EA201001344A1 - Азотсодержащие бициклические соединения, активные при состояниях хронической боли - Google Patents

Азотсодержащие бициклические соединения, активные при состояниях хронической боли

Info

Publication number
EA201001344A1
EA201001344A1 EA201001344A EA201001344A EA201001344A1 EA 201001344 A1 EA201001344 A1 EA 201001344A1 EA 201001344 A EA201001344 A EA 201001344A EA 201001344 A EA201001344 A EA 201001344A EA 201001344 A1 EA201001344 A1 EA 201001344A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
active
conditions
chronic pain
nitrogen
Prior art date
Application number
EA201001344A
Other languages
English (en)
Other versions
EA017737B1 (ru
Inventor
Карла Гелардини
Мариза Мартинелли
Карло Парини
Сильвано Ронцони
Original Assignee
Нойротуне Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Нойротуне Аг filed Critical Нойротуне Аг
Publication of EA201001344A1 publication Critical patent/EA201001344A1/ru
Publication of EA017737B1 publication Critical patent/EA017737B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

Изобретение относится к соединениям общей формулы (I)где группы R независимо представляют собой H, Cалкил, арил, CF; Y представляет собой CH, C=O; X представляет собой химическую связь, C=O, SOили C=N-CN; m равно 0, 1; n равно 0, 1; A представляет собой гетероцикл или фенильную группу, при необходимости замещенные, как описано в спецификации. Соединения являются активными при состояниях хронической боли различного происхождения; их можно вводить сами по себе или с другими лекарствами. Большинство этих соединений являются новыми. Изобретение включает способ получения указанных соединений и фармацевтические композиции, применимые для их введения пациенту.
EA201001344A 2008-02-22 2009-02-17 Азотсодержащие бициклические соединения, активные при состояниях хронической боли EA017737B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08101879.8A EP2098526B1 (en) 2008-02-22 2008-02-22 Nitrogen-containing bicyclic compounds active on chronic pain conditions
PCT/CH2009/000064 WO2009103176A1 (en) 2008-02-22 2009-02-17 Nitrogen-containing bycyclic compounds active on chronic pain conditions

Publications (2)

Publication Number Publication Date
EA201001344A1 true EA201001344A1 (ru) 2011-02-28
EA017737B1 EA017737B1 (ru) 2013-02-28

Family

ID=39472460

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201001344A EA017737B1 (ru) 2008-02-22 2009-02-17 Азотсодержащие бициклические соединения, активные при состояниях хронической боли

Country Status (17)

Country Link
US (1) US8334286B2 (ru)
EP (1) EP2098526B1 (ru)
JP (1) JP5400804B2 (ru)
CN (1) CN101945876B (ru)
AR (1) AR070465A1 (ru)
AU (1) AU2009217201B2 (ru)
BR (1) BRPI0908495A2 (ru)
CA (1) CA2716230C (ru)
CL (1) CL2009000388A1 (ru)
EA (1) EA017737B1 (ru)
ES (1) ES2454366T3 (ru)
IL (1) IL207669A (ru)
MX (1) MX2010009228A (ru)
PE (1) PE20091398A1 (ru)
PL (1) PL2098526T3 (ru)
WO (1) WO2009103176A1 (ru)
ZA (1) ZA201005704B (ru)

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US9125898B2 (en) 2008-11-14 2015-09-08 Neurotune Ag Acetam derivatives for pain relief
EP2665729B1 (en) * 2011-01-19 2015-04-01 Convergence Pharmaceuticals Limited Piperazine derivatives as cav2.2 calcium channel blockers
WO2013049174A1 (en) * 2011-09-29 2013-04-04 Abbvie Inc. Substituted octahydropyrrolo[1,2-a]pyrazine sulfonamides as calcium channel blockers
US8669255B2 (en) 2011-09-29 2014-03-11 Abbvie Inc. Substituted octahydropyrrolo[1,2-a]pyrazines as calcium channel blockers
AU2013359533A1 (en) 2012-12-12 2015-05-28 Abbvie, Inc. Diazepine derivatives useful as calcium channel blockers in the treatment of pain
PT3114128T (pt) 2014-03-07 2019-02-27 Hoffmann La Roche Novas heteroarildihidropirimidinas fundidas em 6 para o tratamento e profilaxia da infeção pelo vírus da hepatite b.
KR20220020412A (ko) 2015-03-16 2022-02-18 에프. 호프만-라 로슈 아게 Tlr7 작용제 및 hbv 캡시드 조립 억제제를 사용하는 병용 치료
BR112019004560A2 (pt) 2016-09-13 2019-07-02 Hoffmann La Roche tratamento combinado com agonista de tlr7 e um inibidor de formação de capsídeo de hbv
JOP20190251A1 (ar) 2017-05-31 2019-10-21 Metys Pharmaceuticals AG تركيبات تآزرية تشتمل على (r)-ديميراسيتام (1) و(s)-ديميراسيتام (2) بنسبة غير راسيمية
JP2022510363A (ja) 2018-12-04 2022-01-26 メティス ファーマシューティカルズ アクチェンゲゼルシャフト （ｒ）－２－（２－オキソピロリジン－１－イル）ブタンアミドと（ｓ）－２－（２－オキソピロリジン－１－イル）ブタンアミドを非ラセミ比で含む相乗的組成物
EP3891150A1 (en) * 2018-12-04 2021-10-13 Metys Pharmaceuticals AG Synergistic compositions comprising-r-2-(substituted-sulfonyl)-hexahydro-pyrrolo[1,2-a]pyrazin-6(2h)-ones and s-2-(substituted-sulfonyl)-hexahydro-pyrrolo[1,2-a]pyrazin-6(2h)-ones in a non-racemic ratio
CN113614088A (zh) 2019-03-25 2021-11-05 豪夫迈·罗氏有限公司 Hbv核心蛋白变构修饰剂化合物的固体形式

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US3225077A (en) 1963-03-05 1965-12-21 American Cyanamid Co N-cyanoimidates and processes for preparing same
JP3058945B2 (ja) * 1990-10-26 2000-07-04 三共株式会社 Ｎ−（３，３−ジ置換アクリロイル）ピペラジン誘導体
US5925648A (en) 1997-07-29 1999-07-20 Schering Corporation Tricyclic N-cyanoimines useful as inhibitors of a farnesyl-protein transferase
EP1118612A1 (en) 2000-01-21 2001-07-25 Universita Degli Studi di Firenze Piperazine derivatives possesing nootropic activity
PE20060241A1 (es) * 2004-05-18 2006-04-01 Schering Corp 2-quinolil-oxazoles sustituidos como inhibidores de pde4
AU2006289281B2 (en) * 2005-09-09 2012-05-17 KaNDy Therapeutics Ltd. Pyridine derivatives and their use in the treatment of psychotic disorders
AR057828A1 (es) * 2005-09-29 2007-12-19 Astrazeneca Ab Compuestos derivados de azetidina, su preparacion y composicion farmaceuutica

Also Published As

Publication number Publication date
CN101945876A (zh) 2011-01-12
ZA201005704B (en) 2013-01-30
JP2011512365A (ja) 2011-04-21
PL2098526T3 (pl) 2014-06-30
AU2009217201A1 (en) 2009-08-27
AU2009217201B2 (en) 2013-06-20
CA2716230C (en) 2016-11-01
CA2716230A1 (en) 2009-08-27
EP2098526B1 (en) 2014-01-15
WO2009103176A1 (en) 2009-08-27
AR070465A1 (es) 2010-04-07
CL2009000388A1 (es) 2010-02-19
PE20091398A1 (es) 2009-10-13
IL207669A0 (en) 2010-12-30
ES2454366T3 (es) 2014-04-10
EP2098526A1 (en) 2009-09-09
IL207669A (en) 2014-08-31
BRPI0908495A2 (pt) 2019-09-24
US8334286B2 (en) 2012-12-18
US20110015200A1 (en) 2011-01-20
EA017737B1 (ru) 2013-02-28
MX2010009228A (es) 2010-11-12
CN101945876B (zh) 2014-04-30
JP5400804B2 (ja) 2014-01-29

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