EA200870555A1 - Слитые белки, их применение и способы их получения - Google Patents
Слитые белки, их применение и способы их полученияInfo
- Publication number
- EA200870555A1 EA200870555A1 EA200870555A EA200870555A EA200870555A1 EA 200870555 A1 EA200870555 A1 EA 200870555A1 EA 200870555 A EA200870555 A EA 200870555A EA 200870555 A EA200870555 A EA 200870555A EA 200870555 A1 EA200870555 A1 EA 200870555A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- proteins
- amino acids
- peptide
- present
- peptide linker
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 4
- 108090000623 proteins and genes Proteins 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 150000001413 amino acids Chemical class 0.000 abstract 3
- 239000012634 fragment Substances 0.000 abstract 3
- 102000037865 fusion proteins Human genes 0.000 abstract 2
- 108020001507 fusion proteins Proteins 0.000 abstract 2
- 102000025850 HLA-A2 Antigen Human genes 0.000 abstract 1
- 108010074032 HLA-A2 Antigen Proteins 0.000 abstract 1
- 102000008949 Histocompatibility Antigens Class I Human genes 0.000 abstract 1
- 108010088652 Histocompatibility Antigens Class I Proteins 0.000 abstract 1
- 241000701024 Human betaherpesvirus 5 Species 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 102000015736 beta 2-Microglobulin Human genes 0.000 abstract 1
- 108010081355 beta 2-Microglobulin Proteins 0.000 abstract 1
- 238000010276 construction Methods 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
Abstract
Настоящее изобретение относится к слитому белку, содержащему последовательные аминокислоты, которые, начиная с аминоконца белка, соответствуют последовательным аминокислотам, присутствующим в (i) пептиде цитомегаловируса человека, рестриктированному по МНС, (ii) первом пептидном линкере, (iii) β-2-микроглобулине человека, (iv) втором пептидном линкере, (v) цепи HLA-A2 молекулы МНС человека класса I, (vi) третьем пептидном линкере, (vii) вариабельной области тяжелой цепи фрагмента scFv антитела и (viii) вариабельной области легкой цепи такого фрагмента scFv, причем последовательные аминокислоты, соответствующие (vii) и (viii), непосредственно связаны друг с другом пептидной связью или с помощью последовательных аминокислот, соответствующих четвертому пептидному линкеру, и антитело, из которого происходит фрагмент scFv, специфически связывается с мезотелином. Настоящее изобретение относится к конструкции нуклеиновых кислот, кодирующих указанные слитые белки, способам продуцирования указанных слитых белов, композиции и применению указанных слитых белов.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80179806P | 2006-05-19 | 2006-05-19 | |
PCT/US2007/011953 WO2007136778A2 (en) | 2006-05-19 | 2007-05-17 | Fusion proteins, uses thereof and processes for producing same |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200870555A1 true EA200870555A1 (ru) | 2009-04-28 |
Family
ID=38723866
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200870555A EA200870555A1 (ru) | 2006-05-19 | 2007-05-17 | Слитые белки, их применение и способы их получения |
Country Status (16)
Country | Link |
---|---|
US (4) | US7977457B2 (ru) |
EP (1) | EP2024507B1 (ru) |
JP (1) | JP5225266B2 (ru) |
KR (1) | KR101442209B1 (ru) |
CN (1) | CN101448951B (ru) |
AU (1) | AU2007254167B2 (ru) |
BR (1) | BRPI0712716A2 (ru) |
CA (1) | CA2652538C (ru) |
EA (1) | EA200870555A1 (ru) |
ES (1) | ES2549128T3 (ru) |
HK (1) | HK1122335A1 (ru) |
IL (1) | IL195191A (ru) |
MX (1) | MX2008014722A (ru) |
NO (1) | NO342211B1 (ru) |
WO (1) | WO2007136778A2 (ru) |
ZA (1) | ZA200810677B (ru) |
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CN109324190A (zh) | 2012-12-11 | 2019-02-12 | 艾伯特叶史瓦大学爱因斯坦医学院 | 高通量受体:配体鉴定方法 |
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US20030017134A1 (en) | 2001-06-19 | 2003-01-23 | Technion Research And Development Foundation Ltd. | Methods and pharmaceutical compositions for immune deception, particularly useful in the treatment of cancer |
US8022190B2 (en) | 2001-06-19 | 2011-09-20 | Technion Research & Development Foundation Ltd. | Immuno-molecules containing viral proteins, compositions thereof and methods of using |
GB0115071D0 (en) | 2001-06-20 | 2001-08-15 | Avidex Ltd | Substances |
US7362707B2 (en) | 2001-07-23 | 2008-04-22 | Acme Packet, Inc. | System and method for determining flow quality statistics for real-time transport protocol data flows |
US6992176B2 (en) * | 2002-02-13 | 2006-01-31 | Technion Research & Development Foundation Ltd. | Antibody having a T-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease |
EP1485075A4 (en) * | 2002-02-20 | 2006-04-26 | Dyax Corp | MHC-PEPTIDE COMPLEX BINDING LIGANDS |
US7632866B2 (en) * | 2002-10-21 | 2009-12-15 | Ramot At Tel Aviv University | Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators |
CN101448951B (zh) | 2006-05-19 | 2013-04-10 | 泰华制药工业有限公司 | 融合蛋白、其用途以及制备方法 |
-
2007
- 2007-05-17 CN CN2007800181965A patent/CN101448951B/zh not_active Expired - Fee Related
- 2007-05-17 EP EP07777164.0A patent/EP2024507B1/en active Active
- 2007-05-17 JP JP2009512056A patent/JP5225266B2/ja not_active Expired - Fee Related
- 2007-05-17 BR BRPI0712716-2A patent/BRPI0712716A2/pt not_active IP Right Cessation
- 2007-05-17 ES ES07777164.0T patent/ES2549128T3/es active Active
- 2007-05-17 KR KR1020087030875A patent/KR101442209B1/ko active IP Right Grant
- 2007-05-17 EA EA200870555A patent/EA200870555A1/ru unknown
- 2007-05-17 WO PCT/US2007/011953 patent/WO2007136778A2/en active Application Filing
- 2007-05-17 US US11/804,541 patent/US7977457B2/en not_active Expired - Fee Related
- 2007-05-17 AU AU2007254167A patent/AU2007254167B2/en not_active Ceased
- 2007-05-17 MX MX2008014722A patent/MX2008014722A/es active IP Right Grant
- 2007-05-17 CA CA2652538A patent/CA2652538C/en not_active Expired - Fee Related
- 2007-05-17 ZA ZA200810677A patent/ZA200810677B/xx unknown
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2008
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- 2008-12-16 NO NO20085272A patent/NO342211B1/no not_active IP Right Cessation
-
2009
- 2009-03-20 HK HK09102717.9A patent/HK1122335A1/xx not_active IP Right Cessation
-
2010
- 2010-12-20 US US12/972,560 patent/US20110150874A1/en not_active Abandoned
-
2014
- 2014-10-29 US US14/526,667 patent/US20150152161A1/en not_active Abandoned
-
2017
- 2017-04-06 US US15/480,462 patent/US20170211076A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20080014208A1 (en) | 2008-01-17 |
KR20090048397A (ko) | 2009-05-13 |
EP2024507A4 (en) | 2009-09-23 |
MX2008014722A (es) | 2011-04-15 |
NO20085272L (no) | 2009-02-18 |
IL195191A0 (en) | 2009-08-03 |
CA2652538C (en) | 2016-06-28 |
IL195191A (en) | 2017-01-31 |
ES2549128T3 (es) | 2015-10-23 |
US20150152161A1 (en) | 2015-06-04 |
KR101442209B1 (ko) | 2014-11-18 |
NO342211B1 (no) | 2018-04-16 |
JP5225266B2 (ja) | 2013-07-03 |
JP2009537175A (ja) | 2009-10-29 |
US20110150874A1 (en) | 2011-06-23 |
BRPI0712716A2 (pt) | 2012-05-22 |
WO2007136778A3 (en) | 2008-03-27 |
CN101448951A (zh) | 2009-06-03 |
US7977457B2 (en) | 2011-07-12 |
AU2007254167A1 (en) | 2007-11-29 |
HK1122335A1 (en) | 2009-05-15 |
ZA200810677B (en) | 2010-03-31 |
EP2024507B1 (en) | 2015-07-22 |
US20170211076A1 (en) | 2017-07-27 |
CA2652538A1 (en) | 2007-11-29 |
WO2007136778A2 (en) | 2007-11-29 |
CN101448951B (zh) | 2013-04-10 |
EP2024507A2 (en) | 2009-02-18 |
AU2007254167B2 (en) | 2012-11-15 |
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