EA201391644A1 - Частично насыщенные трициклические соединения и способы их получения и применения - Google Patents
Частично насыщенные трициклические соединения и способы их получения и примененияInfo
- Publication number
- EA201391644A1 EA201391644A1 EA201391644A EA201391644A EA201391644A1 EA 201391644 A1 EA201391644 A1 EA 201391644A1 EA 201391644 A EA201391644 A EA 201391644A EA 201391644 A EA201391644 A EA 201391644A EA 201391644 A1 EA201391644 A1 EA 201391644A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- methods
- tricyclic compounds
- reception
- application
- partially saturated
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
В изобретении представлены трициклические соединения и их применение при лечении медицинских расстройств, таких как ожирение. Представлены фармацевтические композиции и способы получения различных трициклических соединений. Предполагается, что указанные соединения обладают активностью против метионил-аминопептидазы 2.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161483257P | 2011-05-06 | 2011-05-06 | |
US201161559856P | 2011-11-15 | 2011-11-15 | |
PCT/US2012/036789 WO2012154676A1 (en) | 2011-05-06 | 2012-05-07 | Partially saturated tricyclic compounds and methods of making and using same |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201391644A1 true EA201391644A1 (ru) | 2014-11-28 |
EA025526B1 EA025526B1 (ru) | 2017-01-30 |
Family
ID=46147038
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201391644A EA025526B1 (ru) | 2011-05-06 | 2012-05-07 | Частично насыщенные трициклические соединения и способы их получения и применения |
Country Status (13)
Country | Link |
---|---|
US (3) | US9290472B2 (ru) |
EP (1) | EP2705030B1 (ru) |
JP (1) | JP6062423B2 (ru) |
KR (1) | KR101979039B1 (ru) |
CN (1) | CN103764641B (ru) |
AU (1) | AU2012253757B2 (ru) |
BR (1) | BR112013028534A2 (ru) |
CA (1) | CA2835261C (ru) |
EA (1) | EA025526B1 (ru) |
IL (1) | IL229246A (ru) |
MX (1) | MX345535B (ru) |
SG (1) | SG194812A1 (ru) |
WO (1) | WO2012154676A1 (ru) |
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2012
- 2012-05-07 BR BR112013028534A patent/BR112013028534A2/pt not_active Application Discontinuation
- 2012-05-07 JP JP2014509510A patent/JP6062423B2/ja not_active Expired - Fee Related
- 2012-05-07 CA CA2835261A patent/CA2835261C/en not_active Expired - Fee Related
- 2012-05-07 WO PCT/US2012/036789 patent/WO2012154676A1/en active Application Filing
- 2012-05-07 AU AU2012253757A patent/AU2012253757B2/en not_active Ceased
- 2012-05-07 EA EA201391644A patent/EA025526B1/ru not_active IP Right Cessation
- 2012-05-07 SG SG2013082219A patent/SG194812A1/en unknown
- 2012-05-07 CN CN201280033359.8A patent/CN103764641B/zh not_active Expired - Fee Related
- 2012-05-07 KR KR1020137032337A patent/KR101979039B1/ko active IP Right Grant
- 2012-05-07 EP EP12722591.0A patent/EP2705030B1/en active Active
- 2012-05-07 US US14/116,023 patent/US9290472B2/en not_active Expired - Fee Related
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2016
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IL229246A0 (en) | 2014-01-30 |
JP6062423B2 (ja) | 2017-01-18 |
MX2013012921A (es) | 2014-02-27 |
WO2012154676A1 (en) | 2012-11-15 |
CA2835261C (en) | 2019-06-04 |
SG194812A1 (en) | 2013-12-30 |
CA2835261A1 (en) | 2012-11-15 |
EA025526B1 (ru) | 2017-01-30 |
US9617237B2 (en) | 2017-04-11 |
WO2012154676A9 (en) | 2014-03-27 |
BR112013028534A2 (pt) | 2016-09-06 |
EP2705030A1 (en) | 2014-03-12 |
JP2014514349A (ja) | 2014-06-19 |
CN103764641A (zh) | 2014-04-30 |
AU2012253757A1 (en) | 2013-11-21 |
US9290472B2 (en) | 2016-03-22 |
KR101979039B1 (ko) | 2019-05-15 |
EP2705030B1 (en) | 2016-07-27 |
AU2012253757A8 (en) | 2015-10-22 |
NZ617388A (en) | 2015-11-27 |
KR20140047611A (ko) | 2014-04-22 |
US20180002307A1 (en) | 2018-01-04 |
IL229246A (en) | 2017-05-29 |
CN103764641B (zh) | 2016-10-26 |
US20140088078A1 (en) | 2014-03-27 |
AU2012253757B2 (en) | 2017-04-13 |
MX345535B (es) | 2017-02-03 |
US20170001973A1 (en) | 2017-01-05 |
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