EA201370184A1 - Гетероарильные производные - Google Patents
Гетероарильные производныеInfo
- Publication number
- EA201370184A1 EA201370184A1 EA201370184A EA201370184A EA201370184A1 EA 201370184 A1 EA201370184 A1 EA 201370184A1 EA 201370184 A EA201370184 A EA 201370184A EA 201370184 A EA201370184 A EA 201370184A EA 201370184 A1 EA201370184 A1 EA 201370184A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compound
- disclosed
- analogs
- heteroaryl derivatives
- neniya
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
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- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
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- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
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- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
Раскрыто соединение формулы Iгде Z, m и R-Rявляются такими, как описано в настоящем документе, используемое в качестве модулятора никотиновых ацетилхолиновых рецепторов, особенно подтипа α7, у субъекта, нуждающегося в этом, а также его аналоги, пролекарства, изотопно замещенные аналоги, метаболиты, фармацевтически приемлемые соли, полиморфы, сольваты, изомеры, клатраты и совместные кристаллы для применения либо отдельно, либо в комбинации с подходящими другими лекарственными препаратами и фармацевтические композиции, содержащие такие соединения и аналоги. Также раскрыт способ получения соединений и их предполагаемые применения в терапии, особенно в профилактике и терапии расстройств, таких как болезнь Альцгеймера, умеренное когнитивное нарушение, сенильная деменция и т.п.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN242KO2011 | 2011-02-23 | ||
IN1184KO2011 | 2011-09-09 | ||
PCT/IB2012/050806 WO2012114285A1 (en) | 2011-02-23 | 2012-02-22 | Heteroaryl derivatives as alpha7 nachr modulators |
Publications (2)
Publication Number | Publication Date |
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EA201370184A1 true EA201370184A1 (ru) | 2013-12-30 |
EA024170B1 EA024170B1 (ru) | 2016-08-31 |
Family
ID=45873193
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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EA201370184A EA024170B1 (ru) | 2011-02-23 | 2012-02-22 | ГЕТЕРОАРИЛЬНЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ МОДУЛЯТОРОВ nAChR АЛЬФА7 |
Country Status (36)
Country | Link |
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US (2) | US9072731B2 (ru) |
EP (1) | EP2678327B9 (ru) |
JP (1) | JP6118270B2 (ru) |
KR (1) | KR20140026378A (ru) |
CN (1) | CN103402994B (ru) |
AP (1) | AP3649A (ru) |
AU (1) | AU2012221800B2 (ru) |
BR (1) | BR112013021602A2 (ru) |
CA (1) | CA2826792A1 (ru) |
CL (1) | CL2013002449A1 (ru) |
CO (1) | CO6761374A2 (ru) |
CR (1) | CR20130415A (ru) |
CU (1) | CU24177B1 (ru) |
CY (1) | CY1118107T1 (ru) |
DK (1) | DK2678327T3 (ru) |
DO (1) | DOP2013000191A (ru) |
EA (1) | EA024170B1 (ru) |
EC (1) | ECSP13012891A (ru) |
ES (1) | ES2594409T3 (ru) |
GE (1) | GEP20156318B (ru) |
GT (1) | GT201300207A (ru) |
HR (1) | HRP20161481T1 (ru) |
HU (1) | HUE030659T2 (ru) |
IL (1) | IL228052A (ru) |
LT (1) | LT2678327T (ru) |
MA (1) | MA34957B1 (ru) |
MX (1) | MX343788B (ru) |
NI (1) | NI201300072A (ru) |
PE (1) | PE20140703A1 (ru) |
PL (1) | PL2678327T3 (ru) |
RS (1) | RS55433B1 (ru) |
SG (1) | SG192625A1 (ru) |
SI (1) | SI2678327T1 (ru) |
SM (1) | SMT201600409B (ru) |
WO (1) | WO2012114285A1 (ru) |
ZA (1) | ZA201306223B (ru) |
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PL2678327T3 (pl) | 2011-02-23 | 2017-02-28 | Lupin Limited | Pochodne heteroarylowe jako modulatory Alfa 7 NACHR |
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