DE69330690T2 - Verfahren zur Herstellung hoch-wasserlöslicher Zyklodextrinkomplexe - Google Patents
Verfahren zur Herstellung hoch-wasserlöslicher ZyklodextrinkomplexeInfo
- Publication number
- DE69330690T2 DE69330690T2 DE69330690T DE69330690T DE69330690T2 DE 69330690 T2 DE69330690 T2 DE 69330690T2 DE 69330690 T DE69330690 T DE 69330690T DE 69330690 T DE69330690 T DE 69330690T DE 69330690 T2 DE69330690 T2 DE 69330690T2
- Authority
- DE
- Germany
- Prior art keywords
- optionally substituted
- derivative
- highly water
- soluble cyclodextrin
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nanotechnology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1523692 | 1992-01-30 | ||
| JP33202192 | 1992-12-11 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69330690D1 DE69330690D1 (de) | 2001-10-11 |
| DE69330690T2 true DE69330690T2 (de) | 2002-06-20 |
Family
ID=26351355
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69330690T Expired - Fee Related DE69330690T2 (de) | 1992-01-30 | 1993-01-28 | Verfahren zur Herstellung hoch-wasserlöslicher Zyklodextrinkomplexe |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US5536623A (de) |
| EP (1) | EP0555693B1 (de) |
| AT (1) | ATE205092T1 (de) |
| CA (1) | CA2088428A1 (de) |
| DE (1) | DE69330690T2 (de) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2210600A1 (en) * | 1996-07-17 | 1998-01-17 | Takashi Houkan | Inhibitor of tumor metastasis or recurrence |
| KR100357541B1 (ko) * | 1998-05-15 | 2002-10-18 | 주식회사종근당 | 5-데메톡시 푸마질롤 유도체 및 그 제조방법 |
| KR100357542B1 (ko) * | 1998-05-15 | 2002-10-18 | 주식회사종근당 | 푸마질롤 유도체 및 그 제조방법 |
| CA2685447C (en) * | 2000-08-10 | 2013-05-28 | Takeda Pharmaceutical Company Limited | Pharmaceutical composition |
| JP4922507B2 (ja) * | 2000-08-10 | 2012-04-25 | 武田薬品工業株式会社 | 医薬組成物 |
| KR100451485B1 (ko) * | 2002-03-28 | 2004-10-06 | 주식회사종근당 | 푸마질롤 유도체 또는 그 염의 포접 화합물, 및 이를포함하는 약제학적 조성물 |
| NZ590732A (en) * | 2008-07-18 | 2012-09-28 | Zafgen Inc | Methods of treating an overweight or obese subject using fumagillin |
| US8642650B2 (en) | 2008-12-04 | 2014-02-04 | Zafgen, Inc. | Methods of treating an overweight or obese subject |
| WO2013055385A2 (en) | 2011-10-03 | 2013-04-18 | Zafgen Corporation | Methods of treating age related disorders |
| WO2010065877A2 (en) | 2008-12-04 | 2010-06-10 | Zafgen Corporation | Methods of treating an overweight or obese subject |
| KR20120083905A (ko) | 2009-10-09 | 2012-07-26 | 자프겐 코포레이션 | 비만의 치료에 사용하기 위한 설폰 화합물 |
| WO2011085201A1 (en) | 2010-01-08 | 2011-07-14 | Zafgen Corporation | Fumagillol type compounds and methods of making and using same |
| US8815309B2 (en) | 2010-01-08 | 2014-08-26 | Zafgen, Inc. | Methods of treating a subject with benign prostate hyperplasia |
| WO2011127304A2 (en) | 2010-04-07 | 2011-10-13 | Zafgen Corporation | Methods of treating an overweight subject |
| EP2595988B1 (de) | 2010-07-22 | 2014-12-17 | Zafgen, Inc. | Tricyclische verbindungen und verfahren zu ihrer herstellung |
| EP2638023B1 (de) | 2010-11-09 | 2016-09-07 | Zafgen, Inc. | Crystalline feststoffe von einem metap-2-hemmer, verfahren zu deren herstellung und verwendung |
| CA2819251A1 (en) | 2010-11-29 | 2012-06-07 | Zafgen Corporation | Treatment of obesity using non-daily administration of 6 - 0 - (4 - dimethylaminoethoxy) cinnamoyl fumagillol |
| BR112013018771A2 (pt) | 2011-01-26 | 2019-09-17 | Zafgen Inc | compostos de tetrazol e métodos para fazer e usar os mesmos |
| CA2829204C (en) | 2011-03-08 | 2019-12-24 | Zafgen, Inc. | Oxaspiro[2.5]octane derivatives and analogs |
| US9290472B2 (en) | 2011-05-06 | 2016-03-22 | Zafgen, Inc. | Partially saturated tricyclic compounds and methods of making and using same |
| US9242997B2 (en) | 2011-05-06 | 2016-01-26 | Zafgen, Inc. | Tricyclic pyrazole sulphonamide compunds and methods of making and using same |
| JP5941981B2 (ja) | 2011-05-06 | 2016-06-29 | ザフゲン，インコーポレイテッド | 三環式スルホンアミド化合物ならびにその製造および使用方法 |
| CN104169268A (zh) | 2012-01-18 | 2014-11-26 | 扎夫根股份有限公司 | 三环砜化合物及其制备和使用方法 |
| MX2014008706A (es) | 2012-01-18 | 2015-03-05 | Zafgen Inc | Compuestos tricíclicos de sulfonamida y métodos para elaborarlos y usarlos. |
| AU2013259760A1 (en) | 2012-05-07 | 2014-11-20 | Zafgen, Inc. | Polymorphic salt of the oxalate salt of 6-O-(4-dimethylaminoethoxy) cinnamoyl fumagillol and methods of making and using same |
| CA2872876A1 (en) | 2012-05-08 | 2013-11-14 | Zafgen, Inc. | Treating hypothalamic obesity with metap2 inhibitors |
| AU2013259620B2 (en) | 2012-05-09 | 2017-05-18 | Zafgen, Inc. | Fumigillol type compounds and methods of making and using same |
| KR20150079952A (ko) | 2012-11-05 | 2015-07-08 | 자프겐 인크. | 트리시클릭 화합물 및 그의 제조 및 사용 방법 |
| BR112015010223A2 (pt) | 2012-11-05 | 2017-07-11 | Zafgen Inc | compostos tricíclicos para o uso no tratamento e/ou controle de obesidade |
| KR20150079951A (ko) | 2012-11-05 | 2015-07-08 | 자프겐 인크. | 간 질환의 치료 방법 |
| CA2904353A1 (en) | 2013-03-14 | 2014-09-25 | Zafgen, Inc. | Methods of treating renal disease and other disorders |
| AR105671A1 (es) | 2015-08-11 | 2017-10-25 | Zafgen Inc | Compuestos heterocíclicos de fumagillol y sus métodos de elaboración y uso |
| CN106432255A (zh) | 2015-08-11 | 2017-02-22 | 扎夫根公司 | 烟曲霉素醇螺环化合物和制备和使用其的方法 |
| CN113321753B (zh) * | 2021-05-19 | 2022-08-30 | 山东滨州智源生物科技有限公司 | 多元糖基氨基酸基环糊精衍生物、水凝胶的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0764884B2 (ja) * | 1986-11-27 | 1995-07-12 | 株式会社トクヤマ | シクロデキストリン組成物 |
| EP0325199B1 (de) * | 1988-01-19 | 1993-10-27 | Takeda Chemical Industries, Ltd. | Fumagillin als angiostatisches Mittel |
| DE68906942T3 (de) * | 1988-03-29 | 1999-05-12 | Univ Florida | Pharmazeutische Zusammensetzungen für die parenterale Anwendung. |
| US5227372A (en) * | 1990-03-07 | 1993-07-13 | Children's Medical Center Corporation | Method for retaining ophthalmological agents in ocular tissues |
| TW282399B (de) * | 1990-05-25 | 1996-08-01 | Takeda Pharm Industry Co Ltd | |
| DE69231457T2 (de) * | 1991-06-21 | 2001-05-23 | Takeda Chemical Industries Ltd | Zyklodextrin-Zusammensetzung enthaltend Fumagillol-Derivate |
-
1993
- 1993-01-28 DE DE69330690T patent/DE69330690T2/de not_active Expired - Fee Related
- 1993-01-28 EP EP93101237A patent/EP0555693B1/de not_active Expired - Lifetime
- 1993-01-28 AT AT93101237T patent/ATE205092T1/de active
- 1993-01-29 US US08/011,457 patent/US5536623A/en not_active Expired - Fee Related
- 1993-01-29 CA CA002088428A patent/CA2088428A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US5536623A (en) | 1996-07-16 |
| EP0555693B1 (de) | 2001-09-05 |
| CA2088428A1 (en) | 1993-07-31 |
| DE69330690D1 (de) | 2001-10-11 |
| EP0555693A1 (de) | 1993-08-18 |
| ATE205092T1 (de) | 2001-09-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69330690D1 (de) | Verfahren zur Herstellung hoch-wasserlöslicher Zyklodextrinkomplexe | |
| ATE148993T1 (de) | Zyklodextrinkomplex | |
| DE3867268D1 (de) | Heterocyclische verbindungen und deren herstellung und verwendung. | |
| DE68923274D1 (de) | Verfahren zur herstellung eines mit metall-radionuklid-markierten proteins. | |
| JP3673888B2 (ja) | ポルフィリン類金属錯体の製造方法 | |
| ATE145209T1 (de) | Tri-aza-makrocyclen und verfahren zu ihrer herstellung | |
| ATE138571T1 (de) | Verwendung von dioxabicyclo (3.3.0>octane derivaten zur herstellung eines arzneimittels zur hemmung des cholesterinmetabolismus. | |
| HUP0102599A2 (hu) | Artemizinin-származékok, eljárás a vegyületek előállítására, és a vegyületeket tartalmazó gyógyszerészeti készítmények | |
| Lydon et al. | Synthesis and characterization of coordinated disulfides. Single-crystal structural analysis of [(en) 2Co (S (SC (CH3) 2COOH) C (CH3) 2COO)](ClO4) 2. cntdot. H2O | |
| Derek | Kinetics of aminolysis of some benzoyl fluorides and benzoic anhydrides in non-hydroxylic solvents | |
| HUP0302912A2 (hu) | Béta-tio-aminosavak, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
| ATE96464T1 (de) | Verfahren zur herstellung von thiolen. | |
| DE69013528D1 (de) | Eine Perfluoralkylgruppe enthaltende Verbindung. | |
| ATE122343T1 (de) | Triazolyl-hydrazidderivate und verfahren zu ihrer herstellung. | |
| RO92245A (ro) | Procedeu pentru prepararea unor derivati de 1,6-naftiridina | |
| ATE215934T1 (de) | Neue histidinderivate, verfahren zu ihrer herstellung und ihre verwendung als mittel gegen freie radikale | |
| KR890000406A (ko) | 신나모일아미드 유도체, 그들의 제조방법, 그들을 함유하는 제약학적 조성물 및 그들의 사용 | |
| ATE7917T1 (de) | Pyranoindolderivat und verfahren zu seiner herstellung. | |
| AU4301189A (en) | New thienyloxy-alkylamine derivates, their process of production and medicaments containing these compounds | |
| Elliott et al. | Pentaammineruthenium (II/III) imidazole and imidazolate complexes of 2-carboxylatoimidazolate and 2-imidazolecarboxaldehyde | |
| KR910006238A (ko) | 피라즐-3-카르복스아미드 | |
| SE9802643L (sv) | 2,3-Disubstituerade cyklopentanonderivat, förfarande för framställning av den och medicinsk användning därav | |
| DE60232786D1 (de) | "komplexkatalysator, verfahren zur herstellung des komplexkatalysators und verfahren zur herstellung von alkoholderivaten mit dem komplexkatalysator" | |
| IL106692A (en) | AZIDOALKYL DERIVATIVES AND THEIR USE FOR THE PREPARATION OF 99mTc COMPLEXES FOR IMAGING | |
| ATE228512T1 (de) | Verfahren zur herstellung von 3-isochromanonen durch cyclisierung von o- chlormehtylphenylessigsäuren |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |