EA201301267A1 - Альдолазы, кодирующие их нуклеиновые кислоты и способы их получения и применения - Google Patents
Альдолазы, кодирующие их нуклеиновые кислоты и способы их получения и примененияInfo
- Publication number
- EA201301267A1 EA201301267A1 EA201301267A EA201301267A EA201301267A1 EA 201301267 A1 EA201301267 A1 EA 201301267A1 EA 201301267 A EA201301267 A EA 201301267A EA 201301267 A EA201301267 A EA 201301267A EA 201301267 A1 EA201301267 A1 EA 201301267A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- polypeptides
- activity
- methods
- monatin
- polynucleotides
- Prior art date
Links
- 102000003677 Aldehyde-Lyases Human genes 0.000 title 1
- 108090000072 Aldehyde-Lyases Proteins 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
- 230000000694 effects Effects 0.000 abstract 7
- 229920001184 polypeptide Polymers 0.000 abstract 7
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 7
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 7
- 102000001390 Fructose-Bisphosphate Aldolase Human genes 0.000 abstract 4
- 108010068561 Fructose-Bisphosphate Aldolase Proteins 0.000 abstract 4
- 102000040430 polynucleotide Human genes 0.000 abstract 4
- 108091033319 polynucleotide Proteins 0.000 abstract 4
- 239000002157 polynucleotide Substances 0.000 abstract 4
- RMLYXMMBIZLGAQ-HZMBPMFUSA-N (2s,4s)-4-amino-2-hydroxy-2-(1h-indol-3-ylmethyl)pentanedioic acid Chemical compound C1=CC=C2C(C[C@](O)(C[C@H](N)C(O)=O)C(O)=O)=CNC2=C1 RMLYXMMBIZLGAQ-HZMBPMFUSA-N 0.000 abstract 3
- RMLYXMMBIZLGAQ-UHFFFAOYSA-N (-)-monatin Natural products C1=CC=C2C(CC(O)(CC(N)C(O)=O)C(O)=O)=CNC2=C1 RMLYXMMBIZLGAQ-UHFFFAOYSA-N 0.000 abstract 2
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- SLWQCDYJBNGHQV-CQSZACIVSA-N (2r)-2-hydroxy-2-(1h-indol-3-ylmethyl)-4-oxopentanedioic acid Chemical compound C1=CC=C2C(C[C@@](O)(CC(=O)C(=O)O)C(O)=O)=CNC2=C1 SLWQCDYJBNGHQV-CQSZACIVSA-N 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 230000006696 biosynthetic metabolic pathway Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1022—Transferases (2.) transferring aldehyde or ketonic groups (2.2)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/03—Oxo-acid-lyases (4.1.3)
- C12Y401/03016—4-Hydroxy-2-oxoglutarate aldolase (4.1.3.16)
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- C12Y—ENZYMES
- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/03—Oxo-acid-lyases (4.1.3)
- C12Y401/03017—4-Hydroxy-4-methyl-2-oxoglutarate aldolase (4.1.3.17)
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
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- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
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- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nutrition Science (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Fodder In General (AREA)
Abstract
Это изобретение относится к полипептидам, обладающим активностью альдолазы, включая активность в отношении пирувата, такую как, но не ограничиваясь этим, активность альдолазы HMG и/или KHG, к полинуклеотидам, кодирующим эти полипептиды, и к способам получения и применения этих полинуклеотидов и полипептидов. В некоторых вариантах осуществления это изобретение относится к полипептидам, обладающим активностью альдолазы, включая активность в отношении пирувата, такую как, но не ограничиваясь этим, активность альдолазы HMG и/или KHG, включая термостабильную или термоустойчивую активность, и к полинуклеотидам, кодирующим эти ферменты, и к получению и применению этих полинуклеотидов и полипептидов. Полипептиды по этому изобретению можно применять во множестве фармацевтических, сельскохозяйственных и промышленных направлений. В некоторых вариантах осуществления это изобретение относится к полипептидам и к биосинтетическим каскадам, которые пригодны для получения R-2-гидрокси-2-(индол-3-илметил)-4-кетоглутаровой кислоты (R-MP) и определенных стереоизомеров монатина, таких как R,R- и S,R-монатин, и их солей, а также определенных стереоизомеров производных монатина, таких как R,R- и S,R-конфигурации, и их солей.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78051506P | 2006-03-07 | 2006-03-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201301267A1 true EA201301267A1 (ru) | 2014-11-28 |
EA029538B1 EA029538B1 (ru) | 2018-04-30 |
Family
ID=38475839
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200870329A EA019971B1 (ru) | 2006-03-07 | 2007-03-07 | Альдолазы, кодирующие их нуклеиновые кислоты и способы их получения и применения |
EA201301267A EA029538B1 (ru) | 2006-03-07 | 2007-03-07 | Полипептид, обладающий активностью альдолазы, полинуклеотид, кодирующий этот полипептид, и способы получения и применения полинуклеотида и полипептида |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200870329A EA019971B1 (ru) | 2006-03-07 | 2007-03-07 | Альдолазы, кодирующие их нуклеиновые кислоты и способы их получения и применения |
Country Status (13)
Country | Link |
---|---|
US (3) | US8546118B2 (ru) |
EP (4) | EP1999256B1 (ru) |
JP (3) | JP5733777B2 (ru) |
KR (4) | KR101588539B1 (ru) |
CN (3) | CN102690833B (ru) |
AT (1) | ATE548450T1 (ru) |
AU (1) | AU2007223086B2 (ru) |
BR (2) | BRPI0708614A2 (ru) |
CA (1) | CA2645225A1 (ru) |
EA (2) | EA019971B1 (ru) |
ES (1) | ES2383767T3 (ru) |
MX (1) | MX2008011442A (ru) |
WO (1) | WO2007103989A2 (ru) |
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US8158389B2 (en) * | 2005-04-20 | 2012-04-17 | Cargill, Incorporated | Products and methods for in vivo secretion of monatin |
WO2006113897A2 (en) * | 2005-04-20 | 2006-10-26 | Cargill, Incorporated | Products and methods for in vivo secretion of monatin |
US8076108B2 (en) | 2005-04-26 | 2011-12-13 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors |
EP2322643B1 (en) | 2006-03-07 | 2014-07-09 | Cargill, Incorporated | Aldolases, nucleic acids encoding them and methods for making and using them |
EP2479272A4 (en) | 2010-10-14 | 2013-11-20 | Ajinomoto Kk | PROCESS FOR THE PRODUCTION OF MONATIN |
CN102181471B (zh) * | 2011-03-23 | 2014-07-02 | 深圳大学 | 莱茵衣藻分泌型表达载体及分泌型表达***的构建方法 |
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CN102559722B (zh) * | 2012-03-12 | 2017-05-17 | 杭州师范大学 | 一种高酶活、耐热醛缩酶基因、酶、载体、工程菌及应用 |
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JP2015513904A (ja) | 2012-03-26 | 2015-05-18 | プロニュートリア・インコーポレイテッドPronutria, Inc. | 栄養断片、タンパク質、および方法 |
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US9850512B2 (en) | 2013-03-15 | 2017-12-26 | The Research Foundation For The State University Of New York | Hydrolysis of cellulosic fines in primary clarified sludge of paper mills and the addition of a surfactant to increase the yield |
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US9951363B2 (en) | 2014-03-14 | 2018-04-24 | The Research Foundation for the State University of New York College of Environmental Science and Forestry | Enzymatic hydrolysis of old corrugated cardboard (OCC) fines from recycled linerboard mill waste rejects |
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CN111796039B (zh) | 2014-11-13 | 2023-03-17 | 沃特世科技公司 | 快速标记的n-聚糖的液相色谱校准方法 |
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CN109690297A (zh) * | 2016-07-01 | 2019-04-26 | 沃特世科技公司 | 使用分子量截留过滤和过滤器上去糖基化从复杂基质快速制备标记的葡基胺的方法 |
CN108079315B (zh) * | 2016-11-21 | 2021-09-24 | 厦门华绰生物医药科技有限公司 | FBP aldolase在制备激活AMPK的药物中的用途 |
EP3330380A1 (en) * | 2016-12-05 | 2018-06-06 | Evonik Degussa GmbH | Process for producing l-methionine from methional |
CN107541540B (zh) * | 2017-10-18 | 2021-07-20 | 南京财经大学 | 一种活性炭串联大孔树脂纯化菜籽肽的方法 |
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