EA201190297A1 - Инъецируемые композиции мелфалана, содержащие производное циклодекстрина, и способы их получения и применения - Google Patents
Инъецируемые композиции мелфалана, содержащие производное циклодекстрина, и способы их получения и примененияInfo
- Publication number
- EA201190297A1 EA201190297A1 EA201190297A EA201190297A EA201190297A1 EA 201190297 A1 EA201190297 A1 EA 201190297A1 EA 201190297 A EA201190297 A EA 201190297A EA 201190297 A EA201190297 A EA 201190297A EA 201190297 A1 EA201190297 A1 EA 201190297A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- methods
- melfalan
- receiving
- application
- cyclodextrin derivative
- Prior art date
Links
- SGDBTWWWUNNDEQ-LBPRGKRZSA-N melphalan Chemical group OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-LBPRGKRZSA-N 0.000 title abstract 2
- 229960001924 melphalan Drugs 0.000 title abstract 2
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical class O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
- C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/16—Cyclodextrin; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Polymers & Plastics (AREA)
- Nanotechnology (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Materials Engineering (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
Настоящее изобретение относится к фармацевтическим композициям, содержащим мелфалан и производное циклодекстрина, и к способам получения я применения указанных композиций.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18256009P | 2009-05-29 | 2009-05-29 | |
PCT/US2010/036736 WO2010138920A1 (en) | 2009-05-29 | 2010-05-28 | Injectable melphalan compositions comprising a cyclodextrin derivative and methods of making and using the same |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201190297A1 true EA201190297A1 (ru) | 2013-01-30 |
EA022890B1 EA022890B1 (ru) | 2016-03-31 |
Family
ID=43223125
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201190297A EA022890B1 (ru) | 2009-05-29 | 2010-05-28 | Инъецируемые композиции мелфалана, содержащие производное циклодекстрина, и способы их применения |
Country Status (15)
Country | Link |
---|---|
US (4) | US20100311838A1 (ru) |
EP (1) | EP2434886B1 (ru) |
JP (2) | JP5914328B2 (ru) |
KR (1) | KR101522918B1 (ru) |
CN (2) | CN106389307A (ru) |
AU (1) | AU2010253905B2 (ru) |
BR (1) | BRPI1012301A2 (ru) |
CA (1) | CA2763365C (ru) |
EA (1) | EA022890B1 (ru) |
ES (1) | ES2767880T3 (ru) |
IL (1) | IL216405A (ru) |
MX (2) | MX357677B (ru) |
NZ (1) | NZ596515A (ru) |
PL (1) | PL2434886T3 (ru) |
WO (1) | WO2010138920A1 (ru) |
Families Citing this family (19)
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US7635773B2 (en) | 2008-04-28 | 2009-12-22 | Cydex Pharmaceuticals, Inc. | Sulfoalkyl ether cyclodextrin compositions |
PL2434886T3 (pl) | 2009-05-29 | 2020-05-18 | Cydex Pharmaceuticals, Inc. | Kompozycje do wstrzykiwania melfalanu zawierające pochodną cyklodekstryny i sposoby ich wytwarzania i stosowania |
US11020363B2 (en) | 2009-05-29 | 2021-06-01 | Cydex Pharmaceuticals, Inc. | Injectable nitrogen mustard compositions comprising a cyclodextrin derivative and methods of making and using the same |
DK2814849T3 (da) | 2012-02-15 | 2020-03-09 | Cydex Pharmaceuticals Inc | Fremgangsmåde til fremstilling af cyclodextrin-derivater |
KR20160033795A (ko) | 2012-02-28 | 2016-03-28 | 사이덱스 파마슈티칼스, 인크. | 알킬화된 시클로덱스트린 조성물 및 이의 제조 및 사용 방법 |
JP6557144B2 (ja) | 2012-10-22 | 2019-08-07 | サイデックス・ファーマシューティカルズ・インコーポレイテッド | アルキル化シクロデキストリン組成物ならびにその調製方法および使用方法 |
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WO2017002030A1 (en) * | 2015-06-30 | 2017-01-05 | Leiutis Pharmaceuticals Pvt Ltd | Stable liquid formulations of melphalan |
US20180237377A1 (en) * | 2015-07-29 | 2018-08-23 | Biophore India Pharmaceuticals Pvt. Ltd. | Process for the Synthesis of Melphalan and the Hydrochloride Salt |
WO2017085696A1 (en) * | 2015-11-20 | 2017-05-26 | Leiutis Pharmaceuticals Pvt Ltd | Parenteral formulations of melphalan |
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EP3873502A4 (en) * | 2018-11-01 | 2022-06-29 | Children's Hospital Medical Center | Reduced intensity conditioning with melphalan |
WO2020232368A1 (en) * | 2019-05-16 | 2020-11-19 | Children's Hospital Medical Center | Methods for determining personalized full dose of melphalan in reduced intensity regimen prior to hematopoietic cell transplantation |
US10682326B1 (en) | 2019-06-03 | 2020-06-16 | Shilpa Medicare Limited | Stable melphalan liquid injectable formulations |
WO2021090183A1 (en) * | 2019-11-04 | 2021-05-14 | Intas Pharmaceuticals Ltd. | Liquid melphalan composition |
US11857677B2 (en) * | 2019-12-19 | 2024-01-02 | Rk Pharma Inc. | Ready to use injectable formulations of melphalan and processes for preparation thereof |
JP1661983S (ru) | 2019-12-19 | 2020-06-22 | ||
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- 2010-05-28 BR BRPI1012301A patent/BRPI1012301A2/pt not_active Application Discontinuation
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US10940128B2 (en) | 2021-03-09 |
EP2434886A4 (en) | 2014-01-15 |
BRPI1012301A2 (pt) | 2015-09-22 |
CA2763365C (en) | 2016-09-13 |
KR101522918B1 (ko) | 2015-05-27 |
CA2763365A1 (en) | 2010-12-02 |
CN106389307A (zh) | 2017-02-15 |
US20240156766A1 (en) | 2024-05-16 |
JP5914328B2 (ja) | 2016-05-11 |
MX357677B (es) | 2018-07-19 |
EP2434886B1 (en) | 2019-10-16 |
AU2010253905A1 (en) | 2011-12-08 |
MX2011012640A (es) | 2012-01-12 |
JP6060289B2 (ja) | 2017-01-11 |
AU2010253905B2 (en) | 2014-10-02 |
KR20120041701A (ko) | 2012-05-02 |
ES2767880T3 (es) | 2020-06-18 |
IL216405A (en) | 2017-12-31 |
US20210379000A1 (en) | 2021-12-09 |
EA022890B1 (ru) | 2016-03-31 |
US20140221488A1 (en) | 2014-08-07 |
US20100311838A1 (en) | 2010-12-09 |
PL2434886T3 (pl) | 2020-05-18 |
CN102458114A (zh) | 2012-05-16 |
JP2012528795A (ja) | 2012-11-15 |
WO2010138920A1 (en) | 2010-12-02 |
IL216405A0 (en) | 2012-02-29 |
JP2016117748A (ja) | 2016-06-30 |
MX2018008597A (es) | 2019-07-29 |
NZ596515A (en) | 2014-03-28 |
EP2434886A1 (en) | 2012-04-04 |
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