EA201290103A1 - HETEROCYCLIC COMPOUNDS AND THEIR USE - Google Patents

HETEROCYCLIC COMPOUNDS AND THEIR USE

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Publication number
EA201290103A1
EA201290103A1 EA201290103A EA201290103A EA201290103A1 EA 201290103 A1 EA201290103 A1 EA 201290103A1 EA 201290103 A EA201290103 A EA 201290103A EA 201290103 A EA201290103 A EA 201290103A EA 201290103 A1 EA201290103 A1 EA 201290103A1
Authority
EA
Eurasian Patent Office
Prior art keywords
heterocyclic compounds
objects
heterocyclic
kinase activity
modulate
Prior art date
Application number
EA201290103A
Other languages
Russian (ru)
Other versions
EA026693B1 (en
Inventor
Пингда Рен
Йи Лиу
Лианьшен Ли
Катрина Чан
Трой Эдвард Уилсон
Саймон Фрейзер Кэмпбелл
Original Assignee
ИНТЕЛЛИКАЙН, ЭлЭлСи
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43607312&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201290103(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ИНТЕЛЛИКАЙН, ЭлЭлСи filed Critical ИНТЕЛЛИКАЙН, ЭлЭлСи
Publication of EA201290103A1 publication Critical patent/EA201290103A1/en
Publication of EA026693B1 publication Critical patent/EA026693B1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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Abstract

Описаны гетероциклические объекты, которые модулируют PI3 киназную активность, фармацевтические композиции, содержащие данные гетероциклические объекты, и способы использования этих химических объектов для лечения болезней и состояний, которые ассоциируются с PI3 киназной активностью.Heterocyclic objects that modulate PI3 kinase activity, pharmaceutical compositions containing these heterocyclic objects, and methods of using these chemical objects to treat diseases and conditions associated with PI3 kinase activity are described.

EA201290103A 2009-08-17 2010-08-17 Benzoxazole and benzothiazole derivatives as pi3 kinase inhibitors EA026693B1 (en)

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