 Massachusetts Institute Of Technology Immunostimulatory compositions and methods of use thereof
CA2874367C (en) * 2012-05-25 2020-08-18 Camurus Ab Somatostatin receptor agonist formulations
EP3791861A1 (en) 2012-07-26 2021-03-17 Camurus AB Opioid formulations
US10300145B2 (en) 2016-07-15 2019-05-28 Massachusetts Institute Of Technology Synthetic nanoparticles for delivery of immunomodulatory compounds
PT3512495T (pt) 2016-09-15 2023-02-15 Camurus Ab Formulações análogas a prostaciclina
IL295457A (en) 2016-09-27 2022-10-01 Camurus Ab Mixtures and formulations containing alkyl ammonium salt edta
CA3045114A1 (en) 2016-12-07 2018-06-14 Ra Pharmaceuticals, Inc. Modulators of complement activity
WO2019099735A1 (en) * 2017-11-15 2019-05-23 Rhythm Pharmaceuticals, Inc. Sustained release peptide formulations
CN109091451B (zh) * 2018-09-10 2021-08-13 武汉百纳礼康生物制药有限公司 亲水性药物的油相液晶凝胶前体制剂及其制备方法
US20220202898A1 (en) * 2019-05-29 2022-06-30 Camurus Ab Lipid-controlled release compositions
CN113368041B (zh) * 2020-07-17 2023-01-03 丽珠医药集团股份有限公司 药物组合物、缓释制剂及其制备方法
AU2022271139A1 (en) * 2021-05-04 2023-10-12 Camurus Ab Compositions and methods for treating neuroendocrine tumors

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8865021B2 (en) * 2003-11-07 2014-10-21 Camurus Ab Compositions of lipids and cationic peptides
WO2006075124A1 (en) * 2005-01-14 2006-07-20 Camurus Ab Somatostatin analogue formulations
JP5127449B2 (ja) * 2004-06-04 2013-01-23 カムルス エービー 流体デポ製剤
GB0412530D0 (en) * 2004-06-04 2004-07-07 Camurus Ab Formulation
CA2575906C (en) 2004-08-04 2014-04-15 Camurus Ab Compositions forming non-lamellar dispersions
GB0417388D0 (en) * 2004-08-04 2004-09-08 Camurus Ab Composition
SI1845942T1 (sl) * 2005-01-14 2014-06-30 Camurus Ab Gnrh analogne formulacije
KR101245022B1 (ko) * 2005-01-21 2013-03-19 카무러스 에이비 약제학적 지질 조성물
CN101193652B (zh) * 2005-04-08 2011-11-02 安米林药品公司 包含肠降血糖素肽和非质子极性溶剂的药物制剂
CA2609810C (en) * 2005-06-06 2012-05-22 Camurus Ab Glp-1 analogue formulations
GB0711656D0 (en) * 2007-06-15 2007-07-25 Camurus Ab Formulations
GB0716385D0 (en) * 2007-08-22 2007-10-03 Camurus Ab Formulations
GB0815435D0 (en) * 2008-08-22 2008-10-01 Camurus Ab Formulations
US8931272B2 (en) * 2010-10-29 2015-01-13 Ford Global Technologies, Llc Method and system for limiting output of a boosted engine
JP6081480B2 (ja) * 2011-12-05 2017-02-15 カムルス エービー 頑強な徐放性製剤
CA2874367C (en) * 2012-05-25 2020-08-18 Camurus Ab Somatostatin receptor agonist formulations
US20230285502A1 (en) * 2016-09-07 2023-09-14 Camurus Ab Mixtures and formulations
IL295457A (en) * 2016-09-27 2022-10-01 Camurus Ab Mixtures and formulations containing alkyl ammonium salt edta

Also Published As

Publication number Publication date
IL229376B (en) 2019-11-28
MX361716B (es) 2018-12-14
EA036213B1 (ru) 2020-10-14
US11433120B2 (en) 2022-09-06
US20210308226A1 (en) 2021-10-07
KR102066755B1 (ko) 2020-01-15
CO6900117A2 (es) 2014-03-20
SG194865A1 (en) 2013-12-30
ZA201309653B (en) 2016-05-25
CN103702662B (zh) 2018-07-20
JP2018076327A (ja) 2018-05-17
AR086577A1 (es) 2014-01-08
GT201300292A (es) 2014-08-05
CN103702662A (zh) 2014-04-02
JP2014520090A (ja) 2014-08-21
BR112013030104A8 (pt) 2021-09-08
TWI624271B (zh) 2018-05-21
CA2836847C (en) 2021-06-29
CN108283619A (zh) 2018-07-17
EP2714004A1 (en) 2014-04-09
BR112013030104A2 (pt) 2016-09-20
CR20130653A (es) 2014-03-05
AU2016202156A1 (en) 2016-04-28
WO2012160213A1 (en) 2012-11-29
NI201300127A (es) 2014-02-25
ECSP13013107A (es) 2015-03-31
CN108283619B (zh) 2021-09-14
CA2836847A1 (en) 2012-11-29
FI2714004T3 (fi) 2024-07-15
PE20141484A1 (es) 2014-10-31
DK2714004T3 (da) 2024-06-10
PH12013502550A1 (en) 2015-08-10
MY177820A (en) 2020-09-23
CU20130158A7 (es) 2014-04-24
PH12013502550B1 (en) 2015-08-10
JP6415673B2 (ja) 2018-10-31
JP6265888B2 (ja) 2018-01-24
AU2016202156B2 (en) 2018-03-22
TW201249463A (en) 2012-12-16
US20140162944A1 (en) 2014-06-12
KR20140045438A (ko) 2014-04-16
DOP2013000275A (es) 2014-05-15
AU2012260821B2 (en) 2016-01-07
IL229376A0 (en) 2014-01-30
CL2013003365A1 (es) 2014-07-25
NZ617828A (en) 2016-11-25
MX2013013401A (es) 2013-12-12
EP2714004B1 (en) 2024-05-15

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