EA201301267A1 - Альдолазы, кодирующие их нуклеиновые кислоты и способы их получения и применения - Google Patents

Альдолазы, кодирующие их нуклеиновые кислоты и способы их получения и применения

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Publication number
EA201301267A1
EA201301267A1 EA201301267A EA201301267A EA201301267A1 EA 201301267 A1 EA201301267 A1 EA 201301267A1 EA 201301267 A EA201301267 A EA 201301267A EA 201301267 A EA201301267 A EA 201301267A EA 201301267 A1 EA201301267 A1 EA 201301267A1
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Eurasian Patent Office
Prior art keywords
polypeptides
activity
methods
monatin
polynucleotides
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EA201301267A
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English (en)
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EA029538B1 (ru
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Эллен Берк
Паула М. Хикс
Питер Лугинбул
Тоби Ричардсон
Дэвид П. Уэйнер
Лишань Чжао
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Верениум Корпорейшн
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Publication of EA201301267A1 publication Critical patent/EA201301267A1/ru
Publication of EA029538B1 publication Critical patent/EA029538B1/ru

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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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Abstract

Это изобретение относится к полипептидам, обладающим активностью альдолазы, включая активность в отношении пирувата, такую как, но не ограничиваясь этим, активность альдолазы HMG и/или KHG, к полинуклеотидам, кодирующим эти полипептиды, и к способам получения и применения этих полинуклеотидов и полипептидов. В некоторых вариантах осуществления это изобретение относится к полипептидам, обладающим активностью альдолазы, включая активность в отношении пирувата, такую как, но не ограничиваясь этим, активность альдолазы HMG и/или KHG, включая термостабильную или термоустойчивую активность, и к полинуклеотидам, кодирующим эти ферменты, и к получению и применению этих полинуклеотидов и полипептидов. Полипептиды по этому изобретению можно применять во множестве фармацевтических, сельскохозяйственных и промышленных направлений. В некоторых вариантах осуществления это изобретение относится к полипептидам и к биосинтетическим каскадам, которые пригодны для получения R-2-гидрокси-2-(индол-3-илметил)-4-кетоглутаровой кислоты (R-MP) и определенных стереоизомеров монатина, таких как R,R- и S,R-монатин, и их солей, а также определенных стереоизомеров производных монатина, таких как R,R- и S,R-конфигурации, и их солей.
EA201301267A 2006-03-07 2007-03-07 Полипептид, обладающий активностью альдолазы, полинуклеотид, кодирующий этот полипептид, и способы получения и применения полинуклеотида и полипептида EA029538B1 (ru)

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US78051506P 2006-03-07 2006-03-07

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EA201301267A1 true EA201301267A1 (ru) 2014-11-28
EA029538B1 EA029538B1 (ru) 2018-04-30

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EA200870329A EA019971B1 (ru) 2006-03-07 2007-03-07 Альдолазы, кодирующие их нуклеиновые кислоты и способы их получения и применения
EA201301267A EA029538B1 (ru) 2006-03-07 2007-03-07 Полипептид, обладающий активностью альдолазы, полинуклеотид, кодирующий этот полипептид, и способы получения и применения полинуклеотида и полипептида

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EA200870329A EA019971B1 (ru) 2006-03-07 2007-03-07 Альдолазы, кодирующие их нуклеиновые кислоты и способы их получения и применения

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US (3) US8546118B2 (ru)
EP (4) EP1999256B1 (ru)
JP (3) JP5733777B2 (ru)
KR (4) KR101588539B1 (ru)
CN (3) CN102690833B (ru)
AT (1) ATE548450T1 (ru)
AU (1) AU2007223086B2 (ru)
BR (2) BRPI0708614A2 (ru)
CA (1) CA2645225A1 (ru)
EA (2) EA019971B1 (ru)
ES (1) ES2383767T3 (ru)
MX (1) MX2008011442A (ru)
WO (1) WO2007103989A2 (ru)

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