EA201190210A1 - Ингибиторы связывания киназы с белком - Google Patents

Ингибиторы связывания киназы с белком

Info

Publication number
EA201190210A1
EA201190210A1 EA201190210A EA201190210A EA201190210A1 EA 201190210 A1 EA201190210 A1 EA 201190210A1 EA 201190210 A EA201190210 A EA 201190210A EA 201190210 A EA201190210 A EA 201190210A EA 201190210 A1 EA201190210 A1 EA 201190210A1
Authority
EA
Eurasian Patent Office
Prior art keywords
inhibitors
protein
kinase binding
compounds
predisposed
Prior art date
Application number
EA201190210A
Other languages
English (en)
Inventor
Стивен Н. Хочуалд
Дэвид А. Остров
Уиллиам Г. Кенс
Елена Куренова
Original Assignee
Юниверсити Оф Флорида Ресерч Фаундэйшн, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Юниверсити Оф Флорида Ресерч Фаундэйшн, Инк. filed Critical Юниверсити Оф Флорида Ресерч Фаундэйшн, Инк.
Publication of EA201190210A1 publication Critical patent/EA201190210A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2913—Rod, strand, filament or fiber
    • Y10T428/2933—Coated or with bond, impregnation or core

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Laminated Bodies (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)

Abstract

Изобретение обеспечивает соединения, которые пригодны для лечения субъекта, страдающего от клеточного пролиферативного нарушения (особенно рака) или предрасположенного к нему, и относится к способу определения и применения соединений, фармацевтическим композициям и их наборам.
EA201190210A 2009-03-12 2010-03-12 Ингибиторы связывания киназы с белком EA201190210A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21005309P 2009-03-12 2009-03-12
PCT/US2010/000754 WO2010104598A2 (en) 2009-03-12 2010-03-12 Kinase protein binding inhibitors

Publications (1)

Publication Number Publication Date
EA201190210A1 true EA201190210A1 (ru) 2012-12-28

Family

ID=42728999

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201190210A EA201190210A1 (ru) 2009-03-12 2010-03-12 Ингибиторы связывания киназы с белком

Country Status (10)

Country Link
US (2) US8051947B2 (ru)
EP (1) EP2413938A4 (ru)
JP (1) JP2012520299A (ru)
KR (1) KR20110132446A (ru)
CN (1) CN102427814A (ru)
AU (1) AU2010223058A1 (ru)
BR (1) BRPI1013623A2 (ru)
CA (1) CA2755191A1 (ru)
EA (1) EA201190210A1 (ru)
WO (1) WO2010104598A2 (ru)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2419899B1 (en) * 2009-06-25 2020-06-24 Defence Research And Development Organisation An acoustic energy reflector
WO2012048298A2 (en) 2010-10-08 2012-04-12 Caridianbct, Inc. Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions
CA2747167C (en) * 2011-07-22 2018-07-24 Hitek Urethane Global Ltd. Electrical pedestal
CN105793411B (zh) 2013-11-16 2018-04-17 泰尔茂比司特公司 生物反应器中的细胞扩增
WO2015148704A1 (en) 2014-03-25 2015-10-01 Terumo Bct, Inc. Passive replacement of media
WO2016049421A1 (en) 2014-09-26 2016-03-31 Terumo Bct, Inc. Scheduled feed
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
EP3464565A4 (en) 2016-05-25 2020-01-01 Terumo BCT, Inc. CELL EXPANSION
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
EP3656841A1 (en) 2017-03-31 2020-05-27 Terumo BCT, Inc. Cell expansion
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
US20210137953A1 (en) * 2019-11-12 2021-05-13 Emory University Inhibitors of Mcl-1 and Akt Binding, Pharmaceutical Compositions, and Uses in Treating Cancer
CN111334002B (zh) * 2020-04-26 2022-04-12 湖南翰坤实业有限公司 一种耳塞制作材料及其制备方法

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US684984A (en) 1900-06-26 1901-10-22 John C Graft Dentist's tool.
US3300479A (en) * 1965-08-05 1967-01-24 Upjohn Co Deazapurine riboside cyclic 3', 5'-phosphates and process therefor
US3738979A (en) * 1969-10-23 1973-06-12 Department Health Education We O2,2'-cyclocytidine-3'-phosphate and process for producing same
US4415391A (en) * 1982-04-06 1983-11-15 Reid Glenn J Reinforced molded rubber muffler hanger and method of making of same
JPS62151642A (ja) * 1985-12-25 1987-07-06 Bridgestone Corp マフラ−用防振ゴム
JPS6348321A (ja) * 1986-08-15 1988-03-01 Nippon Steel Corp 制振材料用粘弾性樹脂の製法
JPH0784541B2 (ja) * 1987-08-24 1995-09-13 日本ゼオン株式会社 熱可塑性エラストマ−状組成物
JP2623316B2 (ja) * 1987-10-20 1997-06-25 東洋紡績株式会社 複合型制振材料及び制振材料用粘弾性樹脂組成物
US5262232A (en) * 1992-01-22 1993-11-16 Minnesota Mining And Manufacturing Company Vibration damping constructions using acrylate-containing damping materials
JP3419531B2 (ja) 1994-01-31 2003-06-23 旭化成株式会社 ポリエーテルエステルブロック共重合体
DE69520898T2 (de) * 1994-02-10 2002-03-28 Teijin Ltd Polyestermischung und daraus geformte Relaiskomponente
TW318861B (ru) * 1994-08-16 1997-11-01 Mitsui Toatsu Chemicals
DE10004632A1 (de) * 1999-02-15 2000-08-17 Phoenix Ag Thermoplastisches Vulkanisat und Verfahren zur Herstellung
JP2000327894A (ja) 1999-05-24 2000-11-28 Nof Corp 制振用不飽和ポリエステル樹脂組成物及びその硬化物
EP1212375A2 (en) 1999-06-09 2002-06-12 Carnegie-Mellon University Ph sensitive cyanine dyes as reactive fluorescent reagents
DE19933901A1 (de) * 1999-07-22 2001-02-01 Clariant Gmbh Flammschutzmittel-Kombination
WO2001016231A1 (en) 1999-08-27 2001-03-08 General Electric Company Sound damping polyester molding compositions
AU1894001A (en) * 1999-12-17 2001-06-25 Asahi Kasei Kabushiki Kaisha Molded flame-retardant polycarbonate resin composition
US6362287B1 (en) * 2000-03-27 2002-03-26 Dow Corning Corportion Thermoplastic silicone elastomers formed from nylon resins
JP2002012317A (ja) 2000-06-29 2002-01-15 Sony Miyuujitsuku Entertainment:Kk 搬送物の搬送方法及び搬送装置
US6849684B2 (en) 2000-10-20 2005-02-01 E. I. Du Pont De Nemours And Company Molded soft elastomer/hard polyester composition with noise damping properties
US6569985B2 (en) * 2001-08-08 2003-05-27 General Electric Company Method for making polycarbonate
JP3898584B2 (ja) * 2002-07-03 2007-03-28 ダイセル・デグサ株式会社 樹脂組成物及びそれを用いた複合体とその製造方法
US8013067B2 (en) * 2002-09-30 2011-09-06 E.I. Du Pont De Nemours And Company Curable thermoplastic elastomeric blend, method of manufacture, and use thereof
AU2003283988A1 (en) * 2002-09-30 2004-04-19 E.I. Du Pont De Nemours And Company Curable thermoplastic elastomeric blend, method of manufacture, and use thereof
AU2003277643A1 (en) * 2002-11-25 2004-06-18 Three Bond Co., Ltd. Laminated structural body
WO2004106052A1 (en) 2003-05-29 2004-12-09 E.I. Du Pont De Nemours And Company Housings of layered and bonded polymeric materials suitable for sound dampening and their manufacture
JP4595488B2 (ja) * 2003-12-09 2010-12-08 東海ゴム工業株式会社 防振ゴム組成物
EP1621535A1 (en) * 2004-07-27 2006-02-01 Aventis Pharma S.A. Substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
US20090277716A1 (en) * 2004-08-19 2009-11-12 Rajan Eadara Constrained layer, composite, acoustic damping material
JP4654089B2 (ja) * 2004-12-03 2011-03-16 新日本製鐵株式会社 耐久密着性に優れたクロメートフリー樹脂複合型制振材料
EP1710126B1 (en) * 2005-04-04 2009-04-01 Rieter Technologies AG Sealed thin multi-layer sound absorber
KR100697236B1 (ko) * 2005-08-11 2007-03-22 한국생명공학연구원 오보바톨 또는 오보바탈을 포함하는 항암제 조성물
WO2007026653A1 (ja) 2005-08-29 2007-03-08 Mitsubishi Gas Chemical Company, Inc. 制振材料およびその製造方法
EP2062181A2 (en) * 2006-08-28 2009-05-27 Dan Theodorescu Prediction of an agent's or agents' activity across different cells and tissue types
US20080118576A1 (en) * 2006-08-28 2008-05-22 Dan Theodorescu Prediction of an agent's or agents' activity across different cells and tissue types
US7790790B2 (en) * 2006-11-14 2010-09-07 E. I. Du Pont De Nemours And Company Flame retardant thermoplastic elastomer compositions
EA200901249A1 (ru) * 2007-03-16 2010-04-30 Юниверсити Оф Флорида Ресерч Фаундэйшн, Инк. Ингибиторы связывания протеинкиназ
US8163380B2 (en) * 2007-03-30 2012-04-24 Sika Technology Ag Damping composition with improved bakability
JP2009063122A (ja) * 2007-09-07 2009-03-26 Nitto Denko Corp 制振シート

Also Published As

Publication number Publication date
JP2012520299A (ja) 2012-09-06
EP2413938A2 (en) 2012-02-08
BRPI1013623A2 (pt) 2016-04-19
KR20110132446A (ko) 2011-12-07
WO2010104598A2 (en) 2010-09-16
US20100230203A1 (en) 2010-09-16
US20120107323A1 (en) 2012-05-03
CA2755191A1 (en) 2010-09-16
AU2010223058A1 (en) 2011-10-06
WO2010104598A3 (en) 2011-03-31
EP2413938A4 (en) 2012-12-12
CN102427814A (zh) 2012-04-25
US8051947B2 (en) 2011-11-08

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