EA201200617A1 - Полимеры на основе циклодекстрина для доставки лекарственных средств - Google Patents
Полимеры на основе циклодекстрина для доставки лекарственных средствInfo
- Publication number
- EA201200617A1 EA201200617A1 EA201200617A EA201200617A EA201200617A1 EA 201200617 A1 EA201200617 A1 EA 201200617A1 EA 201200617 A EA201200617 A EA 201200617A EA 201200617 A EA201200617 A EA 201200617A EA 201200617 A1 EA201200617 A1 EA 201200617A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- cyclodextrine
- medicines
- polymers
- delivery
- basis
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/595—Polyamides, e.g. nylon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/40—Polyamides containing oxygen in the form of ether groups
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Polymers & Plastics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Materials Engineering (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polyamides (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
В данной заявке описаны способы и композиции, относящиеся к конъюгатам CDP-таксан.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26374909P | 2009-11-23 | 2009-11-23 | |
US39192210P | 2010-10-11 | 2010-10-11 | |
PCT/US2010/057913 WO2011063421A1 (en) | 2009-11-23 | 2010-11-23 | Cyclodextrin-based polymers for therapeutic delivery |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201200617A1 true EA201200617A1 (ru) | 2012-11-30 |
Family
ID=44060087
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201200617A EA201200617A1 (ru) | 2009-11-23 | 2010-11-23 | Полимеры на основе циклодекстрина для доставки лекарственных средств |
Country Status (11)
Country | Link |
---|---|
US (1) | US20110237540A1 (ru) |
EP (1) | EP2503888A4 (ru) |
JP (3) | JP6220126B2 (ru) |
CN (3) | CN102781237A (ru) |
AU (1) | AU2010321533A1 (ru) |
BR (1) | BR112012012210B8 (ru) |
CA (1) | CA2781669A1 (ru) |
EA (1) | EA201200617A1 (ru) |
IL (1) | IL219699B (ru) |
MX (1) | MX2012005987A (ru) |
WO (1) | WO2011063421A1 (ru) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
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ES2377318T3 (es) | 2002-09-06 | 2012-03-26 | Cerulean Pharma Inc. | Polímeros a base de ciclodextrina para el suministro de los agentes terapéuticos enlazados covalentemente a ellos |
JP2010516625A (ja) | 2007-01-24 | 2010-05-20 | インサート セラピューティクス, インコーポレイテッド | 制御された薬物送達のためのテザー基を有するポリマー−薬物コンジュゲート |
CN102770131A (zh) | 2009-10-29 | 2012-11-07 | 安万特医药股份有限公司 | 卡巴他赛的新颖抗肿瘤用途 |
US20120058971A1 (en) * | 2009-11-23 | 2012-03-08 | Cerulean Pharma Inc. | Cyclodextrin-based polymers for therapeutic delivery |
WO2011146638A1 (en) * | 2010-05-18 | 2011-11-24 | Cerulean Pharma Inc. | Compositions and methods for treatment of autoimmune and other diseases |
JP2014526506A (ja) * | 2011-09-15 | 2014-10-06 | ノバルティス アーゲー | 中等度肝障害患者の癌治療における4−アミノ−5−フルオロ−3−[6−(4−メチルピペラジン−1−イル)−1h−ベンゾイミダゾール−2−イル]−1h−キノリン−2−オンの使用 |
EP2809686A4 (en) * | 2012-01-31 | 2015-11-25 | Cerulean Pharma Inc | POLYMERS ON CYCLODEXTRINBASIS FOR THERAPEUTIC ADMINISTRATION |
EP2812008A4 (en) * | 2012-01-31 | 2015-10-28 | Cerulean Pharma Inc | CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTIC ADMINISTRATION |
CN103242267B (zh) * | 2012-02-03 | 2015-03-18 | 福建南方制药股份有限公司 | 卡巴他赛及其中间体的制备方法及卡巴他赛中间体 |
CN104334172A (zh) * | 2012-02-10 | 2015-02-04 | 安万特医药股份有限公司 | 卡巴利他索(cabazitaxel)之新颖小儿药用途 |
EP2838653A4 (en) | 2012-04-18 | 2015-11-25 | Cerulean Pharma Inc | METHODS AND SYSTEMS FOR POLYMER PRECIPITATION AND PARTICLE GENERATION |
US20150337121A1 (en) * | 2012-06-26 | 2015-11-26 | The Johns Hopkins University | Multifunctional tunable biomaterials for tissue engineering |
WO2014015422A1 (en) * | 2012-07-27 | 2014-01-30 | Ontario Institute For Cancer Research | Cellulose-based nanoparticles for drug delivery |
US9018246B2 (en) | 2012-09-05 | 2015-04-28 | Lp Pharmaceutical (Xiamen) Co., Ltd. | Transmucosal administration of taxanes |
WO2014055493A1 (en) | 2012-10-02 | 2014-04-10 | Cerulean Pharma Inc. | Methods and systems for polymer precipitation and generation of particles |
US20140357557A1 (en) * | 2013-05-31 | 2014-12-04 | Cerulean Pharma Inc. | Cyclodextrin-based polymers for therapeutic delivery |
EP3093014A1 (en) * | 2015-05-13 | 2016-11-16 | Aventis Pharma S.A. | Cabazitaxel and its use for treating cancer |
US10980765B2 (en) * | 2015-08-14 | 2021-04-20 | Board Of Supervisors Of Louisiana State University | Isothiocyanatostilbenes as a novel method and product for treating cancer |
EP3541370A4 (en) * | 2016-11-16 | 2020-09-16 | Aivita Biomedical, Inc. | USE OF SIGNALING FACTORS RELATED TO A CELLULAR MEMBRANE |
WO2019099861A1 (en) | 2017-11-16 | 2019-05-23 | Aivita Biomedical, Inc. | Use of cell membrane-bound signaling factors |
CN111440253B (zh) * | 2019-01-17 | 2021-08-27 | 中国科学院上海药物研究所 | 立方形环糊精骨架-rgd组合物及其制备方法 |
WO2021034335A1 (en) * | 2019-08-16 | 2021-02-25 | Odonate Therapeutics, Inc. | Methods of administering tesetaxel with glucocorticoids that are cyp3a4 inducers |
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-
2010
- 2010-11-23 BR BR112012012210A patent/BR112012012210B8/pt active IP Right Grant
- 2010-11-23 CA CA2781669A patent/CA2781669A1/en not_active Abandoned
- 2010-11-23 EP EP10832380.9A patent/EP2503888A4/en not_active Withdrawn
- 2010-11-23 WO PCT/US2010/057913 patent/WO2011063421A1/en active Application Filing
- 2010-11-23 CN CN2010800528968A patent/CN102781237A/zh active Pending
- 2010-11-23 AU AU2010321533A patent/AU2010321533A1/en not_active Abandoned
- 2010-11-23 EA EA201200617A patent/EA201200617A1/ru unknown
- 2010-11-23 MX MX2012005987A patent/MX2012005987A/es unknown
- 2010-11-23 CN CN201410155387.8A patent/CN104208716A/zh active Pending
- 2010-11-23 JP JP2012540162A patent/JP6220126B2/ja active Active
- 2010-11-23 US US12/953,390 patent/US20110237540A1/en not_active Abandoned
- 2010-11-23 CN CN201710505766.9A patent/CN107261150A/zh active Pending
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2012
- 2012-05-09 IL IL219699A patent/IL219699B/en not_active IP Right Cessation
-
2014
- 2014-11-26 JP JP2014238415A patent/JP2015071624A/ja not_active Withdrawn
-
2016
- 2016-09-23 JP JP2016185276A patent/JP2016216508A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
BR112012012210B1 (pt) | 2021-02-09 |
EP2503888A4 (en) | 2015-07-29 |
CN104208716A (zh) | 2014-12-17 |
CN107261150A (zh) | 2017-10-20 |
MX2012005987A (es) | 2012-06-25 |
JP2016216508A (ja) | 2016-12-22 |
AU2010321533A1 (en) | 2012-05-31 |
CA2781669A1 (en) | 2011-05-26 |
CN102781237A (zh) | 2012-11-14 |
BR112012012210B8 (pt) | 2021-05-25 |
WO2011063421A1 (en) | 2011-05-26 |
EP2503888A1 (en) | 2012-10-03 |
BR112012012210A2 (pt) | 2015-09-08 |
IL219699A0 (en) | 2012-07-31 |
IL219699B (en) | 2018-10-31 |
US20110237540A1 (en) | 2011-09-29 |
JP6220126B2 (ja) | 2017-10-25 |
JP2013511558A (ja) | 2013-04-04 |
JP2015071624A (ja) | 2015-04-16 |
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